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in a pattern suggestive of lymph node sarcoidosis&#46; No lesions were found in the pulmonary parenchyma&#46; Angiotensin converting enzyme &#40;ACE&#41; level was significantly elevated &#40;117<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; range 20&#8211;70&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was submitted to a skin biopsy&#44; in which were also visible epithelioid granulomas with rare giant multinucleated cells&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Confirmed the diagnosis of sarcoidosis with bone&#44; skin&#44; liver and lymph node involvement&#44; the patient started prednisolone 40<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; with rapid improvement of the joint pain&#44; skin lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and analytical abnormalities&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Sarcoidosis is a rare disease with heterogeneous presentation characterized by the formation of non-caseating granulomas&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Bone involvement is usually associated to lung&#44; skin and lymph node involvement&#44;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2</span></a> as in the case described&#46; Bone lesions are asymptomatic in half of the cases&#44; although they may present with bone or joint pain or edema&#46; In conventional X-ray&#44; bone lesions usually appear as cystic&#44; lytic or permeative lesions&#44; and are usually visible on phalanges&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;3</span></a> Asymptomatic patients usually do not require specific treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Symptomatic patients may need treatment&#58; NSAIDs&#44; corticosteroids&#44; methotrexate&#44; hydroxychloroquine&#44; and infliximab are described in the literature for this purpose&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Skin lesions have a predilection for black women&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> They are divided into two large groups&#58; those specific of sarcoidosis &#40;with evidence of granuloma&#41; and nonspecific &#40;with inflammatory changes but no identifiable granulomas&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">5&#44;6</span></a> Erythema nodosum is the most common non-specific injury of sarcoidosis&#44; and is a sign of the L&#246;fgren syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> The specific cutaneous lesions of sarcoidosis usually cause no other symptoms beyond the cosmetic changes and are very heterogeneous in their appearance&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> In this group stands out lupus pernio for being one of the few lesions with some distinctive features&#58; violet papules and nodules that coalesce on plaques&#44; with predilection for face&#44; especially nose&#44; ears and perioral region&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> They can also appear in the fingers&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#44;6</span></a> but the simultaneous involvement in both hands and feet never was described to the best of our knowledge&#44; as seen in this case presented&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Most patients remain asymptomatic and have only a slight increase in liver function enzymes&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> Treatment with corticosteroids usually normalize liver enzymes&#44; but is not recommended for asymptomatic patients with no involvement of other organs&#44; since delay in treatment rarely leads to significant liver damage&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Our clinical case emphasizes the difficulty in diagnosis with an atypical presentation&#46; It is very important to keep a high level of awareness to the diagnosis of sarcoidosis&#46; Joint and bone involvement is uncommon&#44; the skin lesions will be variable and it is important to know them&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de un hombre de 35 a&#241;os con una historia de artralgia y con la piel de los dedos y los pies de color viol&#225;ceo&#44; de 3 a&#241;os de duraci&#243;n&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La radiograf&#237;a de pies y manos mostr&#243; lesiones qu&#237;sticas &#243;seas en las falanges&#44; indicativas de sarcoidosis&#46; Las pruebas de laboratorio revelaron una elevaci&#243;n de las enzimas hep&#225;ticas&#46; La resonancia magn&#233;tica hep&#225;tica puso de manifiesto hepatomegalia y linfadenopat&#237;a retroperitoneal&#46; El an&#225;lisis histol&#243;gico de la piel de los dedos&#44; los ganglios linf&#225;ticos y el h&#237;gado mostr&#243; la existencia de granulomas&#44; lo que confirm&#243; el diagn&#243;stico de sarcoidosis&#46; El paciente comenz&#243; el tratamiento con prednisolona con una r&#225;pida mejor&#237;a de los s&#237;ntomas&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Las lesiones de la piel se dividen en 2 grupos&#58; espec&#237;ficas de la sarcoidosis &#40;con granulomas y lupus caracter&#237;stico del eritema pernio&#41; e inespec&#237;ficas &#40;sin granulomas y de tipo eritema nudoso&#41;&#46; Las lesiones cut&#225;neas espec&#237;ficas generalmente no causan m&#225;s s&#237;ntomas que los cambios est&#233;ticos&#46; El lupus pernio destaca por presentar caracter&#237;sticas distintivas&#44; pero no nos consta que se haya descrito nunca la afectaci&#243;n simult&#225;nea de ambas manos y pies&#46;</p></span>"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osseous sarcoidosis&#58; clinical characteristics&#44; treatment&#44; and outcomes &#8211; experience from a large&#44; academic hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Sparks"
                            1 => "J&#46;I&#46; McSparron"
                            2 => "N&#46; Shah"
                            3 => "P&#46; Aliabadi"
                            4 => "V&#46; Paulson"
                            5 => "C&#46;H&#46; Fanta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2014.07.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2014"
                        "volumen" => "44"
                        "paginaInicial" => "371"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25129260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteo-articular manifestations of sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;Z&#46; Alaoui"
                            1 => "M&#46; Talaoui"
                            2 => "S&#46; Benamour"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Presse Med"
                        "fecha" => "2005"
                        "volumen" => "34"
                        "paginaInicial" => "19"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16158025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extra-pulmonary manifestations of sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Vardhanabhuti"
                            1 => "N&#46; Venkatanarasimha"
                            2 => "G&#46; Bhatnagar"
                            3 => "M&#46; Maviki"
                            4 => "S&#46; Iyengar"
                            5 => "W&#46;M&#46; Adams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.crad.2011.04.018"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Radiol"
                        "fecha" => "2012"
                        "volumen" => "67"
                        "paginaInicial" => "263"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22094184"
                            "web" => "Medline"
                          ]
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                          "issn" => "0022510X"
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                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic cutaneous lesions of sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;M&#46; Marchell"
                            1 => "M&#46;A&#46; Judson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2007.03.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "295"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560307"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical features of sarcoidosis&#58; a comprehensive review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Judson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Clin Rev Allergy Immunol"
                        "fecha" => "2014"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;M&#46; Marchell"
                            1 => "M&#46;A&#46; Judson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0030-1262212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Respir Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "31"
                        "paginaInicial" => "442"
                        "paginaFinal" => "451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20665394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous sarcoidosis&#58; differential diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Fernandez-Faith"
                            1 => "J&#46; McDonnell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2007.03.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "276"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560305"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sarcoidosis of the liver&#58; to treat or not to treat&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "G&#46;J&#46; Bakker"
                            1 => "Y&#46;C&#46; Haan"
                            2 => "L&#46;J&#46; Maillette de Buy Wenniger"
                            3 => "U&#46; Beuers"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neth J Med"
                        "fecha" => "2012"
                        "volumen" => "70"
                        "paginaInicial" => "349"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23065982"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atypical sarcoidosis&#58; case reports and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Giovinale"
                            1 => "C&#46; Fonnesu"
                            2 => "A&#46; Soriano"
                            3 => "C&#46; Cerquaglia"
                            4 => "V&#46; Curigliano"
                            5 => "E&#46; Verrecchia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Rev Med Pharmacol Sci"
                        "fecha" => "2009"
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                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "37"
                        "paginaFinal" => "44"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19530510"
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Case report
Sarcoidosis: An unusual presentation
Sarcoidosis: un cuadro clínico inicial poco frecuente
Pedro Madureiraa,b,
Corresponding author
pmsmadureira@gmail.com

Corresponding author.
, Sofia Pimentaa,b, Hélder Cardosoc, Rui Guimarães Cunhad, Lúcia Costaa
a Rheumatology Department, Centro Hospitalar de São João, Porto, Portugal
b Rheumatology Department, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
c Gastrenterology Department, Centro Hospitalar de São João, Porto, Portugal
d Radiology Department, Centro Hospitalar de São João, Porto, Portugal
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alkaline phosphatase 561<span class="elsevierStyleHsp" style=""></span>U&#47;L &#40;30&#8211;120&#41;&#44; hypergammaglobulinemia&#44; a low titer positive rheumatoid test and a positive anti-smooth muscle antibody&#46; Abdominal ultrasound and a liver MRI evidenced an enlarged liver &#40;without focal lesions&#41; and retroperitoneal lymphadenopathy&#46; A lymphoproliferative disease was suspected&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Liver and lymph node biopsies showed the presence of epithelioid granulomas&#46; Infectious causes associated with granulomatous processes were excluded&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Hands and feet radiography evidenced the presence of bone cystic lesions on phalanges suggestive of sarcoidosis&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We also assessed the involvement of other organs&#46; Full body scintigraphy with gallium showed hyperfixation in several mediastinal and abdominal lymph nodes and high resolution chest-CT confirmed these findings&#44; in a pattern suggestive of lymph node sarcoidosis&#46; No lesions were found in the pulmonary parenchyma&#46; Angiotensin converting enzyme &#40;ACE&#41; level was significantly elevated &#40;117<span class="elsevierStyleHsp" style=""></span>U&#47;L&#44; range 20&#8211;70&#41;&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient was submitted to a skin biopsy&#44; in which were also visible epithelioid granulomas with rare giant multinucleated cells&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Confirmed the diagnosis of sarcoidosis with bone&#44; skin&#44; liver and lymph node involvement&#44; the patient started prednisolone 40<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#44; with rapid improvement of the joint pain&#44; skin lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; and analytical abnormalities&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">Sarcoidosis is a rare disease with heterogeneous presentation characterized by the formation of non-caseating granulomas&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Bone involvement is usually associated to lung&#44; skin and lymph node involvement&#44;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2</span></a> as in the case described&#46; Bone lesions are asymptomatic in half of the cases&#44; although they may present with bone or joint pain or edema&#46; In conventional X-ray&#44; bone lesions usually appear as cystic&#44; lytic or permeative lesions&#44; and are usually visible on phalanges&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;3</span></a> Asymptomatic patients usually do not require specific treatment&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Symptomatic patients may need treatment&#58; NSAIDs&#44; corticosteroids&#44; methotrexate&#44; hydroxychloroquine&#44; and infliximab are described in the literature for this purpose&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Skin lesions have a predilection for black women&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> They are divided into two large groups&#58; those specific of sarcoidosis &#40;with evidence of granuloma&#41; and nonspecific &#40;with inflammatory changes but no identifiable granulomas&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">5&#44;6</span></a> Erythema nodosum is the most common non-specific injury of sarcoidosis&#44; and is a sign of the L&#246;fgren syndrome&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> The specific cutaneous lesions of sarcoidosis usually cause no other symptoms beyond the cosmetic changes and are very heterogeneous in their appearance&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> In this group stands out lupus pernio for being one of the few lesions with some distinctive features&#58; violet papules and nodules that coalesce on plaques&#44; with predilection for face&#44; especially nose&#44; ears and perioral region&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> They can also appear in the fingers&#44;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4&#44;6</span></a> but the simultaneous involvement in both hands and feet never was described to the best of our knowledge&#44; as seen in this case presented&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Most patients remain asymptomatic and have only a slight increase in liver function enzymes&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> Treatment with corticosteroids usually normalize liver enzymes&#44; but is not recommended for asymptomatic patients with no involvement of other organs&#44; since delay in treatment rarely leads to significant liver damage&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Our clinical case emphasizes the difficulty in diagnosis with an atypical presentation&#46; It is very important to keep a high level of awareness to the diagnosis of sarcoidosis&#46; Joint and bone involvement is uncommon&#44; the skin lesions will be variable and it is important to know them&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflicts of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 35-year-old man presented with a 3-year history of arthralgia and purple coloration of the skin of his fingers and feet&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hand and foot radiography showed cystic bone lesions on phalanges suggestive of sarcoidosis&#46; Lab tests revealed increased liver enzymes&#46; Liver MRI evidenced an enlarged liver and retroperitoneal lymphadenopathy&#46; Histological analysis of the finger skin&#44; lymph nodes and liver demonstrated the presence of granulomas&#44; confirming the diagnosis of sarcoidosis&#46; The patient started prednisolone with rapid improvement of the symptoms&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Skin lesions are divided into two groups&#58; specific for sarcoidosis &#40;with granulomas&#44; lupus pernio-like&#41; and nonspecific &#40;without granulomas&#44; erythema nodosum-like&#41;&#46; Specific cutaneous lesions usually cause no other symptoms beyond cosmetic changes&#46; Lupus pernio stands out for having distinctive features but&#44; to the best of our knowledge&#44; the simultaneous involvement of both hands and feet has never been reported&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se presenta el caso de un hombre de 35 a&#241;os con una historia de artralgia y con la piel de los dedos y los pies de color viol&#225;ceo&#44; de 3 a&#241;os de duraci&#243;n&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La radiograf&#237;a de pies y manos mostr&#243; lesiones qu&#237;sticas &#243;seas en las falanges&#44; indicativas de sarcoidosis&#46; Las pruebas de laboratorio revelaron una elevaci&#243;n de las enzimas hep&#225;ticas&#46; La resonancia magn&#233;tica hep&#225;tica puso de manifiesto hepatomegalia y linfadenopat&#237;a retroperitoneal&#46; El an&#225;lisis histol&#243;gico de la piel de los dedos&#44; los ganglios linf&#225;ticos y el h&#237;gado mostr&#243; la existencia de granulomas&#44; lo que confirm&#243; el diagn&#243;stico de sarcoidosis&#46; El paciente comenz&#243; el tratamiento con prednisolona con una r&#225;pida mejor&#237;a de los s&#237;ntomas&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Las lesiones de la piel se dividen en 2 grupos&#58; espec&#237;ficas de la sarcoidosis &#40;con granulomas y lupus caracter&#237;stico del eritema pernio&#41; e inespec&#237;ficas &#40;sin granulomas y de tipo eritema nudoso&#41;&#46; Las lesiones cut&#225;neas espec&#237;ficas generalmente no causan m&#225;s s&#237;ntomas que los cambios est&#233;ticos&#46; El lupus pernio destaca por presentar caracter&#237;sticas distintivas&#44; pero no nos consta que se haya descrito nunca la afectaci&#243;n simult&#225;nea de ambas manos y pies&#46;</p></span>"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osseous sarcoidosis&#58; clinical characteristics&#44; treatment&#44; and outcomes &#8211; experience from a large&#44; academic hospital"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Sparks"
                            1 => "J&#46;I&#46; McSparron"
                            2 => "N&#46; Shah"
                            3 => "P&#46; Aliabadi"
                            4 => "V&#46; Paulson"
                            5 => "C&#46;H&#46; Fanta"
                          ]
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.semarthrit.2014.07.003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Arthritis Rheum"
                        "fecha" => "2014"
                        "volumen" => "44"
                        "paginaInicial" => "371"
                        "paginaFinal" => "379"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25129260"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Osteo-articular manifestations of sarcoidosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;Z&#46; Alaoui"
                            1 => "M&#46; Talaoui"
                            2 => "S&#46; Benamour"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Presse Med"
                        "fecha" => "2005"
                        "volumen" => "34"
                        "paginaInicial" => "19"
                        "paginaFinal" => "24"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16158025"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0060"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extra-pulmonary manifestations of sarcoidosis"
                      "autores" => array:1 [
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                          "autores" => array:6 [
                            0 => "V&#46; Vardhanabhuti"
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                            2 => "G&#46; Bhatnagar"
                            3 => "M&#46; Maviki"
                            4 => "S&#46; Iyengar"
                            5 => "W&#46;M&#46; Adams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.crad.2011.04.018"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Radiol"
                        "fecha" => "2012"
                        "volumen" => "67"
                        "paginaInicial" => "263"
                        "paginaFinal" => "276"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22094184"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic cutaneous lesions of sarcoidosis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;M&#46; Marchell"
                            1 => "M&#46;A&#46; Judson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2007.03.007"
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                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "295"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560307"
                            "web" => "Medline"
                          ]
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                ]
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "The clinical features of sarcoidosis&#58; a comprehensive review"
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                          "autores" => array:1 [
                            0 => "M&#46;A&#46; Judson"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Clin Rev Allergy Immunol"
                        "fecha" => "2014"
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0075"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
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                          "autores" => array:2 [
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                            1 => "M&#46;A&#46; Judson"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-0030-1262212"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Respir Crit Care Med"
                        "fecha" => "2010"
                        "volumen" => "31"
                        "paginaInicial" => "442"
                        "paginaFinal" => "451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20665394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous sarcoidosis&#58; differential diagnosis"
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                        0 => array:2 [
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                          "autores" => array:2 [
                            0 => "E&#46; Fernandez-Faith"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2007.03.004"
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                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2007"
                        "volumen" => "25"
                        "paginaInicial" => "276"
                        "paginaFinal" => "287"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17560305"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                            0 => "G&#46;J&#46; Bakker"
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                            2 => "L&#46;J&#46; Maillette de Buy Wenniger"
                            3 => "U&#46; Beuers"
                          ]
                        ]
                      ]
                    ]
                  ]
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                      "Revista" => array:6 [
                        "tituloSerie" => "Neth J Med"
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                        "paginaInicial" => "349"
                        "paginaFinal" => "356"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23065982"
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                          ]
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              "identificador" => "bib0090"
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              "referencia" => array:1 [
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                            3 => "C&#46; Cerquaglia"
                            4 => "V&#46; Curigliano"
                            5 => "E&#46; Verrecchia"
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                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Rev Med Pharmacol Sci"
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                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "37"
                        "paginaFinal" => "44"
                        "link" => array:1 [
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Article information
ISSN: 21735743
Original language: English
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Idiomas
Reumatología Clínica (English Edition)
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