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a non-smoker&#44; of Brazilian origin&#44; who presented with an intermittent cough&#44; for whom a chest X-ray showed nodular opacity in the URL &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; The patient had been studied some months previously by the primary care physician after non cohabitant contact with a case of tuberculosis&#44; and a positive tuberculin test&#46; A chest CT scan confirmed pseudonodular opacity in the URL of ground-glass attenuation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; No enlarged lymph nodes&#44; tree-in-bud opacities or radiological stigmas &#40;calcified granulomas&#44; bronchiectases&#44; calcified adenopathies&#41; were observed from previous tuberculosis&#46; Although the tuberculin test was positive&#44; bronchoalveolar lavage &#40;BAL&#41; and a transbronchial biopsy did not show any microbiological or granuloma changes&#46; Several sputum smears tested negative as well&#46; Despite the absence of microbiological confirmation it was decided the patient was to be treated with 4 antituberculosis drugs&#46; A control chest X-ray four months following treatment initiation showed radiological worsening with the appearance of bilateral parenchymal opacities&#46; However&#44; the patient did not present with new symptoms&#46; A further chest CT scan detected enlarged lymph nodes without necrosis in the right pulmonary hilum and ipsilateral mediastinum&#44; together with various dominant solid pulmonary nodules which characteristically presented with innumerable satellite 1&#8211;2<span class="elsevierStyleHsp" style=""></span>mm nodules around them &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a><span class="elsevierStyleSmallCaps">C</span>&#41;&#46; This radiological presentation is called the galaxy sign&#46; No tree-in-bud images or carious lesions were observed&#46; In view of these findings&#44; stage II pulmonary sarcoidosis was diagnosed&#46; Fine needle aspiration endobronchial ultrasound guided biopsy &#40;EBUS&#41; of the enlarged lymph nodes demonstrated the presence of non-necrotising epithelioid granulomas&#44; confirming the clinical diagnosis of sarcoidosis&#46; No microbacteria were isolated in the BAL&#46; Single-photo emission CT &#40;SPECT&#41; with gallium &#40;67<span class="elsevierStyleHsp" style=""></span>Ga&#41; was combined with CT &#40;SPECT&#47;TC&#41; which showed metabolic uptakes in the dominant pulmonary nodules and in the enlarged lymph nodes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Tuberculosis and sarcoidosis are 2 granulomatous diseases which usually mostly affect the chest and which may present clinical&#44; radiological and even histological similarities&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> This peculiarity means that differential diagnosis between these 2 conditions presents a challenge to clinicians&#44; and particularly in countries where the incidence of tuberculosis is high&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Studies have demonstrated that microbacterial antigens may trigger immunological response and eventually induce sarcoidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> However&#44; patients with sarcoidosis treated with corticoids may present with tuberculosis as an infectious complication&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> In our case&#44; a non-cohabitant contact of the patient with a case of tuberculosis &#40;some months earlier&#41;&#44; together with a positive tuberculin test and an X-ray arousing suspicion were &#8220;sufficient&#8221; to justify treatment initiation with antituberculosis drugs&#44; despite the absence of microbiological confirmation in sputum smears and the BAL&#46; The appearance of non-necrotising enlarged lymph nodes in a further chest CT&#44; the absence of standard tuberculosis radiological stigma &#40;calcified adenopathies and granulomas&#44; bronchiectasis&#44; etc&#46;&#41; and above all the galaxy sign indicated that sarcoidosis was responsible for the clinical and radiological symptoms&#46; This suspicion was finally confirmed in the EBUS performed on the patients several weeks later&#46; The galaxy sign was originally described in 2002 in chest CT studies of patients with sarcoidosis &#40;although it is not specific of this entity&#41; and consists of a central dominant pulmonary nodule formed by the confluence of many small-sized nodules&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> These tiny nodules separate from one another as they fade away from the dominant nodule&#44; forming satellite nodules which look like a galaxy of stars&#46; Histologically the galaxy sign represents the coalescence of many interstitial granulomas which form an inseparable large dominant nodule&#46; On the periphery&#44; the granulomas are less concentrated and separate from one another&#44; forming satellite nodules&#46; Although this sign was initially described in patients with sarcoidosis &#40;in fact the term &#8220;sarcoid galaxy&#8221; was coined&#41; it has also been described as being associated with massive progressive fibrosis in patients with silicosis&#44; with some pulmonary tumours and on occasion with active tuberculosis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> In the immense majority of cases the usefulness of the galaxy sign indicates a benign type of pulmonary tumour&#46; The only exception to this would be that of a peripheral lung adenocarcinoma small in size&#44; although in this case&#44; bilateral and symmetrical adenopathies are not usually found in the mediastinum and the pulmonary hilar structures &#40;as occurs in sarcoidosis&#41;&#44; nor signs of infectious bronchiolitis with necrotic enlarged lymph nodes &#40;as occurs in tuberculosis&#41; nor radiological signs of a complicated type of silicosis&#46; In our specific case it was not just the galaxy sign in isolation&#44; that suggested correct diagnosis of sarcoidosis&#44; but the combination of this radiological finding in a patient with radiological worsening of lung injuries despite having received antituberculosis treatment&#44; together with the appearance of mediastinal adenopathies&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0020" class="elsevierStylePara elsevierViewall">We believe that in some clinical and radiological contexts&#44; and especially if there is radiological progression despite antituberculosis treatment or if there is no microbiological confirmation of microbacteria or radiological stigmas which are typical of tuberculosis&#44; the galaxy sign in chest CT may be highly useful for indicating diagnosis of sarcoidosis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that for this research no experimentation has been carried out on human beings or animals&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have adhered to their centre of work on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of Interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La sarcoidosis y la tuberculosis son 2 enfermedades granulomatosas frecuentes que comparten presentaciones cl&#237;nicas y radiol&#243;gicas&#46; Entre los signos radiol&#243;gicos caracter&#237;sticos de sarcoidosis pulmonar descritos recientemente en la tomograf&#237;a computarizada de t&#243;rax destaca el signo de la &#171;galaxia&#187;&#46; Presentamos un caso de sarcoidosis que inicialmente fue confundido con una tuberculosis en el que este signo radiol&#243;gico fue &#250;til para indicar el diagn&#243;stico correcto&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gorospe Saras&#250;a L&#44; Ure&#241;a-Vacas A&#44; Arrieta P&#44; Santos-Carre&#241;o AL&#44; Navas-Elorza E&#44; de la Puente-Bujidos C&#46; Sarcoidosis pulmonar simulando una tuberculosis&#58; importancia del signo de la galaxia en TC de t&#243;rax&#46; Reumatol Clin&#46; 2019&#59;15&#58;e133&#8211;e135&#46;</p>"
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Case Report
Pulmonary Sarcoidosis Mimicking Tuberculosis: Importance of the Galaxy Sign on Thoracic Computed Tomography
Sarcoidosis pulmonar simulando una tuberculosis: importancia del signo de la galaxia en TC de tórax
Luis Gorospe Sarasúaa,
Corresponding author
luisgorospe@yahoo.com

Corresponding author.
, Almudena Ureña-Vacasa, Paola Arrietab, Astrid Lucía Santos-Carreñoc, Enrique Navas-Elorzad, Carlos de la Puente-Bujidose
a Servicio de Radiodiagnóstico, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Neumología, Hospital Universitario Ramón y Cajal, Madrid, Spain
c Servicio de Medicina Nuclear, Hospital Universitario Ramón y Cajal, Madrid, Spain
d Servicio de Enfermedades Infecciosas, Hospital Universitario Ramón y Cajal, Madrid, Spain
e Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
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a non-smoker&#44; of Brazilian origin&#44; who presented with an intermittent cough&#44; for whom a chest X-ray showed nodular opacity in the URL &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; The patient had been studied some months previously by the primary care physician after non cohabitant contact with a case of tuberculosis&#44; and a positive tuberculin test&#46; A chest CT scan confirmed pseudonodular opacity in the URL of ground-glass attenuation &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; No enlarged lymph nodes&#44; tree-in-bud opacities or radiological stigmas &#40;calcified granulomas&#44; bronchiectases&#44; calcified adenopathies&#41; were observed from previous tuberculosis&#46; Although the tuberculin test was positive&#44; bronchoalveolar lavage &#40;BAL&#41; and a transbronchial biopsy did not show any microbiological or granuloma changes&#46; Several sputum smears tested negative as well&#46; Despite the absence of microbiological confirmation it was decided the patient was to be treated with 4 antituberculosis drugs&#46; A control chest X-ray four months following treatment initiation showed radiological worsening with the appearance of bilateral parenchymal opacities&#46; However&#44; the patient did not present with new symptoms&#46; A further chest CT scan detected enlarged lymph nodes without necrosis in the right pulmonary hilum and ipsilateral mediastinum&#44; together with various dominant solid pulmonary nodules which characteristically presented with innumerable satellite 1&#8211;2<span class="elsevierStyleHsp" style=""></span>mm nodules around them &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a><span class="elsevierStyleSmallCaps">C</span>&#41;&#46; This radiological presentation is called the galaxy sign&#46; No tree-in-bud images or carious lesions were observed&#46; In view of these findings&#44; stage II pulmonary sarcoidosis was diagnosed&#46; Fine needle aspiration endobronchial ultrasound guided biopsy &#40;EBUS&#41; of the enlarged lymph nodes demonstrated the presence of non-necrotising epithelioid granulomas&#44; confirming the clinical diagnosis of sarcoidosis&#46; No microbacteria were isolated in the BAL&#46; Single-photo emission CT &#40;SPECT&#41; with gallium &#40;67<span class="elsevierStyleHsp" style=""></span>Ga&#41; was combined with CT &#40;SPECT&#47;TC&#41; which showed metabolic uptakes in the dominant pulmonary nodules and in the enlarged lymph nodes &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>D&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Tuberculosis and sarcoidosis are 2 granulomatous diseases which usually mostly affect the chest and which may present clinical&#44; radiological and even histological similarities&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">1</span></a> This peculiarity means that differential diagnosis between these 2 conditions presents a challenge to clinicians&#44; and particularly in countries where the incidence of tuberculosis is high&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">2</span></a> Studies have demonstrated that microbacterial antigens may trigger immunological response and eventually induce sarcoidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">4</span></a> However&#44; patients with sarcoidosis treated with corticoids may present with tuberculosis as an infectious complication&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">5</span></a> In our case&#44; a non-cohabitant contact of the patient with a case of tuberculosis &#40;some months earlier&#41;&#44; together with a positive tuberculin test and an X-ray arousing suspicion were &#8220;sufficient&#8221; to justify treatment initiation with antituberculosis drugs&#44; despite the absence of microbiological confirmation in sputum smears and the BAL&#46; The appearance of non-necrotising enlarged lymph nodes in a further chest CT&#44; the absence of standard tuberculosis radiological stigma &#40;calcified adenopathies and granulomas&#44; bronchiectasis&#44; etc&#46;&#41; and above all the galaxy sign indicated that sarcoidosis was responsible for the clinical and radiological symptoms&#46; This suspicion was finally confirmed in the EBUS performed on the patients several weeks later&#46; The galaxy sign was originally described in 2002 in chest CT studies of patients with sarcoidosis &#40;although it is not specific of this entity&#41; and consists of a central dominant pulmonary nodule formed by the confluence of many small-sized nodules&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">3</span></a> These tiny nodules separate from one another as they fade away from the dominant nodule&#44; forming satellite nodules which look like a galaxy of stars&#46; Histologically the galaxy sign represents the coalescence of many interstitial granulomas which form an inseparable large dominant nodule&#46; On the periphery&#44; the granulomas are less concentrated and separate from one another&#44; forming satellite nodules&#46; Although this sign was initially described in patients with sarcoidosis &#40;in fact the term &#8220;sarcoid galaxy&#8221; was coined&#41; it has also been described as being associated with massive progressive fibrosis in patients with silicosis&#44; with some pulmonary tumours and on occasion with active tuberculosis&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">6</span></a> In the immense majority of cases the usefulness of the galaxy sign indicates a benign type of pulmonary tumour&#46; The only exception to this would be that of a peripheral lung adenocarcinoma small in size&#44; although in this case&#44; bilateral and symmetrical adenopathies are not usually found in the mediastinum and the pulmonary hilar structures &#40;as occurs in sarcoidosis&#41;&#44; nor signs of infectious bronchiolitis with necrotic enlarged lymph nodes &#40;as occurs in tuberculosis&#41; nor radiological signs of a complicated type of silicosis&#46; In our specific case it was not just the galaxy sign in isolation&#44; that suggested correct diagnosis of sarcoidosis&#44; but the combination of this radiological finding in a patient with radiological worsening of lung injuries despite having received antituberculosis treatment&#44; together with the appearance of mediastinal adenopathies&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusions</span><p id="par0020" class="elsevierStylePara elsevierViewall">We believe that in some clinical and radiological contexts&#44; and especially if there is radiological progression despite antituberculosis treatment or if there is no microbiological confirmation of microbacteria or radiological stigmas which are typical of tuberculosis&#44; the galaxy sign in chest CT may be highly useful for indicating diagnosis of sarcoidosis&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical Disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that for this research no experimentation has been carried out on human beings or animals&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have adhered to their centre of work on the publication of patient data&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article&#46;</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of Interests</span><p id="par0040" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interests to declare&#46;</p></span></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sarcoidosis and tuberculosis are two common granulomatous conditions that may share clinical and radiological presentations&#46; The galaxy sign &#40;sarcoid galaxy sign&#41; is a characteristic radiological sign of pulmonary sarcoidosis on thoracic computed tomography &#40;CT&#41;&#46; We present the case of a patient with sarcoidosis that was initially misdiagnosed as tuberculosis&#44; in whom the galaxy sign on CT was useful as it suggested the correct diagnosis&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La sarcoidosis y la tuberculosis son 2 enfermedades granulomatosas frecuentes que comparten presentaciones cl&#237;nicas y radiol&#243;gicas&#46; Entre los signos radiol&#243;gicos caracter&#237;sticos de sarcoidosis pulmonar descritos recientemente en la tomograf&#237;a computarizada de t&#243;rax destaca el signo de la &#171;galaxia&#187;&#46; Presentamos un caso de sarcoidosis que inicialmente fue confundido con una tuberculosis en el que este signo radiol&#243;gico fue &#250;til para indicar el diagn&#243;stico correcto&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gorospe Saras&#250;a L&#44; Ure&#241;a-Vacas A&#44; Arrieta P&#44; Santos-Carre&#241;o AL&#44; Navas-Elorza E&#44; de la Puente-Bujidos C&#46; Sarcoidosis pulmonar simulando una tuberculosis&#58; importancia del signo de la galaxia en TC de t&#243;rax&#46; Reumatol Clin&#46; 2019&#59;15&#58;e133&#8211;e135&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Chest X-ray where a nodular opacity in the URL is observed &#40;arrows&#41;&#46; &#40;B&#41; Axial image of the first chest CT &#40;window of pulmonary parenchyma&#41; in which a nodular lesion of ground-glass attenuation is observed &#40;arrow&#41;&#46; &#40;C&#41; MIP &#40;maximum intensity projection&#41; axial image of the second chest CT &#40;window of pulmonary parenchyma&#41; in which a radiological progression is observed despite antituberculosis treatment and the galaxy sign&#58; solid nodular opacities &#40;arrows&#41; surrounded by multiple solid 1&#8211;2<span class="elsevierStyleHsp" style=""></span>mm nodules&#46; &#40;D&#41; Coronal imaging of SPECT&#47;CT with gallium in which uptake by the pulmonary nodules &#40;white arrows&#41; is determined and by the right pulmonary hilar adenopathies and ipsilateral mediastinum &#40;black arrows&#41;&#46;</p>"
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