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we included splenic lymphoma in the differential diagnosis&#44; and splenectomy was performed&#46; The pathological study revealed a chronic&#44; nonspecific&#44; inflammatory process&#44; and Felty&#39;s syndrome was diagnosed&#46; Glucocorticoid therapy was begun with prednisone at 60<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; which was tapered over 2 years&#46; This treatment improved the hematological signs &#40;hematocrit&#44; 42&#37;&#59; leukocytes&#44; 3500&#47;mm<span class="elsevierStyleSup">3</span>&#59; neutrophils&#44; 40&#37;&#41;&#44; and the acute phase reactant levels were normalized&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Two weeks after discontinuation of corticosteroid therapy&#44; the patient presented with chest pain&#44; tachypnea and dyspnea&#44; and was found to have massive pericardial effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; requiring pericardiocentesis &#40;1400<span class="elsevierStyleHsp" style=""></span>cc of bloody fluid&#41;&#46; Culture of the pericardial fluid was negative for common microorganisms and acid- and alcohol-fast bacilli&#46; The pathological finding was nonspecific chronic pericardial sclerosis&#46; Computed tomography of chest&#44; abdomen and pelvis showed no evidence of tuberculosis or neoplasm&#46; Treatment was begun with colchicine and prednisone at 40<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and subsequently with azathioprine at 150<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and the pericardial effusion completely resolved&#46; The prednisone dose was tapered over 2 years&#46; At no time during the aforementioned systemic processes did the patient show signs of active arthritis or radiographic evidence of notable joint destruction&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">At the age of 56 years&#44; 2 months after discontinuation of steroid therapy&#44; the patient experienced a flare of joint symptoms&#44; and Doppler ultrasound confirmed active polyarticular synovitis&#46; Anti-MCV antibodies were &#8805;300<span class="elsevierStyleHsp" style=""></span>U&#47;mL and anti-cyclic citrullinated peptide antibodies were &#62;200<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#46; Corticosteroid therapy was reinitiated and azathioprine was replaced by methotrexate&#44; with a good response&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis offers a wide spectrum of clinical features&#46; The rate of remission of RA ranges between 7&#37; and 32&#37; in different studies&#44; most of which dealt with early arthritis patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;5&#44;6</span></a> In contrast&#44; in established RA&#44; long-term&#44; treatment-free remission is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Moreover&#44; in the case we present here&#44; there were a number of factors associated with a low probability of remission&#44; including an initial prolonged period of aggressive arthritis&#44; a lack of specific DMARD therapy&#44; tobacco use and RF positivity&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In this case&#44; spontaneous remission developed during a pregnancy&#46; In the majority of patients&#44; disease activity is reported to remit&#44; only to return during the postpartum&#46; However&#44; the course varies widely&#44; with complete remission being rare&#44;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a> and the disappearance of the symptoms for years&#44; without medication&#44; following pregnancy is uncommon&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Marked disability during the first 2 years of the disease together with tobacco use and RF positivity have been recognized as strong predictors of the future development of severe extra-articular manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> All these risk factors could be found in our patient&#46; However&#44; what is particularly unusual in this case is the silent manner in which the disease continued its development after her last pregnancy&#44; with no clinically evident activity over a 7-year period&#44; only to flare up after that in the form of Felty&#39;s syndrome&#46; This leads us to suspect that the inflammatory process remained active despite the absence of clinical expression&#46; Felty&#39;s syndrome is observed in less than 1&#37; of the patients with RA&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;9</span></a> and is associated with high rates of morbidity and mortality&#46; The classic triad of splenomegaly&#44; neutropenia and RA that define it are frequently accompanied&#44; as in our patient&#44; by leukopenia&#44; anemia&#44; RF positivity and longstanding RA&#46; However&#44; other common findings&#44; not observed in this case&#44; include a family history of RA&#44; positive ANA&#44; hypocomplementemia and marked joint destruction&#44; although inflammation may be only moderate or may eventually even disappear&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;10</span></a> The syndrome is usually associated with HLA-DR4&#42;0401&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Large granular lymphocyte expansion was ruled out because of the absence both of peripheral blood and bone marrow lymphocytosis&#44; and of clonal expansion of atypical lymphocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Felty&#39;s syndrome is usually associated with other extra-articular manifestations&#44; especially rheumatoid nodules&#44; which were not present in our patient&#46; However&#44; she did develop pericarditis&#44; an uncommon finding in RA patients &#40;2&#37;&#8211;3&#37;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> in this case&#44; with massive bloody pericardial effusion&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0050" class="elsevierStylePara elsevierViewall">The manifestations of RA can be protean&#46; In this report&#44; we stress the unusual course of the disease&#44; especially the prolonged remission without treatment&#44; commencing during a pregnancy&#44; despite the absence of predictors of remission&#44; as well as the development of uncommon extra-articular complications as serious as Felty&#39;s syndrome and pericarditis with massive pericardial effusion&#44; in the absence of concomitant joint activity&#46; Clinical management&#44; control of systemic inflammatory activity&#44; decision-making and the establishment of differential diagnoses constitute a challenge in the care of these patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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            2 => "Pericarditis"
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            0 => "Artritis reumatoide"
            1 => "S&#237;ndrome de Felty"
            2 => "Pericarditis"
            3 => "Manifestaciones extraarticulares"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a chronic autoimmune inflammatory disease occasionally associated with severe extra-articular manifestations&#44; mostly in cases of longstanding highly active disease&#46; We report the case of a 56-year-old woman diagnosed with active RA at the age of 40&#46; After 5 years of high activity&#44; her arthritis subsides spontaneously during pregnancy despite the lack of treatment with disease-modifying anti-rheumatic drugs&#46; She remains without articular symptoms for 7 years&#44; and then she develops a Felty&#39;s syndrome requiring steroid treatment and splenectomy&#46; Following steroid withdrawal she develops pericarditis with massive serohematic pericardial effusion&#44; still in absence of articular activity&#44; and responds to immunosuppressive therapy and colchicine&#46; We emphasize the unusual spontaneous and sustained joint remission without specific treatment&#44; and the development of severe extra-articular manifestations of RA in absence of concomitant articular activity&#44; as well as the importance of controlling inflammation&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La artritis reumatoide &#40;AR&#41; es una enfermedad autoinmune inflamatoria cr&#243;nica&#44; que puede ocasionalmente expresarse con manifestaciones extraarticulares graves&#44; particularmente en casos muy activos de larga evoluci&#243;n&#46; Presentamos el caso de una paciente de 56 a&#241;os&#44; con diagn&#243;stico una AR activa a los 40 a&#241;os de edad&#46; Tras 5 a&#241;os de intensa actividad&#44; su artritis remite espont&#225;neamente sin recibir tratamiento espec&#237;fico con f&#225;rmacos modificadores de la enfermedad&#44; en el curso de su &#250;ltimo embarazo&#46; Persiste sin s&#237;ntomas articulares durante 7 a&#241;os&#44; m&#225;s tarde desarrolla un s&#237;ndrome de Felty que requiere tratamiento con corticoides y esplenectom&#237;a&#46; Al suspender los corticoides presenta pericarditis con derrame peric&#225;rdico serohem&#225;tico masivo&#44; tambi&#233;n en ausencia de actividad articular&#44; que responde al tratamiento inmunosupresor y colchicina&#46; Destacamos lo inusual de la remisi&#243;n espont&#225;nea prolongada sin tratamiento espec&#237;fico y del desarrollo de manifestaciones extraarticulares graves de la AR en ausencia de actividad articular concomitante&#44; as&#237; como la importancia del control de la actividad inflamatoria&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lagrutta M&#44; Alle G&#44; Parodi RL&#44; Greca AA&#46; Manifestaciones extraarticulares graves de artritis reumatoide en ausencia de artritis activa&#44; tras remisi&#243;n espont&#225;nea sostenida&#46; Presentaci&#243;n de un caso&#46; Reumatol Clin&#46; 2016&#59;12&#58;223&#8211;225&#46;</p>"
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Case report
Severe Extra-articular Manifestations of Rheumatoid Arthritis in Absence of Concomitant Articular Activity Following Longstanding Spontaneous Remission. A Case Report
Manifestaciones extraarticulares graves de artritis reumatoide en ausencia de artritis activa, tras remisión espontánea sostenida. Presentación de un caso
Mariana Lagrutta
Corresponding author
marianalagrutta@gmail.com

Corresponding author.
, Gelsomina Alle, Roberto Leandro Parodi, Alcides Alejandro Greca
Servicio de Clínica Médica, Hospital Provincial del Centenario, Rosario, Santa Fe, Argentina
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a chronic&#44; systemic&#44; inflammatory&#44; autoimmune disease&#46; With its fluctuating activity&#44; prolonged remission without treatment is uncommon&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Up to 40&#37;&#8211;50&#37; of the patients develop extra-articular manifestations&#59; however&#44; severe conditions like Felty&#39;s syndrome &#40;RA&#44; splenomegaly and neutropenia&#41; and pericarditis are much less common&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#8211;4</span></a> They usually arise in cases of longstanding and&#47;or highly active disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a woman diagnosed with RA who experienced long-term&#44; spontaneous remission of her arthritis that began during a pregnancy&#44; but who&#44; years later&#44; in the absence of inflammatory joint disease&#44; developed Felty&#39;s syndrome and&#44; subsequently&#44; massive bloody pericardial effusion&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Report</span><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 56-year-old ex-smoker who had been diagnosed with RA at the age of 40 years&#46; She presented with polyarticular involvement&#44; marked morning stiffness and positive rheumatoid factor &#40;RF&#41;&#59; had no family history of RA&#59; and had been treated with corticosteroids and anti-inflammatory agents for 5 years&#46; Although her joint activity was persistent and disabling&#44; keeping her bedridden and making it difficult for her to attend to her personal care&#44; she did not receive disease-modifying antirheumatic drugs &#40;DMARD&#41; because she had no access to specialized centers&#46; On experiencing spontaneous remission of the joint manifestations during her last pregnancy&#44; she discontinued her medication&#46; Although she underwent no further clinical or analytical monitoring&#44; she clearly affirms that her symptoms had disappeared&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Seven years later&#44; she presented to our department with abdominal pain and distension&#46; We observed massive splenomegaly &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and persistent bicytopenia &#40;hematocrit&#44; 24&#37;&#59; leukocytes&#44; 1000&#47;mm<span class="elsevierStyleSup">3</span>&#59; neutrophils&#44; 670&#47;mm<span class="elsevierStyleSup">3</span>&#41;&#46; Laboratory results included&#58; erythrocyte sedimentation rate&#44; 97<span class="elsevierStyleHsp" style=""></span>mm&#47;h&#59; RF&#44; 47<span class="elsevierStyleHsp" style=""></span>IU&#47;mL &#40;upper normal limit&#58; 14<span class="elsevierStyleHsp" style=""></span>IU&#47;mL&#41;&#59; and anti-mutated citrullinated vimentin &#40;anti-MCV&#41; antibodies<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#44; whereas antinuclear &#40;ANA&#41;&#44; anti-native DNA&#44; anti-Smith&#44; anti-ribonucleoprotein&#44; anti-Ro&#44; anti-La and anticardiolipin antibodies were negative&#44; as were cryoglobulins&#59; her complement levels were normal&#46; Serological tests for human immunodeficiency virus and hepatitis B and C viruses were negative&#46; Ultrasound of both hands showed no evidence of synovitis&#44; and radiography revealed few erosions&#46; Biopsy showed reactive bone marrow&#44; with hyperplasia of the granulocytic series&#44; with no neoplastic cells&#59; there were no signs of malignancy on flow cytometry&#46; Given the magnitude of the splenomegaly and the absence of joint activity in recent years&#44; we included splenic lymphoma in the differential diagnosis&#44; and splenectomy was performed&#46; The pathological study revealed a chronic&#44; nonspecific&#44; inflammatory process&#44; and Felty&#39;s syndrome was diagnosed&#46; Glucocorticoid therapy was begun with prednisone at 60<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; which was tapered over 2 years&#46; This treatment improved the hematological signs &#40;hematocrit&#44; 42&#37;&#59; leukocytes&#44; 3500&#47;mm<span class="elsevierStyleSup">3</span>&#59; neutrophils&#44; 40&#37;&#41;&#44; and the acute phase reactant levels were normalized&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Two weeks after discontinuation of corticosteroid therapy&#44; the patient presented with chest pain&#44; tachypnea and dyspnea&#44; and was found to have massive pericardial effusion &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#44; requiring pericardiocentesis &#40;1400<span class="elsevierStyleHsp" style=""></span>cc of bloody fluid&#41;&#46; Culture of the pericardial fluid was negative for common microorganisms and acid- and alcohol-fast bacilli&#46; The pathological finding was nonspecific chronic pericardial sclerosis&#46; Computed tomography of chest&#44; abdomen and pelvis showed no evidence of tuberculosis or neoplasm&#46; Treatment was begun with colchicine and prednisone at 40<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and subsequently with azathioprine at 150<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and the pericardial effusion completely resolved&#46; The prednisone dose was tapered over 2 years&#46; At no time during the aforementioned systemic processes did the patient show signs of active arthritis or radiographic evidence of notable joint destruction&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">At the age of 56 years&#44; 2 months after discontinuation of steroid therapy&#44; the patient experienced a flare of joint symptoms&#44; and Doppler ultrasound confirmed active polyarticular synovitis&#46; Anti-MCV antibodies were &#8805;300<span class="elsevierStyleHsp" style=""></span>U&#47;mL and anti-cyclic citrullinated peptide antibodies were &#62;200<span class="elsevierStyleHsp" style=""></span>U&#47;mL&#46; Corticosteroid therapy was reinitiated and azathioprine was replaced by methotrexate&#44; with a good response&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis offers a wide spectrum of clinical features&#46; The rate of remission of RA ranges between 7&#37; and 32&#37; in different studies&#44; most of which dealt with early arthritis patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;5&#44;6</span></a> In contrast&#44; in established RA&#44; long-term&#44; treatment-free remission is rare&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Moreover&#44; in the case we present here&#44; there were a number of factors associated with a low probability of remission&#44; including an initial prolonged period of aggressive arthritis&#44; a lack of specific DMARD therapy&#44; tobacco use and RF positivity&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#44;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In this case&#44; spontaneous remission developed during a pregnancy&#46; In the majority of patients&#44; disease activity is reported to remit&#44; only to return during the postpartum&#46; However&#44; the course varies widely&#44; with complete remission being rare&#44;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#8211;8</span></a> and the disappearance of the symptoms for years&#44; without medication&#44; following pregnancy is uncommon&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Marked disability during the first 2 years of the disease together with tobacco use and RF positivity have been recognized as strong predictors of the future development of severe extra-articular manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> All these risk factors could be found in our patient&#46; However&#44; what is particularly unusual in this case is the silent manner in which the disease continued its development after her last pregnancy&#44; with no clinically evident activity over a 7-year period&#44; only to flare up after that in the form of Felty&#39;s syndrome&#46; This leads us to suspect that the inflammatory process remained active despite the absence of clinical expression&#46; Felty&#39;s syndrome is observed in less than 1&#37; of the patients with RA&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;9</span></a> and is associated with high rates of morbidity and mortality&#46; The classic triad of splenomegaly&#44; neutropenia and RA that define it are frequently accompanied&#44; as in our patient&#44; by leukopenia&#44; anemia&#44; RF positivity and longstanding RA&#46; However&#44; other common findings&#44; not observed in this case&#44; include a family history of RA&#44; positive ANA&#44; hypocomplementemia and marked joint destruction&#44; although inflammation may be only moderate or may eventually even disappear&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;10</span></a> The syndrome is usually associated with HLA-DR4&#42;0401&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Large granular lymphocyte expansion was ruled out because of the absence both of peripheral blood and bone marrow lymphocytosis&#44; and of clonal expansion of atypical lymphocytes&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Felty&#39;s syndrome is usually associated with other extra-articular manifestations&#44; especially rheumatoid nodules&#44; which were not present in our patient&#46; However&#44; she did develop pericarditis&#44; an uncommon finding in RA patients &#40;2&#37;&#8211;3&#37;&#41;&#44;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;3</span></a> in this case&#44; with massive bloody pericardial effusion&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0050" class="elsevierStylePara elsevierViewall">The manifestations of RA can be protean&#46; In this report&#44; we stress the unusual course of the disease&#44; especially the prolonged remission without treatment&#44; commencing during a pregnancy&#44; despite the absence of predictors of remission&#44; as well as the development of uncommon extra-articular complications as serious as Felty&#39;s syndrome and pericarditis with massive pericardial effusion&#44; in the absence of concomitant joint activity&#46; Clinical management&#44; control of systemic inflammatory activity&#44; decision-making and the establishment of differential diagnoses constitute a challenge in the care of these patients&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article&#46; The corresponding author is in possession of this document&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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            0 => "Artritis reumatoide"
            1 => "S&#237;ndrome de Felty"
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            3 => "Manifestaciones extraarticulares"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a chronic autoimmune inflammatory disease occasionally associated with severe extra-articular manifestations&#44; mostly in cases of longstanding highly active disease&#46; We report the case of a 56-year-old woman diagnosed with active RA at the age of 40&#46; After 5 years of high activity&#44; her arthritis subsides spontaneously during pregnancy despite the lack of treatment with disease-modifying anti-rheumatic drugs&#46; She remains without articular symptoms for 7 years&#44; and then she develops a Felty&#39;s syndrome requiring steroid treatment and splenectomy&#46; Following steroid withdrawal she develops pericarditis with massive serohematic pericardial effusion&#44; still in absence of articular activity&#44; and responds to immunosuppressive therapy and colchicine&#46; We emphasize the unusual spontaneous and sustained joint remission without specific treatment&#44; and the development of severe extra-articular manifestations of RA in absence of concomitant articular activity&#44; as well as the importance of controlling inflammation&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La artritis reumatoide &#40;AR&#41; es una enfermedad autoinmune inflamatoria cr&#243;nica&#44; que puede ocasionalmente expresarse con manifestaciones extraarticulares graves&#44; particularmente en casos muy activos de larga evoluci&#243;n&#46; Presentamos el caso de una paciente de 56 a&#241;os&#44; con diagn&#243;stico una AR activa a los 40 a&#241;os de edad&#46; Tras 5 a&#241;os de intensa actividad&#44; su artritis remite espont&#225;neamente sin recibir tratamiento espec&#237;fico con f&#225;rmacos modificadores de la enfermedad&#44; en el curso de su &#250;ltimo embarazo&#46; Persiste sin s&#237;ntomas articulares durante 7 a&#241;os&#44; m&#225;s tarde desarrolla un s&#237;ndrome de Felty que requiere tratamiento con corticoides y esplenectom&#237;a&#46; Al suspender los corticoides presenta pericarditis con derrame peric&#225;rdico serohem&#225;tico masivo&#44; tambi&#233;n en ausencia de actividad articular&#44; que responde al tratamiento inmunosupresor y colchicina&#46; Destacamos lo inusual de la remisi&#243;n espont&#225;nea prolongada sin tratamiento espec&#237;fico y del desarrollo de manifestaciones extraarticulares graves de la AR en ausencia de actividad articular concomitante&#44; as&#237; como la importancia del control de la actividad inflamatoria&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Lagrutta M&#44; Alle G&#44; Parodi RL&#44; Greca AA&#46; Manifestaciones extraarticulares graves de artritis reumatoide en ausencia de artritis activa&#44; tras remisi&#243;n espont&#225;nea sostenida&#46; Presentaci&#243;n de un caso&#46; Reumatol Clin&#46; 2016&#59;12&#58;223&#8211;225&#46;</p>"
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                  "contribucion" => array:1 [
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                      "titulo" => "Can disease-modifying anti-rheumatic drugs be discontinued in long-standing rheumatoid arthritis&#63; A 15-year follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "T&#46; Tiippana-Kinnunen"
                            1 => "L&#46; Paimela"
                            2 => "H&#46; Kautiainen"
                            3 => "L&#46; Laasonen"
                            4 => "M&#46; Leirisalo-Repo"
                          ]
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                    0 => array:2 [
                      "doi" => "10.3109/03009740903042394"
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                        "fecha" => "2010"
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                        "link" => array:1 [
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                      "titulo" => "Extra-articular rheumatoid arthritis"
                      "autores" => array:1 [
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                      "titulo" => "Incidence of extraarticular rheumatoid arthritis in Olmsted County&#44; Minnesota&#44; in 1995&#8211;2007 versus 1985&#8211;1994&#58; a population-based study"
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                            0 => "E1 Myasoedova"
                            1 => "C&#46;S&#46; Crowson"
                            2 => "C&#46; Turesson"
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