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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Presentation of the Case</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 48-year-old female was diagnosed in 2008 with rheumatoid arthritis with a presence of the rheumatoid factor &#40;RF&#41; and an absence of antibodies against cyclic citrullinated peptides &#40;anti-CCPs&#41;&#46; She met with the 1987 ACR classification criteria &#40;morning stiffness for over 1<span class="elsevierStyleHsp" style=""></span>h&#44; symmetric arthritis of both carpal joints and of the 2nd to 4th bilateral proximal interphalangeal joints&#44; a positive RF result and radiography showing erosions in carpal joints&#41;&#46; She also met with four out of six criteria of the 2002 American&#47;European Consensus Classification &#40;AECC&#41; for Sj&#246;gren&#39;s syndrome &#40;xerostomia&#44; xerophthalmia&#44; Schirmer 4<span class="elsevierStyleHsp" style=""></span>mm test and positive results for anti-Ro&#47;SSA 52 and 60 and anti-La&#47;SSB antibodies&#41;&#44; together with hypergammaglobulinaemia and infiltration of parotid glands viewed in the CT scan&#46; In her clinical history&#44; renal colic is notable&#44; repeated over 10 years ago&#46; It was assessed by the urology department which determined a wait-and-see approach&#46; She is currently undergoing treatment with prednisone&#44; sulfasalazine&#44; methotrexate and ophthalmic cyclosporine&#44; having already completed two cycles of 1<span class="elsevierStyleHsp" style=""></span>g rituximab due to persistent polyarthritis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We observed an incidental finding of bilateral renal calcifications on an X-ray of the abdomen &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Analytically&#44; the levels of creatinine and urea were normal &#40;CKD-EPI 100&#46;7<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#41;&#44; there were no basic&#8211;acid and hydroelectrolitical equilibrium alterations&#44; she did not present with proteinuria and calcium levels were normal in urine at 24<span class="elsevierStyleHsp" style=""></span>h &#40;90<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; as was phosphaturia&#46; The pH balance was slightly alkaline &#40;6&#46;5&#41; and there was insufficient vitamin D &#40;36&#46;8<span class="elsevierStyleHsp" style=""></span>nmol&#47;l&#41; although parathyroid hormone levels were normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis and Evolution</span><p id="par0015" class="elsevierStylePara elsevierViewall">As a result of the radiologic findings&#44; the patient was diagnosed with nephrocalcinosis within the context of SS&#44; despite not presenting with clinical or analytical alterations of nephropathy or alterations in the phosphocalcic metabolism&#46; Close monitoring of renal function with periodical analytical controls was determined as treatment&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Nephrocalcinosis is characterised by calcification of the renal parenchyma&#46; There are many causes including hyperparathyroidism&#44; hypercalcemic nephropathy from excess vitamin D&#44; Cacchi&#8211;Ricci disease &#40;medullary sponge kidney&#41; or distal renal tubular acidosis &#40;dRTA&#41; or type I acidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In SS&#44; specifically&#44; kidney function may be compromised in around 5&#37; of cases&#46; One of the possible causes of kidney compromise is dRTA&#46; This leads to urinary alkalosis &#40;pH<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>5&#46;5&#41;&#44; hyposthenuria&#44; hypercalciuria&#44; hyperphosphatemia and hypocitraturia&#44; with or without metabolic acidosis and in several cases to hypokalaemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a> Those patients with suspected dRTA who do not meet with analytical criteria may be given the ammonium chloride acid loading test to demonstrate the kidney&#39;s inability to acidify urine &#40;pH<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5&#46;5&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">When there is development of basic&#8211;acid and hydroelectrolytic equilibrium alterations&#44; treatment consists of administering bicarbonate and potassium citrate supplements to alkalinise the medium and recover losses&#44; as well as a baseline treatment with glucocorticoids and immunosuppressants&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;5&#44;6</span></a> It should be highlighted that the course of nephrolithiasis is distinct from that of nephrocalcinosis and that an incorrect treatment of metabolic acidosis may lead to the progression of nephrocalcinosis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We would therefore recommend an initial screening in patients with SS to detect possible nephropathy&#46; An analysis of ions in the blood and of the phosphocalcic metabolism should be requested&#44; as should a urine test at 24<span class="elsevierStyleHsp" style=""></span>h&#44; to evaluate the pH level&#44; the proteinuria and excretion of ions&#44; an immunological and serological test and also imaging tests&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Ethical Liabilities</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Protection of people and animals</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no experiments using human beings or animals have been carried out for this research study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Data confidentiality</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare they have followed the protocols of their centre of work on patient data publication&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Right to privacy and informed consent</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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Images in Clinical Rheumatology
Nephrocalcinosis in a Patient With Rheumatoid Arthritis and Secondary Sjögren's Syndrome
Nefrocalcinosis en una paciente con artritis reumatoide y síndrome de Sjögren secundario
Luis María Jiménez Liñán
Corresponding author
luijimlin@gmail.com

Corresponding author.
, Sergio Antonio Rodríguez Montero, José Luis Marenco de la Fuente
Unidad de Gestión Clínica de Reumatología, Hospital Universitario Nuestra Señora de Valme, Sevilla, Spain
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Schirmer 4<span class="elsevierStyleHsp" style=""></span>mm test and positive results for anti-Ro&#47;SSA 52 and 60 and anti-La&#47;SSB antibodies&#41;&#44; together with hypergammaglobulinaemia and infiltration of parotid glands viewed in the CT scan&#46; In her clinical history&#44; renal colic is notable&#44; repeated over 10 years ago&#46; It was assessed by the urology department which determined a wait-and-see approach&#46; She is currently undergoing treatment with prednisone&#44; sulfasalazine&#44; methotrexate and ophthalmic cyclosporine&#44; having already completed two cycles of 1<span class="elsevierStyleHsp" style=""></span>g rituximab due to persistent polyarthritis&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">We observed an incidental finding of bilateral renal calcifications on an X-ray of the abdomen &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Analytically&#44; the levels of creatinine and urea were normal &#40;CKD-EPI 100&#46;7<span class="elsevierStyleHsp" style=""></span>ml&#47;min&#41;&#44; there were no basic&#8211;acid and hydroelectrolitical equilibrium alterations&#44; she did not present with proteinuria and calcium levels were normal in urine at 24<span class="elsevierStyleHsp" style=""></span>h &#40;90<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; as was phosphaturia&#46; The pH balance was slightly alkaline &#40;6&#46;5&#41; and there was insufficient vitamin D &#40;36&#46;8<span class="elsevierStyleHsp" style=""></span>nmol&#47;l&#41; although parathyroid hormone levels were normal&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis and Evolution</span><p id="par0015" class="elsevierStylePara elsevierViewall">As a result of the radiologic findings&#44; the patient was diagnosed with nephrocalcinosis within the context of SS&#44; despite not presenting with clinical or analytical alterations of nephropathy or alterations in the phosphocalcic metabolism&#46; Close monitoring of renal function with periodical analytical controls was determined as treatment&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Discussion</span><p id="par0020" class="elsevierStylePara elsevierViewall">Nephrocalcinosis is characterised by calcification of the renal parenchyma&#46; There are many causes including hyperparathyroidism&#44; hypercalcemic nephropathy from excess vitamin D&#44; Cacchi&#8211;Ricci disease &#40;medullary sponge kidney&#41; or distal renal tubular acidosis &#40;dRTA&#41; or type I acidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">In SS&#44; specifically&#44; kidney function may be compromised in around 5&#37; of cases&#46; One of the possible causes of kidney compromise is dRTA&#46; This leads to urinary alkalosis &#40;pH<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>5&#46;5&#41;&#44; hyposthenuria&#44; hypercalciuria&#44; hyperphosphatemia and hypocitraturia&#44; with or without metabolic acidosis and in several cases to hypokalaemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;3</span></a> Those patients with suspected dRTA who do not meet with analytical criteria may be given the ammonium chloride acid loading test to demonstrate the kidney&#39;s inability to acidify urine &#40;pH<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5&#46;5&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">When there is development of basic&#8211;acid and hydroelectrolytic equilibrium alterations&#44; treatment consists of administering bicarbonate and potassium citrate supplements to alkalinise the medium and recover losses&#44; as well as a baseline treatment with glucocorticoids and immunosuppressants&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;5&#44;6</span></a> It should be highlighted that the course of nephrolithiasis is distinct from that of nephrocalcinosis and that an incorrect treatment of metabolic acidosis may lead to the progression of nephrocalcinosis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We would therefore recommend an initial screening in patients with SS to detect possible nephropathy&#46; An analysis of ions in the blood and of the phosphocalcic metabolism should be requested&#44; as should a urine test at 24<span class="elsevierStyleHsp" style=""></span>h&#44; to evaluate the pH level&#44; the proteinuria and excretion of ions&#44; an immunological and serological test and also imaging tests&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Ethical Liabilities</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Protection of people and animals</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors declare that no experiments using human beings or animals have been carried out for this research study&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Data confidentiality</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare they have followed the protocols of their centre of work on patient data publication&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Right to privacy and informed consent</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflict of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Jim&#233;nez Li&#241;&#225;n LM&#44; Rodr&#237;guez Montero SA&#44; Marenco de la Fuente JL&#46; Nefrocalcinosis en una paciente con artritis reumatoide y s&#237;ndrome de Sj&#246;gren secundario&#46; Reumatol Clin&#46; 2019&#59;15&#58;58&#8211;59&#46;</p>"
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Idiomas
Reumatología Clínica (English Edition)
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