Brief Report
Satisfaction, fulfillment of expectations and adherence to subcutaneous biological drugs in patients with rheumatoid arthritis: ARCO study
Satisfacción, cumplimento de expectativas y adherencia al fármaco biológico subcutáneo en pacientes con artritis reumatoide. Estudio ARCO
Jaime Calvo-Aléna, Paloma Velab, Sagrario Bustabadc, Francisco Maceirasd, Loreto Carmonae, Luis Cea-Calvof,
Corresponding author
a Servicio de Reumatología, Hospital Txagorritxu, Vitoria-Gasteiz, Álava, Spain
b Servicio de Reumatología, Hospital Universitario de Alicante, Alicante, Spain
c Servicio de Reumatología, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Tenerife, Spain
d Servicio de Reumatología, Complexo Universitario de Vigo, Vigo, La Coruña, Spain
e Instituto de Salud Musculoesquelética, Madrid, Spain
f Medical Affairs, Merck Sharp & Dohme de España, Spain
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Estudio ARCO" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis (RA) requires chronic treatment, and adherence to this is important to gain the best therapeutic results.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Nevertheless, adherence to anti-rheumatic medication is sub-optimum,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and the lack of adherence has been associated with the type of medication, the administration regime, the psychological characteristics of patients or beliefs respecting the medication.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">One aspect that has been studied less is the relationship between adherence and the expectations and degree of satisfaction of patients regarding treatment. In the study “Adherence of Rheumatoid arthritis patients to subCutaneous and Oral drugs” (ARCO), of 364 patients with RA, we described how, during the first 14 months of treatment, 14.3% of these patients did not adhere to the prescribed subcutaneous (SC) biological drug,<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> and that the percentage of non-adherent patients was lower in those for whom administration was monthly (6.4%) than it was for patients treated every fortnight (14.4%) or weekly (17.4%). This work has two objectives: 1) to describe the degree of satisfaction and fulfilment of expectations of the patients with their treatment, and 2) to evaluate whether there are differences between administration regimes that may contribute to a higher level of adherence, apart from the regime itself.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">ARCO was a multicentre retrospective study in patients ≥18 years old with RA who had started taking a SC biological therapy 12–18 months before the study. Adherence to the SC biological drug (the primary objective) was evaluated by calculating the Medication Possession Ratio [MPR], considering a MPR ≤ 80% as non-adherence. The information about the design and main findings has already been published.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The patients also filled out a questionnaire developed by the EXPRESAR<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> group on their satisfaction and expectations. This evaluated their degree of satisfaction with the efficacy and tolerability of the treatment on a Likert scale (from “very dissatisfied” to “very satisfied”), and fulfilment of their expectations was assessed from “much better” to “much worse than expected”.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In this work we describe the degree to which patients were satisfied with the treatment and how far it fulfilled their expectations. We study whether there are any differences between administration regimes for the SC biological drug, as well as if the percentage of non-adherence differs according to the degree of satisfaction and the fulfilment of expectations. The patients were classified according to the administration regime of the SC biological drug they were taking, as weekly, fortnightly or monthly. Regarding their level of satisfaction they were divided into “satisfied/very satisfied” or “neutral/dissatisfied”, and respecting the fulfilment of their expectations, they were divided into “much/quite a lot better than expected”, and “more or less as expected” or “quite a lot/much less than expected”. The descriptive data are shown with core tendency measurements, scatter and percentages. The differences between percentages were analysed using the chi-squared test or Fischer’s exact test.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0025" class="elsevierStylePara elsevierViewall">From May 2014 to September 2015 364 patients were recruited (54.9 years old [SD: 12.5]; 77.5% were women, with median duration of RA of 7.8 years [interquartile range: 3.4–15.7]). The interval between administrations of the SC biological drug was weekly (n = 161, 44.2%), fortnightly (n = 140; 38.5%) or monthly (n = 63; 17.3%). As well as the SC biological drug, 77.2% were also being treated with oral anti-rheumatic drugs and 31.6% were taking non-biological SC anti-rheumatic drugs. The 346 patients who filled out the EXPRESAR group questionnaire had similar characteristics.</p><p id="par0030" class="elsevierStylePara elsevierViewall">A very high percentage of the patients were satisfied/very satisfied with the efficacy of the treatment (close to or higher than 80% in all aspects except for foot pain [<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>]). 64.4% considered themselves to be satisfied/very satisfied with tolerability (side effects or discomfort). The percentages of patients who were satisfied/very satisfied with efficacy (question 1) were very similar in the patients with weekly, fortnightly and monthly administration, while the percentages who were satisfied/very satisfied with the side effects or discomfort were 63.9%, 61.2% and 72.9%, respectively (<span class="elsevierStyleItalic">P</span> = .176). The percentage of patients who did not adhere to their SC biological drug regime amounted to 14.7% of those who were satisfied with efficacy and 8.3% of those who were neutral/dissatisfied (<span class="elsevierStyleItalic">P</span> = .339). The percentages of non-adherence were very similar respecting side effects (13.1% vs. 15.4%, respectively; <span class="elsevierStyleItalic">P</span> = .504).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> shows the degree to which expectations were fulfilled. The majority stated that the effect had been greater than expected, without differences here between different administration regimes. The percentages of non-adherence were 15.5% among those who considered the effect to be greater than expected, 12.6% among those considered it to be similar and 10.7% of those who described it as less than expected (<span class="elsevierStyleItalic">P</span> = .667).</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Half of the patients considered that the discomfort caused by administration were quite or much less than expected or were absent, and this percentage was higher in the patients with monthly administration (<span class="elsevierStyleItalic">P</span> = .049, <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>). The percentages who said that it caused no discomfort were 17.8% (weekly administration), 29.3% (fortnightly) and 35.0% (monthly, <span class="elsevierStyleItalic">P</span> = .013). The percentages of non-adherence were 15.6% in those with more discomfort than expected, 18.5% in those with an expected level of discomfort and 11.1% in those with less discomfort than expected or without discomfort (<span class="elsevierStyleItalic">P</span> = .189).</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">In the ARCO study we reported a higher rate of adherence to the SC biological drug with monthly administration.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In the current study we examine possible differences in greater depth from the viewpoint of patient experience which can be associated with adherence, apart from the administration regime itself. Although no significant differences were found in adherence according to degree of satisfaction or the fulfilment of expectations, and with the limitation of sample size, the information supplied by the patients contains relevant data.</p><p id="par0050" class="elsevierStylePara elsevierViewall">There was a very high level of satisfaction with the therapeutic effect, without differences between administration regimes. This finding fits with the high level of efficacy of the biological drugs, which is similar for all of them,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and it also agrees with the findings of a recent survey in our field of 592 patients, who expressed a level of satisfaction with the efficacy of the SC biological drug of ≈80%.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Although there was less satisfaction with the side effects, it still attained a high level (64%), with slight differences that were not significant between administration regimes. This aspect is relevant as these patients generally require chronic treatment.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The expectations patients feel when they start a treatment and whether they are fulfilled are also relevant.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> In our study the percentage who stated that they felt less discomfort than expected or no discomfort at all was highest in the patients with a monthly dose requiring fewer injections. The study cannot determine whether this finding is due to the lower number of injections in itself or to better tolerability of the drug. The percentage of non-adherence stood at 11.1% in the patients with less discomfort than expected or no discomfort. This figure is slightly lower than the 18.5% and 15.6% of non-adherence in patients with “expected or more than expected discomfort”. The doctor–patient relationship was also said to be an important factor in improving adherence: expertise regarding the disease and feeling expectations with the patients about the effect and tolerability of the treatment may lead to benefits in terms of better adhesion and clinical results.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Our study has several limitations. The sample size (n = 346) lacks the power necessary to find significant differences between adherence percentages, although it does suggest that patients whose expectations of tolerability were fulfilled displayed better adherence. The majority of the patients said they were satisfied or very satisfied with the efficacy of the treatment, hindering evaluation of the percentages of adherence according to this variable. At the time the study was undertaken, the only SC biological drugs were anti-TNF alpha; there are now SC biological drugs with other mechanisms of action. Given all of these considerations, exploring patient-related aspects (belief in the medication, expectations and experience) is of interest in taking steps to improve adherence and clinical results,<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> and this work offers interesting information in these fields.</p><p id="par0065" class="elsevierStylePara elsevierViewall">To conclude, the patients with RA who were treated with SC biological drugs expressed a high level of satisfaction and fulfilment of their expectations respecting the efficacy of the treatment. Although the percentage of patients who were satisfied with its tolerability was also high, it was lower than it was for efficacy. The fulfilment of expectations seems to be higher with a monthly injection regime, so that this, together with the fact that fewer SC injections are needed, may contribute to adherence to treatment with the drug.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Financing</span><p id="par0070" class="elsevierStylePara elsevierViewall">The ARCO study was financed by <span class="elsevierStyleGrantSponsor" id="gs0005">Merck Sharp & Dohme, Spain</span>.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0075" class="elsevierStylePara elsevierViewall">Luis Cea-Calvo is a full-time employee of Merck Sharp & Dohme in Spain. The other authors have no conflict of interests to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1331777" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1226884" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1331778" "titulo" => "Resumen" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Pacientes y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1226883" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Methods" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Financing" ] 9 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interests" ] 10 => array:2 [ "identificador" => "xack460007" "titulo" => "Acknowledgements" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-10-05" "fechaAceptado" => "2018-02-22" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1226884" "palabras" => array:4 [ 0 => "Rheumatoid arthritis" 1 => "Biological drugs" 2 => "Adherence" 3 => "Expectations" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1226883" "palabras" => array:4 [ 0 => "Artritis reumatoide" 1 => "Fármacos biológicos" 2 => "Adherencia" 3 => "Expectativas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In the ARCO study, adherence to subcutaneous biological agents by patients with rheumatoid arthritis improved with monthly administration. We assess whether adherence can be related to fulfilment of expectations and satisfaction with treatment.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adherence was assessed by calculating the Medication Possession Ratio, and satisfaction and fulfilment of expectations using the EXPRESAR group questionnaire.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 346 patients, those who were satisfied/very satisfied with efficacy and tolerability were ≥80% and 64.4%, with no differences between weekly, biweekly or monthly administration regimens. Regarding the fulfilment of expectations, 59.9% considered the effect of the treatment greater than expected and 52.6% reported lower/much lower than expected discomfort; the latter percentage was higher in patients with monthly administration (<span class="elsevierStyleItalic">P</span> = .049). The percentages for nonadherence were 15.6% (discomfort greater than expected), 18.5% (expected discomfort) and 11.1% (lower than expected or no discomfort) (<span class="elsevierStyleItalic">P</span> = .189).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Satisfaction and fulfilment of expectations were high. Fulfilment of expectations of tolerability was better with monthly administration, which could contribute to better adherence.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] "es" => array:3 [ "titulo" => "Resumen" "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">En el estudio ARCO, la adherencia al biológico subcutáneo en pacientes con artritis reumatoide fue mejor con administración mensual. Evaluamos si satisfacción y cumplimiento de expectativas pueden relacionarse con la adherencia al tratamiento.</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Pacientes y métodos</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La adherencia se evaluó calculando el Índice de Posesión de Medicación, y satisfacción y cumplimiento de expectativas mediante el cuestionario EXPRESAR.</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">En 346 pacientes, los porcentajes satisfechos/muy satisfechos con eficacia y tolerabilidad fueron ≥80% y 64.4%, sin diferencias entre pautas semanal, cada dos semanas o mensual. Sobre el cumplimiento de expectativas, el 59.9% consideró el efecto del tratamiento mayor al esperado, y el 52.6% las molestias bastante/mucho menores a las esperadas, porcentaje mayor en pacientes con administración mensual p = 0,049. Los porcentajes de no-adherencia fueron 15.6% (molestias mayores a las esperadas), 18.5% (molestias esperadas) y 11.1% menores/sin molestias p = 0,189.</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">La satisfacción y el cumplimiento de expectativas fueron altos. El cumplimiento de expectativas de tolerabilidad fue mejor con administración mensual, lo que podría contribuir a una mejor adherencia.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0025" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0030" "titulo" => "Pacientes y métodos" ] 2 => array:2 [ "identificador" => "abst0035" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0040" "titulo" => "Conclusiones" ] ] ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Calvo-Alén J, Vela P, Bustabad S, Maceiras F, Carmona L, Cea-Calvo L. Satisfacción, cumplimento de expectativas y adherencia al fármaco biológico subcutáneo en pacientes con artritis reumatoide. Estudio ARCO. Reumatol Clin. 2020;16:116–119.</p>" ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No. (%) satisfied or very satisfied \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. Do you feel satisfied with its efficacy? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">301 (86.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2. Do you feel satisfied with how it is controlling symptoms? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">301 (86.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3. Do you feel satisfied with the treatment regarding pain in your joints in general? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">291 (83.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4. Do you feel satisfied with the treatment regarding pain in your hands? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">274 (78.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5. Do you feel satisfied with the treatment regarding pain in your feet? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">239 (68.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6. Do you feel satisfied with the treatment regarding the reduction of joint inflammation? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">297 (85.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7. Do you feel satisfied with the side effects or discomfort (such as dizziness or stomach pain)? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">222 (64.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2282325.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Percentages of patients who answered that they were satisfied or very satisfied in reply to the EXPRESAR group questionnaire.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">SC: subcutaneous.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " rowspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">All (n = 346) %</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="4" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Administration regime</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Weekly (n = 152) % \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Fortnightly (n = 133) % \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Monthly (n = 60) % \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span> value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Do you consider that the effect of treatment for your rheumatoid arthritis has been:</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A lot/quite a lot more than expected \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.573</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>More or less as expected \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Quite/a lot less than expected \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">The presence of discomfort caused by the administration of the treatment has been:</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>A lot/quite a lot more than expected \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">.048</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>More or less as expected \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Quite a lot/a lot less than expected, or it has not caused discomfort \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2282326.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Fulfillment of expectations in terms of efficacy and tolerability according to the administration regime of the SC biological drug.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medication adherence of patients with selected rheumatic conditions: a systematic review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.R. 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Vela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2017" "volumen" => "35" "paginaInicial" => "423" "paginaFinal" => "430" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28032846" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Desarrollo y validación de un cuestionario de satisfacción con el tratamiento en pacientes con artritis reumatoide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Carbonell" 1 => "X. Badia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1699-258X(06)73035-2" "Revista" => array:6 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2006" "volumen" => "2" "paginaInicial" => "137" "paginaFinal" => "145" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794317" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Smolen" 1 => "R. Landewé" 2 => "J. Bijlsma" 3 => "G. Burmester" 4 => "K. Chatzidionysiou" 5 => "M. Dougados" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/annrheumdis-2016-210715" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2017" "volumen" => "76" "paginaInicial" => "960" "paginaFinal" => "977" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28264816" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Perceptions of patients with rheumatic diseases on the impact on daily life and satisfaction with their medications: RHEU-LIFE, a survey to patients treated with subcutaneous biological products" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "C.M. González" 1 => "L. Carmona" 2 => "J. de Toro" 3 => "E. Batlle-Gualda" 4 => "A.I. Torralba" 5 => "M.J. Arteaga" 6 => "L. Cea-Calvo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2147/PPA.S137052" "Revista" => array:7 [ "tituloSerie" => "Patient Prefer Adherence" "fecha" => "2017" "volumen" => "11" "paginaInicial" => "1243" "paginaFinal" => "1252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28790806" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0967586813006450" "estado" => "S300" "issn" => "09675868" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient and physician expectations of add-on treatment with golimumab for rheumatoid arthritis: relationships between expectations and clinical and quality of life outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Dasgupta" 1 => "B. Combe" 2 => "I. Louw" 3 => "J. Wollenhaupt" 4 => "C.A. Zerbini" 5 => "A. Beaulieu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res (Hoboken)" "fecha" => "2014" "volumen" => "66" "paginaInicial" => "1799" "paginaFinal" => "1807" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient-centred care in established rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.J. Voshaar" 1 => "I. Nota" 2 => "M.A. van de Laar" 3 => "B.J. van den Bemt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.berh.2015.09.007" "Revista" => array:6 [ "tituloSerie" => "Best Pract Res Clin Rheumatol" "fecha" => "2015" "volumen" => "29" "paginaInicial" => "643" "paginaFinal" => "663" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26697772" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systematic review of evidence on the links between patient experience and clinical safety and effectiveness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Doyle" 1 => "L. Lennox" 2 => "D. Bell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmjopen-2013-003587" "Revista" => array:4 [ "tituloSerie" => "BMJ Open" "fecha" => "2013" "volumen" => "3" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24176795" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack460007" "titulo" => "Acknowledgements" "texto" => "<p id="par0080" class="elsevierStylePara elsevierViewall">We would like to thank all of the researchers and patients who took part in filling out the questionnaires that were necessary to obtain this information.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/00000016000002P1/v1_202005010847/S2173574320300125/v1_202005010847/en/main.assets" "Apartado" => array:4 [ "identificador" => "43294" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/00000016000002P1/v1_202005010847/S2173574320300125/v1_202005010847/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300125?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 14 | 21 |
| 2024 October | 32 | 25 | 57 |
| 2024 September | 28 | 20 | 48 |
| 2024 August | 48 | 37 | 85 |
| 2024 July | 39 | 21 | 60 |
| 2024 June | 36 | 36 | 72 |
| 2024 May | 50 | 27 | 77 |
| 2024 April | 39 | 24 | 63 |
| 2024 March | 23 | 26 | 49 |
| 2024 February | 24 | 35 | 59 |
| 2024 January | 51 | 31 | 82 |
| 2023 December | 18 | 31 | 49 |
| 2023 November | 40 | 29 | 69 |
| 2023 October | 40 | 25 | 65 |
| 2023 September | 117 | 39 | 156 |
| 2023 August | 31 | 15 | 46 |
| 2023 July | 20 | 18 | 38 |
| 2023 June | 29 | 19 | 48 |
| 2023 May | 30 | 20 | 50 |
| 2023 April | 27 | 7 | 34 |
| 2023 March | 55 | 22 | 77 |
| 2023 February | 35 | 27 | 62 |
| 2023 January | 22 | 12 | 34 |
| 2022 December | 69 | 23 | 92 |
| 2022 November | 33 | 18 | 51 |
| 2022 October | 72 | 27 | 99 |
| 2022 September | 23 | 17 | 40 |
| 2022 August | 24 | 35 | 59 |
| 2022 July | 29 | 39 | 68 |
| 2022 June | 30 | 24 | 54 |
| 2022 May | 29 | 40 | 69 |
| 2022 April | 33 | 22 | 55 |
| 2022 March | 25 | 35 | 60 |
| 2022 February | 40 | 26 | 66 |
| 2022 January | 59 | 31 | 90 |
| 2021 December | 35 | 45 | 80 |
| 2021 November | 41 | 55 | 96 |
| 2021 October | 52 | 51 | 103 |
| 2021 September | 37 | 43 | 80 |
| 2021 August | 34 | 31 | 65 |
| 2021 July | 24 | 25 | 49 |
| 2021 June | 24 | 24 | 48 |
| 2021 May | 32 | 32 | 64 |
| 2021 April | 59 | 69 | 128 |
| 2021 March | 32 | 23 | 55 |
| 2021 February | 17 | 10 | 27 |
| 2021 January | 24 | 25 | 49 |
| 2020 December | 22 | 14 | 36 |
| 2020 November | 16 | 14 | 30 |
| 2020 October | 13 | 15 | 28 |
| 2020 September | 29 | 16 | 45 |
| 2020 May | 1 | 0 | 1 |
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