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A case report" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 772 "Ancho" => 964 "Tamanyo" => 122087 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Ecocardiograma. Se observa derrame pericárdico masivo (estrellas).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mariana Lagrutta, Gelsomina Alle, Roberto Leandro Parodi, Alcides Alejandro Greca" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Mariana" "apellidos" => "Lagrutta" ] 1 => array:2 [ "nombre" => "Gelsomina" "apellidos" => "Alle" ] 2 => array:2 [ "nombre" => "Roberto Leandro" "apellidos" => "Parodi" ] 3 => array:2 [ "nombre" => "Alcides Alejandro" "apellidos" => "Greca" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574316300119" "doi" => "10.1016/j.reumae.2016.04.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574316300119?idApp=UINPBA00004M" ] ] "EPUB" => 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Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Reumatol Clin. 2016;12:219-22" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1397 "formatos" => array:3 [ "EPUB" => 50 "HTML" => 1016 "PDF" => 331 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Coincidence of Tuberous Sclerosis and Systemic Lupus Erythematosus–A Case Report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "219" "paginaFinal" => "222" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Asociación lupus eritematoso sistémico y esclerosis tuberosa, un caso" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1599 "Ancho" => 1300 "Tamanyo" => 283834 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">(a) Renal computed tomography (CT) showing a giant hepatic hemangioma (*) and bilateral low-density renal angiomyolipomas, similar to fat and the vascular pedicle (arrows). (b) Axial short-tau inversion recovery (STIR) images. The hepatic hemangioma is markedly hyperintense and the renal angiomas show low signal intensity with a few hyperintense areas on the left that represent the tumor vascularization. (c and d) T1-weighted gradient echo images in phase and reversed phase, respectively, showing the left renal angiomyolipomas with an intensity similar to fat, and hypointense areas in its interior that correspond to the vascular structures. The reversed phase image (d) shows that the signal of part of the tumor is canceled out because of the fat content. (e) Sagittal maximal intensity projection (MIP) reconstruction of CT images, showing a few vertebral bodies corresponding to bone islands (arrows). (f) Coronal MIP reconstruction of CT images. The hepatic hemangioma has been resected and the black arrows indicate the clips that remained after surgery. The 2 renal angiomyolipomas are clearly seen.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carmen Carrasco Cubero, Verónica Bejarano Moguel, M. Ángeles Fernández Gil, Jose Luis Álvarez Vega" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Carmen" "apellidos" => "Carrasco Cubero" ] 1 => array:2 [ "nombre" => "Verónica" "apellidos" => "Bejarano Moguel" ] 2 => array:2 [ "nombre" => "M. 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A Case Report" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "223" "paginaFinal" => "225" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mariana Lagrutta, Gelsomina Alle, Roberto Leandro Parodi, Alcides Alejandro Greca" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Mariana" "apellidos" => "Lagrutta" "email" => array:1 [ 0 => "marianalagrutta@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Gelsomina" "apellidos" => "Alle" ] 2 => array:2 [ "nombre" => "Roberto Leandro" "apellidos" => "Parodi" ] 3 => array:2 [ "nombre" => "Alcides Alejandro" "apellidos" => "Greca" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Clínica Médica, Hospital Provincial del Centenario, Rosario, Santa Fe, Argentina" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Manifestaciones extraarticulares graves de artritis reumatoide en ausencia de artritis activa, tras remisión espontánea sostenida. Presentación de un caso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1287 "Ancho" => 1607 "Tamanyo" => 176884 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Echocardiogram showing massive pericardial effusion (stars).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, autoimmune disease. With its fluctuating activity, prolonged remission without treatment is uncommon.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Up to 40%–50% of the patients develop extra-articular manifestations; however, severe conditions like Felty's syndrome (RA, splenomegaly and neutropenia) and pericarditis are much less common.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2–4</span></a> They usually arise in cases of longstanding and/or highly active disease.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a woman diagnosed with RA who experienced long-term, spontaneous remission of her arthritis that began during a pregnancy, but who, years later, in the absence of inflammatory joint disease, developed Felty's syndrome and, subsequently, massive bloody pericardial effusion.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Report</span><p id="par0015" class="elsevierStylePara elsevierViewall">The patient was a 56-year-old ex-smoker who had been diagnosed with RA at the age of 40 years. She presented with polyarticular involvement, marked morning stiffness and positive rheumatoid factor (RF); had no family history of RA; and had been treated with corticosteroids and anti-inflammatory agents for 5 years. Although her joint activity was persistent and disabling, keeping her bedridden and making it difficult for her to attend to her personal care, she did not receive disease-modifying antirheumatic drugs (DMARD) because she had no access to specialized centers. On experiencing spontaneous remission of the joint manifestations during her last pregnancy, she discontinued her medication. Although she underwent no further clinical or analytical monitoring, she clearly affirms that her symptoms had disappeared.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Seven years later, she presented to our department with abdominal pain and distension. We observed massive splenomegaly (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) and persistent bicytopenia (hematocrit, 24%; leukocytes, 1000/mm<span class="elsevierStyleSup">3</span>; neutrophils, 670/mm<span class="elsevierStyleSup">3</span>). Laboratory results included: erythrocyte sedimentation rate, 97<span class="elsevierStyleHsp" style=""></span>mm/h; RF, 47<span class="elsevierStyleHsp" style=""></span>IU/mL (upper normal limit: 14<span class="elsevierStyleHsp" style=""></span>IU/mL); and anti-mutated citrullinated vimentin (anti-MCV) antibodies<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>300<span class="elsevierStyleHsp" style=""></span>U/mL, whereas antinuclear (ANA), anti-native DNA, anti-Smith, anti-ribonucleoprotein, anti-Ro, anti-La and anticardiolipin antibodies were negative, as were cryoglobulins; her complement levels were normal. Serological tests for human immunodeficiency virus and hepatitis B and C viruses were negative. Ultrasound of both hands showed no evidence of synovitis, and radiography revealed few erosions. Biopsy showed reactive bone marrow, with hyperplasia of the granulocytic series, with no neoplastic cells; there were no signs of malignancy on flow cytometry. Given the magnitude of the splenomegaly and the absence of joint activity in recent years, we included splenic lymphoma in the differential diagnosis, and splenectomy was performed. The pathological study revealed a chronic, nonspecific, inflammatory process, and Felty's syndrome was diagnosed. Glucocorticoid therapy was begun with prednisone at 60<span class="elsevierStyleHsp" style=""></span>mg/d, which was tapered over 2 years. This treatment improved the hematological signs (hematocrit, 42%; leukocytes, 3500/mm<span class="elsevierStyleSup">3</span>; neutrophils, 40%), and the acute phase reactant levels were normalized.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Two weeks after discontinuation of corticosteroid therapy, the patient presented with chest pain, tachypnea and dyspnea, and was found to have massive pericardial effusion (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>), requiring pericardiocentesis (1400<span class="elsevierStyleHsp" style=""></span>cc of bloody fluid). Culture of the pericardial fluid was negative for common microorganisms and acid- and alcohol-fast bacilli. The pathological finding was nonspecific chronic pericardial sclerosis. Computed tomography of chest, abdomen and pelvis showed no evidence of tuberculosis or neoplasm. Treatment was begun with colchicine and prednisone at 40<span class="elsevierStyleHsp" style=""></span>mg/d, and subsequently with azathioprine at 150<span class="elsevierStyleHsp" style=""></span>mg/d, and the pericardial effusion completely resolved. The prednisone dose was tapered over 2 years. At no time during the aforementioned systemic processes did the patient show signs of active arthritis or radiographic evidence of notable joint destruction.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">At the age of 56 years, 2 months after discontinuation of steroid therapy, the patient experienced a flare of joint symptoms, and Doppler ultrasound confirmed active polyarticular synovitis. Anti-MCV antibodies were ≥300<span class="elsevierStyleHsp" style=""></span>U/mL and anti-cyclic citrullinated peptide antibodies were >200<span class="elsevierStyleHsp" style=""></span>U/mL. Corticosteroid therapy was reinitiated and azathioprine was replaced by methotrexate, with a good response.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0035" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis offers a wide spectrum of clinical features. The rate of remission of RA ranges between 7% and 32% in different studies, most of which dealt with early arthritis patients.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,5,6</span></a> In contrast, in established RA, long-term, treatment-free remission is rare.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Moreover, in the case we present here, there were a number of factors associated with a low probability of remission, including an initial prolonged period of aggressive arthritis, a lack of specific DMARD therapy, tobacco use and RF positivity.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5,6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In this case, spontaneous remission developed during a pregnancy. In the majority of patients, disease activity is reported to remit, only to return during the postpartum. However, the course varies widely, with complete remission being rare,<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6–8</span></a> and the disappearance of the symptoms for years, without medication, following pregnancy is uncommon.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Marked disability during the first 2 years of the disease together with tobacco use and RF positivity have been recognized as strong predictors of the future development of severe extra-articular manifestations.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> All these risk factors could be found in our patient. However, what is particularly unusual in this case is the silent manner in which the disease continued its development after her last pregnancy, with no clinically evident activity over a 7-year period, only to flare up after that in the form of Felty's syndrome. This leads us to suspect that the inflammatory process remained active despite the absence of clinical expression. Felty's syndrome is observed in less than 1% of the patients with RA,<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,9</span></a> and is associated with high rates of morbidity and mortality. The classic triad of splenomegaly, neutropenia and RA that define it are frequently accompanied, as in our patient, by leukopenia, anemia, RF positivity and longstanding RA. However, other common findings, not observed in this case, include a family history of RA, positive ANA, hypocomplementemia and marked joint destruction, although inflammation may be only moderate or may eventually even disappear.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,10</span></a> The syndrome is usually associated with HLA-DR4*0401.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Large granular lymphocyte expansion was ruled out because of the absence both of peripheral blood and bone marrow lymphocytosis, and of clonal expansion of atypical lymphocytes.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Felty's syndrome is usually associated with other extra-articular manifestations, especially rheumatoid nodules, which were not present in our patient. However, she did develop pericarditis, an uncommon finding in RA patients (2%–3%),<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2,3</span></a> in this case, with massive bloody pericardial effusion.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0050" class="elsevierStylePara elsevierViewall">The manifestations of RA can be protean. In this report, we stress the unusual course of the disease, especially the prolonged remission without treatment, commencing during a pregnancy, despite the absence of predictors of remission, as well as the development of uncommon extra-articular complications as serious as Felty's syndrome and pericarditis with massive pericardial effusion, in the absence of concomitant joint activity. Clinical management, control of systemic inflammatory activity, decision-making and the establishment of differential diagnoses constitute a challenge in the care of these patients.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of Interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres824583" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec821063" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres824584" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec821062" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case Report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusion" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical Disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of Interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-02-27" "fechaAceptado" => "2015-07-17" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec821063" "palabras" => array:6 [ 0 => "Rheumatoid arthritis" 1 => "Felty's syndrome" 2 => "Pericarditis" 3 => "Extra-articular manifestations" 4 => "Spontaneous remission" 5 => "Pregnancy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec821062" "palabras" => array:6 [ 0 => "Artritis reumatoide" 1 => "Síndrome de Felty" 2 => "Pericarditis" 3 => "Manifestaciones extraarticulares" 4 => "Remisión espontánea" 5 => "Embarazo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease occasionally associated with severe extra-articular manifestations, mostly in cases of longstanding highly active disease. We report the case of a 56-year-old woman diagnosed with active RA at the age of 40. After 5 years of high activity, her arthritis subsides spontaneously during pregnancy despite the lack of treatment with disease-modifying anti-rheumatic drugs. She remains without articular symptoms for 7 years, and then she develops a Felty's syndrome requiring steroid treatment and splenectomy. Following steroid withdrawal she develops pericarditis with massive serohematic pericardial effusion, still in absence of articular activity, and responds to immunosuppressive therapy and colchicine. We emphasize the unusual spontaneous and sustained joint remission without specific treatment, and the development of severe extra-articular manifestations of RA in absence of concomitant articular activity, as well as the importance of controlling inflammation.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La artritis reumatoide (AR) es una enfermedad autoinmune inflamatoria crónica, que puede ocasionalmente expresarse con manifestaciones extraarticulares graves, particularmente en casos muy activos de larga evolución. Presentamos el caso de una paciente de 56 años, con diagnóstico una AR activa a los 40 años de edad. Tras 5 años de intensa actividad, su artritis remite espontáneamente sin recibir tratamiento específico con fármacos modificadores de la enfermedad, en el curso de su último embarazo. Persiste sin síntomas articulares durante 7 años, más tarde desarrolla un síndrome de Felty que requiere tratamiento con corticoides y esplenectomía. Al suspender los corticoides presenta pericarditis con derrame pericárdico serohemático masivo, también en ausencia de actividad articular, que responde al tratamiento inmunosupresor y colchicina. Destacamos lo inusual de la remisión espontánea prolongada sin tratamiento específico y del desarrollo de manifestaciones extraarticulares graves de la AR en ausencia de actividad articular concomitante, así como la importancia del control de la actividad inflamatoria.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Lagrutta M, Alle G, Parodi RL, Greca AA. Manifestaciones extraarticulares graves de artritis reumatoide en ausencia de artritis activa, tras remisión espontánea sostenida. Presentación de un caso. Reumatol Clin. 2016;12:223–225.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1043 "Ancho" => 900 "Tamanyo" => 131653 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Abdominal computed tomography showing massive splenectomy, with a maximum diameter of 21<span class="elsevierStyleHsp" style=""></span>cm.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1287 "Ancho" => 1607 "Tamanyo" => 176884 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Echocardiogram showing massive pericardial effusion (stars).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Can disease-modifying anti-rheumatic drugs be discontinued in long-standing rheumatoid arthritis? 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