array:24 [
  "pii" => "S2173574315001215"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2015.03.015"
  "estado" => "S300"
  "fechaPublicacion" => "2015-11-01"
  "aid" => "771"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2015;11:403-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 965
    "formatos" => array:3 [
      "EPUB" => 49
      "HTML" => 735
      "PDF" => 181
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X15000510"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2015.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2015-11-01"
      "aid" => "771"
      "copyright" => "Elsevier España, S.L.U. y Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2015;11:403-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 9905
        "formatos" => array:3 [
          "EPUB" => 155
          "HTML" => 8592
          "PDF" => 1158
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Displasia fibrosa poliost&#243;tica&#46; Datos importantes que el reumat&#243;logo debe conocer"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "403"
            "paginaFinal" => "404"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Polyostotic fibrous dysplasia&#46; Important facts that the rheumatologist should know"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ana Isabel Turri&#243;n Nieves, Rafael Mart&#237;n Holguera, Mar&#237;a Liz Romero Bogado, Ana Isabel S&#225;nchez-Atrio"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Ana Isabel"
                "apellidos" => "Turri&#243;n Nieves"
              ]
              1 => array:2 [
                "nombre" => "Rafael"
                "apellidos" => "Mart&#237;n Holguera"
              ]
              2 => array:2 [
                "nombre" => "Mar&#237;a Liz"
                "apellidos" => "Romero Bogado"
              ]
              3 => array:2 [
                "nombre" => "Ana Isabel"
                "apellidos" => "S&#225;nchez-Atrio"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574315001215"
          "doi" => "10.1016/j.reumae.2015.03.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001215?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000510?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001100000006/v1_201512090140/S1699258X15000510/v1_201512090140/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574315001057"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2015.09.006"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "775"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2015;11:404-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 924
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 615
        "PDF" => 260
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Amyloid Goiter as an Initial Manifestation of Systemic Amyloidosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "404"
          "paginaFinal" => "405"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Bocio amiloide como manifestaci&#243;n inicial en amiloidosis sist&#233;mica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 747
              "Ancho" => 995
              "Tamanyo" => 352051
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Amyloid depositions showing the characteristic Congo red staining&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; del Carmen Cabrejas G&#243;mez, Natalia Gonz&#225;lez Cabrera, Carlos G&#243;mez Gonz&#225;lez, Sorkunde Bergara Elorza"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46; del Carmen"
              "apellidos" => "Cabrejas G&#243;mez"
            ]
            1 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Gonz&#225;lez Cabrera"
            ]
            2 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "G&#243;mez Gonz&#225;lez"
            ]
            3 => array:2 [
              "nombre" => "Sorkunde"
              "apellidos" => "Bergara Elorza"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X15000558"
        "doi" => "10.1016/j.reuma.2015.03.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000558?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001057?idApp=UINPBA00004M"
    "url" => "/21735743/0000001100000006/v1_201512160151/S2173574315001057/v1_201512160151/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574315001033"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2015.09.004"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "764"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2015;11:401-2"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1005
      "formatos" => array:3 [
        "EPUB" => 56
        "HTML" => 718
        "PDF" => 231
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
      "titulo" => "Periarticular Nodules&#44; Arthritis and Chronic Nephropathy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "401"
          "paginaFinal" => "402"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "N&#243;dulos periarticulares&#44; artritis y nefropat&#237;a cr&#243;nica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1531
              "Ancho" => 2149
              "Tamanyo" => 410740
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Physical examination of both hands&#46; &#40;A&#41; Tophi in interphalangeal and metacarpophalangeal joints&#46; &#40;B&#41; Plain radiography of both hands&#46; Tophi and signs of arthrosis in interphalangeal joints&#46; Pathology specimen of a tophus stained with hematoxylin and eosin at magnifications of 60&#215; and 10&#215;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fernando Macaya, Alejandro Adrover, Isaac D&#237;az"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Macaya"
            ]
            1 => array:2 [
              "nombre" => "Alejandro"
              "apellidos" => "Adrover"
            ]
            2 => array:2 [
              "nombre" => "Isaac"
              "apellidos" => "D&#237;az"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X15000285"
        "doi" => "10.1016/j.reuma.2015.02.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000285?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001033?idApp=UINPBA00004M"
    "url" => "/21735743/0000001100000006/v1_201512160151/S2173574315001033/v1_201512160151/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Polyostotic fibrous dysplasia&#46; Important facts that the rheumatologist should know"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "403"
        "paginaFinal" => "404"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ana Isabel Turri&#243;n Nieves, Rafael Mart&#237;n Holguera, Mar&#237;a Liz Romero Bogado, Ana Isabel S&#225;nchez-Atrio"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Ana Isabel"
            "apellidos" => "Turri&#243;n Nieves"
            "email" => array:1 [
              0 => "anaturrion&#64;hotmail&#46;com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Rafael"
            "apellidos" => "Mart&#237;n Holguera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mar&#237;a Liz"
            "apellidos" => "Romero Bogado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ana Isabel"
            "apellidos" => "S&#225;nchez-Atrio"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de ESI-Reumatolog&#237;a&#44; Hospital Universitario Pr&#237;ncipe de Asturias&#44; Departamento de Medicina especialidades m&#233;dicas&#44; Alcal&#225; de Henares&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Cirug&#237;a y Ciencias M&#233;dico Sociales&#44; Unidad docente de Anatom&#237;a y Embriolog&#237;a Humanas&#44; Universidad de Alcal&#225; de Henares&#44; Alcal&#225; de Henares&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Displasia fibrosa poliost&#243;tica&#46; Datos importantes que el reumat&#243;logo debe conocer"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Fibrous dysplasia is a monostotic or polyostotic bone growth disorder caused by mosaicism involving the mesenchymal tissue&#46; The presenting signs include pain and spontaneous fractures&#46; Last year&#44; Meneses et al&#46; described a case in this journal<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and&#44; in this letter&#44; we report another&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A year ago&#44; a 36-year-old man was referred to us with pain and a significant increase in his alkaline phosphatase levels&#58; 658<span class="elsevierStyleHsp" style=""></span>U&#47;l &#40;normal range&#58; 40&#8211;130&#41;&#46; He had never been examined by a rheumatologist&#44; despite the fact that he had been diagnosed as having polyostotic fibrous dysplasia at the age of 5 years&#46; He had undergone cranioplasty twice for cranial volume reduction and decompression surgery on another 2 occasions to relieve pressure on the left optic nerve&#46; He had had a clavicular fracture and&#44; shortly before our first encounter&#44; fracture of left femur&#44; without previous trauma&#44; but with the fracture line over preexisting osseous cystic lesions&#46; The examination revealed a head circumference of 67<span class="elsevierStyleHsp" style=""></span>cm&#44; hypertelorism and thoracolumbar scoliosis&#44; with a lump in left costal region that was painful on palpation&#46; Moreover&#44; he presented with right-sided coxa vara and leg length discrepancy&#46; The patient was treated with pamidronate &#40;180<span class="elsevierStyleHsp" style=""></span>mg&#47;iv every 6 months&#41;&#44; which relieved his symptoms and reduced his alkaline phosphatase level by over 20&#37; to 390 U&#47;l&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This disease is caused by a point mutation &#40;activation of the <span class="elsevierStyleItalic">GNAS1</span> gene&#41; in part of the bone tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> It is characterized by the coexistence of cells having the genetic alteration and normal cells &#40;mosaicism&#41;&#46; This mutation induces an expansion of osteoprogenitor cells and their accumulation in the bone marrow spaces&#44; provoking localized hematopoietic tissue loss and bone marrow fibrosis&#46; The collagen shows changes in orientation and biochemical composition&#46; Markers of bone remodeling may be elevated&#44; as occurred in our patient&#46; It is usually asymptomatic and the diagnosis is incidental&#44; although there may be pain&#44; swelling&#44; deformity and&#47;or neurological involvement&#46; Seventy percent of the cases are diagnosed before the age of 30 years&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> The dysplastic tissue is highly vascularized&#44; and is prone to spontaneous bleeding with subsequent cyst formation&#46; The bones widen and the cortical bone thins&#44; and spontaneous fractures can occur as a complication when the condition affects weight-bearing long bones&#46; The presence of intralesional cystic lesions measuring over 2&#46;5<span class="elsevierStyleHsp" style=""></span>cm in diameter increases the risk&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It can affect several adjoining cranial bones&#44; obliterating the sutures&#44; compress cranial nerve pairs at their exit or affect structures of the middle ear&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The changes observed in plain radiography are variable&#44; depending on the proportion of osseous and fibrous components of the lesion and on its location&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment depends on the presenting signs&#44; and ranges from a wait and see attitude&#44; curettage of the lesions&#44; correction of the deformities and nerve decompression&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> to treatment with bisphosphonates in polyostotic forms with active bone remodeling markers&#46; In the monostotic forms&#44; complete ablation of the lesion prevents recurrence&#46; The rate of recurrences after curettage and grafting is high&#44; especially in children&#46; Thus&#44; its use on a routine basis is not recommended&#44; and it is reserved for the decompression of nerve structures&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">To this day&#44; there is no curative treatment for this disease&#46; Uncontrolled studies have demonstrated the utility of pamidronate&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> which improves even the radiological changes and the physical aspect of the patient&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> basically when the facial skeleton is affected&#46; The use of bisphosphonates has been shown to reduce the painful symptoms&#44; with a decrease in remodeling markers and an increase in bone mineral density&#44; and even results in the filling of cysts and cortex thickening&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In another study&#44; a reduced incidence of fractures was observed&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">A pediatric patient treated with denosumab because of the inefficacy of the bisphosphonates developed severe secondary effects&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Chemotherapy and radiotherapy are not effective&#44; and the latter can facilitate fractures and predispose the patient&#44; albeit rarely &#40;0&#46;4&#37;&#41;&#44; to malignant transformation&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">We consider notable the delay in the referral of this patient to our department&#44; despite the elevation of his alkaline phosphatase levels and his pain&#44; a circumstance that suggests a lack of knowledge of the possibility of using beneficial drug therapies&#46; The physicians who may at some time treat these patients should be aware of the risk of secondary fractures in weight-bearing bones when cystic lesions greater than 2&#46;5<span class="elsevierStyleHsp" style=""></span>cm in diameter are observed&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Turri&#243;n Nieves AI&#44; Mart&#237;n Holguera R&#44; Romero Bogado ML&#44; S&#225;nchez-Atrio AI&#46; Displasia fibrosa poliost&#243;tica&#46; Datos importantes que el reumat&#243;logo debe conocer&#46; Reumatol Clin&#46; 2015&#59;11&#58;403&#8211;404&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Displasia fibrosa poliost&#243;tica&#58; presentaci&#243;n de un caso"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;F&#46; Meneses"
                            1 => "A&#46; Eg&#252;es"
                            2 => "M&#46; Uriarte"
                            3 => "BelzuneguiJ&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2014.06.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2014"
                        "volumen" => "10"
                        "paginaInicial" => "413"
                        "paginaFinal" => "415"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25047420"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations of the GNAS1 gene&#44; stromal cell dysfunction&#44; and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Bianco"
                            1 => "M&#46; Riminucci"
                            2 => "A&#46; Majolagbe"
                            3 => "S&#46;A&#46; Kuznetsov"
                            4 => "M&#46;T&#46; Collins"
                            5 => "M&#46;H&#46; Mankani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1359/jbmr.2000.15.1.120"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2000"
                        "volumen" => "15"
                        "paginaInicial" => "120"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10646121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrous dysplasia of bone in a young male"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Alonso"
                            1 => "M&#46; Munoz-Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1575-0922(09)70984-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Nutr"
                        "fecha" => "2009"
                        "volumen" => "56"
                        "paginaInicial" => "195"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19627736"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrous dysplasia&#46; Pathophysiology&#44; evaluation&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;R&#46; DiCaprio"
                            1 => "W&#46;F&#46; Enneking"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2106/JBJS.D.02942"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Joint Surg Am"
                        "fecha" => "2005"
                        "volumen" => "87"
                        "paginaInicial" => "1848"
                        "paginaFinal" => "1864"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16085630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history and treatment of fibrous dysplasia of bone&#58; a multicenter clinicopathologic study promoted by the European Pediatric Orthopaedic Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Ippolito"
                            1 => "E&#46;W&#46; Bray"
                            2 => "A&#46; Corsi"
                            3 => "F&#46; de Maio"
                            4 => "U&#46;G&#46; Exner"
                            5 => "P&#46;G&#46; Robey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.bpb.0000064021.41829.94"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Orthop B"
                        "fecha" => "2003"
                        "volumen" => "12"
                        "paginaInicial" => "155"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12703030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term effects of intravenous pamidronate in fibrous dysplasia of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Chapurlat"
                            1 => "P&#46;D&#46; Delmas"
                            2 => "D&#46; Liens"
                            3 => "P&#46;J&#46; Meunier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1359/jbmr.1997.12.10.1746"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "1997"
                        "volumen" => "12"
                        "paginaInicial" => "1746"
                        "paginaFinal" => "1752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9333137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of monostotic fibrous dysplasia with pamidronate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Kos"
                            1 => "K&#46; Luczak"
                            2 => "J&#46; Godzinski"
                            3 => "J&#46; Klempous"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Craniomaxillofac Surg"
                        "fecha" => "2004"
                        "volumen" => "32"
                        "paginaInicial" => "10"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14729043"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of fibrous dysplasia of bone with intravenous pamidronate&#58; long-term effectiveness and evaluation of predictors of response to treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Chapurlat"
                            1 => "P&#46; Hugueny"
                            2 => "P&#46;D&#46; Delmas"
                            3 => "P&#46;J&#46; Meunier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2004.03.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2004"
                        "volumen" => "35"
                        "paginaInicial" => "235"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15207763"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bisphosphonate treatment of bone fibrous dysplasia in McCune-Albright syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Lala"
                            1 => "P&#46; Matarazzo"
                            2 => "M&#46; Andreo"
                            3 => "D&#46; Marzari"
                            4 => "J&#46; Bellone"
                            5 => "A&#46; Corrias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Endocrinol Metab"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "583"
                        "paginaFinal" => "593"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16789621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Denosumab treatment for fibrous dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Boyce"
                            1 => "W&#46;H&#46; Chong"
                            2 => "J&#46; Yao"
                            3 => "R&#46;I&#46; Gafni"
                            4 => "M&#46;H&#46; Kelly"
                            5 => "C&#46;E&#46; Chamberlain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.1603"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "1462"
                        "paginaFinal" => "1470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22431375"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001100000006/v1_201512160151/S2173574315001215/v1_201512160151/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001100000006/v1_201512160151/S2173574315001215/v1_201512160151/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001215?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Letter to the Editor
Polyostotic fibrous dysplasia. Important facts that the rheumatologist should know
Displasia fibrosa poliostótica. Datos importantes que el reumatólogo debe conocer
Ana Isabel Turrión Nievesa,b,
Corresponding author
anaturrion@hotmail.com

Corresponding author.
, Rafael Martín Holguerab, María Liz Romero Bogadoa, Ana Isabel Sánchez-Atrioa
a Servicio de ESI-Reumatología, Hospital Universitario Príncipe de Asturias, Departamento de Medicina especialidades médicas, Alcalá de Henares, Madrid, Spain
b Departamento de Cirugía y Ciencias Médico Sociales, Unidad docente de Anatomía y Embriología Humanas, Universidad de Alcalá de Henares, Alcalá de Henares, Madrid, Spain
Read
8137
Times
was read the article
2032
Total PDF
6105
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173574315001215"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2015.03.015"
  "estado" => "S300"
  "fechaPublicacion" => "2015-11-01"
  "aid" => "771"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2014"
  "documento" => "simple-article"
  "crossmark" => 1
  "subdocumento" => "cor"
  "cita" => "Reumatol Clin. 2015;11:403-4"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 965
    "formatos" => array:3 [
      "EPUB" => 49
      "HTML" => 735
      "PDF" => 181
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X15000510"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2015.03.004"
      "estado" => "S300"
      "fechaPublicacion" => "2015-11-01"
      "aid" => "771"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; y Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "cor"
      "cita" => "Reumatol Clin. 2015;11:403-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 9905
        "formatos" => array:3 [
          "EPUB" => 155
          "HTML" => 8592
          "PDF" => 1158
        ]
      ]
      "es" => array:10 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>"
        "titulo" => "Displasia fibrosa poliost&#243;tica&#46; Datos importantes que el reumat&#243;logo debe conocer"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "403"
            "paginaFinal" => "404"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Polyostotic fibrous dysplasia&#46; Important facts that the rheumatologist should know"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Ana Isabel Turri&#243;n Nieves, Rafael Mart&#237;n Holguera, Mar&#237;a Liz Romero Bogado, Ana Isabel S&#225;nchez-Atrio"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "Ana Isabel"
                "apellidos" => "Turri&#243;n Nieves"
              ]
              1 => array:2 [
                "nombre" => "Rafael"
                "apellidos" => "Mart&#237;n Holguera"
              ]
              2 => array:2 [
                "nombre" => "Mar&#237;a Liz"
                "apellidos" => "Romero Bogado"
              ]
              3 => array:2 [
                "nombre" => "Ana Isabel"
                "apellidos" => "S&#225;nchez-Atrio"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574315001215"
          "doi" => "10.1016/j.reumae.2015.03.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001215?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000510?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001100000006/v1_201512090140/S1699258X15000510/v1_201512090140/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574315001057"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2015.09.006"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "775"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "cor"
    "cita" => "Reumatol Clin. 2015;11:404-5"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 924
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 615
        "PDF" => 260
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
      "titulo" => "Amyloid Goiter as an Initial Manifestation of Systemic Amyloidosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "404"
          "paginaFinal" => "405"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Bocio amiloide como manifestaci&#243;n inicial en amiloidosis sist&#233;mica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 747
              "Ancho" => 995
              "Tamanyo" => 352051
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Amyloid depositions showing the characteristic Congo red staining&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; del Carmen Cabrejas G&#243;mez, Natalia Gonz&#225;lez Cabrera, Carlos G&#243;mez Gonz&#225;lez, Sorkunde Bergara Elorza"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46; del Carmen"
              "apellidos" => "Cabrejas G&#243;mez"
            ]
            1 => array:2 [
              "nombre" => "Natalia"
              "apellidos" => "Gonz&#225;lez Cabrera"
            ]
            2 => array:2 [
              "nombre" => "Carlos"
              "apellidos" => "G&#243;mez Gonz&#225;lez"
            ]
            3 => array:2 [
              "nombre" => "Sorkunde"
              "apellidos" => "Bergara Elorza"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X15000558"
        "doi" => "10.1016/j.reuma.2015.03.008"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000558?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001057?idApp=UINPBA00004M"
    "url" => "/21735743/0000001100000006/v1_201512160151/S2173574315001057/v1_201512160151/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574315001033"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2015.09.004"
    "estado" => "S300"
    "fechaPublicacion" => "2015-11-01"
    "aid" => "764"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2015;11:401-2"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1005
      "formatos" => array:3 [
        "EPUB" => 56
        "HTML" => 718
        "PDF" => 231
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
      "titulo" => "Periarticular Nodules&#44; Arthritis and Chronic Nephropathy"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "401"
          "paginaFinal" => "402"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "N&#243;dulos periarticulares&#44; artritis y nefropat&#237;a cr&#243;nica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1531
              "Ancho" => 2149
              "Tamanyo" => 410740
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Physical examination of both hands&#46; &#40;A&#41; Tophi in interphalangeal and metacarpophalangeal joints&#46; &#40;B&#41; Plain radiography of both hands&#46; Tophi and signs of arthrosis in interphalangeal joints&#46; Pathology specimen of a tophus stained with hematoxylin and eosin at magnifications of 60&#215; and 10&#215;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fernando Macaya, Alejandro Adrover, Isaac D&#237;az"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Macaya"
            ]
            1 => array:2 [
              "nombre" => "Alejandro"
              "apellidos" => "Adrover"
            ]
            2 => array:2 [
              "nombre" => "Isaac"
              "apellidos" => "D&#237;az"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X15000285"
        "doi" => "10.1016/j.reuma.2015.02.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X15000285?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001033?idApp=UINPBA00004M"
    "url" => "/21735743/0000001100000006/v1_201512160151/S2173574315001033/v1_201512160151/en/main.assets"
  ]
  "en" => array:13 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>"
    "titulo" => "Polyostotic fibrous dysplasia&#46; Important facts that the rheumatologist should know"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "403"
        "paginaFinal" => "404"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Ana Isabel Turri&#243;n Nieves, Rafael Mart&#237;n Holguera, Mar&#237;a Liz Romero Bogado, Ana Isabel S&#225;nchez-Atrio"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "Ana Isabel"
            "apellidos" => "Turri&#243;n Nieves"
            "email" => array:1 [
              0 => "anaturrion&#64;hotmail&#46;com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Rafael"
            "apellidos" => "Mart&#237;n Holguera"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Mar&#237;a Liz"
            "apellidos" => "Romero Bogado"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ana Isabel"
            "apellidos" => "S&#225;nchez-Atrio"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de ESI-Reumatolog&#237;a&#44; Hospital Universitario Pr&#237;ncipe de Asturias&#44; Departamento de Medicina especialidades m&#233;dicas&#44; Alcal&#225; de Henares&#44; Madrid&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Cirug&#237;a y Ciencias M&#233;dico Sociales&#44; Unidad docente de Anatom&#237;a y Embriolog&#237;a Humanas&#44; Universidad de Alcal&#225; de Henares&#44; Alcal&#225; de Henares&#44; Madrid&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Displasia fibrosa poliost&#243;tica&#46; Datos importantes que el reumat&#243;logo debe conocer"
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Fibrous dysplasia is a monostotic or polyostotic bone growth disorder caused by mosaicism involving the mesenchymal tissue&#46; The presenting signs include pain and spontaneous fractures&#46; Last year&#44; Meneses et al&#46; described a case in this journal<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and&#44; in this letter&#44; we report another&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A year ago&#44; a 36-year-old man was referred to us with pain and a significant increase in his alkaline phosphatase levels&#58; 658<span class="elsevierStyleHsp" style=""></span>U&#47;l &#40;normal range&#58; 40&#8211;130&#41;&#46; He had never been examined by a rheumatologist&#44; despite the fact that he had been diagnosed as having polyostotic fibrous dysplasia at the age of 5 years&#46; He had undergone cranioplasty twice for cranial volume reduction and decompression surgery on another 2 occasions to relieve pressure on the left optic nerve&#46; He had had a clavicular fracture and&#44; shortly before our first encounter&#44; fracture of left femur&#44; without previous trauma&#44; but with the fracture line over preexisting osseous cystic lesions&#46; The examination revealed a head circumference of 67<span class="elsevierStyleHsp" style=""></span>cm&#44; hypertelorism and thoracolumbar scoliosis&#44; with a lump in left costal region that was painful on palpation&#46; Moreover&#44; he presented with right-sided coxa vara and leg length discrepancy&#46; The patient was treated with pamidronate &#40;180<span class="elsevierStyleHsp" style=""></span>mg&#47;iv every 6 months&#41;&#44; which relieved his symptoms and reduced his alkaline phosphatase level by over 20&#37; to 390 U&#47;l&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">This disease is caused by a point mutation &#40;activation of the <span class="elsevierStyleItalic">GNAS1</span> gene&#41; in part of the bone tissue&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> It is characterized by the coexistence of cells having the genetic alteration and normal cells &#40;mosaicism&#41;&#46; This mutation induces an expansion of osteoprogenitor cells and their accumulation in the bone marrow spaces&#44; provoking localized hematopoietic tissue loss and bone marrow fibrosis&#46; The collagen shows changes in orientation and biochemical composition&#46; Markers of bone remodeling may be elevated&#44; as occurred in our patient&#46; It is usually asymptomatic and the diagnosis is incidental&#44; although there may be pain&#44; swelling&#44; deformity and&#47;or neurological involvement&#46; Seventy percent of the cases are diagnosed before the age of 30 years&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> The dysplastic tissue is highly vascularized&#44; and is prone to spontaneous bleeding with subsequent cyst formation&#46; The bones widen and the cortical bone thins&#44; and spontaneous fractures can occur as a complication when the condition affects weight-bearing long bones&#46; The presence of intralesional cystic lesions measuring over 2&#46;5<span class="elsevierStyleHsp" style=""></span>cm in diameter increases the risk&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">It can affect several adjoining cranial bones&#44; obliterating the sutures&#44; compress cranial nerve pairs at their exit or affect structures of the middle ear&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The changes observed in plain radiography are variable&#44; depending on the proportion of osseous and fibrous components of the lesion and on its location&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment depends on the presenting signs&#44; and ranges from a wait and see attitude&#44; curettage of the lesions&#44; correction of the deformities and nerve decompression&#44;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> to treatment with bisphosphonates in polyostotic forms with active bone remodeling markers&#46; In the monostotic forms&#44; complete ablation of the lesion prevents recurrence&#46; The rate of recurrences after curettage and grafting is high&#44; especially in children&#46; Thus&#44; its use on a routine basis is not recommended&#44; and it is reserved for the decompression of nerve structures&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">To this day&#44; there is no curative treatment for this disease&#46; Uncontrolled studies have demonstrated the utility of pamidronate&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> which improves even the radiological changes and the physical aspect of the patient&#44;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> basically when the facial skeleton is affected&#46; The use of bisphosphonates has been shown to reduce the painful symptoms&#44; with a decrease in remodeling markers and an increase in bone mineral density&#44; and even results in the filling of cysts and cortex thickening&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In another study&#44; a reduced incidence of fractures was observed&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">A pediatric patient treated with denosumab because of the inefficacy of the bisphosphonates developed severe secondary effects&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Chemotherapy and radiotherapy are not effective&#44; and the latter can facilitate fractures and predispose the patient&#44; albeit rarely &#40;0&#46;4&#37;&#41;&#44; to malignant transformation&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">We consider notable the delay in the referral of this patient to our department&#44; despite the elevation of his alkaline phosphatase levels and his pain&#44; a circumstance that suggests a lack of knowledge of the possibility of using beneficial drug therapies&#46; The physicians who may at some time treat these patients should be aware of the risk of secondary fractures in weight-bearing bones when cystic lesions greater than 2&#46;5<span class="elsevierStyleHsp" style=""></span>cm in diameter are observed&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a></p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Turri&#243;n Nieves AI&#44; Mart&#237;n Holguera R&#44; Romero Bogado ML&#44; S&#225;nchez-Atrio AI&#46; Displasia fibrosa poliost&#243;tica&#46; Datos importantes que el reumat&#243;logo debe conocer&#46; Reumatol Clin&#46; 2015&#59;11&#58;403&#8211;404&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Displasia fibrosa poliost&#243;tica&#58; presentaci&#243;n de un caso"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;F&#46; Meneses"
                            1 => "A&#46; Eg&#252;es"
                            2 => "M&#46; Uriarte"
                            3 => "BelzuneguiJ&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2014.06.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2014"
                        "volumen" => "10"
                        "paginaInicial" => "413"
                        "paginaFinal" => "415"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25047420"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mutations of the GNAS1 gene&#44; stromal cell dysfunction&#44; and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Bianco"
                            1 => "M&#46; Riminucci"
                            2 => "A&#46; Majolagbe"
                            3 => "S&#46;A&#46; Kuznetsov"
                            4 => "M&#46;T&#46; Collins"
                            5 => "M&#46;H&#46; Mankani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1359/jbmr.2000.15.1.120"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2000"
                        "volumen" => "15"
                        "paginaInicial" => "120"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10646121"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrous dysplasia of bone in a young male"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46; Alonso"
                            1 => "M&#46; Munoz-Torres"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1575-0922(09)70984-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Endocrinol Nutr"
                        "fecha" => "2009"
                        "volumen" => "56"
                        "paginaInicial" => "195"
                        "paginaFinal" => "200"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19627736"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrous dysplasia&#46; Pathophysiology&#44; evaluation&#44; and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;R&#46; DiCaprio"
                            1 => "W&#46;F&#46; Enneking"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2106/JBJS.D.02942"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Joint Surg Am"
                        "fecha" => "2005"
                        "volumen" => "87"
                        "paginaInicial" => "1848"
                        "paginaFinal" => "1864"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16085630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history and treatment of fibrous dysplasia of bone&#58; a multicenter clinicopathologic study promoted by the European Pediatric Orthopaedic Society"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Ippolito"
                            1 => "E&#46;W&#46; Bray"
                            2 => "A&#46; Corsi"
                            3 => "F&#46; de Maio"
                            4 => "U&#46;G&#46; Exner"
                            5 => "P&#46;G&#46; Robey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.bpb.0000064021.41829.94"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Orthop B"
                        "fecha" => "2003"
                        "volumen" => "12"
                        "paginaInicial" => "155"
                        "paginaFinal" => "177"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12703030"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term effects of intravenous pamidronate in fibrous dysplasia of bone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Chapurlat"
                            1 => "P&#46;D&#46; Delmas"
                            2 => "D&#46; Liens"
                            3 => "P&#46;J&#46; Meunier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1359/jbmr.1997.12.10.1746"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "1997"
                        "volumen" => "12"
                        "paginaInicial" => "1746"
                        "paginaFinal" => "1752"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9333137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of monostotic fibrous dysplasia with pamidronate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Kos"
                            1 => "K&#46; Luczak"
                            2 => "J&#46; Godzinski"
                            3 => "J&#46; Klempous"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Craniomaxillofac Surg"
                        "fecha" => "2004"
                        "volumen" => "32"
                        "paginaInicial" => "10"
                        "paginaFinal" => "15"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14729043"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of fibrous dysplasia of bone with intravenous pamidronate&#58; long-term effectiveness and evaluation of predictors of response to treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Chapurlat"
                            1 => "P&#46; Hugueny"
                            2 => "P&#46;D&#46; Delmas"
                            3 => "P&#46;J&#46; Meunier"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.bone.2004.03.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Bone"
                        "fecha" => "2004"
                        "volumen" => "35"
                        "paginaInicial" => "235"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15207763"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bisphosphonate treatment of bone fibrous dysplasia in McCune-Albright syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Lala"
                            1 => "P&#46; Matarazzo"
                            2 => "M&#46; Andreo"
                            3 => "D&#46; Marzari"
                            4 => "J&#46; Bellone"
                            5 => "A&#46; Corrias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Pediatr Endocrinol Metab"
                        "fecha" => "2006"
                        "volumen" => "19"
                        "paginaInicial" => "583"
                        "paginaFinal" => "593"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16789621"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Denosumab treatment for fibrous dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;M&#46; Boyce"
                            1 => "W&#46;H&#46; Chong"
                            2 => "J&#46; Yao"
                            3 => "R&#46;I&#46; Gafni"
                            4 => "M&#46;H&#46; Kelly"
                            5 => "C&#46;E&#46; Chamberlain"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/jbmr.1603"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Miner Res"
                        "fecha" => "2012"
                        "volumen" => "27"
                        "paginaInicial" => "1462"
                        "paginaFinal" => "1470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22431375"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001100000006/v1_201512160151/S2173574315001215/v1_201512160151/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "8400"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Letters to the Editor"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001100000006/v1_201512160151/S2173574315001215/v1_201512160151/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574315001215?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 6 4 10
2024 October 105 26 131
2024 September 99 14 113
2024 August 141 35 176
2024 July 168 30 198
2024 June 110 35 145
2024 May 99 31 130
2024 April 115 27 142
2024 March 104 34 138
2024 February 70 24 94
2024 January 85 26 111
2023 December 94 29 123
2023 November 79 23 102
2023 October 95 31 126
2023 September 131 37 168
2023 August 78 20 98
2023 July 70 19 89
2023 June 70 28 98
2023 May 100 29 129
2023 April 72 12 84
2023 March 73 26 99
2023 February 65 36 101
2023 January 58 21 79
2022 December 70 34 104
2022 November 90 41 131
2022 October 71 27 98
2022 September 96 36 132
2022 August 94 42 136
2022 July 119 40 159
2022 June 120 54 174
2022 May 110 40 150
2022 April 121 49 170
2022 March 129 52 181
2022 February 118 36 154
2022 January 124 34 158
2021 December 75 40 115
2021 November 94 37 131
2021 October 76 54 130
2021 September 59 35 94
2021 August 48 36 84
2021 July 60 44 104
2021 June 98 37 135
2021 May 113 37 150
2021 April 321 160 481
2021 March 194 20 214
2021 February 131 34 165
2021 January 100 26 126
2020 December 122 27 149
2020 November 99 18 117
2020 October 81 11 92
2020 September 79 27 106
2020 August 59 19 78
2020 July 34 28 62
2020 June 53 31 84
2020 May 56 12 68
2020 April 46 22 68
2020 March 22 14 36
2020 February 2 0 2
2018 December 1 0 1
2018 May 5 0 5
2018 April 68 4 72
2018 March 53 8 61
2018 February 40 1 41
2018 January 66 6 72
2017 December 17 6 23
2017 November 20 5 25
2017 October 18 7 25
2017 September 16 6 22
2017 August 18 5 23
2017 July 21 10 31
2017 June 32 8 40
2017 May 36 5 41
2017 April 27 4 31
2017 March 15 6 21
2017 February 15 2 17
2017 January 21 11 32
2016 December 55 8 63
2016 November 32 7 39
2016 October 41 9 50
2016 September 45 5 50
2016 August 33 2 35
2016 July 35 3 38
2016 January 0 39 39
2015 December 4 14 18
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?