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Larrarte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Ivonne Margarita" "apellidos" => "Iglesias González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Alberto Juan" "apellidos" => "Dorta-Contreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Instituto de Ciencias Básicas y Preclínicas Victoria de Girón, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Laboratorio Central del Líquido Cefalorraquídeo (LABCEL), Facultad de Ciencias Médicas Miguel Enríquez, Universidad de Ciencias Médicas de La Habana, La Habana, Cuba" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta neuroinmunológica en neuro-Behçet" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1924 "Ancho" => 1337 "Tamanyo" => 244802 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Reibergram and its areas.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Neuro-Behçet (NB) is the product of the primary impact of Behçet's disease on the CNS, systemic manifestations of neurological complications or it may be secondary to treatment.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Immunological studies of cerebrospinal fluid (CSF) in this entity were confined to the quantifying of some immunoglobulins.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The Reibergram makes an integrated analysis of the functioning of the blood/CSF barrier and the intrathecal synthesis of immunoglobulins from serum and LCF coupling (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). This method is a useful tool for diagnosing diseases which involve the CNS.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">4,5</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The aim of this article is to assess the neuroimmunological response through the Reibergram in a patient with NB.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Clinical Case</span><p id="par0025" class="elsevierStylePara elsevierViewall">We report the case of a female, Caucasian patient aged 16 who presented with headaches (occipital) and back pain on the left side of her body, of 15days onset. Five days later she suffered from dizziness and paresia on the left side of her body which made walking impossible.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Neurological examination highlighted cranial nerve VI paralysis and bilateral papilloedema. Four days after admittance an ulcer appeared in the labia majora region, and the patient was questioned again and stated having a prior history of oral aphthous ulcers on at least 3 occasions in the last year, which were not resolved with standard treatment and which disappeared spontaneously. The pathergy skin test was positive.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Erythrocite sedimentation rate: 84<span class="elsevierStyleHsp" style=""></span>mm/h. Blood chemistry, complete haemogram and coagulation profile tested within normal parameters. Computerised tomography informed of diffuse cortical atrophy, and cytochemical, microbiological and cytological analyses of the CSF produced normal results.</p><p id="par0040" class="elsevierStylePara elsevierViewall">IgG, IgA, IgM and albumin concentration were quantified in serum and CSF by single radial immunodiffusion. The result of this neuroimmunological study revealed intrathecal synthesis for the three classes of the largest immunoglobulins, as a synthesis pattern, without any impairment of the blood/CSF barrier, concluding that this was an inflammatory process of the CNS (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>, Reibergram 1).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The patient was diagnosed with NB and treatment was administered with methylprednisolone to which she responded favourably.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Four months later the patient had a relapse with neurological symptoms (paralysis of the <span class="elsevierStyleSmallCaps">iii</span>, <span class="elsevierStyleSmallCaps">iv</span>, <span class="elsevierStyleSmallCaps">vi</span> and <span class="elsevierStyleSmallCaps">v</span>—ophthalmic branch—cranial nerves) and ophthalmological nerves (anterior uveitis and chronic bilateral papilloedema).</p><p id="par0055" class="elsevierStylePara elsevierViewall">Erythrocite sedimentation rate: 93<span class="elsevierStyleHsp" style=""></span>mm/h; the other ancillary tests were normal. The patient was referred for neuroimmunological analysis, which revealed intrathecal synthesis for the three largest immunoglobulins as a synthesis pattern, without any impairment of the blood/CSF barrier, concluding that this was an inflammatory process of the CNS (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>, reibergram 2).</p><p id="par0060" class="elsevierStylePara elsevierViewall">Due to the clinical symptoms of the patient, the results from the ancillary tests and the background of NB, this was interpreted as an exacerbation or outbreak of the disease. Treatment was administered with methylprednisolone.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0065" class="elsevierStylePara elsevierViewall">CSF studies in patients with NB have reported the increase in pro-inflammatory cytokines, particularly interleukin 6, which is characteristic of the active phase of the illness, playing a major role in the processes of neuronal damage and neuroapoptosis.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6,7</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Secondary to the autoimmune processes in Behçet's disease, we find the deposit of inmunoglobulins, demonstrated by immunofluorescence. Of these, the endothelial anticellular, anti-kinectin and antinuclear antibodies are the ones with a key function in the physiopathology of this vasculitis and are one of the causes of tissue damage.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">6–8</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">This patient presented with a pattern of intrathecal synthesis for the three classes of immunoglobulins in both exacerbations of the disease. However, there was no dysfunction of the blood/CSF barrier.</p><p id="par0080" class="elsevierStylePara elsevierViewall">We suggest that this barrier is highly relevant, since it not only limits access of circulating molecules towards the brain, but also limits access towards the brain of antigens from the systemic immune system.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">The latter is an indicator of complete disease remission and this corresponded with the course of this disease in our clinical case patient.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0090" class="elsevierStylePara elsevierViewall">The findings from this case are the first study where the Reibergram was used to assess the neuro-immunological response in a patient with NB, and its use may therefore be indicated for the active phase of the disease.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Liabilities</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of people and animals</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that the procedures followed comply with the ethical standards of the Committee responsible for human experimentation and are in keeping with the World Medical Association and the Declaration of Helsinki.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Data confidentiality</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare they have followed the protocols of their centre of work on patient data publication.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of Interests</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare with regard to this article.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1156700" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1084025" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1156701" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1084026" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Clinical Case" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusions" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical Liabilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of people and animals" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Data confidentiality" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflict of Interests" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-09-27" "fechaAceptado" => "2017-02-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1084025" "palabras" => array:6 [ 0 => "Blood–cerebrospinal fluid barrier" 1 => "Behçet's disease" 2 => "Immunoglobulins" 3 => "Neuro-Behçet's disease" 4 => "Reibergram" 5 => "Intrathecal synthesis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1084026" "palabras" => array:6 [ 0 => "Barrera sangre-líquido cefalorraquídeo" 1 => "Enfermedad de Behçet" 2 => "Inmunoglobulinas" 3 => "Neurobeçhet" 4 => "Reibergrama" 5 => "Síntesis intratecal" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Behçet's disease is a chronic, multisystem, autoimmune vasculitis characterised by a triad of key signs. We report the case of a 16-year-old Caucasian girl, who complained of headache, dizziness and paresis of the left side of her body. After physical examination and ancillary tests, she was diagnosed with Behçet's disease with neurological manifestations (neuro-Behçet's disease). She had a good response to treatment. IgG, IgA, IgM and albumin were quantified in serum and cerebrospinal fluid by single radial immunodiffusion. Intrathecal synthesis was found for the three classes of immunoglobulins. This is the first case in which the Reibergram was used to evaluate the neuroimmunological response in a patient with Behçet's disease, suggesting the use of this diagnostic means for the active phase of the disease.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Behçet es una vasculitis crónica, multisistémica y autoinmune caracterizada por una tríada de signos claves presentes en los pacientes que la padecen. Se presenta una paciente femenina, caucásica, de 16 años, con cefalea, mareos y paresia en hemicuerpo izquierdo que, tras examen físico y métodos complementarios, se diagnosticó como enfermedad de Behçet con manifestaciones neurológicas (neurobehçet), y a la que se impuso tratamiento, con buena respuesta. Se cuantificó IgG, IgA, IgM y albúmina en suero y LCR, por inmunodifusión radial simple, encontrándose síntesis intratecal de las 3 clases de inmunoglobulinas mayores. Los hallazgos en este caso constituyen el primer estudio donde se utiliza el reibergrama para evaluar la respuesta neuroinmunológica en un paciente con enfermedad de Behçet, siendo indicativo este medio diagnóstico de fase activa de la enfermedad.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Garcia-Rivero AA, Gonzalez-Argote J, Martínez Larrarte JP, Iglesias González IM, Dorta-Contreras AJ. Respuesta neuroinmunológica en neurobehçet. Reumatol Clín. 2019;15:117–120.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1924 "Ancho" => 1337 "Tamanyo" => 244802 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Reibergram and its areas.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 3450 "Ancho" => 2387 "Tamanyo" => 701946 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Reibergrams of the patient.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enfermedad de Behçet" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "W. 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