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Letter to the Editor
Eosinophilic Pneumonia: Autoinmune or Immunoallergic Phenomenon?
Neumonía eosinofílica, ¿fenómeno autoinmune o inmunoalérgico?
Jorge Jaimes-Hernández
División de Medicina Interna, Servicio de Reumatología, Centro Médico ISSEMYM, Toluca, Estado de México, Mexico
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">I read with interest the clinical case reported by Hiroaki Satoh et al&#46; and&#44; as is known&#44; chronic eosinophilic pneumonia &#40;CEN&#41; is a rare condition with distinctive presenting features&#44; which are&#58; the presence of cough&#44; dyspnea&#44; fever and pulmonary infiltrates with the presence of inflammatory cells&#44; and eosinophil accumulation&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In this case-report&#44; it is associated with both the presence of antinuclear antibodies&#44; such as anti-centromere antibodies&#44; which show a clear non-specific autoimmune response&#44; even knowing that the centromere antibodies related to certain conditions &#40;scleroderma&#41; have not been demonstrated to have a pathogenic role&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">As we have reported previously&#44; it is unknown if the phenomenon of autoimmunity is involved in CEN as a part of itself or as a serological demonstration of overlap due to the nonspecific immune response of the host&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Hypersensitivity responses include autoimmune diseases&#44; directed toward self antigens&#46; Not only Type I hypersensitivity&#44; but also III and IV may be present in CEN&#44; conditioning different signals of an inflammatory process as allergic or autoimmune phenomena&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">It has recently been described that the eosinophil can act as an antigen presenting cell&#46; When presenting antigens&#44; eosinophils provide costimulation signals to lymphocytes&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The surface membrane glycoprotein CD40 interacts with its ligand CD40-CD40L and in vivo studies have demonstrated activation and proliferation of eosinophils and mast cells associated with a Th2 cell response&#44; suggesting that eosinophils can actively modulate the immune response with amplification of Th2&#44; so perhaps this would be the link in relation to the autoimmune response associated with the role of the eosinophil&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Meanwhile&#44; research into this field goes on and for the time being we get to add one more case to those reported around the world&#44; revealing that we still have a poor understanding of immunopathology in these interesting diseases&#46;</p></span>"
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Article information
ISSN: 21735743
Original language: English
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Idiomas
Reumatología Clínica (English Edition)
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¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?