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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Chikungunya fever&#44; first reported in the 1950s&#44; is a viral disease produced by an alphavirus&#46; Until recently&#44; because of its geographic distribution&#44; it was considered a tropical disease&#46; However&#44; the virus has mutated and become adapted to a vector&#44; <span class="elsevierStyleItalic">Aedes albopictus</span>&#44; the tiger mosquito&#44; that is more widely distributed than its classical vector&#44; <span class="elsevierStyleItalic">Aedes aegypti</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> and is found in regions including the Spanish Mediterranean basin&#46; The area of autochthonous transmission now encompasses Africa&#44; Asia&#44; Europe &#40;Italy and France&#41; and&#44; since the epidemic involving more than 1 000 000 cases declared in the Caribbean at the end of 2013&#44; the American continent&#44; as well&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Reports</span><p id="par0010" class="elsevierStylePara elsevierViewall">Between July and September 2014&#44; 3 patients from primary care and 1 from the emergency department were referred to our rheumatology department after several weeks of arthralgia or arthritis&#46; The epidemiologic factor that they shared was a trip to the Dominican Republic in the weeks prior to onset&#46; All 4 developed fever&#44; rash and musculoskeletal symptoms&#44; which began during their stay in Santo Domingo in 3 and a few days after returning to Spain in the fourth&#46; They presented with severe arthralgia&#44; which was accompanied by polyarthritis suggestive of rheumatoid arthritis only in the patient of advanced age&#44; a factor that has been related to the persistence of arthropathy&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> The diagnosis was confirmed by serological tests&#46; One of the patients tested negative for IgM and positive for IgG&#44; a finding explained by the interval of over 2 months between clinical onset and the analyses&#46; The dengue serology revealed signs of previous contact in the 3 Dominican patients&#46; Rheumatoid factor &#40;RF&#41; and anti-cyclic citrullinated peptide &#40;CCP&#41; antibodies were negative in all the patients&#46; In 1 case&#44; antinuclear antibodies were positive but later became negative&#44; a circumstance reported in numerous infections&#46; There was no radiological evidence of joint damage&#46; When they first came to our department&#44; all the patients had already received a nonsteroidal anti-inflammatory drug and corticosteroids&#44; a fact that reflects the severity of the symptoms&#46; Only the woman with polyarthritis required maintenance of prednisone&#44; which was tapered over several weeks&#46; In no case did the disease last more than 4 weeks&#46; There was 1 recurrence&#44; with a subsequent positive response &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Chikungunya fever presents with nonspecific clinical features&#44; often including joint pain&#46; The recent trip was the decisive epidemiologic factor for the diagnosis in our patients&#44; as occurred in the 10 patients reported in Catalonia&#44; Spain&#44; in July 2014<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and the 79 cases declared up to November 2014 in the Community of Madrid &#40;<span class="elsevierStyleItalic">Bolet&#237;n de Informaci&#243;n Epidemiol&#243;gica de la Consejer&#237;a de Sanidad</span> &#91;Bulletin of Epidemiological Information of the Madrid Health Administration&#93;&#41;&#46; However&#44; we must keep in mind the possibility of autochthonous transmission in zones inhabited by the tiger mosquito &#40;in Spain&#44; Catalonia&#44; the Valencian Community and the Region of Murcia&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> should an individual carrying the chikungunya virus come to these regions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">All our patients tested negative for RF and anti-CCP antibodies&#44; contrasting with previously reported rates of seropositivity of 20&#37;-30&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> Their conditions resolved within a maximum of 16 weeks&#46; However&#44; the transition to chronic joint involvement is a well-known complication&#44; sometimes in the form of nonspecific arthralgia&#44; soft tissue disease or an inflammatory process suggestive of rheumatoid arthritis&#44; spondyloarthritis or undifferentiated arthritis&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a> which have been found to respond well to treatment with synthetic or biologic disease-modifying antirheumatic drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> These are the patients that benefit the most from early referral to a rheumatology department&#44; as occurred in our series&#44; making it possible to take advantage of a hypothetical therapeutic window&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Chikungunya can be included in the differential diagnosis not only of travelers from regions in which the virus is endemic&#44; but of any individual with the typical signs and symptoms living in a region where transmission is viable&#46; As rheumatologists&#44; we must be knowledgeable about the situation in order to contribute to controlling the possible expansion of this virus&#44; which is a notifiable disease&#44; and to offer patients optimal specialized care&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors received no funding&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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        8 => array:3 [
          "identificador" => "sec0025"
          "titulo" => "Ethical Disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0030"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0035"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        9 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Funding"
        ]
        10 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Conflicts of Interest"
        ]
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          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-05-28"
    "fechaAceptado" => "2015-08-06"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec821067"
          "palabras" => array:2 [
            0 => "Chikungunya"
            1 => "Arthropathy"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec821066"
          "palabras" => array:2 [
            0 => "Chikungunya"
            1 => "Artropat&#237;a"
          ]
        ]
      ]
    ]
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chikungunya fever is a mosquito-transmitted viral disease that causes fever&#44; rash and musculoskeletal complaints&#46; The latest may persist for several months&#44; or even years or developed a relapsing course&#44; that deserve an adequate treatment&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Due to the large outbreak declared in the Caribbean in 2013&#44; imported cases of Chikungunya as well as the risk of autochthonous transmission in case of available vectors have increased in non-endemic countries&#44; like Spain&#46; We described four cases of Chikungunya treated in our clinic&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La fiebre chikungunya es una infecci&#243;n viral&#44; transmitida por mosquitos&#44; que cursa con fiebre&#44; rash y s&#237;ntomas musculoesquel&#233;ticos que pueden persistir meses&#44; incluso a&#241;os&#44; de una forma cr&#243;nica o recidivante precisando adecuado tratamiento&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La extensa epidemia declarada en el Caribe en 2013<span class="elsevierStyleHsp" style=""></span>ha provocado el aumento de los casos importados en los pa&#237;ses no end&#233;micos&#44; as&#237; como del riesgo de transmisi&#243;n aut&#243;ctona en aquellas zonas donde se encuentran vectores&#44; como es el caso de Espa&#241;a&#46; Describimos 4 casos de chikungunya atendidos en nuestras consultas&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Richi Alberti P&#44; Steiner M&#44; Illera Mart&#237;n &#211;&#44; Alcocer Amores P&#44; Cobo Ib&#225;&#241;ez T&#44; Mu&#241;oz Fern&#225;ndez S&#46; Fiebre chikungunya importada en Madrid&#46; Reumatol Clin&#46; 2016&#59;12&#58;226&#8211;227&#46;</p>"
      ]
    ]
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">ANA&#44; antinuclear antibodies&#59; Anti-CCP&#44; anti-cyclic citrullinated peptide antibodies&#59; F&#44; female&#59; M&#44; male&#59; Neg&#44; negative&#59; NSAID&#44; nonsteroidal anti-inflammatory drug&#59; RF&#44; rheumatoid factor&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serologic findings chikungunya&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serologic findings dengue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">RF&#47;Anti-CCP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ANA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#43;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSAID<br>Corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Remission &#40;4<span class="elsevierStyleHsp" style=""></span>m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthralgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#43;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSAID<br>Corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Recurrence remission &#40;4<span class="elsevierStyleHsp" style=""></span>m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthralgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSAID<br>Corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Remission &#40;2<span class="elsevierStyleHsp" style=""></span>m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthralgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#43;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSAID<br>Corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Remission &#40;1<span class="elsevierStyleHsp" style=""></span>m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Patient Characteristics&#46;</p>"
        ]
      ]
    ]
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chikungunya virus infection&#58; an overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Caglioti"
                            1 => "E&#46; Lalle"
                            2 => "C&#46; Castilletti"
                            3 => "F&#46; Carletti"
                            4 => "M&#46;R&#46; Capobianchi"
                            5 => "L&#46; Bordi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "New Microbiol"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "211"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23912863"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Chikungunya WHO Fact sheet No&#46; 327&#46; Updated February 2015 &#91;accessed 15 Abr 2015&#93;&#46; Available from&#58; <a href="http://www.who.int/mediacentre/factsheets/fs327/en/">http&#58;&#47;&#47;www&#46;who&#46;int&#47;mediacentre&#47;factsheets&#47;fs327&#47;en&#47;</a>"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of Chikungunya rheumatism&#58; a prognostic survey ancillary to the TELECHIK cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; G&#233;rardin"
                            1 => "A&#46; Fianu"
                            2 => "A&#46; Michault"
                            3 => "C&#46; Mussard"
                            4 => "K&#46; Boussa&#239;d"
                            5 => "O&#46; Rollot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2013"
                        "volumen" => "15"
                        "numero" => "R9"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term chikungunya infection clinical manifestations after an outbreak in Italy&#58; a prognostic cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;L&#46; Moro"
                            1 => "E&#46; Grilli"
                            2 => "A&#46; Corvetta"
                            3 => "G&#46; Silvi"
                            4 => "R&#46; Angelini"
                            5 => "F&#46; Mascella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jinf.2012.04.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect"
                        "fecha" => "2012"
                        "volumen" => "65"
                        "paginaInicial" => "165"
                        "paginaFinal" => "172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22522292"
                            "web" => "Medline"
                          ]
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                    ]
                  ]
                ]
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              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cases of chikungunya virus infection in travellers returning to Spain from Haiti or Dominican Republic&#44; April&#8211;June 2014"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Requena-M&#233;ndez"
                            1 => "C&#46; Garc&#237;a"
                            2 => "E&#46; Aldasoro"
                            3 => "J&#46;A&#46; Vicente"
                            4 => "M&#46;J&#46; Mart&#237;nez"
                            5 => "J&#46;A&#46; P&#233;rez-Molina"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Euro Surveill"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "paginaInicial" => "20853"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25060571"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nuevos datos sobre el proceso de expansi&#243;n de Aedes albopictus &#40;Skuse&#44; 1894&#41; &#40;Diptera Culicidae&#41; por el sureste de la Pen&#237;nsula Ib&#233;rica&#58; hallazgo de la especie en Mazarr&#243;n &#40;Murcia&#44; Espa&#241;a&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46; Bueno Mar&#237;"
                            1 => "P&#46; Garc&#237;a M&#250;jica"
                            2 => "J&#46; Rico Miralles"
                            3 => "A&#46; Agull&#243; Ronc"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
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                        "fecha" => "2012"
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              ]
            ]
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              "identificador" => "bib0085"
              "etiqueta" => "7"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chikungunya virus aches and pains&#58; an emerging challenge"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Chopra"
                            1 => "V&#46; Anuradha"
                            2 => "V&#46; Lagoo Joshi"
                            3 => "V&#46; Kunjir"
                            4 => "S&#46; Salvi"
                            5 => "M&#46; Saluja"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.23753"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "2921"
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                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Javelle E&#44; Ribera A&#44; Degasne I&#44; Ga&#252;z&#232;re BA&#44; Marimoutou C&#44; Simon F&#46; Specific management of post-chikungunya rheumatic disorders&#58; a retrospective study of 159 cases in Reunion Island from 2006&#8211;2012&#46; PLOS Neglected Tropical Diseases 2015&#44; March 11 &#91;accessed 3 May 2015&#93;&#46; Available from&#58; <a href="http://www.plosntds.org/article/Metrics/info:doi/10.1371/journal.pntd.0003603">http&#58;&#47;&#47;www&#46;plosntds&#46;org&#47;article&#47;Metrics&#47;info&#58;doi&#47;10&#46;1371&#47;journal&#46;pntd&#46;0003603</a>"
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chikungunya fever&#46; Rheumatic manifestations of an emerging disease in Europe"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;L&#46; Horcada"
                            1 => "C&#46; D&#237;az-Calder&#243;n"
                            2 => "L&#46; Garrido"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.reuma.2014.07.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Reumatol Clin"
                        "fecha" => "2015"
                        "volumen" => "11"
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Case Report
Imported Chikungunya Fever in Madrid
Fiebre chikungunya importada en Madrid
Patricia Richi Alberti
Corresponding author
patricia.richi@salud.madrid.org

Corresponding author.
, Martina Steiner, Óscar Illera Martín, Patricia Alcocer Amores, Tatiana Cobo Ibáñez, Santiago Muñoz Fernández
Hospital Universitario Infanta Sofía, San Sebastián de los Reyes, Madrid, Spain
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and&#44; since the epidemic involving more than 1 000 000 cases declared in the Caribbean at the end of 2013&#44; the American continent&#44; as well&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case Reports</span><p id="par0010" class="elsevierStylePara elsevierViewall">Between July and September 2014&#44; 3 patients from primary care and 1 from the emergency department were referred to our rheumatology department after several weeks of arthralgia or arthritis&#46; The epidemiologic factor that they shared was a trip to the Dominican Republic in the weeks prior to onset&#46; All 4 developed fever&#44; rash and musculoskeletal symptoms&#44; which began during their stay in Santo Domingo in 3 and a few days after returning to Spain in the fourth&#46; They presented with severe arthralgia&#44; which was accompanied by polyarthritis suggestive of rheumatoid arthritis only in the patient of advanced age&#44; a factor that has been related to the persistence of arthropathy&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> The diagnosis was confirmed by serological tests&#46; One of the patients tested negative for IgM and positive for IgG&#44; a finding explained by the interval of over 2 months between clinical onset and the analyses&#46; The dengue serology revealed signs of previous contact in the 3 Dominican patients&#46; Rheumatoid factor &#40;RF&#41; and anti-cyclic citrullinated peptide &#40;CCP&#41; antibodies were negative in all the patients&#46; In 1 case&#44; antinuclear antibodies were positive but later became negative&#44; a circumstance reported in numerous infections&#46; There was no radiological evidence of joint damage&#46; When they first came to our department&#44; all the patients had already received a nonsteroidal anti-inflammatory drug and corticosteroids&#44; a fact that reflects the severity of the symptoms&#46; Only the woman with polyarthritis required maintenance of prednisone&#44; which was tapered over several weeks&#46; In no case did the disease last more than 4 weeks&#46; There was 1 recurrence&#44; with a subsequent positive response &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Chikungunya fever presents with nonspecific clinical features&#44; often including joint pain&#46; The recent trip was the decisive epidemiologic factor for the diagnosis in our patients&#44; as occurred in the 10 patients reported in Catalonia&#44; Spain&#44; in July 2014<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> and the 79 cases declared up to November 2014 in the Community of Madrid &#40;<span class="elsevierStyleItalic">Bolet&#237;n de Informaci&#243;n Epidemiol&#243;gica de la Consejer&#237;a de Sanidad</span> &#91;Bulletin of Epidemiological Information of the Madrid Health Administration&#93;&#41;&#46; However&#44; we must keep in mind the possibility of autochthonous transmission in zones inhabited by the tiger mosquito &#40;in Spain&#44; Catalonia&#44; the Valencian Community and the Region of Murcia&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> should an individual carrying the chikungunya virus come to these regions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">All our patients tested negative for RF and anti-CCP antibodies&#44; contrasting with previously reported rates of seropositivity of 20&#37;-30&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7&#44;8</span></a> Their conditions resolved within a maximum of 16 weeks&#46; However&#44; the transition to chronic joint involvement is a well-known complication&#44; sometimes in the form of nonspecific arthralgia&#44; soft tissue disease or an inflammatory process suggestive of rheumatoid arthritis&#44; spondyloarthritis or undifferentiated arthritis&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a> which have been found to respond well to treatment with synthetic or biologic disease-modifying antirheumatic drugs&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> These are the patients that benefit the most from early referral to a rheumatology department&#44; as occurred in our series&#44; making it possible to take advantage of a hypothetical therapeutic window&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0025" class="elsevierStylePara elsevierViewall">Chikungunya can be included in the differential diagnosis not only of travelers from regions in which the virus is endemic&#44; but of any individual with the typical signs and symptoms living in a region where transmission is viable&#46; As rheumatologists&#44; we must be knowledgeable about the situation in order to contribute to controlling the possible expansion of this virus&#44; which is a notifiable disease&#44; and to offer patients optimal specialized care&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Funding</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors received no funding&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conflicts of Interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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          "titulo" => "Introduction"
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          "identificador" => "sec0010"
          "titulo" => "Case Reports"
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          "titulo" => "Discussion"
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          "titulo" => "Conclusions"
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          "titulo" => "Ethical Disclosures"
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              "titulo" => "Protection of human and animal subjects"
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              "identificador" => "sec0035"
              "titulo" => "Confidentiality of data"
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              "identificador" => "sec0040"
              "titulo" => "Right to privacy and informed consent"
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    "fechaRecibido" => "2015-05-28"
    "fechaAceptado" => "2015-08-06"
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          "clase" => "keyword"
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          "palabras" => array:2 [
            0 => "Chikungunya"
            1 => "Arthropathy"
          ]
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
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          "palabras" => array:2 [
            0 => "Chikungunya"
            1 => "Artropat&#237;a"
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    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chikungunya fever is a mosquito-transmitted viral disease that causes fever&#44; rash and musculoskeletal complaints&#46; The latest may persist for several months&#44; or even years or developed a relapsing course&#44; that deserve an adequate treatment&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Due to the large outbreak declared in the Caribbean in 2013&#44; imported cases of Chikungunya as well as the risk of autochthonous transmission in case of available vectors have increased in non-endemic countries&#44; like Spain&#46; We described four cases of Chikungunya treated in our clinic&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La fiebre chikungunya es una infecci&#243;n viral&#44; transmitida por mosquitos&#44; que cursa con fiebre&#44; rash y s&#237;ntomas musculoesquel&#233;ticos que pueden persistir meses&#44; incluso a&#241;os&#44; de una forma cr&#243;nica o recidivante precisando adecuado tratamiento&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La extensa epidemia declarada en el Caribe en 2013<span class="elsevierStyleHsp" style=""></span>ha provocado el aumento de los casos importados en los pa&#237;ses no end&#233;micos&#44; as&#237; como del riesgo de transmisi&#243;n aut&#243;ctona en aquellas zonas donde se encuentran vectores&#44; como es el caso de Espa&#241;a&#46; Describimos 4 casos de chikungunya atendidos en nuestras consultas&#46;</p></span>"
      ]
    ]
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Richi Alberti P&#44; Steiner M&#44; Illera Mart&#237;n &#211;&#44; Alcocer Amores P&#44; Cobo Ib&#225;&#241;ez T&#44; Mu&#241;oz Fern&#225;ndez S&#46; Fiebre chikungunya importada en Madrid&#46; Reumatol Clin&#46; 2016&#59;12&#58;226&#8211;227&#46;</p>"
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          "leyenda" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">ANA&#44; antinuclear antibodies&#59; Anti-CCP&#44; anti-cyclic citrullinated peptide antibodies&#59; F&#44; female&#59; M&#44; male&#59; Neg&#44; negative&#59; NSAID&#44; nonsteroidal anti-inflammatory drug&#59; RF&#44; rheumatoid factor&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age&#44; years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Symptoms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serologic findings chikungunya&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Serologic findings dengue&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">RF&#47;Anti-CCP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">ANA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#43;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSAID<br>Corticosteroids&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthralgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#43;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSAID<br>Corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Recurrence remission &#40;4<span class="elsevierStyleHsp" style=""></span>m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthralgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#8722;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Remission &#40;2<span class="elsevierStyleHsp" style=""></span>m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " align="char" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">M&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Fever<br>Rash<br>Arthralgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#43;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IgM&#8722;<br>IgG&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&#47;Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Neg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">NSAID<br>Corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Remission &#40;1<span class="elsevierStyleHsp" style=""></span>m&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Patient Characteristics&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chikungunya virus infection&#58; an overview"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46; Caglioti"
                            1 => "E&#46; Lalle"
                            2 => "C&#46; Castilletti"
                            3 => "F&#46; Carletti"
                            4 => "M&#46;R&#46; Capobianchi"
                            5 => "L&#46; Bordi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "New Microbiol"
                        "fecha" => "2013"
                        "volumen" => "36"
                        "paginaInicial" => "211"
                        "paginaFinal" => "227"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23912863"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Chikungunya WHO Fact sheet No&#46; 327&#46; Updated February 2015 &#91;accessed 15 Abr 2015&#93;&#46; Available from&#58; <a href="http://www.who.int/mediacentre/factsheets/fs327/en/">http&#58;&#47;&#47;www&#46;who&#46;int&#47;mediacentre&#47;factsheets&#47;fs327&#47;en&#47;</a>"
                ]
              ]
            ]
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              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of Chikungunya rheumatism&#58; a prognostic survey ancillary to the TELECHIK cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; G&#233;rardin"
                            1 => "A&#46; Fianu"
                            2 => "A&#46; Michault"
                            3 => "C&#46; Mussard"
                            4 => "K&#46; Boussa&#239;d"
                            5 => "O&#46; Rollot"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2013"
                        "volumen" => "15"
                        "numero" => "R9"
                      ]
                    ]
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                ]
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            ]
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              "identificador" => "bib0070"
              "etiqueta" => "4"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term chikungunya infection clinical manifestations after an outbreak in Italy&#58; a prognostic cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;L&#46; Moro"
                            1 => "E&#46; Grilli"
                            2 => "A&#46; Corvetta"
                            3 => "G&#46; Silvi"
                            4 => "R&#46; Angelini"
                            5 => "F&#46; Mascella"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jinf.2012.04.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect"
                        "fecha" => "2012"
                        "volumen" => "65"
                        "paginaInicial" => "165"
                        "paginaFinal" => "172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22522292"
                            "web" => "Medline"
                          ]
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Article information
ISSN: 21735743
Original language: English
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