Role of physical activity in the management and assessment of rheumatoid arthritis patients

array:24 ["pii" => "S2173574317300837" "issn" => "21735743" "doi" => "10.1016/j.reumae.2016.04.014" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "917" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Reumatol Clin. 2017;13:214-20" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 563 "formatos" => array:3 [ "EPUB" => 40 "HTML" => 356 "PDF" => 167 ] ] "Traduccion" => array:1 [ "en" => array:19 [ "pii" => "S1699258X1630016X" "issn" => "1699258X" "doi" => "10.1016/j.reuma.2016.04.003" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "917" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Reumatol Clin. 2017;13:214-20" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4453 "formatos" => array:3 [ "EPUB" => 168 "HTML" => 3027 "PDF" => 1258 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Review Article" "titulo" => "Role of physical activity in the management and assessment of rheumatoid arthritis patients" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "214" "paginaFinal" => "220" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Papel de la actividad física en el manejo y evaluación de la artritis reumatoide" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1685 "Ancho" => 2170 "Tamanyo" => 157009 ] ] "descripcion" => array:1 [ "en" => "Literature review flowchart." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "María Vanesa Hernández-Hernández, Federico Díaz-González" "autores" => array:2 [ 0 => array:2 [ "nombre" => "María Vanesa" "apellidos" => "Hernández-Hernández" ] 1 => array:2 [ "nombre" => "Federico" "apellidos" => "Díaz-González" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2173574317300837" "doi" => "10.1016/j.reumae.2016.04.014" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300837?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1630016X?idApp=UINPBA00004M" "url" => "/1699258X/0000001300000004/v1_201706290122/S1699258X1630016X/v1_201706290122/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2173574317300862" "issn" => "21735743" "doi" => "10.1016/j.reumae.2016.05.009" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "929" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Reumatol Clin. 2017;13:221-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 517 "formatos" => array:3 [ "EPUB" => 44 "HTML" => 353 "PDF" => 120 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "Case report" "titulo" => "Coexistence of sarcoidosis and Familial Mediterranean Fever" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "221" "paginaFinal" => "223" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Coexistencia de sarcoidosis y fiebre mediterránea familiar" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1481 "Ancho" => 1717 "Tamanyo" => 270930 ] ] "descripcion" => array:1 [ "en" => "Torax CT showed bilateral multiple mediastinal and hilar lymphadenopathy." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Hüseyin Semiz, Senol Kobak" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Hüseyin" "apellidos" => "Semiz" ] 1 => array:2 [ "nombre" => "Senol" "apellidos" => "Kobak" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1699258X16300456" "doi" => "10.1016/j.reuma.2016.05.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300456?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300862?idApp=UINPBA00004M" "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300862/v1_201707050008/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173574317300886" "issn" => "21735743" "doi" => "10.1016/j.reumae.2016.06.004" "estado" => "S300" "fechaPublicacion" => "2017-07-01" "aid" => "944" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Reumatol Clin. 2017;13:210-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 463 "formatos" => array:3 [ "EPUB" => 46 "HTML" => 230 "PDF" => 187 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "Brief report" "titulo" => "Sustained remission after long-term biological therapy in patients with large vessel vasculitis: an analysis of ten cases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "210" "paginaFinal" => "213" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Remisión sostenida tras terapia biológica en pacientes con vasculitis de grandes vasos: análisis de 10 casos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan P. Vinicki, Rosario García-Vicuña, Miguel Arredondo, Juan P. López-Bote, Jesús A. García-Vadillo, Santos Castañeda, José M. Álvaro-Gracia" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Juan P." "apellidos" => "Vinicki" ] 1 => array:2 [ "nombre" => "Rosario" "apellidos" => "García-Vicuña" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Arredondo" ] 3 => array:2 [ "nombre" => "Juan P." "apellidos" => "López-Bote" ] 4 => array:2 [ "nombre" => "Jesús A." "apellidos" => "García-Vadillo" ] 5 => array:2 [ "nombre" => "Santos" "apellidos" => "Castañeda" ] 6 => array:2 [ "nombre" => "José M." "apellidos" => "Álvaro-Gracia" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1699258X16300638" "doi" => "10.1016/j.reuma.2016.06.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300638?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300886?idApp=UINPBA00004M" "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300886/v1_201707050008/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Review Article" "titulo" => "Role of physical activity in the management and assessment of rheumatoid arthritis patients" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "214" "paginaFinal" => "220" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María Vanesa Hernández-Hernández, Federico Díaz-González" "autores" => array:2 [ 0 => array:3 [ "nombre" => "María Vanesa" "apellidos" => "Hernández-Hernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Federico" "apellidos" => "Díaz-González" "email" => array:1 [ 0 => "federico.diaz.gonzalez@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología, Hospital Universitario de Canarias, La Laguna, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Laguna, La Laguna, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Papel de la actividad física en el manejo y evaluación de la artritis reumatoide" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1684 "Ancho" => 2170 "Tamanyo" => 203912 ] ] "descripcion" => array:1 [ "en" => "Literature review flowchart." ] ] ] "textoCompleto" => "IntroductionAlthough there are extensive data showing the beneficial effects of physical activity (PA) on cardiovascular disease and all-cause mortality, physical inactivity is a major health problem worldwide.<a class="elsevierStyleCrossRef" href="#bib0360">1</a> The precise measurement of PA is key to study its association with diseases, but the assessment of PA is complex and it is conditioned by a balance between accuracy and ease of use.<a class="elsevierStyleCrossRef" href="#bib0365">2</a>Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disorder of unknown etiology. Because the central pathology of RA occurs in the synovial membrane, joint limitation is a typical manifestation of the disease. This, in addition to the fact that most RA patients also suffer from muscle loss, contributes to decreased physical function and quality of life in these patients. In this regard, it has been shown that RA patients tend to exercise less than healthy controls when PA is measured by both subjective<a class="elsevierStyleCrossRefs" href="#bib0370">3–5</a> and objective methods.<a class="elsevierStyleCrossRefs" href="#bib0380">5–8</a> Moreover, there remain two important unanswered questions concerning PA vis-à-vis RA: (1) Do patients who are sufficiently physically active suffer less aggressive disease? and (2) Does disease activity influence PA in RA patients? With regard to the former, there is considerably more evidence favoring the prescribing PA for RA patients than there is against.<a class="elsevierStyleCrossRefs" href="#bib0400">9–11</a> With regard to the latter, although there is less evidence, recent data suggest that disease activity influences negatively the PA in RA patients.<a class="elsevierStyleCrossRefs" href="#bib0380">5,7</a>This work reviews the current evidence about the relationship between PA and RA, specifically how the former influences joint inflammation, disability, pain and quality of life in these individuals, and also how RA disease activity potentially impacts on PA in these patients. We purpose that periodic monitoring of PA using objective methods, as the accelerometry would help to better handling of RA patients.Strategy and results of literature searchingA review was conducted by the documentation department of the Spanish Rheumatology Society (SER) to identify all published literature relating to PA and/or energy expenditure in people with RA. The search strategy combined 2 sets of keywords. For Embase, EMTREE terms were used. In this case the search consisted of rheumatoid arthritis AND physical activity OR motor activity OR energy expenditure OR leisure activity AND accelerometry OR questionnaire OR calorimetry. For MEDLINE, the MeSH terms were: arthritis, rheumatoid AND leisure activities OR motor activity OR energy metabolism AND accelerometry OR questionnaires. The results included all publications published from 1 January 2000 to January 2015, that included at least 1 search term from each of the 2 categories. Only English language publications were included.To be included in the review, studies had to be: (1) either observational studies or interventional studies with programs of exercises measuring free living PA or total/activity related energy expenditure levels, using either subjective or objective methods and (2) related to adult RA population with all subjects included in studies fulfilling the criteria set down by the American College of Rheumatology, 1987. Studies which were: (1) interventional in nature with new pharmacological treatments; (2) not in English; or (3) published only in abstract format were excluded. The article selection flowchart is described in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>.<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Assessment of PAPA is defined as any bodily movement produced by skeletal muscles that result in energy expenditure.<a class="elsevierStyleCrossRef" href="#bib0415">12</a> Under this broad concept, activities relating to leisure-time, exercise, sports, locomotion (e.g., walking, biking), and work must be considered parts of PA. Sedentarism has been defined as expenditure below 10% of total daily energy expenditure performing moderate- and high-intensity activities.<a class="elsevierStyleCrossRef" href="#bib0420">13</a> Since, sedentarism has been associated with high incidences of obesity, type-2 diabetes mellitus, cardiovascular disease and other chronic illnesses,<a class="elsevierStyleCrossRef" href="#bib0425">14</a> its prevention has become a priority of the public healthcare systems. To avoid the consequences of sedentarism, U.S. Department of Health and Human Services recommends that adults should do at least 150min a week of moderate-intensity exercise (e.g., brisk walking).<a class="elsevierStyleCrossRef" href="#bib0430">15</a>A very accurate measurement of PA can be obtained by the assessing the total daily energy expenditure, albeit using expensive and cumbersome procedures such as the doubly-labeled water technique<a class="elsevierStyleCrossRef" href="#bib0435">16</a> or calorimetry.<a class="elsevierStyleCrossRef" href="#bib0365">2</a> Viable alternatives, involving less precise but more accessible methods, are available, however. These include questionnaires and triaxial accelerometers, approaches that are gaining acceptance for assessing PA both in healthy individuals and in patients suffering chronic diseases.<a class="elsevierStyleCrossRefs" href="#bib0440">17–19</a> Although questionnaires provide a evaluation limited by subjectivity, in the last 10 years a significant number of them have been developed to assess PA in different diseases; one of them, the International Physical Activity Questionnaire (IPAQ), has been used mainly for research purpose in rheumatic diseases.<a class="elsevierStyleCrossRefs" href="#bib0375">4,5,20</a> This self-report method is the cheapest and easiest way to quickly compile PA data from a large number of people providing an assessment of PA by domains. Alternatively, accelerometers are easily portable devices that offer one important advantage in objectively measuring PA based on the fact that it can capture continuously, for days and weeks distinctive characteristics of movement including the direction, frequency, intensity and duration of PA, as well as resting periods.<a class="elsevierStyleCrossRef" href="#bib0460">21</a> Although accelerometry has already been employed in clinical osteoarthritis trials,<a class="elsevierStyleCrossRefs" href="#bib0465">22–24</a> it was not until recently that this technique was used to evaluate PA patterns in inflammatory joint disorders such as RA.<a class="elsevierStyleCrossRefs" href="#bib0380">5,7,8,25</a>PA in RA patientsRegular exercise with a moderate to high level of intensity has proven to be effective in improving muscle strength and cardiovascular fitness in healthy populations and in patients with chronic illnesses, including RA.<a class="elsevierStyleCrossRefs" href="#bib0410">11,26–28</a> RA, if left uncontrolled, leads to joint deformity and destruction due to the erosion of cartilage and bone. Consequently, it has been assumed than RA patients are less active than the general population because of such joint manifestations. An additional factor that may have contributed to this inactivity tendency stems from recommendations, classically given by physicians, which restrict exercise due to concerns that excessive PA might aggravate both joint inflammation<a class="elsevierStyleCrossRef" href="#bib0500">29</a> and pain,<a class="elsevierStyleCrossRef" href="#bib0505">30</a> and accelerate joint damage in RA patients. However, currently, evidence suggests that exercise has no deleterious effects either on disease activity or on joint damage<a class="elsevierStyleCrossRefs" href="#bib0490">27,31</a> and improves muscle strength<a class="elsevierStyleCrossRef" href="#bib0515">32</a> in RA. In this regard, recently it has been suggested that RA patients who are physically active before clinical disease onset present with a milder disease, both in terms of inflammation, pain and function.<a class="elsevierStyleCrossRef" href="#bib0520">33</a>Patients with RA have an increased risk of developing cardiovascular diseases, resulting from a proatherogenic profile driven by systemic inflammation.<a class="elsevierStyleCrossRef" href="#bib0525">34</a> In healthy populations there is an inverse relationship between PA and cardiovascular risk (CVR) factors such as BMI, body composition (increased whole body fat and visceral fat)<a class="elsevierStyleCrossRef" href="#bib0530">35</a> and blood lipid levels.<a class="elsevierStyleCrossRef" href="#bib0535">36</a> Although different studies on the relationships between PA, BMI, fat mass and lipid levels in RA populations have yielded controversial data,<a class="elsevierStyleCrossRefs" href="#bib0380">5,37,38</a> the evidence clearly suggests that PA improves the CVR profile in RA patients.<a class="elsevierStyleCrossRefs" href="#bib0380">5,11,39</a>Different questionnaire-based surveys have indicated that RA patients tend to exercise less than what is currently recommended.<a class="elsevierStyleCrossRefs" href="#bib0370">3,40,41</a> When PA is objectively assessed by doubly-labeled water or accelerometry, the main disparity in PA between RA patients and healthy individuals can be seen in the time devoted to different intense activities. RA patients dedicate less time than control to high-intensity PA and to moderately intensive activities<a class="elsevierStyleCrossRefs" href="#bib0380">5,7,8,25</a> probably due to local limitations causing joint pain and disability and systemic effects like fatigue and sarcopenia. A recent systematic review of the literature about this issue, encompassing both objective and subjective methods for evaluating PA, suggests that PA levels among RA individuals tends to be lower than in healthy controls.<a class="elsevierStyleCrossRef" href="#bib0565">42</a> Although, this review concluded that owing to methodological limitations, a definitive conclusion could not be drawn, currently it is generally accepted that RA patients spend less time than controls doing moderate and vigorous PA.Effect of PA on joints and disease activity in RA patientsAs in the general population, regular PA in RA patients may, apart from providing general health gains, also yield disease-specific benefits such as reduced pain, improved muscle function, and delayed onset of disability,<a class="elsevierStyleCrossRefs" href="#bib0405">10,31,43–45</a> without deleterious effects on joint.<a class="elsevierStyleCrossRefs" href="#bib0490">27,31</a>Interestingly, moderate-intensity PA exerts anti-inflammatory effects both in healthy individuals and in those affected by various chronic illnesses.<a class="elsevierStyleCrossRef" href="#bib0585">46</a> Indeed, regular PA has been associated with a diminution in C-reactive protein (CRP)<a class="elsevierStyleCrossRefs" href="#bib0410">11,39</a> and erythrocyte sedimentation rate (ESR)<a class="elsevierStyleCrossRef" href="#bib0590">47</a> levels in RA patients. Although the exact mechanism by which these positive effects arise remains unknown, it seems linked to reductions in blood pressure, lipids, and fatty mass<a class="elsevierStyleCrossRef" href="#bib0595">48</a>. Taking into account that the main tissular source of IL-6 is the adipose tissue,<a class="elsevierStyleCrossRef" href="#bib0600">49</a> and that several lipids have proinflammatory effects, the reduction of fat accumulation in the skeletal muscle and liver is likely one of the most relevant anti-inflammatory benefits of exercise. Furthermore, it has been well established that PA releases IL-6 from skeletal muscle, a potent inducer of IL-1 receptor antagonist (IL-1ra) by monocytes and macrophages, which constitutes an important anti-inflammatory mechanism of exercise.<a class="elsevierStyleCrossRef" href="#bib0605">50</a>A number of clinical trials evaluating the effects of PA on RA patients have been developed. While much evidence suggests that some exercise is better than none at all, specific exercise parameters (intensity, duration, frequency, and type) resulting in real benefits have not been clearly defined. Some short-term and several long-term clinical trials have evaluated the effects of both aerobic and resistance exercises on outcome measures in RA patients<a class="elsevierStyleCrossRefs" href="#bib0410">11,27,28,32,47,51–60</a> (see <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Aerobic exercise in RA patientsAlthough intuitively, long-term regular exercise should be beneficial for RA patients because of the increased cardiovascular mobility and mortality in these patients, reports about aerobic exercise interventions in RA populations are scarce. A systematic review and meta-analysis of aerobic exercise,<a class="elsevierStyleCrossRef" href="#bib0405">10</a> which examined 14 randomized controlled trials, showed that cardiorespiratory aerobic conditioning in stable RA appears to be safe and improves quality of life, functionality and pain levels, but not DAS28 or joint count. This meta-analysis suggests that the sooner the exercise program is initiated, the better are the results obtained in terms of quality of life and functionality. Other clinical trials published afterwards also found an improvement in functionality<a class="elsevierStyleCrossRef" href="#bib0640">57</a> and pain<a class="elsevierStyleCrossRefs" href="#bib0640">57,60</a> in RA patients who were participating in aerobic exercise programs.Both, program duration and disease duration impacted on pain, with better results in cases of RA established, and short-term programs. However, data concerning to quality of life suggested than exercise was more benefits in patients with early RA than in established RA patients. When patients were followed up for a long period of time,<a class="elsevierStyleCrossRef" href="#bib0490">27</a> it was found that no significant decrease in aerobic fitness occurred after a relatively brief period of detraining; rather, long-term exercises produced a prolonged positive effect on functional ability. Therefore, the maintenance of a structured PA program after intervention seems to be critical for long-term benefits.<a class="elsevierStyleCrossRefs" href="#bib0640">57,61</a>Of all the studies referenced in this review that focused on aerobic exercise in RA patients (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>), three assessed disease activity changes using composite disease activity measurements.<a class="elsevierStyleCrossRefs" href="#bib0490">27,32,57</a> These studies concluded that aerobic exercise has a positive impact on disease activity, reducing DAS28, albeit without reaching statistical significance.Resistance exercise in RA populationThe value of resistance exercise for RA patients remains controversial because its effects on cardiovascular risk are not clear,<a class="elsevierStyleCrossRefs" href="#bib0410">11,62</a> and its real impact on disability seems to be very small.<a class="elsevierStyleCrossRef" href="#bib0635">56</a> However, despite design differences, the results of previous studies suggest that high-intensity strength training is feasible and safe for many patients with RA.<a class="elsevierStyleCrossRefs" href="#bib0615">52,56,63</a>A systematic review by Baillet et al.<a class="elsevierStyleCrossRef" href="#bib0400">9</a> showed that resistance exercise programs in RA patients can provide a mild, but significant, improvement in terms of functional capacity, the number of tender and swollen joints and a decrease in ESR. Resistance exercise had no impact on DAS28 or on structural damage in any of the studies analyzed. The HAQ response has proven more variable in several reports,<a class="elsevierStyleCrossRefs" href="#bib0410">11,47,53</a> which may reflect the fact that this outcome was designed for monitoring patients in pharmacologic trials and is not be suitable for evaluating physical interventions in patients with mild disabilities. Although the short-term effects of strength training in RA patients have been described in several studies<a class="elsevierStyleCrossRefs" href="#bib0675">64–66</a> the length of time that positive results achieved after cessation remains controversial.<a class="elsevierStyleCrossRefs" href="#bib0515">32,53,67</a>There is no clear evidence of the superiority of supervised strengthening exercises versus home-based exercises, since the results are varied.Effects of disease activity on PA in RA patientsSome studies indicate that PA levels (as measured by questionnaires or by accelerometry) have an inverse relationship with disease activity (as assessed by DAS28 or SDAI) in RA patients.<a class="elsevierStyleCrossRefs" href="#bib0380">5,7,25,68</a> One of these studies involved RA patients lacking lower-limb disease activity, which suggests that it is the state of inflammation as a whole that influences patients’ tendency to reduce their levels of PA.<a class="elsevierStyleCrossRef" href="#bib0380">5</a> In these studies, accelerometry was sufficiently sensitive to detect PA-changes related with disease activity both in RA patients, who showed clinical improvements in response to treatment<a class="elsevierStyleCrossRef" href="#bib0390">7</a> and in patients who suffered a disease flare.<a class="elsevierStyleCrossRef" href="#bib0380">5</a>Several disease activity indexes – such as the DAS, CDAI, SDAI or ACR – are available and allow physicians to quantify changes in the disease activity of RA over time. These indexes are liable to certain limitations related to both patient subjectivity and inter- and intraobserver variability.<a class="elsevierStyleCrossRef" href="#bib0700">69</a> As stated above, by measuring variations in PA, accelerometry appears to be sufficiently sensitive to register changes in the clinical activity of RA,<a class="elsevierStyleCrossRefs" href="#bib0380">5,7</a> and could be used as a complementary objective method for assessing changes in disease activity. Consequently, variation in accelerometry might aid physicians in optimizing the pharmacologic management of RA patients. In addition, accelerometry can help to determine whether or not PA level in a given patient is appropriate to reduce their cardiovascular risk, main cause of premature mortality in these patients.Practical applications and exercise recommendationsAlong the last 15 years, a number of interventional clinical trials have been developed in order to obtain recommendations on aerobic (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>) and resistance exercises (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>) in RA patients. The high variability in the type, intensity and duration of PA studied, as well as limitations in trial quality and size, suggest that the conclusions of these studies should be still considered to be tentative and further research in the field of PA and RA is warranted. However, a number of practical recommendations can be elaborated respect to exercise in patients with RA.All RA patients benefit from a balanced program of strengthening and endurance or aerobic exercise. Therefore, current data indicate that the benefits from performing moderate and high-intensity PA frequently (both aerobic and resistance exercises 2–3 times per week for 30–60min) in RA patients include: improved quality of life, functionality, reduced pain, improvement in the number of swollen joints, and lower levels of radiologic damage.<a class="elsevierStyleCrossRefs" href="#bib0410">11,28,31</a>Low-impact exercises, such as walking, swimming or biking are aerobic exercises recommended for arthritis patients. Aerobic exercise has been shown to improve cardiovascular fitness and patient quality of life, while reducing RA-associated disability and pain.<a class="elsevierStyleCrossRefs" href="#bib0405">10,54,55,60</a> As a result of the little number of studies, it has been suggested that the intensity levels in aerobic exercise should be moderate to hard (i.e., 60–85% of maximum heart rate), and such exercise should be performed 3 times weekly in sessions of 30–60min, divided in 3–4 periods of 15–20min a day. Progressive adjustment of the intensity level is recommended.<a class="elsevierStyleCrossRef" href="#bib0705">70</a>The strengthening exercises are designed to increase the joint stability. Movements should be smooth, performed 8–10 times twice a day and without joint pain. The weight must be increased slowly and always that it does not cause pain. Information derived from the reviewed studies<a class="elsevierStyleCrossRef" href="#bib0705">70</a> suggest that the load level objective for strengthening exercises should be moderate to hard (i.e., 50–80% of a maximal voluntary contraction), and said exercises should be performed along 20–30min 2–3 times per week. Exercises may be static or dynamic, done against body weight or with different kinds of equipment (resistance training equipment, pulley apparatuses, dumbbells, or elastic bands). Progressive adjustment of the load is recommended in a supervised clinical environment or at home under professional guidance.Adherence is difficult to maintain in long-term programs. To this end, physicians must be in contact with other health professionals (i.e., occupational therapists, nurses, dietitians, psychologists, and social workers) in order to support and motivate patients by helping them to cope with the disease in a positive way. Health professionals must convince RA patients that becoming more physically active is the best choice they can make to take care of themselves and their joints.Although there is a lack of studies designed to evaluate the role of PA during RA flare, the most extended attitude among physicians is to recommend a reduction in the duration and intensity of exercises, specifically avoiding the resistance exercise in these periods of high disease activity.A study in 2013 involving an online survey of more than 7000 smartphone owners in the U.S. showed that 79% of people 18–44-years-old have their smartphones with them 22hours a day.<a class="elsevierStyleCrossRef" href="#bib0710">71</a> The newest generation of smartphones now on the market features built-in accelerometer sensors. This technological advance, in tandem with the increased and continuous social connectedness exhibited by our society, can provide a convenient and inexpensive method for accurately evaluating PA in today's population, including RA patients. Although these devices have not yet been validated in RA patients, the implementation of such tools will enable clinicians to better gauge the actual PA undertaken by patients. Since there appears to be a relationship between levels of PA, disease activity<a class="elsevierStyleCrossRef" href="#bib0380">5</a> and response to treatment<a class="elsevierStyleCrossRef" href="#bib0390">7</a> in RA patients, the use of smartphones to evaluate PA might help physicians, not only in establishing recommendations about cardiovascular risk, but also in making therapeutic decisions in these patients.Concluding remarksAerobic and resistance exercises, 2–3 times per week for 30–60min not only provide general health gains, but have also been shown to confer disease-specific advantages such as reduced pain, improved muscle function, and delayed onset of disability in RA patients. Consequently, a periodic assessment of PA constitutes a useful tool for adjusting the exercise habits of RA patients in order to reduce their high cardiovascular risks and improve locomotion function and health status in general. Since, disease activity negatively impacts the PA capacity of RA patients, the assessment of PA with objective methods (e.g., mobile devices built-in accelerometry) may be helpful to evaluate the overall response to treatment and disease activity in RA patients.Ethical disclosuresProtection of human and animal subjectsThe authors declare that no experiments were performed on humans or animals for this study.Confidentiality of dataThe authors declare that no patient data appear in this article.Right to privacy and informed consentThe authors declare that no patient data appear in this article.FundingThis work was supported by a grant from the Spanish Ministry of Health (Fondo de Investigaciones Sanitarias) (FIS PI12/02499) and cofinanced by the European Regional Development Fund to F.D.G and by REUNINVES (Asociación para la Ayuda a la Investigación en Reumatología del Hospital Universitario de Canarias).Conflicts of interestThe authors have declared no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:19 [ 0 => array:3 [ "identificador" => "xres859813" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec853921" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres859812" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec853922" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Strategy and results of literature searching" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Assessment of PA" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "PA in RA patients" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Effect of PA on joints and disease activity in RA patients" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Aerobic exercise in RA patients" ] 10 => array:2 [ "identificador" => "sec0035" "titulo" => "Resistance exercise in RA population" ] 11 => array:2 [ "identificador" => "sec0040" "titulo" => "Effects of disease activity on PA in RA patients" ] 12 => array:2 [ "identificador" => "sec0045" "titulo" => "Practical applications and exercise recommendations" ] 13 => array:2 [ "identificador" => "sec0050" "titulo" => "Concluding remarks" ] 14 => array:3 [ "identificador" => "sec0055" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0060" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0065" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0070" "titulo" => "Right to privacy and informed consent" ] ] ] 15 => array:2 [ "identificador" => "sec0075" "titulo" => "Funding" ] 16 => array:2 [ "identificador" => "sec0080" "titulo" => "Conflicts of interest" ] 17 => array:2 [ "identificador" => "xack288224" "titulo" => "Acknowledgments" ] 18 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-12-24" "fechaAceptado" => "2016-04-04" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec853921" "palabras" => array:4 [ 0 => "Rheumatoid arthritis" 1 => "Physical activity" 2 => "Disease activity" 3 => "Accelerometry" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec853922" "palabras" => array:4 [ 0 => "Artritis reumatoide" 1 => "Actividad física" 2 => "Actividad clínica" 3 => "Acelerometría" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "ObjectivesRheumatoid arthritis (RA) is a chronic inflammatory disease affecting diarthrodial joints, in which patients tend to perform less physical activity (PA) than recommended. This review focuses on the existing evidence about the relationship of PA and RA, specifically how the former influences joint inflammation, disability, quality of life and pain in RA patients, and also how disease activity potentially impacts PA in these patients. MethodsA literature search of EMBASE and MEDLINE databases from January 2000 to January 2015. ResultsThe evidence indicating that PA in RA patients is safe and the benefits from regularly performing, both aerobic and resistance exercises, in these patients include improvement in: quality of life, functionality, pain and number of swollen joints. Interestingly, recent studies suggest that changes in disease activity in RA patients inversely correlate with variations in PA, as assessed by accelerometry. ConclusionsThe regular monitoring of PA in RA patients might facilitate a more objective evaluation of variations in disease activity, helping physicians to make general and therapeutic recommendations that will improve both the health status and the joint functionality of these patients." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "ObjetivosLa artritis reumatoide (AR) es una enfermedad inflamatoria crónica que afecta a las articulaciones diartrodiales, en la que los pacientes tienden a realizar menos actividad física (AF) de lo que se recomienda. Esta revisión se centra en la evidencia existente sobre la relación entre AF y AR, específicamente cómo la primera influye en la inflamación articular, la discapacidad, la calidad de vida y el dolor en los pacientes con AR, y también cómo la actividad clínica de la AR puede afectar a la AF de estos pacientes. MétodosSe realizó una búsqueda bibliográfica desde enero del 2000 hasta enero del 2015 en las bases EMBASE y MEDLINE. ResultadosLa evidencia indica que la AF en pacientes con AR es segura y que los beneficios de la realización periódica de ejercicios, tanto aeróbicos como de resistencia, en estos pacientes incluyen mejoras en: calidad de vida, funcionalidad, dolor y número de articulaciones inflamadas. Curiosamente, estudios muy recientes muestran que los cambios en la actividad de la enfermedad en pacientes con AR se correlacionan inversamente con variaciones en su AF, medida por acelerometría. ConclusionesEl control sistemático de la AF en pacientes con AR podría facilitar una evaluación más objetiva de las variaciones en la actividad de la enfermedad, lo que ayudaría a los médicos a hacer recomendaciones generales y terapéuticas para mejorar tanto el estado de salud como la funcionalidad articular de estos pacientes." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1684 "Ancho" => 2170 "Tamanyo" => 203912 ] ] "descripcion" => array:1 [ "en" => "Literature review flowchart." ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "AIMS2-SF: Arthritis Impact Measurement Scales 2 short form; BMD: bone mineral density; BMI: body mass index; CRP: c-reactive protein; DEXA: dual energy X-ray absorptiometry; ESR: erythrocyte sedimentation rate; HADS: Hospital Anxiety and Depression Scale; HAQ: Health Assessment Questionnaire; MACTAR: McMaster Toronto Arthritis patient preference disability questionnaire; VAS: visual analog scale." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study type \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intervention \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Time follow-up \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcomes \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Westby et al., 2000<a class="elsevierStyleCrossRef" href="#bib0610">51</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dynamic exercise program \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Disease activity (ESR, active joint count) - Functional ability (HAQ) - BMD \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Van den Ende et al., 2000<a class="elsevierStyleCrossRef" href="#bib0515">32</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised cardiovascular exercise \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Disease activity (ESR, DAS, VAS) - Functional capacity (muscle strength) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De Jong et al., 2003<a class="elsevierStyleCrossRef" href="#bib0495">28</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">150 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled multicenter trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised cardiovascular exercise (bicycle, exercise, sports 75min 2 times/week) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional ability (MACTAR y HAQ) - Functional capacity: aerobic fitness (standardized ergometer test) an muscle strength (dynamometer) - Emotional status by HADS - Radiological damage by Larsen score \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Melikoglu et al., 2006<a class="elsevierStyleCrossRef" href="#bib0625">54</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised cardiovascular exercise \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Pain (VAS) - Disease activity (duration of morning stiffness, active joint count, ESR, CRP) - Functional ability (HAQ) - BMI (DEXA) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neuberger et al., 2007<a class="elsevierStyleCrossRef" href="#bib0630">55</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">310 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised cardiovascular exercise (low impact aerobic exercise 1hour 3 times/week) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">12 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Fatigue (FACIT) - Pain (McGill pain questionnaire short form) - Depression (studies depression scale) - Disease activity (active joint count, ESR, CRP) - Functional capacity: walk time and grip strength, bicycle ergometer testing. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De Jong et al., 2009<a class="elsevierStyleCrossRef" href="#bib0490">27</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Observational study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cardiovascular exercise biweekly \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">18 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional ability (MACTAR y HAQ) - Aerobic fitness (standardized ergometer test) - Muscle strength (dynamometer) - Disease activity (DAS4) - Radiological damage (Larsen score) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sjöquist et al., 2011<a class="elsevierStyleCrossRef" href="#bib0640">57</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">288 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Multicenter randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised and Home cardiovascular exercise \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional ability: HAQ - Disease activity: DAS28 - Pain: VAS - Health perception: VAS \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Jahanbin 2014,<a class="elsevierStyleCrossRef" href="#bib0655">60</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised two 45-min sessions per week of conditioning exercises \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">2 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Pain: VAS. - Health status: AIMS2-SF \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1453257.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Studies of aerobic exercise programs in RA." ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "BMD: bone mineral density; DEXA: dual energy X-ray absorptiometry; EQ-5D: EuroQol-5D; ESR: erythrocyte sedimentation rate; HAQ: Health Assessment Questionnaire; MHQ: Michigan Hand outcomes Questionnaire; SF-12: short form 12; VAS: visual analog scale." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">n \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study type \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intervention \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Time follow-up \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcomes \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Häkkinen et al., 2001<a class="elsevierStyleCrossRef" href="#bib0590">47</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Home dynamic strength training \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional capacity: muscle strength (dynamometry knee extensors, trunk flexors-extensors), walk time. - Functional ability: HAQ. - Disease activity: DAS28, VAS, ESR. - Pain: VAS. - BMD: DEXA - Radiological damage: Larsen score \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Häkkinen et al., 2003<a class="elsevierStyleCrossRef" href="#bib0615">52</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Observational study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised six training sessions in a 2-week period \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">21 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional capacity: maximal muscle strength (dynamometry), walking speed, vertical squat jump - Functional ability: HAQ - Disease activity: Joint index score, ESR - Pain: VAS \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Häkkinen et al., 2004<a class="elsevierStyleCrossRef" href="#bib0620">53</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Observational study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Home dynamic strength training \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">3 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">-Functional capacity: muscle strength (dynamometry knee extensors, trunk flexors-extensors), walk time. - Functional ability: HAQ. - Disease activity: DAS28, VAS, ESR \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lemmey et al., 2009<a class="elsevierStyleCrossRef" href="#bib0635">56</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised resistance training program twice a week \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">24 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional capacity: walk test, arm curl test, knee extensor strength. - Functional ability: HAQ - Disease activity: DAS28, ESR. - Body composition: DEXA. - Muscle IGFs: muscle biopsies \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bosch et al., 2009<a class="elsevierStyleCrossRef" href="#bib0645">58</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised exercise sessions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional capacity: balance (Berg balance test) - Functional ability: HAQ. - Pain: VAS - Depression: Beck Depression Inventory - Cortisol levels - Heart rate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Flint-Wagner et al., 2009<a class="elsevierStyleCrossRef" href="#bib0650">59</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised exercise sessions \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">16 weeks \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Functional capacity: muscle strength (dynamometry elbow and knee flexors-extensors), walk time - Functional ability: HAQ - Pain: VAS \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stavropoulos-Kalinoglou et al., 2013<a class="elsevierStyleCrossRef" href="#bib0410">11</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Randomized controlled trial \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Supervised aerobic and resistance high intensity exercises three times per week \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">- Disease activity (DAS28, CRP) - Functional ability (HAQ) - Cardiovascular risk: BMI, body fat, blood pressure, lipoproteins \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1453256.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Studies of strengthening programs in RA." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:71 [ 0 => array:3 [ "identificador" => "bib0360" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of exercise is a major cause of chronic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "F.W. Booth" 1 => "C.K. Roberts" 2 => "M.J. Laye" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cphy.c110025" "Revista" => array:6 [ "tituloSerie" => "Compr Physiol" "fecha" => "2012" "volumen" => "2" "paginaInicial" => "1143" "paginaFinal" => "1211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23798298" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0365" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of physical activity – a review of methodologies with reference to epidemiological research: a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.M. Warren" 1 => "U. Ekelund" 2 => "H. Besson" 3 => "A. Mezzani" 4 => "N. Geladas" 5 => "L. Vanhees" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/HJR.0b013e32832ed875" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiovasc Prev Rehabil" "fecha" => "2010" "volumen" => "17" "paginaInicial" => "127" "paginaFinal" => "139" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20215971" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0370" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity, physical fitness, and general health perception among individuals with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Eurenius" 1 => "C.H. Stenstrom" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.20924" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2005" "volumen" => "53" "paginaInicial" => "48" "paginaFinal" => "55" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15696555" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0375" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disease activity and low physical activity associate with number of hospital admissions and length of hospitalisation in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.S. Metsios" 1 => "A. Stavropoulos-Kalinoglou" 2 => "G.J. Treharne" 3 => "A.M. Nevill" 4 => "A. Sandoo" 5 => "V.F. Panoulas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar3390" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2011" "volumen" => "13" "paginaInicial" => "R108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21714856" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0380" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of disease activity on the physical activity of rheumatoid arthritis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V. Hernandez-Hernandez" 1 => "I. Ferraz-Amaro" 2 => "F. Diaz-Gonzalez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2014" "volumen" => "53" "paginaInicial" => "722" "paginaFinal" => "731" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0385" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity measured by the SenseWear Armband in women with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.J. Almeida" 1 => "M.C. Wasko" 2 => "K. Jeong" 3 => "C.G. Moore" 4 => "S.R. Piva" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2522/ptj.20100291" "Revista" => array:6 [ "tituloSerie" => "Phys Ther" "fecha" => "2011" "volumen" => "91" "paginaInicial" => "1367" "paginaFinal" => "1376" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21719635" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0390" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in physical activity measured by accelerometry following initiation of DMARD therapy in rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Prioreschi" 1 => "B. Hodkinson" 2 => "M. Tikly" 3 => "J.A. McVeigh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2014" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0395" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessing physical activity in persons with rheumatoid arthritis using accelerometry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Semanik" 1 => "J. Song" 2 => "R.W. Chang" 3 => "L. Manheim" 4 => "B. Ainsworth" 5 => "D. Dunlop" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1249/MSS.0b013e3181cfc9da" "Revista" => array:6 [ "tituloSerie" => "Med Sci Sports Exerc" "fecha" => "2010" "volumen" => "42" "paginaInicial" => "1493" "paginaFinal" => "1501" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20139792" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0400" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of resistance exercises in rheumatoid arthritis: meta-analysis of randomized controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Baillet" 1 => "M. Vaillant" 2 => "M. Guinot" 3 => "R. Juvin" 4 => "P. Gaudin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2012" "volumen" => "51" "paginaInicial" => "519" "paginaFinal" => "527" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0405" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of cardiorespiratory aerobic exercise in rheumatoid arthritis: meta-analysis of randomized controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Baillet" 1 => "N. Zeboulon" 2 => "L. Gossec" 3 => "C. Combescure" 4 => "L.A. Bodin" 5 => "R. Juvin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res (Hoboken)" "fecha" => "2010" "volumen" => "62" "paginaInicial" => "984" "paginaFinal" => "992" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0410" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Stavropoulos-Kalinoglou" 1 => "G.S. Metsios" 2 => "J.J. Veldhuijzen van Zanten" 3 => "P. Nightingale" 4 => "G.D. Kitas" 5 => "Y. Koutedakis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/annrheumdis-2012-202075" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2013" "volumen" => "72" "paginaInicial" => "1819" "paginaFinal" => "1825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23155222" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0415" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.J. Caspersen" 1 => "K.E. Powell" 2 => "G.M. Christenson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Public Health Rep" "fecha" => "1985" "volumen" => "100" "paginaInicial" => "126" "paginaFinal" => "131" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3920711" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0420" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Definition and prevalence of sedentarism in an urban population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.S. Bernstein" 1 => "A. Morabia" 2 => "D. Sloutskis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Public Health" "fecha" => "1999" "volumen" => "89" "paginaInicial" => "862" "paginaFinal" => "867" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10358676" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0425" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Health benefits of physical activity: the evidence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.E. Warburton" 1 => "C.W. Nicol" 2 => "S.S. Bredin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1503/cmaj.051351" "Revista" => array:6 [ "tituloSerie" => "CMAJ" "fecha" => "2006" "volumen" => "174" "paginaInicial" => "801" "paginaFinal" => "809" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16534088" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0430" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "http://www.health.gov/paguidelines/" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Secondary 2008 Physical Activity Guidelines Advisory Committee report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "U.S. Department of Health & Human Services" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2008" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0435" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of physical activity: a critical appraisal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.R. Westerterp" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00421-009-1000-2" "Revista" => array:6 [ "tituloSerie" => "Eur J Appl Physiol" "fecha" => "2009" "volumen" => "105" "paginaInicial" => "823" "paginaFinal" => "828" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19205725" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0440" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estimating energy expenditure using accelerometers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.E. Crouter" 1 => "J.R. Churilla" 2 => "D.R. Bassett Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00421-006-0307-5" "Revista" => array:6 [ "tituloSerie" => "Eur J Appl Physiol" "fecha" => "2006" "volumen" => "98" "paginaInicial" => "601" "paginaFinal" => "612" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17058102" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0445" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantitating physical activity in COPD using a triaxial accelerometer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B.G. Steele" 1 => "L. Holt" 2 => "B. Belza" 3 => "S. Ferris" 4 => "S. Lakshminaryan" 5 => "D.M. Buchner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "117" "paginaInicial" => "1359" "paginaFinal" => "1367" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10807823" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0450" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Accelerometry in persons with multiple sclerosis: measurement of physical activity or walking mobility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Weikert" 1 => "R.W. Motl" 2 => "Y. Suh" 3 => "E. McAuley" 4 => "D. Wynn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jns.2009.12.021" "Revista" => array:6 [ "tituloSerie" => "J Neurol Sci" "fecha" => "2010" "volumen" => "290" "paginaInicial" => "6" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20060544" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0455" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International physical activity questionnaire: 12-country reliability and validity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.L. Craig" 1 => "A.L. Marshall" 2 => "M. Sjostrom" 3 => "A.E. Bauman" 4 => "M.L. Booth" 5 => "B.E. Ainsworth" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1249/01.MSS.0000078924.61453.FB" "Revista" => array:6 [ "tituloSerie" => "Med Sci Sports Exerc" "fecha" => "2003" "volumen" => "35" "paginaInicial" => "1381" "paginaFinal" => "1395" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12900694" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0460" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The technology of accelerometry-based activity monitors: current and future" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "K.Y. Chen" 1 => "D.R. Bassett Jr." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Sci Sports Exerc" "fecha" => "2005" "volumen" => "37" "paginaInicial" => "S490" "paginaFinal" => "S500" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16294112" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0465" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity levels in patients with early knee osteoarthritis measured by accelerometry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.N. Farr" 1 => "S.B. Going" 2 => "T.G. Lohman" 3 => "L. Rankin" 4 => "S. Kasle" 5 => "M. Cornett" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.24007" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2008" "volumen" => "59" "paginaInicial" => "1229" "paginaFinal" => "1236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18759320" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0470" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of momentary pain and fatigue on physical activity in women with osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.L. Murphy" 1 => "D.M. Smith" 2 => "D.J. Clauw" 3 => "N.B. Alexander" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.23710" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2008" "volumen" => "59" "paginaInicial" => "849" "paginaFinal" => "856" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18512720" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0475" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obesity and other modifiable factors for physical inactivity measured by accelerometer in adults with knee osteoarthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Lee" 1 => "J. Song" 2 => "J.M. Hootman" 3 => "P.A. Semanik" 4 => "R.W. Chang" 5 => "L. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res (Hoboken)" "fecha" => "2013" "volumen" => "65" "paginaInicial" => "53" "paginaFinal" => "61" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0480" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The clinical utility of accelerometry in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Prioreschi" 1 => "B. Hodkinson" 2 => "I. Avidon" 3 => "M. Tikly" 4 => "J.A. McVeigh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2013" "volumen" => "52" "paginaInicial" => "1721" "paginaFinal" => "1727" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0485" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Kodama" 1 => "K. Saito" 2 => "S. Tanaka" 3 => "M. Maki" 4 => "Y. Yachi" 5 => "M. Asumi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2009.681" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2009" "volumen" => "301" "paginaInicial" => "2024" "paginaFinal" => "2035" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454641" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0490" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term follow-up of a high-intensity exercise program in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Z. de Jong" 1 => "M. Munneke" 2 => "H.M. Kroon" 3 => "D. van Schaardenburg" 4 => "B.A. Dijkmans" 5 => "J.M. Hazes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-009-1125-z" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2009" "volumen" => "28" "paginaInicial" => "663" "paginaFinal" => "671" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19247575" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0495" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis? Results of a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Z. de Jong" 1 => "M. Munneke" 2 => "A.H. Zwinderman" 3 => "H.M. Kroon" 4 => "A. Jansen" 5 => "K.H. Ronday" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.11216" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2003" "volumen" => "48" "paginaInicial" => "2415" "paginaFinal" => "2424" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13130460" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0500" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Benefits of hospitalization in rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Lee" 1 => "A.C. Kennedy" 2 => "J. Anderson" 3 => "W.W. Buchanan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Q J Med" "fecha" => "1974" "volumen" => "43" "paginaInicial" => "205" "paginaFinal" => "214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4850737" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0505" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of resting splints by patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Feinberg" 1 => "K.D. Brandt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Occup Ther" "fecha" => "1981" "volumen" => "35" "paginaInicial" => "173" "paginaFinal" => "178" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7234956" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0510" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of physical activity in rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Plasqui" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.physbeh.2007.12.012" "Revista" => array:6 [ "tituloSerie" => "Physiol Behav" "fecha" => "2008" "volumen" => "94" "paginaInicial" => "270" "paginaFinal" => "275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18234247" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0515" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of intensive exercise on patients with active rheumatoid arthritis: a randomised clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.H. van den Ende" 1 => "F.C. Breedveld" 2 => "S. le Cessie" 3 => "B.A. Dijkmans" 4 => "A.W. de Mug" 5 => "J.M. Hazes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2000" "volumen" => "59" "paginaInicial" => "615" "paginaFinal" => "621" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10913058" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0520" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.E. Sandberg" 1 => "S. Wedren" 2 => "L. Klareskog" 3 => "I.E. Lundberg" 4 => "C.H. Opava" 5 => "L. Alfredsson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/annrheumdis-2014-205180" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2014" "volumen" => "73" "paginaInicial" => "1541" "paginaFinal" => "1544" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24641943" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0525" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.H. Solomon" 1 => "E.W. Karlson" 2 => "E.B. Rimm" 3 => "C.C. Cannuscio" 4 => "L.A. Mandl" 5 => "J.E. Manson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2003" "volumen" => "107" "paginaInicial" => "1303" "paginaFinal" => "1307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12628952" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0530" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity across adulthood in relation to fat and lean body mass in early old age: findings from the Medical Research Council National Survey of Health and Development, 1946–2010" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Bann" 1 => "D. Kuh" 2 => "A.K. Wills" 3 => "J. Adams" 4 => "S. Brage" 5 => "R. Cooper" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/aje/kwu033" "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "2014" "volumen" => "179" "paginaInicial" => "1197" "paginaFinal" => "1207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24722997" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0535" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of leisure time physical activity on blood lipid levels: the ATTICA study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.B. Panagiotakos" 1 => "C. Pitsavos" 2 => "C. Chrysohoou" 3 => "J. Skoumas" 4 => "A. Zeimbekis" 5 => "I. Papaioannou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.mca.0000096082.14788.9f" "Revista" => array:6 [ "tituloSerie" => "Coron Artery Dis" "fecha" => "2003" "volumen" => "14" "paginaInicial" => "533" "paginaFinal" => "539" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14646674" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0540" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What predicts obesity in patients with rheumatoid arthritis? An investigation of the interactions between lifestyle and inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Stavropoulos-Kalinoglou" 1 => "G.S. Metsios" 2 => "J.P. Smith" 3 => "V.F. Panoulas" 4 => "K.M. Douglas" 5 => "A.Z. Jamurtas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Int J Obes (Lond)" "fecha" => "2010" "volumen" => "34" "paginaInicial" => "295" "paginaFinal" => "301" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0545" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low level of physical activity in women with rheumatoid arthritis is associated with cardiovascular risk factors but not with body fat mass – a cross sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.C. Elkan" 1 => "N. Hakansson" 2 => "J. Frostegard" 3 => "I. Hafstrom" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-2474-12-13" "Revista" => array:5 [ "tituloSerie" => "BMC Musculoskelet Disord" "fecha" => "2011" "volumen" => "12" "paginaInicial" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21235741" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0550" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.S. Metsios" 1 => "A. Stavropoulos-Kalinoglou" 2 => "V.F. Panoulas" 3 => "M. Wilson" 4 => "A.M. Nevill" 5 => "Y. Koutedakis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/HJR.0b013e3283271ceb" "Revista" => array:6 [ "tituloSerie" => "Eur J Cardiovasc Prev Rehabil" "fecha" => "2009" "volumen" => "16" "paginaInicial" => "188" "paginaFinal" => "194" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19238083" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0555" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical inactivity in patients with rheumatoid arthritis: data from twenty-one countries in a cross-sectional, international study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Sokka" 1 => "A. Hakkinen" 2 => "H. Kautiainen" 3 => "M.J. Nissen" 4 => "B. Allenet" 5 => "P. Francois" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.23255" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2008" "volumen" => "59" "paginaInicial" => "42" "paginaFinal" => "50" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18163412" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0560" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity level and physical fitness in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Acar" 1 => "E. Tonga" 2 => "A. Daskapan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2013" "paginaInicial" => "72" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0565" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity in rheumatoid arthritis: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Tierney" 1 => "A. Fraser" 2 => "N. Kennedy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Phys Act Health" "fecha" => "2012" "volumen" => "9" "paginaInicial" => "1036" "paginaFinal" => "1048" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22971883" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0570" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dynamic exercise programs (aerobic capacity and/or muscle strength training) in patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E. Hurkmans" 1 => "F.J. van der Giesen" 2 => "T.P. Vliet Vlieland" 3 => "J. Schoones" 4 => "E.C. Van den Ende" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2009" "paginaInicial" => "CD006853" ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0575" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dynamic exercise therapy for rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.H. Van Den Ende" 1 => "T.P. Vliet Vlieland" 2 => "M. Munneke" 3 => "J.M. Hazes" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Cochrane Database Syst Rev" "fecha" => "2000" "paginaInicial" => "CD000322" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0580" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity and rheumatoid arthritis: results from quest-RA Moroccan study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. El Kabbaj" 1 => "H. Rkain" 2 => "I. Benslama" 3 => "T. Lakhdar" 4 => "F. Znat" 5 => "L. Benbrahim" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2013" "paginaInicial" => "72" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0585" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Ertek" 1 => "A. Cicero" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5114/aoms.2012.31614" "Revista" => array:6 [ "tituloSerie" => "Arch Med Sci" "fecha" => "2012" "volumen" => "8" "paginaInicial" => "794" "paginaFinal" => "804" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23185187" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0590" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized two-year study of the effects of dynamic strength training on muscle strength, disease activity, functional capacity, and bone mineral density in early rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Hakkinen" 1 => "T. Sokka" 2 => "A. Kotaniemi" 3 => "P. Hannonen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(200103)44:3<515::AID-ANR98>3.0.CO;2-5" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2001" "volumen" => "44" "paginaInicial" => "515" "paginaFinal" => "522" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11263764" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0595" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differentiation between obesity and insulin resistance in the association with C-reactive protein" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. McLaughlin" 1 => "F. Abbasi" 2 => "C. Lamendola" 3 => "L. Liang" 4 => "G. Reaven" 5 => "P. Schaaf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2002" "volumen" => "106" "paginaInicial" => "2908" "paginaFinal" => "2912" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12460870" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0600" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-6 and insulin resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.H. Kim" 1 => "R.A. Bachmann" 2 => "J. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0083-6729(08)00621-3" "Revista" => array:6 [ "tituloSerie" => "Vitam Horm" "fecha" => "2009" "volumen" => "80" "paginaInicial" => "613" "paginaFinal" => "633" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19251052" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0605" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The immunomodulating role of exercise in metabolic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G.I. Lancaster" 1 => "M.A. Febbraio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Trends Immunol" "fecha" => "2014" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0610" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A randomized controlled trial to evaluate the effectiveness of an exercise program in women with rheumatoid arthritis taking low dose prednisone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.D. Westby" 1 => "J.P. Wade" 2 => "K.K. Rangno" 3 => "J. Berkowitz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2000" "volumen" => "27" "paginaInicial" => "1674" "paginaFinal" => "1680" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10914850" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0615" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of concurrent strength and endurance training in women with early or longstanding rheumatoid arthritis: comparison with healthy subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Hakkinen" 1 => "P. Hannonen" 2 => "K. Nyman" 3 => "T. Lyyski" 4 => "K. Hakkinen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.11466" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2003" "volumen" => "49" "paginaInicial" => "789" "paginaFinal" => "797" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14673965" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0620" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A home-based two-year strength training period in early rheumatoid arthritis led to good long-term compliance: a five-year followup" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Hakkinen" 1 => "T. Sokka" 2 => "P. Hannonen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.20088" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2004" "volumen" => "51" "paginaInicial" => "56" "paginaFinal" => "62" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14872456" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0625" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between dynamic exercise therapy and IGF-1 and IGFBP-3 concentrations in the patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.A. Melikoglu" 1 => "S. Karatay" 2 => "K. Senel" 3 => "F. Akcay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00296-005-0605-y" "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2006" "volumen" => "26" "paginaInicial" => "309" "paginaFinal" => "313" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15933856" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0630" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of exercise and effects of exercise on symptoms, function, aerobic fitness, and disease outcomes of rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.B. Neuberger" 1 => "L.S. Aaronson" 2 => "B. Gajewski" 3 => "S.E. Embretson" 4 => "P.E. Cagle" 5 => "J.K. Loudon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.22903" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "943" "paginaFinal" => "952" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17665488" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0635" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of high-intensity resistance training in patients with rheumatoid arthritis: a randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.B. Lemmey" 1 => "S.M. Marcora" 2 => "K. Chester" 3 => "S. Wilson" 4 => "F. Casanova" 5 => "P.J. Maddison" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.24891" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2009" "volumen" => "61" "paginaInicial" => "1726" "paginaFinal" => "1734" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19950325" "web" => "Medline" ] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0640" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity coaching of patients with rheumatoid arthritis in everyday practice: a long-term follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.S. Sjoquist" 1 => "N. Brodin" 2 => "J. Lampa" 3 => "I. Jensen" 4 => "C.H. Opava" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/msc.199" "Revista" => array:6 [ "tituloSerie" => "Musculoskeletal Care" "fecha" => "2011" "volumen" => "9" "paginaInicial" => "75" "paginaFinal" => "85" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21618399" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0645" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional and physiological effects of yoga in women with rheumatoid arthritis: a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.R. Bosch" 1 => "T. Traustadottir" 2 => "P. Howard" 3 => "K.S. Matt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Altern Ther Health Med" "fecha" => "2009" "volumen" => "15" "paginaInicial" => "24" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19623830" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0650" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of a sixteen-week training program on strength, pain, and function in rheumatoid arthritis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H.G. Flint-Wagner" 1 => "J. Lisse" 2 => "T.G. Lohman" 3 => "S.B. Going" 4 => "T. Guido" 5 => "E. Cussler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RHU.0b013e318190f95f" "Revista" => array:6 [ "tituloSerie" => "J Clin Rheumatol" "fecha" => "2009" "volumen" => "15" "paginaInicial" => "165" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19279507" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0655" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of conditioning exercise on the health status and pain in patients with rheumatoid arthritis: a randomized controlled clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "I. Jahanbin" 1 => "M. Hoseini Moghadam" 2 => "M.A. Nazarinia" 3 => "F. Ghodsbin" 4 => "Z. Bagheri" 5 => "A.R. Ashraf" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Community Based Nurs Midwifery" "fecha" => "2014" "volumen" => "2" "paginaInicial" => "169" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25349859" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0660" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A dynamic exercise programme to improve patients’ disability in rheumatoid arthritis: a prospective randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Baillet" 1 => "E. Payraud" 2 => "V.A. Niderprim" 3 => "M.J. Nissen" 4 => "B. Allenet" 5 => "P. François" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2009" "volumen" => "48" "paginaInicial" => "410" "paginaFinal" => "415" ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0665" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Resistance training improves cardiovascular risk factors in obese women despite a significative decrease in serum adiponectin levels" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Ibanez" 1 => "M. Izquierdo" 2 => "C. Martinez-Labari" 3 => "F. Ortega" 4 => "A. Grijalba" 5 => "L. Forja" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Obesity (Silver Spring)" "fecha" => "2010" "volumen" => "18" "paginaInicial" => "535" "paginaFinal" => "541" ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0670" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sustained maintenance of exercise induced muscle strength gains and normal bone mineral density in patients with early rheumatoid arthritis: a 5 year follow up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Hakkinen" 1 => "T. Sokka" 2 => "H. Kautiainen" 3 => "A. Kotaniemi" 4 => "P. Hannonen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2003.013003" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2004" "volumen" => "63" "paginaInicial" => "910" "paginaFinal" => "916" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15249317" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0675" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of strength training on neuromuscular function and disease activity in patients with recent-onset inflammatory arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Hakkinen" 1 => "K. Hakkinen" 2 => "P. Hannonen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol" "fecha" => "1994" "volumen" => "23" "paginaInicial" => "237" "paginaFinal" => "242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7973476" "web" => "Medline" ] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0680" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of low load resistive muscle training in patients with rheumatoid arthritis functional class II and III" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.R. Komatireddy" 1 => "R.W. Leitch" 2 => "K. Cella" 3 => "G. Browning" …1 ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "1531" "paginaFinal" => "1539" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0685" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dynamic training versus relaxation training as home exercise for patients with inflammatory rheumatic diseases. A randomized controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol" "fecha" => "1996" "volumen" => "25" "paginaInicial" => "28" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0690" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Are the benefits of a high-intensity progressive resistance training program sustained in rheumatoid arthritis patients? A 3-year followup study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res (Hoboken)" "fecha" => "2012" "volumen" => "64" "paginaInicial" => "71" "paginaFinal" => "75" ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0695" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Physical activity and energy expenditure in rheumatoid arthritis patients and matched controls" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford)" "fecha" => "2012" "volumen" => "51" "paginaInicial" => "1500" "paginaFinal" => "1507" ] ] ] ] ] ] 68 => array:3 [ "identificador" => "bib0700" "etiqueta" => "69" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis: influence on Disease Activity Score-28 values (SEA-Repro study part I)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3899/jrheum.090879" "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2010" "volumen" => "37" "paginaInicial" => "932" "paginaFinal" => "937" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 69 => array:3 [ "identificador" => "bib0705" "etiqueta" => "70" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence for the benefit of aerobic and strengthening exercise in rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.11051" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2003" "volumen" => "49" "paginaInicial" => "428" "paginaFinal" => "434" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 70 => array:3 [ "identificador" => "bib0710" "etiqueta" => "71" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "www.nu.nl/files/IDC-Facebook Always Connected (1).pdf" "contribucion" => array:1 [ 0 => array:1 [ "titulo" => "How smartphones and social keep us engaged" ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:1 [ "fecha" => "2013" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack288224" "titulo" => "Acknowledgments" "texto" => "The authors would like to thank Mercedes Guerra from the Spanish Rheumatology Society for the systematic search of the literature, and the members of the Department of Rheumatology of Hospital Universitario de Canarias for their continuous support. Authors also are indebted with Prof. Jose Antonio L. Calbet, Department of Physical Education of University of Las Palmas de Gran Canaria for the critical reading of the manuscript." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300837/v1_201707050008/en/main.assets" "Apartado" => array:4 [ "identificador" => "67060" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Reviews" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000004/v1_201707050008/S2173574317300837/v1_201707050008/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300837?idApp=UINPBA00004M"]

Statistics

Review Article

Role of physical activity in the management and assessment of rheumatoid arthritis patients

Papel de la actividad física en el manejo y evaluación de la artritis reumatoide

María Vanesa Hernández-Hernándeza, Federico Díaz-Gonzáleza,b,

Corresponding author

federico.diaz.gonzalez@gmail.com

Corresponding author.

a Servicio de Reumatología, Hospital Universitario de Canarias, La Laguna, Spain

b Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Laguna, La Laguna, Spain

Read

11126

Times
was read the article

3991

Total PDF

7135

Total HTML

Share statistics

 array:24 [
  "pii" => "S2173574317300837"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2016.04.014"
  "estado" => "S300"
  "fechaPublicacion" => "2017-07-01"
  "aid" => "917"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2015"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "ssu"
  "cita" => "Reumatol Clin. 2017;13:214-20"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 563
    "formatos" => array:3 [
      "EPUB" => 40
      "HTML" => 356
      "PDF" => 167
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S1699258X1630016X"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2016.04.003"
      "estado" => "S300"
      "fechaPublicacion" => "2017-07-01"
      "aid" => "917"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "ssu"
      "cita" => "Reumatol Clin. 2017;13:214-20"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4453
        "formatos" => array:3 [
          "EPUB" => 168
          "HTML" => 3027
          "PDF" => 1258
        ]
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>"
        "titulo" => "Role of physical activity in the management and assessment of rheumatoid arthritis patients"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "214"
            "paginaFinal" => "220"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Papel de la actividad f&#237;sica en el manejo y evaluaci&#243;n de la artritis reumatoide"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Fig&#46; 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1685
                "Ancho" => 2170
                "Tamanyo" => 157009
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Literature review flowchart&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Mar&#237;a Vanesa Hern&#225;ndez-Hern&#225;ndez, Federico D&#237;az-Gonz&#225;lez"
            "autores" => array:2 [
              0 => array:2 [
                "nombre" => "Mar&#237;a Vanesa"
                "apellidos" => "Hern&#225;ndez-Hern&#225;ndez"
              ]
              1 => array:2 [
                "nombre" => "Federico"
                "apellidos" => "D&#237;az-Gonz&#225;lez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574317300837"
          "doi" => "10.1016/j.reumae.2016.04.014"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300837?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1630016X?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001300000004/v1_201706290122/S1699258X1630016X/v1_201706290122/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574317300862"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.05.009"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "929"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2017;13:221-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 517
      "formatos" => array:3 [
        "EPUB" => 44
        "HTML" => 353
        "PDF" => 120
      ]
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Coexistence of sarcoidosis and Familial Mediterranean Fever"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "221"
          "paginaFinal" => "223"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Coexistencia de sarcoidosis y fiebre mediterr&#225;nea familiar"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1481
              "Ancho" => 1717
              "Tamanyo" => 270930
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Torax CT showed bilateral multiple mediastinal and hilar lymphadenopathy&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "H&#252;seyin Semiz, Senol Kobak"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "H&#252;seyin"
              "apellidos" => "Semiz"
            ]
            1 => array:2 [
              "nombre" => "Senol"
              "apellidos" => "Kobak"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1699258X16300456"
        "doi" => "10.1016/j.reuma.2016.05.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300456?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300862?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300862/v1_201707050008/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574317300886"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2016.06.004"
    "estado" => "S300"
    "fechaPublicacion" => "2017-07-01"
    "aid" => "944"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2017;13:210-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 463
      "formatos" => array:3 [
        "EPUB" => 46
        "HTML" => 230
        "PDF" => 187
      ]
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>"
      "titulo" => "Sustained remission after long-term biological therapy in patients with large vessel vasculitis&#58; an analysis of ten cases"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "210"
          "paginaFinal" => "213"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Remisi&#243;n sostenida tras terapia biol&#243;gica en pacientes con vasculitis de grandes vasos&#58; an&#225;lisis de 10 casos"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Juan P&#46; Vinicki, Rosario Garc&#237;a-Vicu&#241;a, Miguel Arredondo, Juan P&#46; L&#243;pez-Bote, Jes&#250;s A&#46; Garc&#237;a-Vadillo, Santos Casta&#241;eda, Jos&#233; M&#46; &#193;lvaro-Gracia"
          "autores" => array:7 [
            0 => array:2 [
              "nombre" => "Juan P&#46;"
              "apellidos" => "Vinicki"
            ]
            1 => array:2 [
              "nombre" => "Rosario"
              "apellidos" => "Garc&#237;a-Vicu&#241;a"
            ]
            2 => array:2 [
              "nombre" => "Miguel"
              "apellidos" => "Arredondo"
            ]
            3 => array:2 [
              "nombre" => "Juan P&#46;"
              "apellidos" => "L&#243;pez-Bote"
            ]
            4 => array:2 [
              "nombre" => "Jes&#250;s A&#46;"
              "apellidos" => "Garc&#237;a-Vadillo"
            ]
            5 => array:2 [
              "nombre" => "Santos"
              "apellidos" => "Casta&#241;eda"
            ]
            6 => array:2 [
              "nombre" => "Jos&#233; M&#46;"
              "apellidos" => "&#193;lvaro-Gracia"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1699258X16300638"
        "doi" => "10.1016/j.reuma.2016.06.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X16300638?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300886?idApp=UINPBA00004M"
    "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300886/v1_201707050008/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>"
    "titulo" => "Role of physical activity in the management and assessment of rheumatoid arthritis patients"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "214"
        "paginaFinal" => "220"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Mar&#237;a Vanesa Hern&#225;ndez-Hern&#225;ndez, Federico D&#237;az-Gonz&#225;lez"
        "autores" => array:2 [
          0 => array:3 [
            "nombre" => "Mar&#237;a Vanesa"
            "apellidos" => "Hern&#225;ndez-Hern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Federico"
            "apellidos" => "D&#237;az-Gonz&#225;lez"
            "email" => array:1 [
              0 => "federico&#46;diaz&#46;gonzalez&#64;gmail&#46;com"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Reumatolog&#237;a&#44; Hospital Universitario de Canarias&#44; La Laguna&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Medicina Interna&#44; Facultad de Medicina&#44; Universidad de La Laguna&#44; La Laguna&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Papel de la actividad f&#237;sica en el manejo y evaluaci&#243;n de la artritis reumatoide"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1684
            "Ancho" => 2170
            "Tamanyo" => 203912
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Literature review flowchart&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Although there are extensive data showing the beneficial effects of physical activity &#40;PA&#41; on cardiovascular disease and all-cause mortality&#44; physical inactivity is a major health problem worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">1</span></a> The precise measurement of PA is key to study its association with diseases&#44; but the assessment of PA is complex and it is conditioned by a balance between accuracy and ease of use&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a chronic&#44; systemic&#44; inflammatory disorder of unknown etiology&#46; Because the central pathology of RA occurs in the synovial membrane&#44; joint limitation is a typical manifestation of the disease&#46; This&#44; in addition to the fact that most RA patients also suffer from muscle loss&#44; contributes to decreased physical function and quality of life in these patients&#46; In this regard&#44; it has been shown that RA patients tend to exercise less than healthy controls when PA is measured by both subjective<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">3&#8211;5</span></a> and objective methods&#46;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#8211;8</span></a> Moreover&#44; there remain two important unanswered questions concerning PA vis-&#224;-vis RA&#58; &#40;1&#41; Do patients who are sufficiently physically active suffer less aggressive disease&#63; and &#40;2&#41; Does disease activity influence PA in RA patients&#63; With regard to the former&#44; there is considerably more evidence favoring the prescribing PA for RA patients than there is against&#46;<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">9&#8211;11</span></a> With regard to the latter&#44; although there is less evidence&#44; recent data suggest that disease activity influences negatively the PA in RA patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#44;7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">This work reviews the current evidence about the relationship between PA and RA&#44; specifically how the former influences joint inflammation&#44; disability&#44; pain and quality of life in these individuals&#44; and also how RA disease activity potentially impacts on PA in these patients&#46; We purpose that periodic monitoring of PA using objective methods&#44; as the accelerometry would help to better handling of RA patients&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Strategy and results of literature searching</span><p id="par0020" class="elsevierStylePara elsevierViewall">A review was conducted by the documentation department of the Spanish Rheumatology Society &#40;SER&#41; to identify all published literature relating to PA and&#47;or energy expenditure in people with RA&#46; The search strategy combined 2 sets of keywords&#46; For Embase&#44; EMTREE terms were used&#46; In this case the search consisted of rheumatoid arthritis AND physical activity OR motor activity OR energy expenditure OR leisure activity AND accelerometry OR questionnaire OR calorimetry&#46; For MEDLINE&#44; the MeSH terms were&#58; arthritis&#44; rheumatoid AND leisure activities OR motor activity OR energy metabolism AND accelerometry OR questionnaires&#46; The results included all publications published from 1 January 2000 to January 2015&#44; that included at least 1 search term from each of the 2 categories&#46; Only English language publications were included&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">To be included in the review&#44; studies had to be&#58; &#40;1&#41; either observational studies or interventional studies with programs of exercises measuring free living PA or total&#47;activity related energy expenditure levels&#44; using either subjective or objective methods and &#40;2&#41; related to adult RA population with all subjects included in studies fulfilling the criteria set down by the American College of Rheumatology&#44; 1987&#46; Studies which were&#58; &#40;1&#41; interventional in nature with new pharmacological treatments&#59; &#40;2&#41; not in English&#59; or &#40;3&#41; published only in abstract format were excluded&#46; The article selection flowchart is described in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Assessment of PA</span><p id="par0030" class="elsevierStylePara elsevierViewall">PA is defined as any bodily movement produced by skeletal muscles that result in energy expenditure&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">12</span></a> Under this broad concept&#44; activities relating to leisure-time&#44; exercise&#44; sports&#44; locomotion &#40;e&#46;g&#46;&#44; walking&#44; biking&#41;&#44; and work must be considered parts of PA&#46; Sedentarism has been defined as expenditure below 10&#37; of total daily energy expenditure performing moderate- and high-intensity activities&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">13</span></a> Since&#44; sedentarism has been associated with high incidences of obesity&#44; type-2 diabetes mellitus&#44; cardiovascular disease and other chronic illnesses&#44;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">14</span></a> its prevention has become a priority of the public healthcare systems&#46; To avoid the consequences of sedentarism&#44; U&#46;S&#46; Department of Health and Human Services recommends that adults should do at least 150<span class="elsevierStyleHsp" style=""></span>min a week of moderate-intensity exercise &#40;e&#46;g&#46;&#44; brisk walking&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">15</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A very accurate measurement of PA can be obtained by the assessing the total daily energy expenditure&#44; albeit using expensive and cumbersome procedures such as the doubly-labeled water technique<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">16</span></a> or calorimetry&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">2</span></a> Viable alternatives&#44; involving less precise but more accessible methods&#44; are available&#44; however&#46; These include questionnaires and triaxial accelerometers&#44; approaches that are gaining acceptance for assessing PA both in healthy individuals and in patients suffering chronic diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0440"><span class="elsevierStyleSup">17&#8211;19</span></a> Although questionnaires provide a evaluation limited by subjectivity&#44; in the last 10 years a significant number of them have been developed to assess PA in different diseases&#59; one of them&#44; the International Physical Activity Questionnaire &#40;IPAQ&#41;&#44; has been used mainly for research purpose in rheumatic diseases&#46;<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">4&#44;5&#44;20</span></a> This self-report method is the cheapest and easiest way to quickly compile PA data from a large number of people providing an assessment of PA by domains&#46; Alternatively&#44; accelerometers are easily portable devices that offer one important advantage in objectively measuring PA based on the fact that it can capture continuously&#44; for days and weeks distinctive characteristics of movement including the direction&#44; frequency&#44; intensity and duration of PA&#44; as well as resting periods&#46;<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">21</span></a> Although accelerometry has already been employed in clinical osteoarthritis trials&#44;<a class="elsevierStyleCrossRefs" href="#bib0465"><span class="elsevierStyleSup">22&#8211;24</span></a> it was not until recently that this technique was used to evaluate PA patterns in inflammatory joint disorders such as RA&#46;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#44;7&#44;8&#44;25</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">PA in RA patients</span><p id="par0040" class="elsevierStylePara elsevierViewall">Regular exercise with a moderate to high level of intensity has proven to be effective in improving muscle strength and cardiovascular fitness in healthy populations and in patients with chronic illnesses&#44; including RA&#46;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">11&#44;26&#8211;28</span></a> RA&#44; if left uncontrolled&#44; leads to joint deformity and destruction due to the erosion of cartilage and bone&#46; Consequently&#44; it has been assumed than RA patients are less active than the general population because of such joint manifestations&#46; An additional factor that may have contributed to this inactivity tendency stems from recommendations&#44; classically given by physicians&#44; which restrict exercise due to concerns that excessive PA might aggravate both joint inflammation<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">29</span></a> and pain&#44;<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">30</span></a> and accelerate joint damage in RA patients&#46; However&#44; currently&#44; evidence suggests that exercise has no deleterious effects either on disease activity or on joint damage<a class="elsevierStyleCrossRefs" href="#bib0490"><span class="elsevierStyleSup">27&#44;31</span></a> and improves muscle strength<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">32</span></a> in RA&#46; In this regard&#44; recently it has been suggested that RA patients who are physically active before clinical disease onset present with a milder disease&#44; both in terms of inflammation&#44; pain and function&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">33</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with RA have an increased risk of developing cardiovascular diseases&#44; resulting from a proatherogenic profile driven by systemic inflammation&#46;<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">34</span></a> In healthy populations there is an inverse relationship between PA and cardiovascular risk &#40;CVR&#41; factors such as BMI&#44; body composition &#40;increased whole body fat and visceral fat&#41;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">35</span></a> and blood lipid levels&#46;<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">36</span></a> Although different studies on the relationships between PA&#44; BMI&#44; fat mass and lipid levels in RA populations have yielded controversial data&#44;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#44;37&#44;38</span></a> the evidence clearly suggests that PA improves the CVR profile in RA patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#44;11&#44;39</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Different questionnaire-based surveys have indicated that RA patients tend to exercise less than what is currently recommended&#46;<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">3&#44;40&#44;41</span></a> When PA is objectively assessed by doubly-labeled water or accelerometry&#44; the main disparity in PA between RA patients and healthy individuals can be seen in the time devoted to different intense activities&#46; RA patients dedicate less time than control to high-intensity PA and to moderately intensive activities<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#44;7&#44;8&#44;25</span></a> probably due to local limitations causing joint pain and disability and systemic effects like fatigue and sarcopenia&#46; A recent systematic review of the literature about this issue&#44; encompassing both objective and subjective methods for evaluating PA&#44; suggests that PA levels among RA individuals tends to be lower than in healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">42</span></a> Although&#44; this review concluded that owing to methodological limitations&#44; a definitive conclusion could not be drawn&#44; currently it is generally accepted that RA patients spend less time than controls doing moderate and vigorous PA&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Effect of PA on joints and disease activity in RA patients</span><p id="par0055" class="elsevierStylePara elsevierViewall">As in the general population&#44; regular PA in RA patients may&#44; apart from providing general health gains&#44; also yield disease-specific benefits such as reduced pain&#44; improved muscle function&#44; and delayed onset of disability&#44;<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">10&#44;31&#44;43&#8211;45</span></a> without deleterious effects on joint&#46;<a class="elsevierStyleCrossRefs" href="#bib0490"><span class="elsevierStyleSup">27&#44;31</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Interestingly&#44; moderate-intensity PA exerts anti-inflammatory effects both in healthy individuals and in those affected by various chronic illnesses&#46;<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">46</span></a> Indeed&#44; regular PA has been associated with a diminution in C-reactive protein &#40;CRP&#41;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">11&#44;39</span></a> and erythrocyte sedimentation rate &#40;ESR&#41;<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">47</span></a> levels in RA patients&#46; Although the exact mechanism by which these positive effects arise remains unknown&#44; it seems linked to reductions in blood pressure&#44; lipids&#44; and fatty mass<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">48</span></a>&#46; Taking into account that the main tissular source of IL-6 is the adipose tissue&#44;<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">49</span></a> and that several lipids have proinflammatory effects&#44; the reduction of fat accumulation in the skeletal muscle and liver is likely one of the most relevant anti-inflammatory benefits of exercise&#46; Furthermore&#44; it has been well established that PA releases IL-6 from skeletal muscle&#44; a potent inducer of IL-1 receptor antagonist &#40;IL-1ra&#41; by monocytes and macrophages&#44; which constitutes an important anti-inflammatory mechanism of exercise&#46;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">50</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">A number of clinical trials evaluating the effects of PA on RA patients have been developed&#46; While much evidence suggests that some exercise is better than none at all&#44; specific exercise parameters &#40;intensity&#44; duration&#44; frequency&#44; and type&#41; resulting in real benefits have not been clearly defined&#46; Some short-term and several long-term clinical trials have evaluated the effects of both aerobic and resistance exercises on outcome measures in RA patients<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">11&#44;27&#44;28&#44;32&#44;47&#44;51&#8211;60</span></a> &#40;see <a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Aerobic exercise in RA patients</span><p id="par0070" class="elsevierStylePara elsevierViewall">Although intuitively&#44; long-term regular exercise should be beneficial for RA patients because of the increased cardiovascular mobility and mortality in these patients&#44; reports about aerobic exercise interventions in RA populations are scarce&#46; A systematic review and meta-analysis of aerobic exercise&#44;<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">10</span></a> which examined 14 randomized controlled trials&#44; showed that cardiorespiratory aerobic conditioning in stable RA appears to be safe and improves quality of life&#44; functionality and pain levels&#44; but not DAS28 or joint count&#46; This meta-analysis suggests that the sooner the exercise program is initiated&#44; the better are the results obtained in terms of quality of life and functionality&#46; Other clinical trials published afterwards also found an improvement in functionality<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">57</span></a> and pain<a class="elsevierStyleCrossRefs" href="#bib0640"><span class="elsevierStyleSup">57&#44;60</span></a> in RA patients who were participating in aerobic exercise programs&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Both&#44; program duration and disease duration impacted on pain&#44; with better results in cases of RA established&#44; and short-term programs&#46; However&#44; data concerning to quality of life suggested than exercise was more benefits in patients with early RA than in established RA patients&#46; When patients were followed up for a long period of time&#44;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">27</span></a> it was found that no significant decrease in aerobic fitness occurred after a relatively brief period of detraining&#59; rather&#44; long-term exercises produced a prolonged positive effect on functional ability&#46; Therefore&#44; the maintenance of a structured PA program after intervention seems to be critical for long-term benefits&#46;<a class="elsevierStyleCrossRefs" href="#bib0640"><span class="elsevierStyleSup">57&#44;61</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Of all the studies referenced in this review that focused on aerobic exercise in RA patients &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; three assessed disease activity changes using composite disease activity measurements&#46;<a class="elsevierStyleCrossRefs" href="#bib0490"><span class="elsevierStyleSup">27&#44;32&#44;57</span></a> These studies concluded that aerobic exercise has a positive impact on disease activity&#44; reducing DAS28&#44; albeit without reaching statistical significance&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Resistance exercise in RA population</span><p id="par0085" class="elsevierStylePara elsevierViewall">The value of resistance exercise for RA patients remains controversial because its effects on cardiovascular risk are not clear&#44;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">11&#44;62</span></a> and its real impact on disability seems to be very small&#46;<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">56</span></a> However&#44; despite design differences&#44; the results of previous studies suggest that high-intensity strength training is feasible and safe for many patients with RA&#46;<a class="elsevierStyleCrossRefs" href="#bib0615"><span class="elsevierStyleSup">52&#44;56&#44;63</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">A systematic review by Baillet et al&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">9</span></a> showed that resistance exercise programs in RA patients can provide a mild&#44; but significant&#44; improvement in terms of functional capacity&#44; the number of tender and swollen joints and a decrease in ESR&#46; Resistance exercise had no impact on DAS28 or on structural damage in any of the studies analyzed&#46; The HAQ response has proven more variable in several reports&#44;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">11&#44;47&#44;53</span></a> which may reflect the fact that this outcome was designed for monitoring patients in pharmacologic trials and is not be suitable for evaluating physical interventions in patients with mild disabilities&#46; Although the short-term effects of strength training in RA patients have been described in several studies<a class="elsevierStyleCrossRefs" href="#bib0675"><span class="elsevierStyleSup">64&#8211;66</span></a> the length of time that positive results achieved after cessation remains controversial&#46;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">32&#44;53&#44;67</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">There is no clear evidence of the superiority of supervised strengthening exercises versus home-based exercises&#44; since the results are varied&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Effects of disease activity on PA in RA patients</span><p id="par0100" class="elsevierStylePara elsevierViewall">Some studies indicate that PA levels &#40;as measured by questionnaires or by accelerometry&#41; have an inverse relationship with disease activity &#40;as assessed by DAS28 or SDAI&#41; in RA patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#44;7&#44;25&#44;68</span></a> One of these studies involved RA patients lacking lower-limb disease activity&#44; which suggests that it is the state of inflammation as a whole that influences patients&#8217; tendency to reduce their levels of PA&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">5</span></a> In these studies&#44; accelerometry was sufficiently sensitive to detect PA-changes related with disease activity both in RA patients&#44; who showed clinical improvements in response to treatment<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">7</span></a> and in patients who suffered a disease flare&#46;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">5</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Several disease activity indexes &#8211; such as the DAS&#44; CDAI&#44; SDAI or ACR &#8211; are available and allow physicians to quantify changes in the disease activity of RA over time&#46; These indexes are liable to certain limitations related to both patient subjectivity and inter- and intraobserver variability&#46;<a class="elsevierStyleCrossRef" href="#bib0700"><span class="elsevierStyleSup">69</span></a> As stated above&#44; by measuring variations in PA&#44; accelerometry appears to be sufficiently sensitive to register changes in the clinical activity of RA&#44;<a class="elsevierStyleCrossRefs" href="#bib0380"><span class="elsevierStyleSup">5&#44;7</span></a> and could be used as a complementary objective method for assessing changes in disease activity&#46; Consequently&#44; variation in accelerometry might aid physicians in optimizing the pharmacologic management of RA patients&#46; In addition&#44; accelerometry can help to determine whether or not PA level in a given patient is appropriate to reduce their cardiovascular risk&#44; main cause of premature mortality in these patients&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Practical applications and exercise recommendations</span><p id="par0110" class="elsevierStylePara elsevierViewall">Along the last 15 years&#44; a number of interventional clinical trials have been developed in order to obtain recommendations on aerobic &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; and resistance exercises &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41; in RA patients&#46; The high variability in the type&#44; intensity and duration of PA studied&#44; as well as limitations in trial quality and size&#44; suggest that the conclusions of these studies should be still considered to be tentative and further research in the field of PA and RA is warranted&#46; However&#44; a number of practical recommendations can be elaborated respect to exercise in patients with RA&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">All RA patients benefit from a balanced program of strengthening and endurance or aerobic exercise&#46; Therefore&#44; current data indicate that the benefits from performing moderate and high-intensity PA frequently &#40;both aerobic and resistance exercises 2&#8211;3 times per week for 30&#8211;60<span class="elsevierStyleHsp" style=""></span>min&#41; in RA patients include&#58; improved quality of life&#44; functionality&#44; reduced pain&#44; improvement in the number of swollen joints&#44; and lower levels of radiologic damage&#46;<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">11&#44;28&#44;31</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Low-impact exercises&#44; such as walking&#44; swimming or biking are aerobic exercises recommended for arthritis patients&#46; Aerobic exercise has been shown to improve cardiovascular fitness and patient quality of life&#44; while reducing RA-associated disability and pain&#46;<a class="elsevierStyleCrossRefs" href="#bib0405"><span class="elsevierStyleSup">10&#44;54&#44;55&#44;60</span></a> As a result of the little number of studies&#44; it has been suggested that the intensity levels in aerobic exercise should be moderate to hard &#40;i&#46;e&#46;&#44; 60&#8211;85&#37; of maximum heart rate&#41;&#44; and such exercise should be performed 3 times weekly in sessions of 30&#8211;60<span class="elsevierStyleHsp" style=""></span>min&#44; divided in 3&#8211;4 periods of 15&#8211;20<span class="elsevierStyleHsp" style=""></span>min a day&#46; Progressive adjustment of the intensity level is recommended&#46;<a class="elsevierStyleCrossRef" href="#bib0705"><span class="elsevierStyleSup">70</span></a></p><p id="par0125" class="elsevierStylePara elsevierViewall">The strengthening exercises are designed to increase the joint stability&#46; Movements should be smooth&#44; performed 8&#8211;10 times twice a day and without joint pain&#46; The weight must be increased slowly and always that it does not cause pain&#46; Information derived from the reviewed studies<a class="elsevierStyleCrossRef" href="#bib0705"><span class="elsevierStyleSup">70</span></a> suggest that the load level objective for strengthening exercises should be moderate to hard &#40;i&#46;e&#46;&#44; 50&#8211;80&#37; of a maximal voluntary contraction&#41;&#44; and said exercises should be performed along 20&#8211;30<span class="elsevierStyleHsp" style=""></span>min 2&#8211;3 times per week&#46; Exercises may be static or dynamic&#44; done against body weight or with different kinds of equipment &#40;resistance training equipment&#44; pulley apparatuses&#44; dumbbells&#44; or elastic bands&#41;&#46; Progressive adjustment of the load is recommended in a supervised clinical environment or at home under professional guidance&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Adherence is difficult to maintain in long-term programs&#46; To this end&#44; physicians must be in contact with other health professionals &#40;i&#46;e&#46;&#44; occupational therapists&#44; nurses&#44; dietitians&#44; psychologists&#44; and social workers&#41; in order to support and motivate patients by helping them to cope with the disease in a positive way&#46; Health professionals must convince RA patients that becoming more physically active is the best choice they can make to take care of themselves and their joints&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Although there is a lack of studies designed to evaluate the role of PA during RA flare&#44; the most extended attitude among physicians is to recommend a reduction in the duration and intensity of exercises&#44; specifically avoiding the resistance exercise in these periods of high disease activity&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">A study in 2013 involving an online survey of more than 7000 smartphone owners in the U&#46;S&#46; showed that 79&#37; of people 18&#8211;44-years-old have their smartphones with them 22<span class="elsevierStyleHsp" style=""></span>hours a day&#46;<a class="elsevierStyleCrossRef" href="#bib0710"><span class="elsevierStyleSup">71</span></a> The newest generation of smartphones now on the market features built-in accelerometer sensors&#46; This technological advance&#44; in tandem with the increased and continuous social connectedness exhibited by our society&#44; can provide a convenient and inexpensive method for accurately evaluating PA in today&#39;s population&#44; including RA patients&#46; Although these devices have not yet been validated in RA patients&#44; the implementation of such tools will enable clinicians to better gauge the actual PA undertaken by patients&#46; Since there appears to be a relationship between levels of PA&#44; disease activity<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">5</span></a> and response to treatment<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">7</span></a> in RA patients&#44; the use of smartphones to evaluate PA might help physicians&#44; not only in establishing recommendations about cardiovascular risk&#44; but also in making therapeutic decisions in these patients&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Concluding remarks</span><p id="par0145" class="elsevierStylePara elsevierViewall">Aerobic and resistance exercises&#44; 2&#8211;3 times per week for 30&#8211;60<span class="elsevierStyleHsp" style=""></span>min not only provide general health gains&#44; but have also been shown to confer disease-specific advantages such as reduced pain&#44; improved muscle function&#44; and delayed onset of disability in RA patients&#46; Consequently&#44; a periodic assessment of PA constitutes a useful tool for adjusting the exercise habits of RA patients in order to reduce their high cardiovascular risks and improve locomotion function and health status in general&#46; Since&#44; disease activity negatively impacts the PA capacity of RA patients&#44; the assessment of PA with objective methods &#40;e&#46;g&#46;&#44; mobile devices built-in accelerometry&#41; may be helpful to evaluate the overall response to treatment and disease activity in RA patients&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Ethical disclosures</span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Protection of human and animal subjects</span><p id="par0150" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Confidentiality of data</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Right to privacy and informed consent</span><p id="par0160" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Funding</span><p id="par0165" class="elsevierStylePara elsevierViewall">This work was supported by a grant from the <span class="elsevierStyleGrantSponsor" id="gs1">Spanish Ministry of Health</span> &#40;Fondo de Investigaciones Sanitarias&#41; &#40;<span class="elsevierStyleGrantNumber" refid="gs1">FIS PI12&#47;02499</span>&#41; and cofinanced by the <span class="elsevierStyleGrantSponsor" id="gs2">European Regional Development Fund</span> to F&#46;D&#46;G and by <span class="elsevierStyleGrantSponsor" id="gs3">REUNINVES</span> &#40;Asociaci&#243;n para la Ayuda a la Investigaci&#243;n en Reumatolog&#237;a del Hospital Universitario de Canarias&#41;&#46;</p></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflicts of interest</span><p id="par0170" class="elsevierStylePara elsevierViewall">The authors have declared no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:19 [
        0 => array:3 [
          "identificador" => "xres859813"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec853921"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres859812"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "M&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec853922"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Strategy and results of literature searching"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Assessment of PA"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "PA in RA patients"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Effect of PA on joints and disease activity in RA patients"
        ]
        9 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Aerobic exercise in RA patients"
        ]
        10 => array:2 [
          "identificador" => "sec0035"
          "titulo" => "Resistance exercise in RA population"
        ]
        11 => array:2 [
          "identificador" => "sec0040"
          "titulo" => "Effects of disease activity on PA in RA patients"
        ]
        12 => array:2 [
          "identificador" => "sec0045"
          "titulo" => "Practical applications and exercise recommendations"
        ]
        13 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Concluding remarks"
        ]
        14 => array:3 [
          "identificador" => "sec0055"
          "titulo" => "Ethical disclosures"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "sec0060"
              "titulo" => "Protection of human and animal subjects"
            ]
            1 => array:2 [
              "identificador" => "sec0065"
              "titulo" => "Confidentiality of data"
            ]
            2 => array:2 [
              "identificador" => "sec0070"
              "titulo" => "Right to privacy and informed consent"
            ]
          ]
        ]
        15 => array:2 [
          "identificador" => "sec0075"
          "titulo" => "Funding"
        ]
        16 => array:2 [
          "identificador" => "sec0080"
          "titulo" => "Conflicts of interest"
        ]
        17 => array:2 [
          "identificador" => "xack288224"
          "titulo" => "Acknowledgments"
        ]
        18 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-12-24"
    "fechaAceptado" => "2016-04-04"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec853921"
          "palabras" => array:4 [
            0 => "Rheumatoid arthritis"
            1 => "Physical activity"
            2 => "Disease activity"
            3 => "Accelerometry"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec853922"
          "palabras" => array:4 [
            0 => "Artritis reumatoide"
            1 => "Actividad f&#237;sica"
            2 => "Actividad cl&#237;nica"
            3 => "Acelerometr&#237;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rheumatoid arthritis &#40;RA&#41; is a chronic inflammatory disease affecting diarthrodial joints&#44; in which patients tend to perform less physical activity &#40;PA&#41; than recommended&#46; This review focuses on the existing evidence about the relationship of PA and RA&#44; specifically how the former influences joint inflammation&#44; disability&#44; quality of life and pain in RA patients&#44; and also how disease activity potentially impacts PA in these patients&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A literature search of EMBASE and MEDLINE databases from January 2000 to January 2015&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The evidence indicating that PA in RA patients is safe and the benefits from regularly performing&#44; both aerobic and resistance exercises&#44; in these patients include improvement in&#58; quality of life&#44; functionality&#44; pain and number of swollen joints&#46; Interestingly&#44; recent studies suggest that changes in disease activity in RA patients inversely correlate with variations in PA&#44; as assessed by accelerometry&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The regular monitoring of PA in RA patients might facilitate a more objective evaluation of variations in disease activity&#44; helping physicians to make general and therapeutic recommendations that will improve both the health status and the joint functionality of these patients&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La artritis reumatoide &#40;AR&#41; es una enfermedad inflamatoria cr&#243;nica que afecta a las articulaciones diartrodiales&#44; en la que los pacientes tienden a realizar menos actividad f&#237;sica &#40;AF&#41; de lo que se recomienda&#46; Esta revisi&#243;n se centra en la evidencia existente sobre la relaci&#243;n entre AF y AR&#44; espec&#237;ficamente c&#243;mo la primera influye en la inflamaci&#243;n articular&#44; la discapacidad&#44; la calidad de vida y el dolor en los pacientes con AR&#44; y tambi&#233;n c&#243;mo la actividad cl&#237;nica de la AR puede afectar a la AF de estos pacientes&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">M&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; una b&#250;squeda bibliogr&#225;fica desde enero del 2000 hasta enero del 2015 en las bases EMBASE y MEDLINE&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La evidencia indica que la AF en pacientes con AR es segura y que los beneficios de la realizaci&#243;n peri&#243;dica de ejercicios&#44; tanto aer&#243;bicos como de resistencia&#44; en estos pacientes incluyen mejoras en&#58; calidad de vida&#44; funcionalidad&#44; dolor y n&#250;mero de articulaciones inflamadas&#46; Curiosamente&#44; estudios muy recientes muestran que los cambios en la actividad de la enfermedad en pacientes con AR se correlacionan inversamente con variaciones en su AF&#44; medida por acelerometr&#237;a&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">El control sistem&#225;tico de la AF en pacientes con AR podr&#237;a facilitar una evaluaci&#243;n m&#225;s objetiva de las variaciones en la actividad de la enfermedad&#44; lo que ayudar&#237;a a los m&#233;dicos a hacer recomendaciones generales y terap&#233;uticas para mejorar tanto el estado de salud como la funcionalidad articular de estos pacientes&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1684
            "Ancho" => 2170
            "Tamanyo" => 203912
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Literature review flowchart&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">AIMS2-SF&#58; Arthritis Impact Measurement Scales 2 short form&#59; BMD&#58; bone mineral density&#59; BMI&#58; body mass index&#59; CRP&#58; c-reactive protein&#59; DEXA&#58; dual energy X-ray absorptiometry&#59; ESR&#58; erythrocyte sedimentation rate&#59; HADS&#58; Hospital Anxiety and Depression Scale&#59; HAQ&#58; Health Assessment Questionnaire&#59; MACTAR&#58; McMaster Toronto Arthritis patient preference disability questionnaire&#59; VAS&#58; visual analog scale&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Time follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcomes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Westby et al&#46;&#44; 2000<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">51</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Dynamic exercise program&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Disease activity &#40;ESR&#44; active joint count&#41;<br>- Functional ability &#40;HAQ&#41;<br>- BMD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Van den Ende et al&#46;&#44; 2000<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">32</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised cardiovascular exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Disease activity &#40;ESR&#44; DAS&#44; VAS&#41;<br>- Functional capacity &#40;muscle strength&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De Jong et al&#46;&#44; 2003<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">28</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled multicenter trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised cardiovascular exercise<br>&#40;bicycle&#44; exercise&#44; sports 75<span class="elsevierStyleHsp" style=""></span>min 2 times&#47;week&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional ability &#40;MACTAR y HAQ&#41;<br>- Functional capacity&#58; aerobic fitness &#40;standardized ergometer test&#41; an muscle strength &#40;dynamometer&#41;<br>- Emotional status by HADS<br>- Radiological damage by Larsen score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Melikoglu et al&#46;&#44; 2006<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">54</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised cardiovascular exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Pain &#40;VAS&#41;<br>- Disease activity &#40;duration of morning stiffness&#44; active joint count&#44; ESR&#44; CRP&#41;<br>- Functional ability &#40;HAQ&#41;<br>- BMI &#40;DEXA&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Neuberger et al&#46;&#44; 2007<a class="elsevierStyleCrossRef" href="#bib0630"><span class="elsevierStyleSup">55</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">310&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised cardiovascular exercise<br>&#40;low impact aerobic exercise 1<span class="elsevierStyleHsp" style=""></span>hour 3 times&#47;week&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Fatigue &#40;FACIT&#41;<br>- Pain &#40;McGill pain questionnaire short form&#41;<br>- Depression &#40;studies depression scale&#41;<br>- Disease activity &#40;active joint count&#44; ESR&#44; CRP&#41;<br>- Functional capacity&#58; walk time and grip strength&#44; bicycle ergometer testing&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">De Jong et al&#46;&#44; 2009<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">27</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Observational study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cardiovascular exercise biweekly&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional ability &#40;MACTAR y HAQ&#41;<br>- Aerobic fitness &#40;standardized ergometer test&#41;<br>- Muscle strength &#40;dynamometer&#41;<br>- Disease activity &#40;DAS4&#41;<br>- Radiological damage &#40;Larsen score&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sj&#246;quist et al&#46;&#44; 2011<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">57</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">288&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Multicenter randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised and Home cardiovascular exercise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional ability&#58; HAQ<br>- Disease activity&#58; DAS28<br>- Pain&#58; VAS<br>- Health perception&#58; VAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Jahanbin 2014&#44;<a class="elsevierStyleCrossRef" href="#bib0655"><span class="elsevierStyleSup">60</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised two 45-min sessions per week of conditioning exercises&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Pain&#58; VAS&#46;<br>- Health status&#58; AIMS2-SF&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1453257.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Studies of aerobic exercise programs in RA&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">BMD&#58; bone mineral density&#59; DEXA&#58; dual energy X-ray absorptiometry&#59; EQ-5D&#58; EuroQol-5D&#59; ESR&#58; erythrocyte sedimentation rate&#59; HAQ&#58; Health Assessment Questionnaire&#59; MHQ&#58; Michigan Hand outcomes Questionnaire&#59; SF-12&#58; short form 12&#59; VAS&#58; visual analog scale&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Authors&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Study type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Time follow-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcomes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#228;kkinen et al&#46;&#44; 2001<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">47</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Home dynamic strength training&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional capacity&#58; muscle strength &#40;dynamometry knee extensors&#44; trunk flexors-extensors&#41;&#44; walk time&#46;<br>- Functional ability&#58; HAQ&#46;<br>- Disease activity&#58; DAS28&#44; VAS&#44; ESR&#46;<br>- Pain&#58; VAS&#46;<br>- BMD&#58; DEXA<br>- Radiological damage&#58; Larsen score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#228;kkinen et al&#46;&#44; 2003<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">52</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Observational study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised six training sessions in a 2-week period&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">21 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional capacity&#58; maximal muscle strength &#40;dynamometry&#41;&#44; walking speed&#44; vertical squat jump<br>- Functional ability&#58; HAQ<br>- Disease activity&#58; Joint index score&#44; ESR<br>- Pain&#58; VAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">H&#228;kkinen et al&#46;&#44; 2004<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">53</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Observational study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Home dynamic strength training&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">-Functional capacity&#58; muscle strength &#40;dynamometry knee extensors&#44; trunk flexors-extensors&#41;&#44; walk time&#46;<br>- Functional ability&#58; HAQ&#46;<br>- Disease activity&#58; DAS28&#44; VAS&#44; ESR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lemmey et al&#46;&#44; 2009<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">56</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised resistance training program twice a week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">24 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional capacity&#58; walk test&#44; arm curl test&#44; knee extensor strength&#46;<br>- Functional ability&#58; HAQ<br>- Disease activity&#58; DAS28&#44; ESR&#46;<br>- Body composition&#58; DEXA&#46;<br>- Muscle IGFs&#58; muscle biopsies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Bosch et al&#46;&#44; 2009<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">58</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised exercise sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional capacity&#58; balance &#40;Berg balance test&#41;<br>- Functional ability&#58; HAQ&#46;<br>- Pain&#58; VAS<br>- Depression&#58; Beck Depression Inventory<br>- Cortisol levels<br>- Heart rate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Flint-Wagner et al&#46;&#44; 2009<a class="elsevierStyleCrossRef" href="#bib0650"><span class="elsevierStyleSup">59</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised exercise sessions&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">16 weeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Functional capacity&#58; muscle strength &#40;dynamometry elbow and knee flexors-extensors&#41;&#44; walk time<br>- Functional ability&#58; HAQ<br>- Pain&#58; VAS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Stavropoulos-Kalinoglou et al&#46;&#44; 2013<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">11</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Randomized controlled trial&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Supervised aerobic and resistance high intensity exercises three times per week&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">- Disease activity &#40;DAS28&#44; CRP&#41;<br>- Functional ability &#40;HAQ&#41;<br>- Cardiovascular risk&#58; BMI&#44; body fat&#44; blood pressure&#44; lipoproteins&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1453256.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Studies of strengthening programs in RA&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:71 [
            0 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of exercise is a major cause of chronic diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;W&#46; Booth"
                            1 => "C&#46;K&#46; Roberts"
                            2 => "M&#46;J&#46; Laye"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/cphy.c110025"
                      "Revista" => array:6 [
                        "tituloSerie" => "Compr Physiol"
                        "fecha" => "2012"
                        "volumen" => "2"
                        "paginaInicial" => "1143"
                        "paginaFinal" => "1211"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23798298"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of physical activity &#8211; a review of methodologies with reference to epidemiological research&#58; a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Warren"
                            1 => "U&#46; Ekelund"
                            2 => "H&#46; Besson"
                            3 => "A&#46; Mezzani"
                            4 => "N&#46; Geladas"
                            5 => "L&#46; Vanhees"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/HJR.0b013e32832ed875"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cardiovasc Prev Rehabil"
                        "fecha" => "2010"
                        "volumen" => "17"
                        "paginaInicial" => "127"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20215971"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity&#44; physical fitness&#44; and general health perception among individuals with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "E&#46; Eurenius"
                            1 => "C&#46;H&#46; Stenstrom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20924"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2005"
                        "volumen" => "53"
                        "paginaInicial" => "48"
                        "paginaFinal" => "55"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15696555"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disease activity and low physical activity associate with number of hospital admissions and length of hospitalisation in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;S&#46; Metsios"
                            1 => "A&#46; Stavropoulos-Kalinoglou"
                            2 => "G&#46;J&#46; Treharne"
                            3 => "A&#46;M&#46; Nevill"
                            4 => "A&#46; Sandoo"
                            5 => "V&#46;F&#46; Panoulas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/ar3390"
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Res Ther"
                        "fecha" => "2011"
                        "volumen" => "13"
                        "paginaInicial" => "R108"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21714856"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of disease activity on the physical activity of rheumatoid arthritis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V&#46; Hernandez-Hernandez"
                            1 => "I&#46; Ferraz-Amaro"
                            2 => "F&#46; Diaz-Gonzalez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2014"
                        "volumen" => "53"
                        "paginaInicial" => "722"
                        "paginaFinal" => "731"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity measured by the SenseWear Armband in women with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;J&#46; Almeida"
                            1 => "M&#46;C&#46; Wasko"
                            2 => "K&#46; Jeong"
                            3 => "C&#46;G&#46; Moore"
                            4 => "S&#46;R&#46; Piva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2522/ptj.20100291"
                      "Revista" => array:6 [
                        "tituloSerie" => "Phys Ther"
                        "fecha" => "2011"
                        "volumen" => "91"
                        "paginaInicial" => "1367"
                        "paginaFinal" => "1376"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21719635"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in physical activity measured by accelerometry following initiation of DMARD therapy in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Prioreschi"
                            1 => "B&#46; Hodkinson"
                            2 => "M&#46; Tikly"
                            3 => "J&#46;A&#46; McVeigh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2014"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessing physical activity in persons with rheumatoid arthritis using accelerometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46; Semanik"
                            1 => "J&#46; Song"
                            2 => "R&#46;W&#46; Chang"
                            3 => "L&#46; Manheim"
                            4 => "B&#46; Ainsworth"
                            5 => "D&#46; Dunlop"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1249/MSS.0b013e3181cfc9da"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Sci Sports Exerc"
                        "fecha" => "2010"
                        "volumen" => "42"
                        "paginaInicial" => "1493"
                        "paginaFinal" => "1501"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20139792"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of resistance exercises in rheumatoid arthritis&#58; meta-analysis of randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Baillet"
                            1 => "M&#46; Vaillant"
                            2 => "M&#46; Guinot"
                            3 => "R&#46; Juvin"
                            4 => "P&#46; Gaudin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2012"
                        "volumen" => "51"
                        "paginaInicial" => "519"
                        "paginaFinal" => "527"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of cardiorespiratory aerobic exercise in rheumatoid arthritis&#58; meta-analysis of randomized controlled trials"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Baillet"
                            1 => "N&#46; Zeboulon"
                            2 => "L&#46; Gossec"
                            3 => "C&#46; Combescure"
                            4 => "L&#46;A&#46; Bodin"
                            5 => "R&#46; Juvin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Care Res &#40;Hoboken&#41;"
                        "fecha" => "2010"
                        "volumen" => "62"
                        "paginaInicial" => "984"
                        "paginaFinal" => "992"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Individualised aerobic and resistance exercise training improves cardiorespiratory fitness and reduces cardiovascular risk in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Stavropoulos-Kalinoglou"
                            1 => "G&#46;S&#46; Metsios"
                            2 => "J&#46;J&#46; Veldhuijzen van Zanten"
                            3 => "P&#46; Nightingale"
                            4 => "G&#46;D&#46; Kitas"
                            5 => "Y&#46; Koutedakis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2012-202075"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2013"
                        "volumen" => "72"
                        "paginaInicial" => "1819"
                        "paginaFinal" => "1825"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23155222"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity&#44; exercise&#44; and physical fitness&#58; definitions and distinctions for health-related research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46;J&#46; Caspersen"
                            1 => "K&#46;E&#46; Powell"
                            2 => "G&#46;M&#46; Christenson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Public Health Rep"
                        "fecha" => "1985"
                        "volumen" => "100"
                        "paginaInicial" => "126"
                        "paginaFinal" => "131"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3920711"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Definition and prevalence of sedentarism in an urban population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46;S&#46; Bernstein"
                            1 => "A&#46; Morabia"
                            2 => "D&#46; Sloutskis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Public Health"
                        "fecha" => "1999"
                        "volumen" => "89"
                        "paginaInicial" => "862"
                        "paginaFinal" => "867"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10358676"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Health benefits of physical activity&#58; the evidence"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;E&#46; Warburton"
                            1 => "C&#46;W&#46; Nicol"
                            2 => "S&#46;S&#46; Bredin"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1503/cmaj.051351"
                      "Revista" => array:6 [
                        "tituloSerie" => "CMAJ"
                        "fecha" => "2006"
                        "volumen" => "174"
                        "paginaInicial" => "801"
                        "paginaFinal" => "809"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16534088"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "<span class="elsevierStyleInterRef" id="intr0005" href="http://www.health.gov/paguidelines/">http&#58;&#47;&#47;www&#46;health&#46;gov&#47;paguidelines&#47;</span>"
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Secondary 2008 Physical Activity Guidelines Advisory Committee report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "U&#46;S&#46; Department of Health &#38; Human Services"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of physical activity&#58; a critical appraisal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46;R&#46; Westerterp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00421-009-1000-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Appl Physiol"
                        "fecha" => "2009"
                        "volumen" => "105"
                        "paginaInicial" => "823"
                        "paginaFinal" => "828"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19205725"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Estimating energy expenditure using accelerometers"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;E&#46; Crouter"
                            1 => "J&#46;R&#46; Churilla"
                            2 => "D&#46;R&#46; Bassett Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00421-006-0307-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Appl Physiol"
                        "fecha" => "2006"
                        "volumen" => "98"
                        "paginaInicial" => "601"
                        "paginaFinal" => "612"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17058102"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quantitating physical activity in COPD using a triaxial accelerometer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46;G&#46; Steele"
                            1 => "L&#46; Holt"
                            2 => "B&#46; Belza"
                            3 => "S&#46; Ferris"
                            4 => "S&#46; Lakshminaryan"
                            5 => "D&#46;M&#46; Buchner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2000"
                        "volumen" => "117"
                        "paginaInicial" => "1359"
                        "paginaFinal" => "1367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10807823"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Accelerometry in persons with multiple sclerosis&#58; measurement of physical activity or walking mobility"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Weikert"
                            1 => "R&#46;W&#46; Motl"
                            2 => "Y&#46; Suh"
                            3 => "E&#46; McAuley"
                            4 => "D&#46; Wynn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jns.2009.12.021"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Neurol Sci"
                        "fecha" => "2010"
                        "volumen" => "290"
                        "paginaInicial" => "6"
                        "paginaFinal" => "11"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20060544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International physical activity questionnaire&#58; 12-country reliability and validity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;L&#46; Craig"
                            1 => "A&#46;L&#46; Marshall"
                            2 => "M&#46; Sjostrom"
                            3 => "A&#46;E&#46; Bauman"
                            4 => "M&#46;L&#46; Booth"
                            5 => "B&#46;E&#46; Ainsworth"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1249/01.MSS.0000078924.61453.FB"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Sci Sports Exerc"
                        "fecha" => "2003"
                        "volumen" => "35"
                        "paginaInicial" => "1381"
                        "paginaFinal" => "1395"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12900694"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The technology of accelerometry-based activity monitors&#58; current and future"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;Y&#46; Chen"
                            1 => "D&#46;R&#46; Bassett Jr&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Sci Sports Exerc"
                        "fecha" => "2005"
                        "volumen" => "37"
                        "paginaInicial" => "S490"
                        "paginaFinal" => "S500"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16294112"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity levels in patients with early knee osteoarthritis measured by accelerometry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;N&#46; Farr"
                            1 => "S&#46;B&#46; Going"
                            2 => "T&#46;G&#46; Lohman"
                            3 => "L&#46; Rankin"
                            4 => "S&#46; Kasle"
                            5 => "M&#46; Cornett"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.24007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "1229"
                        "paginaFinal" => "1236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18759320"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of momentary pain and fatigue on physical activity in women with osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;L&#46; Murphy"
                            1 => "D&#46;M&#46; Smith"
                            2 => "D&#46;J&#46; Clauw"
                            3 => "N&#46;B&#46; Alexander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.23710"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "849"
                        "paginaFinal" => "856"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18512720"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Obesity and other modifiable factors for physical inactivity measured by accelerometer in adults with knee osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Lee"
                            1 => "J&#46; Song"
                            2 => "J&#46;M&#46; Hootman"
                            3 => "P&#46;A&#46; Semanik"
                            4 => "R&#46;W&#46; Chang"
                            5 => "L&#46; Sharma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Care Res &#40;Hoboken&#41;"
                        "fecha" => "2013"
                        "volumen" => "65"
                        "paginaInicial" => "53"
                        "paginaFinal" => "61"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The clinical utility of accelerometry in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Prioreschi"
                            1 => "B&#46; Hodkinson"
                            2 => "I&#46; Avidon"
                            3 => "M&#46; Tikly"
                            4 => "J&#46;A&#46; McVeigh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2013"
                        "volumen" => "52"
                        "paginaInicial" => "1721"
                        "paginaFinal" => "1727"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Kodama"
                            1 => "K&#46; Saito"
                            2 => "S&#46; Tanaka"
                            3 => "M&#46; Maki"
                            4 => "Y&#46; Yachi"
                            5 => "M&#46; Asumi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.2009.681"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2009"
                        "volumen" => "301"
                        "paginaInicial" => "2024"
                        "paginaFinal" => "2035"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19454641"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Long-term follow-up of a high-intensity exercise program in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; de Jong"
                            1 => "M&#46; Munneke"
                            2 => "H&#46;M&#46; Kroon"
                            3 => "D&#46; van Schaardenburg"
                            4 => "B&#46;A&#46; Dijkmans"
                            5 => "J&#46;M&#46; Hazes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10067-009-1125-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Rheumatol"
                        "fecha" => "2009"
                        "volumen" => "28"
                        "paginaInicial" => "663"
                        "paginaFinal" => "671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19247575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is a long-term high-intensity exercise program effective and safe in patients with rheumatoid arthritis&#63; Results of a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Z&#46; de Jong"
                            1 => "M&#46; Munneke"
                            2 => "A&#46;H&#46; Zwinderman"
                            3 => "H&#46;M&#46; Kroon"
                            4 => "A&#46; Jansen"
                            5 => "K&#46;H&#46; Ronday"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11216"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "2415"
                        "paginaFinal" => "2424"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13130460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Benefits of hospitalization in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Lee"
                            1 => "A&#46;C&#46; Kennedy"
                            2 => "J&#46; Anderson"
                            3 => "W&#46;W&#46; Buchanan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Q J Med"
                        "fecha" => "1974"
                        "volumen" => "43"
                        "paginaInicial" => "205"
                        "paginaFinal" => "214"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4850737"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of resting splints by patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "J&#46; Feinberg"
                            1 => "K&#46;D&#46; Brandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Occup Ther"
                        "fecha" => "1981"
                        "volumen" => "35"
                        "paginaInicial" => "173"
                        "paginaFinal" => "178"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7234956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of physical activity in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "G&#46; Plasqui"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.physbeh.2007.12.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Physiol Behav"
                        "fecha" => "2008"
                        "volumen" => "94"
                        "paginaInicial" => "270"
                        "paginaFinal" => "275"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18234247"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of intensive exercise on patients with active rheumatoid arthritis&#58; a randomised clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C&#46;H&#46; van den Ende"
                            1 => "F&#46;C&#46; Breedveld"
                            2 => "S&#46; le Cessie"
                            3 => "B&#46;A&#46; Dijkmans"
                            4 => "A&#46;W&#46; de Mug"
                            5 => "J&#46;M&#46; Hazes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2000"
                        "volumen" => "59"
                        "paginaInicial" => "615"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10913058"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;E&#46; Sandberg"
                            1 => "S&#46; Wedren"
                            2 => "L&#46; Klareskog"
                            3 => "I&#46;E&#46; Lundberg"
                            4 => "C&#46;H&#46; Opava"
                            5 => "L&#46; Alfredsson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2014-205180"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2014"
                        "volumen" => "73"
                        "paginaInicial" => "1541"
                        "paginaFinal" => "1544"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24641943"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;H&#46; Solomon"
                            1 => "E&#46;W&#46; Karlson"
                            2 => "E&#46;B&#46; Rimm"
                            3 => "C&#46;C&#46; Cannuscio"
                            4 => "L&#46;A&#46; Mandl"
                            5 => "J&#46;E&#46; Manson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2003"
                        "volumen" => "107"
                        "paginaInicial" => "1303"
                        "paginaFinal" => "1307"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12628952"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity across adulthood in relation to fat and lean body mass in early old age&#58; findings from the Medical Research Council National Survey of Health and Development&#44; 1946&#8211;2010"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46; Bann"
                            1 => "D&#46; Kuh"
                            2 => "A&#46;K&#46; Wills"
                            3 => "J&#46; Adams"
                            4 => "S&#46; Brage"
                            5 => "R&#46; Cooper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/aje/kwu033"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Epidemiol"
                        "fecha" => "2014"
                        "volumen" => "179"
                        "paginaInicial" => "1197"
                        "paginaFinal" => "1207"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24722997"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of leisure time physical activity on blood lipid levels&#58; the ATTICA study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;B&#46; Panagiotakos"
                            1 => "C&#46; Pitsavos"
                            2 => "C&#46; Chrysohoou"
                            3 => "J&#46; Skoumas"
                            4 => "A&#46; Zeimbekis"
                            5 => "I&#46; Papaioannou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.mca.0000096082.14788.9f"
                      "Revista" => array:6 [
                        "tituloSerie" => "Coron Artery Dis"
                        "fecha" => "2003"
                        "volumen" => "14"
                        "paginaInicial" => "533"
                        "paginaFinal" => "539"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14646674"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "What predicts obesity in patients with rheumatoid arthritis&#63; An investigation of the interactions between lifestyle and inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Stavropoulos-Kalinoglou"
                            1 => "G&#46;S&#46; Metsios"
                            2 => "J&#46;P&#46; Smith"
                            3 => "V&#46;F&#46; Panoulas"
                            4 => "K&#46;M&#46; Douglas"
                            5 => "A&#46;Z&#46; Jamurtas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Int J Obes &#40;Lond&#41;"
                        "fecha" => "2010"
                        "volumen" => "34"
                        "paginaInicial" => "295"
                        "paginaFinal" => "301"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Low level of physical activity in women with rheumatoid arthritis is associated with cardiovascular risk factors but not with body fat mass &#8211; a cross sectional study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;C&#46; Elkan"
                            1 => "N&#46; Hakansson"
                            2 => "J&#46; Frostegard"
                            3 => "I&#46; Hafstrom"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2474-12-13"
                      "Revista" => array:5 [
                        "tituloSerie" => "BMC Musculoskelet Disord"
                        "fecha" => "2011"
                        "volumen" => "12"
                        "paginaInicial" => "13"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21235741"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of physical inactivity with increased cardiovascular risk in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;S&#46; Metsios"
                            1 => "A&#46; Stavropoulos-Kalinoglou"
                            2 => "V&#46;F&#46; Panoulas"
                            3 => "M&#46; Wilson"
                            4 => "A&#46;M&#46; Nevill"
                            5 => "Y&#46; Koutedakis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/HJR.0b013e3283271ceb"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cardiovasc Prev Rehabil"
                        "fecha" => "2009"
                        "volumen" => "16"
                        "paginaInicial" => "188"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19238083"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical inactivity in patients with rheumatoid arthritis&#58; data from twenty-one countries in a cross-sectional&#44; international study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Sokka"
                            1 => "A&#46; Hakkinen"
                            2 => "H&#46; Kautiainen"
                            3 => "M&#46;J&#46; Nissen"
                            4 => "B&#46; Allenet"
                            5 => "P&#46; Francois"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.23255"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2008"
                        "volumen" => "59"
                        "paginaInicial" => "42"
                        "paginaFinal" => "50"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18163412"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity level and physical fitness in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Acar"
                            1 => "E&#46; Tonga"
                            2 => "A&#46; Daskapan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2013"
                        "paginaInicial" => "72"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity in rheumatoid arthritis&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "M&#46; Tierney"
                            1 => "A&#46; Fraser"
                            2 => "N&#46; Kennedy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Phys Act Health"
                        "fecha" => "2012"
                        "volumen" => "9"
                        "paginaInicial" => "1036"
                        "paginaFinal" => "1048"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22971883"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dynamic exercise programs &#40;aerobic capacity and&#47;or muscle strength training&#41; in patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Hurkmans"
                            1 => "F&#46;J&#46; van der Giesen"
                            2 => "T&#46;P&#46; Vliet Vlieland"
                            3 => "J&#46; Schoones"
                            4 => "E&#46;C&#46; Van den Ende"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2009"
                        "paginaInicial" => "CD006853"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dynamic exercise therapy for rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;H&#46; Van Den Ende"
                            1 => "T&#46;P&#46; Vliet Vlieland"
                            2 => "M&#46; Munneke"
                            3 => "J&#46;M&#46; Hazes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Cochrane Database Syst Rev"
                        "fecha" => "2000"
                        "paginaInicial" => "CD000322"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity and rheumatoid arthritis&#58; results from quest-RA Moroccan study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; El Kabbaj"
                            1 => "H&#46; Rkain"
                            2 => "I&#46; Benslama"
                            3 => "T&#46; Lakhdar"
                            4 => "F&#46; Znat"
                            5 => "L&#46; Benbrahim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2013"
                        "paginaInicial" => "72"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of physical activity on inflammation&#58; effects on cardiovascular disease risk and other inflammatory conditions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Ertek"
                            1 => "A&#46; Cicero"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5114/aoms.2012.31614"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Med Sci"
                        "fecha" => "2012"
                        "volumen" => "8"
                        "paginaInicial" => "794"
                        "paginaFinal" => "804"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23185187"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized two-year study of the effects of dynamic strength training on muscle strength&#44; disease activity&#44; functional capacity&#44; and bone mineral density in early rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Hakkinen"
                            1 => "T&#46; Sokka"
                            2 => "A&#46; Kotaniemi"
                            3 => "P&#46; Hannonen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/1529-0131(200103)44:3<515::AID-ANR98>3.0.CO;2-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2001"
                        "volumen" => "44"
                        "paginaInicial" => "515"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11263764"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differentiation between obesity and insulin resistance in the association with C-reactive protein"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; McLaughlin"
                            1 => "F&#46; Abbasi"
                            2 => "C&#46; Lamendola"
                            3 => "L&#46; Liang"
                            4 => "G&#46; Reaven"
                            5 => "P&#46; Schaaf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2002"
                        "volumen" => "106"
                        "paginaInicial" => "2908"
                        "paginaFinal" => "2912"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12460870"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-6 and insulin resistance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J&#46;H&#46; Kim"
                            1 => "R&#46;A&#46; Bachmann"
                            2 => "J&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0083-6729(08)00621-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Vitam Horm"
                        "fecha" => "2009"
                        "volumen" => "80"
                        "paginaInicial" => "613"
                        "paginaFinal" => "633"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19251052"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The immunomodulating role of exercise in metabolic disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;I&#46; Lancaster"
                            1 => "M&#46;A&#46; Febbraio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Trends Immunol"
                        "fecha" => "2014"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized controlled trial to evaluate the effectiveness of an exercise program in women with rheumatoid arthritis taking low dose prednisone"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;D&#46; Westby"
                            1 => "J&#46;P&#46; Wade"
                            2 => "K&#46;K&#46; Rangno"
                            3 => "J&#46; Berkowitz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2000"
                        "volumen" => "27"
                        "paginaInicial" => "1674"
                        "paginaFinal" => "1680"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10914850"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of concurrent strength and endurance training in women with early or longstanding rheumatoid arthritis&#58; comparison with healthy subjects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Hakkinen"
                            1 => "P&#46; Hannonen"
                            2 => "K&#46; Nyman"
                            3 => "T&#46; Lyyski"
                            4 => "K&#46; Hakkinen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11466"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "49"
                        "paginaInicial" => "789"
                        "paginaFinal" => "797"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14673965"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A home-based two-year strength training period in early rheumatoid arthritis led to good long-term compliance&#58; a five-year followup"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Hakkinen"
                            1 => "T&#46; Sokka"
                            2 => "P&#46; Hannonen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20088"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "51"
                        "paginaInicial" => "56"
                        "paginaFinal" => "62"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14872456"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between dynamic exercise therapy and IGF-1 and IGFBP-3 concentrations in the patients with rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;A&#46; Melikoglu"
                            1 => "S&#46; Karatay"
                            2 => "K&#46; Senel"
                            3 => "F&#46; Akcay"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00296-005-0605-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rheumatol Int"
                        "fecha" => "2006"
                        "volumen" => "26"
                        "paginaInicial" => "309"
                        "paginaFinal" => "313"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15933856"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictors of exercise and effects of exercise on symptoms&#44; function&#44; aerobic fitness&#44; and disease outcomes of rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;B&#46; Neuberger"
                            1 => "L&#46;S&#46; Aaronson"
                            2 => "B&#46; Gajewski"
                            3 => "S&#46;E&#46; Embretson"
                            4 => "P&#46;E&#46; Cagle"
                            5 => "J&#46;K&#46; Loudon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.22903"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "943"
                        "paginaFinal" => "952"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17665488"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of high-intensity resistance training in patients with rheumatoid arthritis&#58; a randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Lemmey"
                            1 => "S&#46;M&#46; Marcora"
                            2 => "K&#46; Chester"
                            3 => "S&#46; Wilson"
                            4 => "F&#46; Casanova"
                            5 => "P&#46;J&#46; Maddison"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.24891"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2009"
                        "volumen" => "61"
                        "paginaInicial" => "1726"
                        "paginaFinal" => "1734"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19950325"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity coaching of patients with rheumatoid arthritis in everyday practice&#58; a long-term follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46;S&#46; Sjoquist"
                            1 => "N&#46; Brodin"
                            2 => "J&#46; Lampa"
                            3 => "I&#46; Jensen"
                            4 => "C&#46;H&#46; Opava"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/msc.199"
                      "Revista" => array:6 [
                        "tituloSerie" => "Musculoskeletal Care"
                        "fecha" => "2011"
                        "volumen" => "9"
                        "paginaInicial" => "75"
                        "paginaFinal" => "85"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21618399"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional and physiological effects of yoga in women with rheumatoid arthritis&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46;R&#46; Bosch"
                            1 => "T&#46; Traustadottir"
                            2 => "P&#46; Howard"
                            3 => "K&#46;S&#46; Matt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Altern Ther Health Med"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "paginaInicial" => "24"
                        "paginaFinal" => "31"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19623830"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of a sixteen-week training program on strength&#44; pain&#44; and function in rheumatoid arthritis patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;G&#46; Flint-Wagner"
                            1 => "J&#46; Lisse"
                            2 => "T&#46;G&#46; Lohman"
                            3 => "S&#46;B&#46; Going"
                            4 => "T&#46; Guido"
                            5 => "E&#46; Cussler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/RHU.0b013e318190f95f"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Rheumatol"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "paginaInicial" => "165"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19279507"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The effect of conditioning exercise on the health status and pain in patients with rheumatoid arthritis&#58; a randomized controlled clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Jahanbin"
                            1 => "M&#46; Hoseini Moghadam"
                            2 => "M&#46;A&#46; Nazarinia"
                            3 => "F&#46; Ghodsbin"
                            4 => "Z&#46; Bagheri"
                            5 => "A&#46;R&#46; Ashraf"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Community Based Nurs Midwifery"
                        "fecha" => "2014"
                        "volumen" => "2"
                        "paginaInicial" => "169"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25349859"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A dynamic exercise programme to improve patients&#8217; disability in rheumatoid arthritis&#58; a prospective randomized controlled trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Baillet"
                            1 => "E&#46; Payraud"
                            2 => "V&#46;A&#46; Niderprim"
                            3 => "M&#46;J&#46; Nissen"
                            4 => "B&#46; Allenet"
                            5 => "P&#46; Fran&#231;ois"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "410"
                        "paginaFinal" => "415"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Resistance training improves cardiovascular risk factors in obese women despite a significative decrease in serum adiponectin levels"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Ibanez"
                            1 => "M&#46; Izquierdo"
                            2 => "C&#46; Martinez-Labari"
                            3 => "F&#46; Ortega"
                            4 => "A&#46; Grijalba"
                            5 => "L&#46; Forja"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Obesity &#40;Silver Spring&#41;"
                        "fecha" => "2010"
                        "volumen" => "18"
                        "paginaInicial" => "535"
                        "paginaFinal" => "541"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sustained maintenance of exercise induced muscle strength gains and normal bone mineral density in patients with early rheumatoid arthritis&#58; a 5 year follow up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Hakkinen"
                            1 => "T&#46; Sokka"
                            2 => "H&#46; Kautiainen"
                            3 => "A&#46; Kotaniemi"
                            4 => "P&#46; Hannonen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2003.013003"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2004"
                        "volumen" => "63"
                        "paginaInicial" => "910"
                        "paginaFinal" => "916"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15249317"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of strength training on neuromuscular function and disease activity in patients with recent-onset inflammatory arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Hakkinen"
                            1 => "K&#46; Hakkinen"
                            2 => "P&#46; Hannonen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Rheumatol"
                        "fecha" => "1994"
                        "volumen" => "23"
                        "paginaInicial" => "237"
                        "paginaFinal" => "242"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7973476"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy of low load resistive muscle training in patients with rheumatoid arthritis functional class II and III"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G&#46;R&#46; Komatireddy"
                            1 => "R&#46;W&#46; Leitch"
                            2 => "K&#46; Cella"
                            3 => "G&#46; Browning"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "1997"
                        "volumen" => "24"
                        "paginaInicial" => "1531"
                        "paginaFinal" => "1539"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0685"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dynamic training versus relaxation training as home exercise for patients with inflammatory rheumatic diseases&#46; A randomized controlled study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Scand J Rheumatol"
                        "fecha" => "1996"
                        "volumen" => "25"
                        "paginaInicial" => "28"
                        "paginaFinal" => "33"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0690"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are the benefits of a high-intensity progressive resistance training program sustained in rheumatoid arthritis patients&#63; A 3-year followup study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arthritis Care Res &#40;Hoboken&#41;"
                        "fecha" => "2012"
                        "volumen" => "64"
                        "paginaInicial" => "71"
                        "paginaFinal" => "75"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0695"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Physical activity and energy expenditure in rheumatoid arthritis patients and matched controls"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2012"
                        "volumen" => "51"
                        "paginaInicial" => "1500"
                        "paginaFinal" => "1507"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            68 => array:3 [
              "identificador" => "bib0700"
              "etiqueta" => "69"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reproducibility of joint swelling assessments in long-lasting rheumatoid arthritis&#58; influence on Disease Activity Score-28 values &#40;SEA-Repro study part I&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3899/jrheum.090879"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Rheumatol"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "932"
                        "paginaFinal" => "937"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            69 => array:3 [
              "identificador" => "bib0705"
              "etiqueta" => "70"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evidence for the benefit of aerobic and strengthening exercise in rheumatoid arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11051"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "49"
                        "paginaInicial" => "428"
                        "paginaFinal" => "434"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            70 => array:3 [
              "identificador" => "bib0710"
              "etiqueta" => "71"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "www&#46;nu&#46;nl&#47;files&#47;IDC-Facebook Always Connected &#40;1&#41;&#46;pdf"
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "titulo" => "How smartphones and social keep us engaged"
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:1 [
                        "fecha" => "2013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack288224"
        "titulo" => "Acknowledgments"
        "texto" => "<p id="par0175" class="elsevierStylePara elsevierViewall">The authors would like to thank Mercedes Guerra from the Spanish Rheumatology Society for the systematic search of the literature&#44; and the members of the Department of Rheumatology of Hospital Universitario de Canarias for their continuous support&#46; Authors also are indebted with Prof&#46; Jose Antonio L&#46; Calbet&#44; Department of Physical Education of University of Las Palmas de Gran Canaria for the critical reading of the manuscript&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001300000004/v1_201707050008/S2173574317300837/v1_201707050008/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "67060"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Reviews"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001300000004/v1_201707050008/S2173574317300837/v1_201707050008/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574317300837?idApp=UINPBA00004M"
]

Article information

ISSN: 21735743
Original language: English

DOI:10.1016/j.reumae.2016.04.014

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	12	19	31
2024 October	113	82	195
2024 September	105	39	144
2024 August	61	44	105
2024 July	68	24	92
2024 June	85	40	125
2024 May	110	53	163
2024 April	155	49	204
2024 March	172	61	233
2024 February	93	29	122
2024 January	119	50	169
2023 December	95	36	131
2023 November	127	96	223
2023 October	119	76	195
2023 September	205	57	262
2023 August	102	29	131
2023 July	56	24	80
2023 June	78	38	116
2023 May	92	39	131
2023 April	116	51	167
2023 March	122	86	208
2023 February	81	37	118
2023 January	84	45	129
2022 December	127	59	186
2022 November	132	92	224
2022 October	106	68	174
2022 September	118	86	204
2022 August	73	65	138
2022 July	77	69	146
2022 June	130	78	208
2022 May	137	58	195
2022 April	214	133	347
2022 March	127	103	230
2022 February	132	80	212
2022 January	119	101	220
2021 December	113	87	200
2021 November	120	89	209
2021 October	128	95	223
2021 September	128	102	230
2021 August	73	75	148
2021 July	93	40	133
2021 June	104	74	178
2021 May	135	99	234
2021 April	263	331	594
2021 March	285	92	377
2021 February	102	53	155
2021 January	164	77	241
2020 December	136	82	218
2020 November	410	83	493
2020 October	121	29	150
2020 September	84	64	148
2020 August	50	38	88
2020 July	33	33	66
2020 June	60	44	104
2020 May	104	66	170
2020 April	159	56	215
2020 March	52	19	71
2018 May	2	1	3
2018 April	28	8	36
2018 March	47	15	62
2018 February	39	16	55
2018 January	29	9	38
2017 December	45	19	64
2017 November	31	10	41
2017 October	32	13	45
2017 September	27	14	41
2017 August	42	30	72
2017 July	34	32	66

Show all

Indexed in:

Follow us:

Subscribe:

Statistics

Indexed in:

Follow us:

Subscribe:

Statistics

Subscribe to our newsletter