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Cervicothoracic CT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed paralysis of left vocal cord&#44; whereas abdominal CT disclosed infrarenal abdominal aortic aneurysm measuring 47<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>48<span class="elsevierStyleHsp" style=""></span>mm&#44; with no other findings&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The study of ear&#44; nose and throat confirmed paralysis of left vocal cord&#46; There was no ophthalmological involvement&#46; Tests for autoimmunity included antinuclear antibodies&#44; antineutrophil cytoplasmic antibodies&#44; antiphospholipid antibodies&#44; rheumatoid factor and anti-cyclic citrullinated peptide antibodies&#44; all negative&#46; Serological tests ruled out bacterial infectious diseases like syphilis&#44; Lyme disease and chlamydiosis and polymerase chain reaction for herpesvirus 1 and 2 and cytomegalovirus was negative&#46; Blood cultures were also negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient underwent a pathergy test in right arm&#44; which was positive&#44; and a punch biopsy of the skin in the region of the acneiform eruption on his back showed evidence only of pseudofolliculitis&#46; Given the clinical suspicion of BD&#44; treatment was begun with oral glucocorticoids at a dose of 20<span class="elsevierStyleHsp" style=""></span>mg a day&#46; The treatment with corticosteroids improved the ulcers and skin lesions&#44; but there was no change in the dysphonia&#46; The aneurysm observed in CT images subsequently required surgical treatment&#44; which was successful&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Beh&#231;et&#39;s disease is an immune-mediated systemic vasculitis&#44; characterized by the presence of recurrent orogenital ulcers&#44; ocular inflammation and skin lesions&#46; The etiology and pathogenesis of BD are unknown&#44; although it has been demonstrated that the presence of human leukocyte antigen &#40;HLA&#41; B51 constitutes an important genetic predisposing factor&#44; especially among patients from the Middle and Far East&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Being a multisystemic vasculitis&#44; almost any part of the organism can be affected&#46; The oral ulcers&#44; recurrent and painful&#44; are present in 90&#37;&#8211;100&#37; of the patients with BD&#46; Other frequent clinical manifestations are genital ulcers &#40;60&#37;&#8211;80&#37;&#41;&#44; ocular lesions &#40;67&#37;&#8211;95&#37;&#41;&#44; skin lesions &#40;41&#37;&#8211;94&#37;&#41;&#44; arthritis &#40;47&#37;&#8211;69&#37;&#41; and neurological involvement &#40;8&#37;&#8211;31&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> The cutaneous manifestations of the patient we describe was nearly diagnostic of BD&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In contrast to central nervous system involvement&#44; which is common in BD&#44; peripheral nervous system manifestations are rare&#46; There have been isolated cases of Guillain&#8211;Barr&#233; syndrome&#44; mononeuritis multiplex&#44; sensorimotor neuropathy&#44; autonomic neuropathies and subclinical nerve conduction abnormalities&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> However&#44; vocal cord involvement is unusual and&#44; to date&#44; only 2 cases have been reported in the medical literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The most probable explanation for this occurrence could be the presence of vasculitis at the level of the recurrent laryngeal nerve&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In the case of this patient we found no other condition to explain the dysphonia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; BD should be taken into account in the differential diagnosis of sudden dysphonia in the absence of other more common findings&#44; especially in regions in which the disease is frequent&#46;</p></span>"
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Letter to the Editor
Vocal cord palsy as a clinical manifestation of Behçet's disease
Parálisis de cuerda vocal como manifestación clínica de enfermedad de Behçet
Elvis Amao-Ruiza,
Corresponding author
tatojar@outlook.com

Corresponding author.
, Ana María Correa-Fernándezb, Jesús Gallego-Gilc
a Servicio de Cardiología, Hospital Clínico de Valladolid, Valladolid, Spain
b Unidad de Insuficiencia Cardiaca y Trasplante, Servicio de Cardiología, Hospital Clínico de Valladolid, Valladolid, Spain
c Servicio de Medicina Interna, Hospital Clínico de Valladolid, Valladolid, Spain
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        "titulo" => "Par&#225;lisis de cuerda vocal como manifestaci&#243;n cl&#237;nica de enfermedad de Beh&#231;et"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">On the left side&#44; a cross-sectional slice of a cervical CT showing the paramedial position of the left vocal cord &#40;arrow&#41;&#46; On the right side&#44; an axial slice showing the same position of the vocal cord &#40;arrow&#41;&#44; findings compatible with paralysis&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Beh&#231;et&#39;s disease &#40;BD&#41; is a rare autoimmune disease&#44; with distinctive features like recurrent oral ulcers and&#44; in most cases&#44; genital ulcers&#46; The symptoms can also include ophthalmological&#44; neurological&#44; dermatological&#44; vascular&#44; musculoskeletal&#44; intestinal and pulmonary manifestations&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a> Involvement of the larynx is not common&#46; We report the case of an individual with BD that affected a vocal cord&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The patient was a 58-year-old man who had stopped smoking 3 years earlier and had no other medical history of interest&#46; He came to the department of internal medicine with recurrent oral and genital ulcers that had developed 2 months earlier&#46; They were accompanied by fever and he felt generally unwell&#46; Moreover&#44; he also had a 2-week history of dysphonia&#44; with no other associated symptoms&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Physical examination revealed dysphonia and the presence of painful scrotal and oral ulcers&#46; In addition&#44; he had an acneiform eruption on his back and lesions compatible with erythema nodosum on lower limbs&#46; He presented no other problems&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Laboratory analyses disclosed leukocytosis&#44; neutrophilia and an elevation of acute-phase reactants&#58; 14&#44;000<span class="elsevierStyleHsp" style=""></span>leukocytes&#47;mm<span class="elsevierStyleSup">3</span> &#40;78&#37; neutrophils&#41; and a C-reactive protein level of 150<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Cranial computed tomography &#40;CT&#41; showed no evidence of ischemic or hemorrhagic cerebral vascular involvement&#46; Cervicothoracic CT &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; revealed paralysis of left vocal cord&#44; whereas abdominal CT disclosed infrarenal abdominal aortic aneurysm measuring 47<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>48<span class="elsevierStyleHsp" style=""></span>mm&#44; with no other findings&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">The study of ear&#44; nose and throat confirmed paralysis of left vocal cord&#46; There was no ophthalmological involvement&#46; Tests for autoimmunity included antinuclear antibodies&#44; antineutrophil cytoplasmic antibodies&#44; antiphospholipid antibodies&#44; rheumatoid factor and anti-cyclic citrullinated peptide antibodies&#44; all negative&#46; Serological tests ruled out bacterial infectious diseases like syphilis&#44; Lyme disease and chlamydiosis and polymerase chain reaction for herpesvirus 1 and 2 and cytomegalovirus was negative&#46; Blood cultures were also negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient underwent a pathergy test in right arm&#44; which was positive&#44; and a punch biopsy of the skin in the region of the acneiform eruption on his back showed evidence only of pseudofolliculitis&#46; Given the clinical suspicion of BD&#44; treatment was begun with oral glucocorticoids at a dose of 20<span class="elsevierStyleHsp" style=""></span>mg a day&#46; The treatment with corticosteroids improved the ulcers and skin lesions&#44; but there was no change in the dysphonia&#46; The aneurysm observed in CT images subsequently required surgical treatment&#44; which was successful&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Beh&#231;et&#39;s disease is an immune-mediated systemic vasculitis&#44; characterized by the presence of recurrent orogenital ulcers&#44; ocular inflammation and skin lesions&#46; The etiology and pathogenesis of BD are unknown&#44; although it has been demonstrated that the presence of human leukocyte antigen &#40;HLA&#41; B51 constitutes an important genetic predisposing factor&#44; especially among patients from the Middle and Far East&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">1</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Being a multisystemic vasculitis&#44; almost any part of the organism can be affected&#46; The oral ulcers&#44; recurrent and painful&#44; are present in 90&#37;&#8211;100&#37; of the patients with BD&#46; Other frequent clinical manifestations are genital ulcers &#40;60&#37;&#8211;80&#37;&#41;&#44; ocular lesions &#40;67&#37;&#8211;95&#37;&#41;&#44; skin lesions &#40;41&#37;&#8211;94&#37;&#41;&#44; arthritis &#40;47&#37;&#8211;69&#37;&#41; and neurological involvement &#40;8&#37;&#8211;31&#37;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">2</span></a> The cutaneous manifestations of the patient we describe was nearly diagnostic of BD&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">In contrast to central nervous system involvement&#44; which is common in BD&#44; peripheral nervous system manifestations are rare&#46; There have been isolated cases of Guillain&#8211;Barr&#233; syndrome&#44; mononeuritis multiplex&#44; sensorimotor neuropathy&#44; autonomic neuropathies and subclinical nerve conduction abnormalities&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">3</span></a> However&#44; vocal cord involvement is unusual and&#44; to date&#44; only 2 cases have been reported in the medical literature&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The most probable explanation for this occurrence could be the presence of vasculitis at the level of the recurrent laryngeal nerve&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">5</span></a> In the case of this patient we found no other condition to explain the dysphonia&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">In conclusion&#44; BD should be taken into account in the differential diagnosis of sudden dysphonia in the absence of other more common findings&#44; especially in regions in which the disease is frequent&#46;</p></span>"
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                            2 => "S&#46; Obeso-Ag&#252;ero"
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                            4 => "M&#46;A&#46; Gonzalez-Gay"
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                        "tituloSerie" => "Lancet Neurol"
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                    0 => array:2 [
                      "titulo" => "Sudden Hoarseness due to unilateral cord vocal paralysis in a patient with Behcet&#39;s disease"
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                      "doi" => "10.1007/s10067-003-0708-3"
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                        "tituloSerie" => "Clin Rheumatol"
                        "fecha" => "2003"
                        "volumen" => "22"
                        "paginaInicial" => "254"
                        "paginaFinal" => "255"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14505224"
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Article information
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Idiomas
Reumatología Clínica (English Edition)
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