Editorial
Osteoarthritis: Something is moving
Artritis: algo se mueve
Francisco J. Blanco
Servicio de Reumatología, INIBIC-Hospital Universitario A Coruña, Spain
Read
4387
Timeswas read the article
1874
Total PDF
2513
Total HTML
Share statistics
array:24 [ "pii" => "S2173574314000197" "issn" => "21735743" "doi" => "10.1016/j.reumae.2014.01.002" "estado" => "S300" "fechaPublicacion" => "2014-01-01" "aid" => "632" "copyright" => "Elsevier España, S.L.. All rights reserved" "copyrightAnyo" => "2013" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2014;10:4-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1728 "formatos" => array:3 [ "EPUB" => 49 "HTML" => 1231 "PDF" => 448 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S1699258X13002283" "issn" => "1699258X" "doi" => "10.1016/j.reuma.2013.12.001" "estado" => "S300" "fechaPublicacion" => "2014-01-01" "aid" => "632" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2014;10:4-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3629 "formatos" => array:3 [ "EPUB" => 137 "HTML" => 2410 "PDF" => 1082 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Osteoarthritis: Something is moving" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "5" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Artrosis: algo se mueve" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco J. Blanco" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Francisco J." "apellidos" => "Blanco" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574314000197" "doi" => "10.1016/j.reumae.2014.01.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574314000197?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13002283?idApp=UINPBA00004M" "url" => "/1699258X/0000001000000001/v2_201402140038/S1699258X13002283/v2_201402140038/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173574313001263" "issn" => "21735743" "doi" => "10.1016/j.reumae.2013.11.001" "estado" => "S300" "fechaPublicacion" => "2014-01-01" "aid" => "566" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Reumatol Clin. 2014;10:6-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2751 "formatos" => array:3 [ "EPUB" => 55 "HTML" => 2175 "PDF" => 521 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Ultrasound in Rheumatology: Where Are We and Where Are We Going?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "6" "paginaFinal" => "9" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La ecografía en reumatología: dónde estamos y hacia dónde nos dirigimos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Eugenio de Miguel, José Luis Andreu, Esperanza Naredo, Ingrid Möller" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Eugenio" "apellidos" => "de Miguel" ] 1 => array:2 [ "nombre" => "José Luis" "apellidos" => "Andreu" ] 2 => array:2 [ "nombre" => "Esperanza" "apellidos" => "Naredo" ] 3 => array:2 [ "nombre" => "Ingrid" "apellidos" => "Möller" ] 4 => array:1 [ "colaborador" => "Grupo de Trabajo de Ecografía de la Sociedad Española de Reumatología (ECOSER)" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X13000983" "doi" => "10.1016/j.reuma.2013.04.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13000983?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574313001263?idApp=UINPBA00004M" "url" => "/21735743/0000001000000001/v2_201402090008/S2173574313001263/v2_201402090008/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173574314000173" "issn" => "21735743" "doi" => "10.1016/j.reumae.2013.12.024" "estado" => "S300" "fechaPublicacion" => "2014-01-01" "aid" => "634" "copyright" => "Elsevier España, S.L." "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2014;10:2-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2077 "formatos" => array:3 [ "EPUB" => 41 "HTML" => 1450 "PDF" => 586 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Editorial" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "2" "paginaFinal" => "3" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X13002428" "doi" => "10.1016/j.reuma.2013.12.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X13002428?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574314000173?idApp=UINPBA00004M" "url" => "/21735743/0000001000000001/v2_201402090008/S2173574314000173/v2_201402090008/en/main.assets" ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Editorial</span>" "titulo" => "Osteoarthritis: Something is moving" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "4" "paginaFinal" => "5" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Francisco J. Blanco" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Francisco J." "apellidos" => "Blanco" "email" => array:1 [ 0 => "fblagar@sergas.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Reumatología, INIBIC-Hospital Universitario A Coruña, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Artritis: algo se mueve" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Osteoarthritis (OA) is the most common rheumatic pathology and classically is associated with ageing. Prevalence studies demonstrate that most individuals above 65 years present evidence of this pathology, giving an idea of its enormous social impact. Global estimates are that 9.6% of men and 18.0% of women over 60 have symptomatic OA. OA is the first cause of permanent job incapacity; it is one of the most frequent causes of incapacity in the elderly, and also one of the most common reasons for primary care visits. Between 2002 and 2007, OA moved from the twelfth to the sixth leading cause of years lost by disability or morbidity (World Health Organization (WHO) data). US studies confirm that OA is responsible of 4 million hospitalizations and the loss of 68 million labour days per year. Given the current rate/tempo of population ageing, it is estimated that the number of people who suffer from this disease will double in the next three decades. Moreover, they estimate the costs of an OA patient (drugs, medical visits, radiographies, etc.) at around 2000<span class="elsevierStyleHsp" style=""></span>dollars/year.</p><p id="par0010" class="elsevierStylePara elsevierViewall">However, although the social, economic and health impact of OA is very high, therapies are symptomatic and pursue only pain alleviation, but have no effect on slowing down the progression of the disease. At least three causes could explain the actual limitation of treating the OA progression. One is the classical OA definition. Although OA has a multifactorial aetiology, for a long time it has been primarily associated with the breakdown of cartilage in joints. A classical definition of OA is referred as a degenerative joint disease involving cartilage degradation, synovial inflammation and subchondral bone sclerosis. Nevertheless, according to our actual knowledge any definition of OA must include degradation of the articular cartilage, thickening of the subchondral bone, osteophyte formation, variable degrees of synovial inflammation, degeneration of ligaments and, in the knee, the menisci, and hypertrophy of the joint capsule. There can also be changes in periarticular muscles, nerves, bursa, and local fat pads that may contribute to OA or the symptoms of OA. The findings of pathological changes in all of the joint tissues are the impetus for considering OA as a disease of the joint as an organ, resulting in an organic dysfunction or joint failure.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Another explanation is regarding the diagnostic criteria of OA. Currently, the diagnosis of OA relies on the description of pain symptoms, stiffness in the affected joints, and radiography, used as the reference technique for determining the grade of joint destruction. Nevertheless, X-ray offers only indirect information about the state of the cartilage, such as narrowing of the joint space or the appearance of bony spurs (osteophytes). Moreover, this procedure lacks sensitivity in detection of slight changes in the joint, making it necessary to wait for several years in order to obtain feasible information about the progression of the disease. Thus, efficient strategies in detecting early phases of OA are essential for the development of new OA modifying therapies and for the evaluation of therapeutic answers. These include the standardization of imaging techniques (magnetic resonance imaging (MRI) and ultra-sound (US)) and the identification of early biomarkers and molecular players of OA. Both MRI and US are more sensitive than radiography in detection of cartilage degradation, sinovitis, subchondral bone modifications and any damaged tissue in the joint. In the past few years, new approaches in OA research such as genomic, proteomic and metabolomic technologies are increasing the number of potential molecular biomarkers for the diagnosis and prognosis of OA.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Some of these biomarkers (after clinical qualification) in combination with the OA risk factors such as ageing, heredity, obesity, and mechanical influences, including joint injury or joint overuse could be parameters to define an index to predict the risk of developing OA similar to the cardiovascular index or FRAX. All of these new approaches must help us with diagnosis of early OA (symptomatic and asymptomatic OA), and early diagnosis will permit earlier treatment to modify the course of this disease.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Finally, OA has been considered and it has been treated as a unique disease, without taking into account the different OA phenotypes. Given our current understanding of OA pathogenesis this concept must change. OA is emerging as a disease that has a variety of phenotypes including metabolic, age-related, inflammatory, hormonal and injury-related phenotypes. In addition, although in some cases the patients present a clear phenotype,<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> in some patients the phenotype is overlapped. From all phenotypes the metabolic phenotype is demonstrating high interest among the scientific community. Evidence from both epidemiological and biological studies support the concept of metabolic OA, defined as a broad clinical phenotype that includes obesity-related OA. Interestingly, studies have demonstrated associations linking OA to several components of the metabolic syndrome, such as hypertension and type 2 diabetes, independently from obesity or any of the other known risk factors for OA. Thus, it is clear that if we want to improve the health of patients with OA, we must treat each OA phenotype with an appropriate therapy.</p><p id="par0025" class="elsevierStylePara elsevierViewall">In conclusion, OA is a prevalent, disabling disease, involving an organ (the joint), resulting in an organic dysfunction or joint failure that currently lacks disease-modifying treatments. The ability to detect early OA as well as to characterize the OA phenotypes are crucial for understanding the disease process, identifying potential disease-modifying treatments, and evaluating the effectiveness of new therapies.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Osteoarthritis: a disease of the joint as an organ" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.F. Loeser" 1 => "S.R. Goldring" 2 => "C.R. Scanzello" 3 => "M.B. Goldring" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.34453" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2012" "volumen" => "64" "paginaInicial" => "1697" "paginaFinal" => "1707" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22392533" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proteomics role in the search for improved diagnosis, prognosis and treatment of osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Ruiz-Romero" 1 => "F.J. Blanco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.joca.2009.11.012" "Revista" => array:6 [ "tituloSerie" => "Osteoarthritis Cartilage" "fecha" => "2010" "volumen" => "18" "paginaInicial" => "500" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20060947" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolic syndrome meets osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Q. Zhuo" 1 => "W. Yang" 2 => "J. Chen" 3 => "Y. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrrheum.2012.135" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Rheumatol" "fecha" => "2012" "volumen" => "8" "paginaInicial" => "729" "paginaFinal" => "737" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22907293" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Osteoarthritis: metabolomic characterization of metabolic phenotypes in OA" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.J. Blanco" 1 => "C. Ruiz-Romero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrrheum.2012.11" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Rheumatol" "fecha" => "2012" "volumen" => "8" "paginaInicial" => "130" "paginaFinal" => "132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22310187" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000001000000001/v2_201402090008/S2173574314000197/v2_201402090008/en/main.assets" "Apartado" => array:4 [ "identificador" => "17335" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Editorial" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001000000001/v2_201402090008/S2173574314000197/v2_201402090008/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574314000197?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 11 | 19 |
| 2024 October | 20 | 19 | 39 |
| 2024 September | 23 | 11 | 34 |
| 2024 August | 42 | 29 | 71 |
| 2024 July | 36 | 25 | 61 |
| 2024 June | 33 | 23 | 56 |
| 2024 May | 37 | 24 | 61 |
| 2024 April | 27 | 21 | 48 |
| 2024 March | 31 | 23 | 54 |
| 2024 February | 26 | 20 | 46 |
| 2024 January | 16 | 18 | 34 |
| 2023 December | 15 | 19 | 34 |
| 2023 November | 23 | 21 | 44 |
| 2023 October | 14 | 31 | 45 |
| 2023 September | 48 | 33 | 81 |
| 2023 August | 26 | 11 | 37 |
| 2023 July | 21 | 27 | 48 |
| 2023 June | 32 | 24 | 56 |
| 2023 May | 27 | 19 | 46 |
| 2023 April | 16 | 9 | 25 |
| 2023 March | 21 | 28 | 49 |
| 2023 February | 18 | 18 | 36 |
| 2023 January | 13 | 26 | 39 |
| 2022 December | 22 | 31 | 53 |
| 2022 November | 30 | 31 | 61 |
| 2022 October | 21 | 32 | 53 |
| 2022 September | 24 | 36 | 60 |
| 2022 August | 25 | 34 | 59 |
| 2022 July | 24 | 40 | 64 |
| 2022 June | 25 | 28 | 53 |
| 2022 May | 22 | 37 | 59 |
| 2022 April | 30 | 46 | 76 |
| 2022 March | 27 | 42 | 69 |
| 2022 February | 19 | 33 | 52 |
| 2022 January | 27 | 29 | 56 |
| 2021 December | 16 | 38 | 54 |
| 2021 November | 23 | 37 | 60 |
| 2021 October | 34 | 36 | 70 |
| 2021 September | 23 | 38 | 61 |
| 2021 August | 23 | 32 | 55 |
| 2021 July | 21 | 26 | 47 |
| 2021 June | 22 | 27 | 49 |
| 2021 May | 20 | 19 | 39 |
| 2021 April | 19 | 61 | 80 |
| 2021 March | 24 | 22 | 46 |
| 2021 February | 26 | 19 | 45 |
| 2021 January | 17 | 22 | 39 |
| 2020 December | 19 | 18 | 37 |
| 2020 November | 16 | 13 | 29 |
| 2020 October | 12 | 18 | 30 |
| 2020 September | 24 | 18 | 42 |
| 2020 August | 11 | 19 | 30 |
| 2020 July | 2 | 7 | 9 |
| 2020 June | 18 | 18 | 36 |
| 2020 May | 15 | 9 | 24 |
| 2020 April | 17 | 17 | 34 |
| 2020 March | 11 | 3 | 14 |
| 2018 September | 0 | 1 | 1 |
| 2018 June | 0 | 1 | 1 |
| 2018 May | 8 | 2 | 10 |
| 2018 April | 37 | 10 | 47 |
| 2018 March | 57 | 11 | 68 |
| 2018 February | 21 | 3 | 24 |
| 2018 January | 18 | 9 | 27 |
| 2017 December | 22 | 8 | 30 |
| 2017 November | 32 | 14 | 46 |
| 2017 October | 25 | 15 | 40 |
| 2017 September | 24 | 11 | 35 |
| 2017 August | 42 | 11 | 53 |
| 2017 July | 34 | 20 | 54 |
| 2017 June | 50 | 17 | 67 |
| 2017 May | 49 | 15 | 64 |
| 2017 April | 29 | 4 | 33 |
| 2017 March | 30 | 9 | 39 |
| 2017 February | 25 | 6 | 31 |
| 2017 January | 30 | 8 | 38 |
| 2016 December | 55 | 14 | 69 |
| 2016 November | 40 | 8 | 48 |
| 2016 October | 38 | 14 | 52 |
| 2016 September | 44 | 5 | 49 |
| 2016 August | 42 | 8 | 50 |
| 2016 July | 18 | 2 | 20 |
| 2016 June | 0 | 13 | 13 |
| 2016 April | 1 | 0 | 1 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 2 | 0 | 2 |
| 2015 August | 2 | 0 | 2 |
| 2015 July | 7 | 6 | 13 |
| 2015 June | 22 | 6 | 28 |
| 2015 May | 36 | 13 | 49 |
| 2015 April | 18 | 7 | 25 |
| 2015 March | 36 | 9 | 45 |
| 2015 February | 17 | 7 | 24 |
| 2015 January | 12 | 8 | 20 |
| 2014 December | 20 | 7 | 27 |
| 2014 November | 18 | 6 | 24 |
| 2014 October | 20 | 10 | 30 |
| 2014 September | 16 | 11 | 27 |
| 2014 August | 16 | 9 | 25 |
| 2014 July | 24 | 14 | 38 |
| 2014 June | 33 | 13 | 46 |
| 2014 May | 32 | 20 | 52 |
| 2014 April | 34 | 16 | 50 |
| 2014 March | 52 | 29 | 81 |
| 2014 February | 40 | 18 | 58 |
Show all
