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Intracavitary polypoid lesion 12<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>9<span class="elsevierStyleHsp" style=""></span>mm dependent on the endocardium in the apical region of the left ventricle, isointense with no significant contrast enhancement. (B) CT angiography of supra-aortic trunks with axial slice image. A thrombus can be observed in the right carotid system adhering to the right internal carotid artery from its origin, reducing its calibre and resulting in occlusion of the artery. (C) Abdominal CT showing thrombosis of the splenic vein of the porta hepatis with an extensive are of splenic infarction.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Javier José Mateos Rodríguez, David Bellido, David Castro, José Portillo Sánchez, Raúl Vanegas, Alicia Núñez García" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Javier José" "apellidos" => "Mateos Rodríguez" ] 1 => array:2 [ "nombre" => "David" "apellidos" => "Bellido" ] 2 => array:2 [ "nombre" => "David" "apellidos" => "Castro" ] 3 => array:2 [ "nombre" => "José" "apellidos" => "Portillo Sánchez" ] 4 => array:2 [ "nombre" => "Raúl" "apellidos" => "Vanegas" ] 5 => array:2 [ "nombre" => "Alicia" "apellidos" => "Núñez García" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X17301018" "doi" => "10.1016/j.reuma.2017.04.010" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X17301018?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431830114X?idApp=UINPBA00004M" "url" => "/21735743/0000001500000005/v1_201910260908/S217357431830114X/v1_201910260908/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173574318301266" "issn" => "21735743" "doi" => "10.1016/j.reumae.2018.09.009" "estado" => "S300" "fechaPublicacion" => "2019-09-01" "aid" => "1079" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Reumatol Clin. 2019;15:e27-e29" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>" "titulo" => "Retroperitoneal Fibrosis Associated With Immunoglobulin IgG4-related Disease in the Differential Diagnosis in Retroperitoneal Tumours. Case Report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "e27" "paginaFinal" => "e29" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fibrosis retroperitoneal nodular asociada a IgG4 como diagnóstico diferencial en tumores retroperitoneales. Reporte de un caso" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1689 "Ancho" => 1600 "Tamanyo" => 640676 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) Macroscopic tumour. (B) Surgical specimen, solid well defined tumour, fibrous in appearance, which does not invade the renal parenchyma. (C) Microphotography (40×). Reaction of the indirect immunoperoxidase with anti-IgG4 antibody, with over 40 plasmatic cells. (D) Microphotography (40×) with Mason staining. Fibrosis with focally steriform pattern. (E) Microphotography (100×). Inflammatory infiltrate predominantly composed of plasmatic cells. (F) Microphotography (10×) obliterating phlebitis consistent with extensive fibrosis and lymphoplasmacytic infiltrate.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gabriela Ruiz Mar, Óscar E. Cárdenas Serrano, Jorge Roldan García, Abraham Cañavera-Constantino, Víctor M. Menéndez Trejo, Óscar Chapa Azuela" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Gabriela" "apellidos" => "Ruiz Mar" ] 1 => array:2 [ "nombre" => "Óscar E." 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"entidad" => "Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Medicina Nuclear, Hospital Universitario Central de Asturias, Oviedo, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome de Cogan de inicio tardío asociado con una vasculitis de gran vaso" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 939 "Ancho" => 950 "Tamanyo" => 63097 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Axial <span class="elsevierStyleSup">18</span>FDG PET/CT view showing an increased uptake of <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose at the thoracic aorta (arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Cogan's syndrome (CS) is an uncommon autoimmune systemic disease classically described as a triad of nonsyphilitic interstitial keratitis, audiovestibular symptoms resembling Meniere's disease, and an interval between ophthalmologic and auditory manifestations of less than 2 years,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">1</span></a> and it usually affects young Caucasian adults with no gender-specific prevalence.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">2,3</span></a> Nevertheless, cases with atypical and systemic manifestations, including large-vessel vasculitis, and affecting children and older patients have also been reported,<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">4,5</span></a> expanding the clinical spectrum of this rare disease.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Herein, we present the case of a late-onset CS associated with a large-vessel vasculitis.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0015" class="elsevierStylePara elsevierViewall">A Caucasian 82 year-old woman, with a history of gluten intolerance, osteoporotic hip fracture under treatment with risedronate and vitamin D, and bilateral dacryocystitis and cataracts, attended our outpatient clinic remitted from the department of Ophthalmology of our hospital to evaluate joint pain. She presented recurrent episodes of bilateral peripheral ulcerative keratitis (PUK) with corneal thinning for three years. A year after the onset of ocular complaints, she progressively developed a bilateral sensorineural hearing loss with impaired word discrimination and dizziness over months. Likewise, she related recurrent episodes of erythema nodosum on the legs, oral ulcers, low-grade fever and arthralgia of ankles, knees and wrists accompanying the episodes of keratitis. On physical examination, the patient had oral ulcers and arthritis of left wrist and right knee. Slit-lamp examination showed ciliary hyperemia, PUK and corneal thinning (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>), with no other relevant findings. The rest of the physical examination was unremarkable.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Acute phase reactants showed a mild elevation (erythrocyte sedimentation rate 26<span class="elsevierStyleHsp" style=""></span>mm [normal values 0–20<span class="elsevierStyleHsp" style=""></span>mm], C reactive protein 2.1<span class="elsevierStyleHsp" style=""></span>mg/dL [normal values 0–0.5<span class="elsevierStyleHsp" style=""></span>mg/dL]). Additional laboratory tests, including complete blood count, urinalysis, serum electrolytes, creatinine, liver transaminases, angiotensin converting enzyme, HLA-B5, antinuclear antibodies, rheumatoid factor, anti-citrullinated protein antibodies, antiphospholipid antibodies, antineutrophilic cytoplasmic antibodies and anti-heat shock protein 70 antibodies, were negative. Infectious workup for Mycobacterium tuberculosis, Treponema pallidum, Chlamydia, Borrelia burfdorferi, hepatitis B and C viruses, and human immunodeficiency virus was also negative. Plain radiographies of chest, hands, feet, and knees, brain magnetic resonance and transthoracic echocardiography showed no relevant findings. Finally, a <span class="elsevierStyleSup">18</span>F-fluoro-desoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) showed an increased metabolic activity of thoracic aorta and subclavian arteries (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) with a maximum standardized uptake value of 2.72<span class="elsevierStyleHsp" style=""></span>g/mL and 2.80<span class="elsevierStyleHsp" style=""></span>g/mL, respectively. The patient was diagnosed with atypical CS based on the presence of ophthalmologic, audiovestibular and systemic symptoms, and an interval between the onset of ophthalmologic and audiovestibular manifestations of less than 2 years, although it has to be acknowledged that hearing loss could be also attributed to degenerative changes as a result of aging. Due to the high risk for the development of glucocorticoid-induced toxicity in this patient, low-dose prednisone (10<span class="elsevierStyleHsp" style=""></span>mg per day) and subcutaneous methotrexate (15<span class="elsevierStyleHsp" style=""></span>mg per week), as a steroid-sparing therapy, were prescribed with resolution of systemic manifestations and a mild improvement of keratitis. Hearing loss remained unchanged.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of CS is based on the characteristic ophthalmologic and audiovestibular manifestations, after exclusion of infectious and other immune-mediated diseases (e.g., tuberculosis, syphilis, sarcoidosis, Takayasu disease or granulomatosis with polyangiitis),<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> and criteria proposed by Haynes et al.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">7</span></a> can be helpful. This fact, along with the uncommonness of the entity, the absence of appropriate diagnostic tools and non-specific clinical manifestations at disease onset, often delay the diagnosis of CS.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">6</span></a> Therefore, a high clinical suspicion is essential to consider CS in the differential diagnosis of patients with symptoms of ocular and/or audiovestibular inflammation. As shown in the case described above, temporal aggregation of symptoms is a diagnostic clue. Additionally, the clinical spectrum of CS has expanded along the years with the description of new systemic or atypical manifestations, or cases of children or older patients,<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">4,5</span></a> adding complexity to the diagnostic process. The previously described case, affecting an old woman with florid systemic expression, would be an illustrative example of the expanded clinical spectrum of CS. Within the associated systemic manifestations, it is worth remark the presence of vasculitis, which is considered by some authors as the underlying pathological mechanism responsible for this syndrome.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">8</span></a> The role of <span class="elsevierStyleSup">18</span>FDG-PET/CT to evaluate underlying vasculitis in CS patients is still under investigation,<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">9</span></a> even though it unveiled aortitis in our patient, a finding that reaffirmed us in our initial clinical suspicion.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The main reason to establish an early diagnosis of CS is to initiate an early therapy in order to prevent irreversible damage of eye and ear, and systemic complications. Classically, glucocorticoids have been considered as the first-line therapy,<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> and immunosuppressant agents, such as methotrexate, azathioprine, cyclophosphamide, cyclosporine or tacrolimus, are prescribed in steroid-resistant CS or due to unacceptable side effects of glucocorticoids.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">10</span></a> Novel biological therapies, e.g., etanercept, infliximab, rituximab and tocilizumab, have been tried in CS patients, with promising results.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">11–13</span></a> However, no conclusive therapeutic recommendations can be stated, since the rarity of CS precludes any attempt to perform randomized clinical trials.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conclusion</span><p id="par0035" class="elsevierStylePara elsevierViewall">CS is a rare autoimmune disease that combines ophthalmologic and audiovestibular manifestations, frequently developed in a short period of time. A high clinical suspicion has to be taken into account to consider this entity in the differential diagnosis of patients with symptoms suggestive of ocular or audiovestibular inflammation, even though the clinical picture differs from the classically described.</p><p id="par0040" class="elsevierStylePara elsevierViewall">An early diagnosis is essential to initiate an early treatment in order to prevent damage of eye and ear, and systemic complications.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Ethical disclosures</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Protection of human and animal subjects</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors state that no human or animal experiments have been performed for this research.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Confidentiality of data</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors state that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Right to privacy and informed consent</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors have obtained the informed consent of the patients and/or subjects referred to in the article. This document is in the possession of the correspondence author.</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflict of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">None declared.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1258193" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1165528" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1258194" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1165527" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Conclusion" ] 8 => array:3 [ "identificador" => "sec0025" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0030" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] ] ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflict of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-02-27" "fechaAceptado" => "2017-05-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1165528" "palabras" => array:3 [ 0 => "Cogan syndrome" 1 => "Late-onset" 2 => "Vasculitis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1165527" "palabras" => array:3 [ 0 => "Síndrome de Cogan" 1 => "Inicio tardío" 2 => "Vasculitis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cogan's syndrome is a rare autoimmune disease that usually affects young Caucasian adults and is classically defined as the combination of nonsyphilitic interstitial keratitis and audiovestibular symptoms resembling Meniere's disease, both of them developed in an interval of less than two years. Nevertheless, cases with atypical ophthalmologic and audiovestibular features, with systemic manifestations or affecting children and older patients have also been reported, expanding the clinical spectrum of Cogan's syndrome.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Herein, we present the case of a late-onset Cogan's syndrome associated with a large-vessel vasculitis.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El síndrome de Cogan es una enfermedad autoinmune rara, que afecta frecuentemente a pacientes jóvenes de raza caucásica y que se define clásicamente por la combinación de queratitis intersticial no sifilítica y síntomas audiovestibulares similares a una enfermedad de Ménière, que se desarrollan en un intervalo de menos de 2 años. Sin embargo, se han descrito casos con manifestaciones oftalmológicas o audiovestibulares atípicas, con síntomas sistémicos o que afectan a niños o pacientes ancianos, expandiendo de este modo el espectro clínico del síndrome de Cogan.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Presentamos aquí el caso de un síndrome de Cogan de inicio tardío asociado con una vasculitis de gran vaso.</p></span>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 535 "Ancho" => 1500 "Tamanyo" => 68635 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Slit lamp photographs showing a peripheral corneal thinning (A, arrow) with a non-homogeneous distribution of fluorescein stain (B, arrow).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 939 "Ancho" => 950 "Tamanyo" => 63097 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Axial <span class="elsevierStyleSup">18</span>FDG PET/CT view showing an increased uptake of <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose at the thoracic aorta (arrow).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0070" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Syndrome of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D.G. 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