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Parasitological analysis of stool was negative&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Thoracic and abdominal computed tomography revealed bilateral pleural effusion&#44; pneumoperitoneum&#44; peritoneal membrane thickening&#44; free fluid in the peritoneal cavity and enlarged lymph nodes&#46; Therefore&#44; he was scheduled for surgery&#44; and was found to have numerous intestinal perforations &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; It was necessary to perform subtotal colectomy and ileostomy&#46; Treatment with meprednisone at 40<span class="elsevierStyleHsp" style=""></span>mg&#47;day resulted in a favorable clinical course&#46; The dose was reduced to 8<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; accompanied by azathioprine at 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; which resulted in 1 year without relapses&#46; A video recording of a follow-up colonoscopy showed active lesions&#44; and he began to receive 40<span class="elsevierStyleHsp" style=""></span>mg of subcutaneous adalimumab every 15 days&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#8211;3</span></a> which achieved clinical and histopathological remission after 4 months of treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Ancillary histopathological studies of a tissue specimen demonstrated colonic ulceration with perilesional inflammation&#59; a skin biopsy revealed septal lobular panniculitis with mononuclear and polymorphonuclear cell infiltrate&#59; and nonspecific inflammation was observed in the scrotal ulcer&#46; Testing was positive for HLA-B52<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> and negative for HLA-B51&#46; The pathergy test was negative&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusions</span><p id="par0035" class="elsevierStylePara elsevierViewall">Patients with Beh&#231;et&#39;s disease can experience oral and genital ulcers for years&#44; with no definitive diagnosis&#44; and consult their physicians only when serious complications arise&#46; Since the diagnosis is mainly clinical&#44; primary care physicians should be familiar with the characteristics of this disease&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> especially in countries like Argentina in which the prevalence is low and the evidence is concealed in a variety of symptoms that must be associated to discovery it&#46; Therefore any delay in the diagnosis increases the rates of mortality and morbidity affecting patients with BD&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To date&#44; when gastrointestinal involvement is detected&#44; good responses have been achieved with sulfasalazine&#44; azathioprine and corticosteroids at low or high doses or as pulse therapy&#44; as well as with pulse cyclophosphamide&#46; However&#44; in the case of intestinal perforation&#44; the treatment must be aggressive and can be initiated directly with adalimumab&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical Disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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Case Report
Behçet's Disease With Intestinal Perforation: A Case Report
Enfermedad de Behçet con perforación intestinal: a propósito de un caso
Maricel Della Maggiora
Corresponding author
dmaricel@hotmail.com

Corresponding author.
, Andrea Baños, Virginia Paolini, Dario Florio, Lorena Takashima, Pedro Aicardi
Servicio de Reumatología, APEsa, Buenos Aires, Argentina
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with no definitive diagnosis&#44; and consult their physicians only when serious complications arise&#46; Since the diagnosis is mainly clinical&#44; primary care physicians should be familiar with the characteristics of this disease&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> especially in countries like Argentina in which the prevalence is low and the evidence is concealed in a variety of symptoms that must be associated to discovery it&#46; Therefore any delay in the diagnosis increases the rates of mortality and morbidity affecting patients with BD&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">To date&#44; when gastrointestinal involvement is detected&#44; good responses have been achieved with sulfasalazine&#44; azathioprine and corticosteroids at low or high doses or as pulse therapy&#44; as well as with pulse cyclophosphamide&#46; However&#44; in the case of intestinal perforation&#44; the treatment must be aggressive and can be initiated directly with adalimumab&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical Disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of Interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Paciente de sexo masculino de 34 a&#241;os con antecedente de &#250;lceras orales y genitales que cursaban en brotes de 8 a&#241;os de evoluci&#243;n&#44; se presenta con fiebre elevada y lesiones en piel durante 21 d&#237;as&#44; sin dolor abdominal&#46; Se realiza tomograf&#237;a computarizada&#44; observ&#225;ndose perforaci&#243;n intestinal&#44; por lo que es intervenido quir&#250;rgicamente&#46; Es tratado con corticoides y azatioprina&#46; Luego&#44; por falta de respuesta&#44; se le administra adalimumab&#46;</p></span>"
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Article information
ISSN: 21735743
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