array:24 [
  "pii" => "S2173574320300186"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2020.02.003"
  "estado" => "S300"
  "fechaPublicacion" => "2021-01-01"
  "aid" => "1356"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2019"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Reumatol Clin. 2021;17:46-8"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X19301172"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2019.07.006"
      "estado" => "S300"
      "fechaPublicacion" => "2021-01-01"
      "aid" => "1356"
      "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Reumatol Clin. 2021;17:46-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4
        "formatos" => array:2 [
          "HTML" => 2
          "PDF" => 2
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Mutaci&#243;n p&#46;RQ92 asociada a amiloidosis"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "46"
            "paginaFinal" => "48"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "p&#46;RQ92 mutation associated with amyloidosis"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 582
                "Ancho" => 1305
                "Tamanyo" => 241800
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A&#41; Dep&#243;sitos en l&#225;mina propia de material amorfo eosin&#243;filo y en paredes capilares &#40;HE&#44; 20&#215;&#41;&#46; B&#41; Tinci&#243;n de rojo Congo&#44; que muestra dep&#243;sitos intensamente positivos de material amiloide&#44; que mostraron birrefringencia verde manzana con luz polarizad &#40;Rojo Congo&#44; 20&#215;&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Francisco Jos&#233; Nicol&#225;s-S&#225;nchez, Juan Ignacio Ar&#243;stegui-Gorospe, Judit Pallar&#233;s-Quixal, Francesc Josep Nicol&#225;s-Sarrat, Rosa Mar&#237;a Sarrat-Nuevo, Ramon Mar&#237;a Nogue Bou, Pablo Jos&#233; Melgarejo-Moreno"
            "autores" => array:7 [
              0 => array:2 [
                "nombre" => "Francisco Jos&#233;"
                "apellidos" => "Nicol&#225;s-S&#225;nchez"
              ]
              1 => array:2 [
                "nombre" => "Juan Ignacio"
                "apellidos" => "Ar&#243;stegui-Gorospe"
              ]
              2 => array:2 [
                "nombre" => "Judit"
                "apellidos" => "Pallar&#233;s-Quixal"
              ]
              3 => array:2 [
                "nombre" => "Francesc Josep"
                "apellidos" => "Nicol&#225;s-Sarrat"
              ]
              4 => array:2 [
                "nombre" => "Rosa Mar&#237;a"
                "apellidos" => "Sarrat-Nuevo"
              ]
              5 => array:2 [
                "nombre" => "Ramon Mar&#237;a Nogue"
                "apellidos" => "Bou"
              ]
              6 => array:2 [
                "nombre" => "Pablo Jos&#233;"
                "apellidos" => "Melgarejo-Moreno"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574320300186"
          "doi" => "10.1016/j.reumae.2020.02.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300186?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X19301172?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001700000001/v1_202101090658/S1699258X19301172/v1_202101090658/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574320301635"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2019.04.002"
    "estado" => "S300"
    "fechaPublicacion" => "2021-01-01"
    "aid" => "1339"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2021;17:49-51"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Malignancy in patients with sarcoidosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "49"
          "paginaFinal" => "51"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Malignidad en pacientes con sarcoidosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Senol Kobak, Fidan Yildiz, Huseyin Semiz, Mehmet Orman"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Senol"
              "apellidos" => "Kobak"
            ]
            1 => array:2 [
              "nombre" => "Fidan"
              "apellidos" => "Yildiz"
            ]
            2 => array:2 [
              "nombre" => "Huseyin"
              "apellidos" => "Semiz"
            ]
            3 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Orman"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301635?idApp=UINPBA00004M"
    "url" => "/21735743/0000001700000001/v1_202101140856/S2173574320301635/v1_202101140856/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574320301568"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2019.03.006"
    "estado" => "S300"
    "fechaPublicacion" => "2021-01-01"
    "aid" => "1338"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "pgl"
    "cita" => "Reumatol Clin. 2021;17:37-45"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Consensus statement</span>"
      "titulo" => "Recommendations of the Mexican College of Rheumatology for the management of spondyloarthritis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "37"
          "paginaFinal" => "45"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recomendaciones del Colegio Mexicano de Reumatolog&#237;a para el manejo de las espondiloartritis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2063
              "Ancho" => 2167
              "Tamanyo" => 183175
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flow chart&#46; Systematic review to update the recommendations of the Mexican College of Rheumatology for the management of spondyloarthritis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Greta Reyes-Cordero, Favio Enr&#237;quez-Sosa, Citlallyc Gomez-Ruiz, Ver&#243;nica Gonzalez-Diaz, Jos&#233; Dionisio Castillo-Ortiz, Sergio Duran-Barrag&#225;n, J&#46; Santos Duran-Ortiz, Rolando Espinosa-Morales, Jorge I&#46; Gamez-Nava, Laura Gonzalez-Lopez, Bernardo Julian-Mart&#237;nez, Ang&#233;lica Mendoza-Fuentes, Cesar Ramos-Remus, Cesar Pacheco-Tena, Ruben Burgos-Vargas"
          "autores" => array:15 [
            0 => array:2 [
              "nombre" => "Greta"
              "apellidos" => "Reyes-Cordero"
            ]
            1 => array:2 [
              "nombre" => "Favio"
              "apellidos" => "Enr&#237;quez-Sosa"
            ]
            2 => array:2 [
              "nombre" => "Citlallyc"
              "apellidos" => "Gomez-Ruiz"
            ]
            3 => array:2 [
              "nombre" => "Ver&#243;nica"
              "apellidos" => "Gonzalez-Diaz"
            ]
            4 => array:2 [
              "nombre" => "Jos&#233; Dionisio"
              "apellidos" => "Castillo-Ortiz"
            ]
            5 => array:2 [
              "nombre" => "Sergio"
              "apellidos" => "Duran-Barrag&#225;n"
            ]
            6 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Santos Duran-Ortiz"
            ]
            7 => array:2 [
              "nombre" => "Rolando"
              "apellidos" => "Espinosa-Morales"
            ]
            8 => array:2 [
              "nombre" => "Jorge I&#46;"
              "apellidos" => "Gamez-Nava"
            ]
            9 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Gonzalez-Lopez"
            ]
            10 => array:2 [
              "nombre" => "Bernardo"
              "apellidos" => "Julian-Mart&#237;nez"
            ]
            11 => array:2 [
              "nombre" => "Ang&#233;lica"
              "apellidos" => "Mendoza-Fuentes"
            ]
            12 => array:2 [
              "nombre" => "Cesar"
              "apellidos" => "Ramos-Remus"
            ]
            13 => array:2 [
              "nombre" => "Cesar"
              "apellidos" => "Pacheco-Tena"
            ]
            14 => array:2 [
              "nombre" => "Ruben"
              "apellidos" => "Burgos-Vargas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X19300804"
        "doi" => "10.1016/j.reuma.2019.03.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X19300804?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301568?idApp=UINPBA00004M"
    "url" => "/21735743/0000001700000001/v1_202101140856/S2173574320301568/v1_202101140856/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
    "titulo" => "p&#46;RQ92 mutation associated with amyloidosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "46"
        "paginaFinal" => "48"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Francisco Jos&#233; Nicol&#225;s-S&#225;nchez, Juan Ignacio Ar&#243;stegui-Gorospe, Judit Pallar&#233;s-Quixal, Francesc Josep Nicol&#225;s-Sarrat, Rosa Mar&#237;a Sarrat-Nuevo, Ramon Mar&#237;a Nogue Bou, Pablo Jos&#233; Melgarejo-Moreno"
        "autores" => array:7 [
          0 => array:4 [
            "nombre" => "Francisco Jos&#233;"
            "apellidos" => "Nicol&#225;s-S&#225;nchez"
            "email" => array:1 [
              0 => "fnicolas@comll.cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Juan Ignacio"
            "apellidos" => "Ar&#243;stegui-Gorospe"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Judit"
            "apellidos" => "Pallar&#233;s-Quixal"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Francesc Josep"
            "apellidos" => "Nicol&#225;s-Sarrat"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Rosa Mar&#237;a"
            "apellidos" => "Sarrat-Nuevo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Ramon Mar&#237;a Nogue"
            "apellidos" => "Bou"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Pablo Jos&#233;"
            "apellidos" => "Melgarejo-Moreno"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital de Santa Mar&#237;a&#44; Lleida&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servei d&#8217;Immunologia&#44; Institut d&#8217;Investigacions Biom&#232;diques Agust&#237; Pi i Sunyer &#40;IDIBAPS&#41;&#44; Hospital Cl&#237;nic&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servei de Anatomia Patol&#242;gica&#44; Hospital Universitari Arnau de Vilanova&#44; Lleida&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Mutaci&#243;n p&#46;RQ92 asociada a amiloidosis"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1600
            "Ancho" => 2153
            "Tamanyo" => 236628
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">p&#46;R92Q mutation in heterozygosis&#46; Exon 4&#44; <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">TNF receptor-associated periodic syndrome &#40;TRAPS&#41; is an autosomal dominant disease characterised by recurrent episodes of fever&#44; migratory myalgias&#44; skin rash&#44; conjunctivitis&#44; orbital oedema and abdominal or chest pain due to muscle inflammation&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and even chronic refractory arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Leukocytosis&#44; neutrophilia&#44; thrombocytosis and elevated acute phase reactants can occur&#46; We present the case of an 83-year-old male with amyloidosis type AA and the p&#46;R92Q variant in the <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Clinical case</span><p id="par0010" class="elsevierStylePara elsevierViewall">An 83-year-old male with a history of gastrointestinal bleeding and iron-deficiency anaemia due to gastritis and duodenal ulcer&#44; benign prostatic hypertrophy&#44; high blood pressure treated with tamsulosin &#40;&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; dutasteride &#40;&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41; and omeprazole &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">He consulted with tiredness and instability&#44; with haemoglobin of 7&#46;3<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#46; Gastroscopy revealed a duodenal ulcer&#46; Gastric biopsy showed mild chronic gastritis&#46; Duodenal biopsy showed focal ulceration of mucosa with preserved villi and lamina propria expanded by deposit of amorphous eosinophilic material &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#59; this deposit was also observed in the capillary walls and the submucosa&#44; it was accompanied by minimal non-specific lymphocytic inflammatory infiltrate&#59; Congo red stain was intensely positive and showed apple-green birefringence in polarised light &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Immunohistochemical staining was also performed for AA protein&#44; which was intensely positive&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Enteroscopy demonstrated from the distal bulb&#44; and continuously the length of the path explored&#44; intestinal mucosa with superficial ulcerations and of infiltrative appearance&#44; with areas of spontaneous bleeding on passing the endoscope&#46; The most significant findings were located in the distal bulb and the second and third duodenal portions&#44; with totally denuded and ulcerated mucosal areas&#46; Colonoscopy was normal&#46; Rectal biopsy showed no amyloid material&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Thoracic CT was normal&#44; while abdominal CT revealed discrete thickening with dilation of the duodenal wall and first jejunal loops &#40;up to 3&#46;2<span class="elsevierStyleHsp" style=""></span>cm&#41; with involvement of the adjacent fat&#44; of probable inflammatory origin&#59; ureteral and bladder lithiasis&#46; Abdominal CT-angiography showed no valuable findings&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Aetiological study of secondary amyloidosis was performed&#46; Liver and kidney function&#44; proteinogram&#44; and serum amyloid A protein were normal&#46; Antinuclear antibodies&#44; rheumatoid factor&#44; citrullinated peptide&#44; neutrophil antibody and serum beta-2-microglobulin were negative&#46; C-reactive protein &#40;CRP&#41; was normal on admission&#44; but intermittent elevations of around 50<span class="elsevierStyleHsp" style=""></span>mg&#47;l <span class="elsevierStyleItalic">&#40;normal &#46;0-6-0</span>&#41; were evidenced in some of the routine checks&#59; there were no associated symptoms&#46; Abdominal fat biopsy showed no amyloid material&#46; The 24-h urine protein test was negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Studies of genes for familial Mediterranean fever &#40;FMF&#41; and familial amyloid polyneuropathy &#40;FAP&#41; were negative&#44; while analysis of the <span class="elsevierStyleItalic">TNFRSF1A</span> gene revealed the heterozygous variant p&#46;R92Q &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The electrocardiogram was normal&#44; and the echocardiogram showed a left ventricle that was neither dilated nor hypertrophied&#44; preserved ejection fraction with impaired relaxation&#46; Electromyography showed slight signs of chronic radicular involvement bilateral L4&#44; L5 and S1&#44; there were no conclusive signs of polyneuropathy&#46; Lumbar-sacral magnetic resonance showed osteodegenerative changes in the interapophyseal joints L4-L5-S1&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">TRAPS syndrome is a monogenic auto-inflammatory disease that can affect different ethnic groups&#46; The mutations that cause this syndrome are located in the <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#44; and about 114 variants have been described&#46; Among them&#44; the p&#46;R92Q variant stands out in terms of frequency&#44; currently classified as a variant of uncertain significance&#44; and also presenting a low incidence of secondary amyloidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In TRAPS syndrome&#44; symptoms usually appear during the first decade of life&#46; In the case of adult onset&#44; it is common to identify low-penetrance variants&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Prolonged febrile episodes &#40;between 1 and 4 weeks&#41; are most frequent manifestation of the syndrome&#44; which recur at irregular intervals of weeks or months&#44; accompanied by myalgias and migratory skin exanthema&#46; There may be triggers such as infections&#44; trauma&#44; stress&#44; etc&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">It is the prolonged elevation of acute phase reactants&#44; and especially serum amyloid protein&#44; that increases the risk of type AA amyloidosis&#46; The patient we describe presented elevated CRP in some of the routine tests without any symptoms&#46; Concentric ventricular hypertrophy was not observed&#44; nor was amyloid deposition evidenced in the abdominal fat or rectal biopsies&#46; Duodenal biopsy ruled out Crohn&#39;s disease &#40;CD&#41;&#44; since in CD there may be ulceration and fissures&#44; but with predominance of severe&#47;moderate lymphoplasmocellular inflammatory infiltration&#44; granulomas and acute glandular inflammation&#44; which were not present in this case&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Thoracic and abdominal CT&#44; gastroscopy&#44; enteroscopy and colonoscopy did not reveal neoplasms&#44; and the proteinogram did not show monoclonal bands&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Amyloidosis can occur in TRAPS&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> but to date its association with the p&#46;RQ92 variant&#44; has not been demonstrated&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In conclusion&#44; amyloidosis may be present in carriers of the p&#46;RQ92 variant&#44; and therefore its diagnosis is important to avoid possible complications&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflict of interests</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:3 [
          "identificador" => "xres1448971"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1321431"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1448972"
          "titulo" => "Resumen"
          "secciones" => array:2 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
            1 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1321430"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Clinical case"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conflict of interests"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-02-18"
    "fechaAceptado" => "2019-07-03"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1321431"
          "palabras" => array:3 [
            0 => "p&#46;RQ92"
            1 => "Amyloidosis"
            2 => "Tumour necrosis factor receptor-associated periodic syndrome"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1321430"
          "palabras" => array:3 [
            0 => "p&#46;RQ92"
            1 => "Amiloidosis"
            2 => "S&#237;ndrome peri&#243;dico asociado al factor de necrosis tumoral"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Secondary amyloidosis can be found in some monogenic autoinflammatory diseases&#46; In this study we present an 83-year-old man with no relevant medical history who presented with iron deficiency anaemia&#46; In the study&#44; a gastroscopy was performed with duodenum biopsy showing secondary AA-type amyloidosis&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Genetic analyses of monogenic autoinflammatory diseases revealed the heterozygous p&#46;R92Q variant in the <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#44; with negative results in the complementary tests for other causes of amyloidosis&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In TRAPS&#44; secondary amyloidosis has usually been associated with mutations affecting cysteine residues&#44; but until now no association has been demonstrated with the p&#46;RQ92 variant&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Secondary amyloidosis may be present in carriers of the p&#46;RQ92 variant&#44; therefore it is important to diagnose it to prevent possible complications&#46;</p></span>"
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La amiloidosis secundaria puede encontrarse en algunas enfermedades autoinflamatorias monog&#233;nicas&#46; Presentamos el caso de un var&#243;n de 83 a&#241;os sin antecedentes patol&#243;gicos de inter&#233;s&#46; Tras detectarse una anaemia ferrop&#233;nica&#44; se realiz&#243; una gastroscopia y la biopsia duodenal evidenci&#243; amiloidosis secundaria de tipo AA&#46; El estudio de enfermedades autoinflamatorias revel&#243; la variante heterocigota p&#46;R92Q en el gen <span class="elsevierStyleItalic">TNFRSF1A</span>&#44; siendo negativas las pruebas complementarias para otras causas de amiloidosis&#46; En el s&#237;ndrome TRAPS la amiloidosis secundaria puede asociarse a mutaciones que afectan a residuos ciste&#237;na&#44; no habi&#233;ndose evidenciado su asociaci&#243;n con la variante p&#46;R92Q&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La amiloidosis secundaria puede estar presente en individuos portadores de la variante p&#46;RQ92&#44; por lo que es importante su diagn&#243;stico para intentar prevenir posibles complicaciones&#46;</p></span>"
        "secciones" => array:2 [
          0 => array:1 [
            "identificador" => "abst0010"
          ]
          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Nicol&#225;s-S&#225;nchez FJ&#44; Ar&#243;stegui-Gorospe JI&#44; Pallar&#233;s-Quixal J&#44; Nicol&#225;s-Sarrat FJ&#44; Sarrat-Nuevo RM&#44; Nogue Bou RM&#44; et al&#46; Mutaci&#243;n p&#46;RQ92 asociada a amiloidosis&#46; Reumatol Clin&#46; 2021&#59;17&#58;46&#8211;48&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 582
            "Ancho" => 1305
            "Tamanyo" => 241679
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Deposits in lamina propria of eosinophilic amorphous material and in the capillary walls &#40;HE&#44; 20&#215;&#41;&#46; &#40;B&#41; Congo red staining showing intensely positive deposits of amyloid material&#44; which showed apple-green birefringence with polarised light &#40;Congo red&#44; 20&#215;&#41;&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1600
            "Ancho" => 2153
            "Tamanyo" => 236628
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">p&#46;R92Q mutation in heterozygosis&#46; Exon 4&#44; <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The autoinflammatory disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Federici"
                            1 => "R&#46; Caorsi"
                            2 => "M&#46; Gattorno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4414/smw.2012.13602"
                      "Revista" => array:5 [
                        "tituloSerie" => "Swiss Med Wkly"
                        "fecha" => "2012"
                        "volumen" => "142"
                        "paginaInicial" => "w13602"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22714396"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The phenotype of TNF receptor-associated autoinflammatory syndrome &#40;TRAPS&#41; at presentation&#58; a series of 158 cases from the Eurofever&#47;EUROTRAPS international registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;J&#46; Lachmann"
                            1 => "R&#46; Papa"
                            2 => "K&#46; Gerhold"
                            3 => "L&#46; Obici"
                            4 => "I&#46; Touitou"
                            5 => "L&#46; Cantarini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2013-204184"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2014"
                        "volumen" => "73"
                        "paginaInicial" => "2160"
                        "paginaFinal" => "2167"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23965844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adult-onset tumour necrosis factor receptor-associated periodic syndrome presenting with refractory chronic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Lopalco"
                            1 => "D&#46; Rigante"
                            2 => "A&#46; Vitale"
                            3 => "M&#46; Galeazzi"
                            4 => "F&#46; Iannone"
                            5 => "L&#46; Cantarini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2015"
                        "volumen" => "33"
                        "numero" => "Suppl&#46; 94"
                        "paginaInicial" => "S171"
                        "paginaFinal" => "S172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25936627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disease phenotype and outcome depending on the age at disease onset in patients carrying the R92Q low-penetrance variant in <span class="elsevierStyleItalic">TNFRSF1A</span> gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Ruiz-Ortiz"
                            1 => "E&#46; Iglesias"
                            2 => "A&#46; Soriano"
                            3 => "S&#46; Buj&#225;n-Rivas"
                            4 => "M&#46; Espa&#241;ol-Rego"
                            5 => "R&#46; Castellanos-Moreira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fimmu.2017.00299"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Immunol"
                        "fecha" => "2017"
                        "volumen" => "8"
                        "paginaInicial" => "299"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28396659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical significance of P46L and R92Q substitutions in the tumour necrosis factor superfamily 1A gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Ravet"
                            1 => "S&#46; Rouaghe"
                            2 => "C&#46; Dod&#233;"
                            3 => "J&#46; Bienvenu"
                            4 => "J&#46; Stirnemann"
                            5 => "P&#46; L&#233;vy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2005.048611"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2006"
                        "volumen" => "65"
                        "paginaInicial" => "1158"
                        "paginaFinal" => "1162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16569687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Aganna"
                            1 => "L&#46; Hammond"
                            2 => "P&#46;N&#46; Hawkins"
                            3 => "A&#46; Aldea"
                            4 => "S&#46;A&#46; McKee"
                            5 => "H&#46;K&#46; van Amstel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11215"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "2632"
                        "paginaFinal" => "2644"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13130484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autosomal-dominant periodic fever with AA amyloidosis&#58; novel mutation in tumor necrosis factor receptor 1 gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Jadoul"
                            1 => "C&#46; Dode"
                            2 => "J&#46;P&#46; Cosyns"
                            3 => "D&#46; Abramowicz"
                            4 => "B&#46; Georges"
                            5 => "M&#46; Delphech"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1755.2001.0590051677.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2001"
                        "volumen" => "59"
                        "paginaInicial" => "1677"
                        "paginaFinal" => "1682"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11318938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of renal amyloidosis with etanercept in tumour necrosis factor receptor-associated periodic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Drewe"
                            1 => "M&#46;L&#46; Huggins"
                            2 => "A&#46;G&#46; Morgan"
                            3 => "M&#46;J&#46; Cassidy"
                            4 => "R&#46;J&#46; Powell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "1405"
                        "paginaFinal" => "1408"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001700000001/v1_202101140856/S2173574320300186/v1_202101140856/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "43296"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case report"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001700000001/v1_202101140856/S2173574320300186/v1_202101140856/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300186?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Case Report
p.RQ92 mutation associated with amyloidosis
Mutación p.RQ92 asociada a amiloidosis
Francisco José Nicolás-Sáncheza,
Corresponding author
fnicolas@comll.cat

Corresponding author.
, Juan Ignacio Aróstegui-Gorospeb, Judit Pallarés-Quixalc, Francesc Josep Nicolás-Sarrata, Rosa María Sarrat-Nuevoa, Ramon María Nogue Boua, Pablo José Melgarejo-Morenoa
a Servicio de Medicina Interna, Hospital de Santa María, Lleida, Spain
b Servei d’Immunologia, Institut d’Investigacions Biomèdiques Agustí Pi i Sunyer (IDIBAPS), Hospital Clínic, Barcelona, Spain
c Servei de Anatomia Patològica, Hospital Universitari Arnau de Vilanova, Lleida, Spain
Read
3050
Times
was read the article
1264
Total PDF
1786
Total HTML
Share statistics
 array:24 [
  "pii" => "S2173574320300186"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2020.02.003"
  "estado" => "S300"
  "fechaPublicacion" => "2021-01-01"
  "aid" => "1356"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2019"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "crp"
  "cita" => "Reumatol Clin. 2021;17:46-8"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S1699258X19301172"
      "issn" => "1699258X"
      "doi" => "10.1016/j.reuma.2019.07.006"
      "estado" => "S300"
      "fechaPublicacion" => "2021-01-01"
      "aid" => "1356"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
      "documento" => "simple-article"
      "crossmark" => 1
      "subdocumento" => "crp"
      "cita" => "Reumatol Clin. 2021;17:46-8"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 4
        "formatos" => array:2 [
          "HTML" => 2
          "PDF" => 2
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Caso cl&#237;nico</span>"
        "titulo" => "Mutaci&#243;n p&#46;RQ92 asociada a amiloidosis"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "46"
            "paginaFinal" => "48"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "p&#46;RQ92 mutation associated with amyloidosis"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 582
                "Ancho" => 1305
                "Tamanyo" => 241800
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A&#41; Dep&#243;sitos en l&#225;mina propia de material amorfo eosin&#243;filo y en paredes capilares &#40;HE&#44; 20&#215;&#41;&#46; B&#41; Tinci&#243;n de rojo Congo&#44; que muestra dep&#243;sitos intensamente positivos de material amiloide&#44; que mostraron birrefringencia verde manzana con luz polarizad &#40;Rojo Congo&#44; 20&#215;&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "Francisco Jos&#233; Nicol&#225;s-S&#225;nchez, Juan Ignacio Ar&#243;stegui-Gorospe, Judit Pallar&#233;s-Quixal, Francesc Josep Nicol&#225;s-Sarrat, Rosa Mar&#237;a Sarrat-Nuevo, Ramon Mar&#237;a Nogue Bou, Pablo Jos&#233; Melgarejo-Moreno"
            "autores" => array:7 [
              0 => array:2 [
                "nombre" => "Francisco Jos&#233;"
                "apellidos" => "Nicol&#225;s-S&#225;nchez"
              ]
              1 => array:2 [
                "nombre" => "Juan Ignacio"
                "apellidos" => "Ar&#243;stegui-Gorospe"
              ]
              2 => array:2 [
                "nombre" => "Judit"
                "apellidos" => "Pallar&#233;s-Quixal"
              ]
              3 => array:2 [
                "nombre" => "Francesc Josep"
                "apellidos" => "Nicol&#225;s-Sarrat"
              ]
              4 => array:2 [
                "nombre" => "Rosa Mar&#237;a"
                "apellidos" => "Sarrat-Nuevo"
              ]
              5 => array:2 [
                "nombre" => "Ramon Mar&#237;a Nogue"
                "apellidos" => "Bou"
              ]
              6 => array:2 [
                "nombre" => "Pablo Jos&#233;"
                "apellidos" => "Melgarejo-Moreno"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173574320300186"
          "doi" => "10.1016/j.reumae.2020.02.003"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300186?idApp=UINPBA00004M"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X19301172?idApp=UINPBA00004M"
      "url" => "/1699258X/0000001700000001/v1_202101090658/S1699258X19301172/v1_202101090658/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574320301635"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2019.04.002"
    "estado" => "S300"
    "fechaPublicacion" => "2021-01-01"
    "aid" => "1339"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2021;17:49-51"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case report</span>"
      "titulo" => "Malignancy in patients with sarcoidosis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "49"
          "paginaFinal" => "51"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Malignidad en pacientes con sarcoidosis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Senol Kobak, Fidan Yildiz, Huseyin Semiz, Mehmet Orman"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "Senol"
              "apellidos" => "Kobak"
            ]
            1 => array:2 [
              "nombre" => "Fidan"
              "apellidos" => "Yildiz"
            ]
            2 => array:2 [
              "nombre" => "Huseyin"
              "apellidos" => "Semiz"
            ]
            3 => array:2 [
              "nombre" => "Mehmet"
              "apellidos" => "Orman"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301635?idApp=UINPBA00004M"
    "url" => "/21735743/0000001700000001/v1_202101140856/S2173574320301635/v1_202101140856/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173574320301568"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2019.03.006"
    "estado" => "S300"
    "fechaPublicacion" => "2021-01-01"
    "aid" => "1338"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "pgl"
    "cita" => "Reumatol Clin. 2021;17:37-45"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Consensus statement</span>"
      "titulo" => "Recommendations of the Mexican College of Rheumatology for the management of spondyloarthritis"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "37"
          "paginaFinal" => "45"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Recomendaciones del Colegio Mexicano de Reumatolog&#237;a para el manejo de las espondiloartritis"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:8 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2063
              "Ancho" => 2167
              "Tamanyo" => 183175
            ]
          ]
          "detalles" => array:1 [
            0 => array:3 [
              "identificador" => "at0005"
              "detalle" => "Fig&#46; "
              "rol" => "short"
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Flow chart&#46; Systematic review to update the recommendations of the Mexican College of Rheumatology for the management of spondyloarthritis&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Greta Reyes-Cordero, Favio Enr&#237;quez-Sosa, Citlallyc Gomez-Ruiz, Ver&#243;nica Gonzalez-Diaz, Jos&#233; Dionisio Castillo-Ortiz, Sergio Duran-Barrag&#225;n, J&#46; Santos Duran-Ortiz, Rolando Espinosa-Morales, Jorge I&#46; Gamez-Nava, Laura Gonzalez-Lopez, Bernardo Julian-Mart&#237;nez, Ang&#233;lica Mendoza-Fuentes, Cesar Ramos-Remus, Cesar Pacheco-Tena, Ruben Burgos-Vargas"
          "autores" => array:15 [
            0 => array:2 [
              "nombre" => "Greta"
              "apellidos" => "Reyes-Cordero"
            ]
            1 => array:2 [
              "nombre" => "Favio"
              "apellidos" => "Enr&#237;quez-Sosa"
            ]
            2 => array:2 [
              "nombre" => "Citlallyc"
              "apellidos" => "Gomez-Ruiz"
            ]
            3 => array:2 [
              "nombre" => "Ver&#243;nica"
              "apellidos" => "Gonzalez-Diaz"
            ]
            4 => array:2 [
              "nombre" => "Jos&#233; Dionisio"
              "apellidos" => "Castillo-Ortiz"
            ]
            5 => array:2 [
              "nombre" => "Sergio"
              "apellidos" => "Duran-Barrag&#225;n"
            ]
            6 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Santos Duran-Ortiz"
            ]
            7 => array:2 [
              "nombre" => "Rolando"
              "apellidos" => "Espinosa-Morales"
            ]
            8 => array:2 [
              "nombre" => "Jorge I&#46;"
              "apellidos" => "Gamez-Nava"
            ]
            9 => array:2 [
              "nombre" => "Laura"
              "apellidos" => "Gonzalez-Lopez"
            ]
            10 => array:2 [
              "nombre" => "Bernardo"
              "apellidos" => "Julian-Mart&#237;nez"
            ]
            11 => array:2 [
              "nombre" => "Ang&#233;lica"
              "apellidos" => "Mendoza-Fuentes"
            ]
            12 => array:2 [
              "nombre" => "Cesar"
              "apellidos" => "Ramos-Remus"
            ]
            13 => array:2 [
              "nombre" => "Cesar"
              "apellidos" => "Pacheco-Tena"
            ]
            14 => array:2 [
              "nombre" => "Ruben"
              "apellidos" => "Burgos-Vargas"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X19300804"
        "doi" => "10.1016/j.reuma.2019.03.010"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X19300804?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301568?idApp=UINPBA00004M"
    "url" => "/21735743/0000001700000001/v1_202101140856/S2173574320301568/v1_202101140856/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
    "titulo" => "p&#46;RQ92 mutation associated with amyloidosis"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "46"
        "paginaFinal" => "48"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Francisco Jos&#233; Nicol&#225;s-S&#225;nchez, Juan Ignacio Ar&#243;stegui-Gorospe, Judit Pallar&#233;s-Quixal, Francesc Josep Nicol&#225;s-Sarrat, Rosa Mar&#237;a Sarrat-Nuevo, Ramon Mar&#237;a Nogue Bou, Pablo Jos&#233; Melgarejo-Moreno"
        "autores" => array:7 [
          0 => array:4 [
            "nombre" => "Francisco Jos&#233;"
            "apellidos" => "Nicol&#225;s-S&#225;nchez"
            "email" => array:1 [
              0 => "fnicolas@comll.cat"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Juan Ignacio"
            "apellidos" => "Ar&#243;stegui-Gorospe"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Judit"
            "apellidos" => "Pallar&#233;s-Quixal"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Francesc Josep"
            "apellidos" => "Nicol&#225;s-Sarrat"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Rosa Mar&#237;a"
            "apellidos" => "Sarrat-Nuevo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Ramon Mar&#237;a Nogue"
            "apellidos" => "Bou"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Pablo Jos&#233;"
            "apellidos" => "Melgarejo-Moreno"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Servicio de Medicina Interna&#44; Hospital de Santa Mar&#237;a&#44; Lleida&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servei d&#8217;Immunologia&#44; Institut d&#8217;Investigacions Biom&#232;diques Agust&#237; Pi i Sunyer &#40;IDIBAPS&#41;&#44; Hospital Cl&#237;nic&#44; Barcelona&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Servei de Anatomia Patol&#242;gica&#44; Hospital Universitari Arnau de Vilanova&#44; Lleida&#44; Spain"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Mutaci&#243;n p&#46;RQ92 asociada a amiloidosis"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1600
            "Ancho" => 2153
            "Tamanyo" => 236628
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">p&#46;R92Q mutation in heterozygosis&#46; Exon 4&#44; <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">TNF receptor-associated periodic syndrome &#40;TRAPS&#41; is an autosomal dominant disease characterised by recurrent episodes of fever&#44; migratory myalgias&#44; skin rash&#44; conjunctivitis&#44; orbital oedema and abdominal or chest pain due to muscle inflammation&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> and even chronic refractory arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Leukocytosis&#44; neutrophilia&#44; thrombocytosis and elevated acute phase reactants can occur&#46; We present the case of an 83-year-old male with amyloidosis type AA and the p&#46;R92Q variant in the <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Clinical case</span><p id="par0010" class="elsevierStylePara elsevierViewall">An 83-year-old male with a history of gastrointestinal bleeding and iron-deficiency anaemia due to gastritis and duodenal ulcer&#44; benign prostatic hypertrophy&#44; high blood pressure treated with tamsulosin &#40;&#46;4<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; dutasteride &#40;&#46;5<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41; and omeprazole &#40;20<span class="elsevierStyleHsp" style=""></span>mg&#47;24<span class="elsevierStyleHsp" style=""></span>h&#41;&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">He consulted with tiredness and instability&#44; with haemoglobin of 7&#46;3<span class="elsevierStyleHsp" style=""></span>g&#47;dl&#46; Gastroscopy revealed a duodenal ulcer&#46; Gastric biopsy showed mild chronic gastritis&#46; Duodenal biopsy showed focal ulceration of mucosa with preserved villi and lamina propria expanded by deposit of amorphous eosinophilic material &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#59; this deposit was also observed in the capillary walls and the submucosa&#44; it was accompanied by minimal non-specific lymphocytic inflammatory infiltrate&#59; Congo red stain was intensely positive and showed apple-green birefringence in polarised light &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#41;&#46; Immunohistochemical staining was also performed for AA protein&#44; which was intensely positive&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Enteroscopy demonstrated from the distal bulb&#44; and continuously the length of the path explored&#44; intestinal mucosa with superficial ulcerations and of infiltrative appearance&#44; with areas of spontaneous bleeding on passing the endoscope&#46; The most significant findings were located in the distal bulb and the second and third duodenal portions&#44; with totally denuded and ulcerated mucosal areas&#46; Colonoscopy was normal&#46; Rectal biopsy showed no amyloid material&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Thoracic CT was normal&#44; while abdominal CT revealed discrete thickening with dilation of the duodenal wall and first jejunal loops &#40;up to 3&#46;2<span class="elsevierStyleHsp" style=""></span>cm&#41; with involvement of the adjacent fat&#44; of probable inflammatory origin&#59; ureteral and bladder lithiasis&#46; Abdominal CT-angiography showed no valuable findings&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Aetiological study of secondary amyloidosis was performed&#46; Liver and kidney function&#44; proteinogram&#44; and serum amyloid A protein were normal&#46; Antinuclear antibodies&#44; rheumatoid factor&#44; citrullinated peptide&#44; neutrophil antibody and serum beta-2-microglobulin were negative&#46; C-reactive protein &#40;CRP&#41; was normal on admission&#44; but intermittent elevations of around 50<span class="elsevierStyleHsp" style=""></span>mg&#47;l <span class="elsevierStyleItalic">&#40;normal &#46;0-6-0</span>&#41; were evidenced in some of the routine checks&#59; there were no associated symptoms&#46; Abdominal fat biopsy showed no amyloid material&#46; The 24-h urine protein test was negative&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Studies of genes for familial Mediterranean fever &#40;FMF&#41; and familial amyloid polyneuropathy &#40;FAP&#41; were negative&#44; while analysis of the <span class="elsevierStyleItalic">TNFRSF1A</span> gene revealed the heterozygous variant p&#46;R92Q &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The electrocardiogram was normal&#44; and the echocardiogram showed a left ventricle that was neither dilated nor hypertrophied&#44; preserved ejection fraction with impaired relaxation&#46; Electromyography showed slight signs of chronic radicular involvement bilateral L4&#44; L5 and S1&#44; there were no conclusive signs of polyneuropathy&#46; Lumbar-sacral magnetic resonance showed osteodegenerative changes in the interapophyseal joints L4-L5-S1&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">TRAPS syndrome is a monogenic auto-inflammatory disease that can affect different ethnic groups&#46; The mutations that cause this syndrome are located in the <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#44; and about 114 variants have been described&#46; Among them&#44; the p&#46;R92Q variant stands out in terms of frequency&#44; currently classified as a variant of uncertain significance&#44; and also presenting a low incidence of secondary amyloidosis&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In TRAPS syndrome&#44; symptoms usually appear during the first decade of life&#46; In the case of adult onset&#44; it is common to identify low-penetrance variants&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Prolonged febrile episodes &#40;between 1 and 4 weeks&#41; are most frequent manifestation of the syndrome&#44; which recur at irregular intervals of weeks or months&#44; accompanied by myalgias and migratory skin exanthema&#46; There may be triggers such as infections&#44; trauma&#44; stress&#44; etc&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">It is the prolonged elevation of acute phase reactants&#44; and especially serum amyloid protein&#44; that increases the risk of type AA amyloidosis&#46; The patient we describe presented elevated CRP in some of the routine tests without any symptoms&#46; Concentric ventricular hypertrophy was not observed&#44; nor was amyloid deposition evidenced in the abdominal fat or rectal biopsies&#46; Duodenal biopsy ruled out Crohn&#39;s disease &#40;CD&#41;&#44; since in CD there may be ulceration and fissures&#44; but with predominance of severe&#47;moderate lymphoplasmocellular inflammatory infiltration&#44; granulomas and acute glandular inflammation&#44; which were not present in this case&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Thoracic and abdominal CT&#44; gastroscopy&#44; enteroscopy and colonoscopy did not reveal neoplasms&#44; and the proteinogram did not show monoclonal bands&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Amyloidosis can occur in TRAPS&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#44;8</span></a> but to date its association with the p&#46;RQ92 variant&#44; has not been demonstrated&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">In conclusion&#44; amyloidosis may be present in carriers of the p&#46;RQ92 variant&#44; and therefore its diagnosis is important to avoid possible complications&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflict of interests</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:9 [
        0 => array:3 [
          "identificador" => "xres1448971"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1321431"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres1448972"
          "titulo" => "Resumen"
          "secciones" => array:2 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
            1 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Conclusi&#243;n"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1321430"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Clinical case"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Discussion"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Conflict of interests"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-02-18"
    "fechaAceptado" => "2019-07-03"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1321431"
          "palabras" => array:3 [
            0 => "p&#46;RQ92"
            1 => "Amyloidosis"
            2 => "Tumour necrosis factor receptor-associated periodic syndrome"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1321430"
          "palabras" => array:3 [
            0 => "p&#46;RQ92"
            1 => "Amiloidosis"
            2 => "S&#237;ndrome peri&#243;dico asociado al factor de necrosis tumoral"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Secondary amyloidosis can be found in some monogenic autoinflammatory diseases&#46; In this study we present an 83-year-old man with no relevant medical history who presented with iron deficiency anaemia&#46; In the study&#44; a gastroscopy was performed with duodenum biopsy showing secondary AA-type amyloidosis&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Genetic analyses of monogenic autoinflammatory diseases revealed the heterozygous p&#46;R92Q variant in the <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#44; with negative results in the complementary tests for other causes of amyloidosis&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In TRAPS&#44; secondary amyloidosis has usually been associated with mutations affecting cysteine residues&#44; but until now no association has been demonstrated with the p&#46;RQ92 variant&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Secondary amyloidosis may be present in carriers of the p&#46;RQ92 variant&#44; therefore it is important to diagnose it to prevent possible complications&#46;</p></span>"
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La amiloidosis secundaria puede encontrarse en algunas enfermedades autoinflamatorias monog&#233;nicas&#46; Presentamos el caso de un var&#243;n de 83 a&#241;os sin antecedentes patol&#243;gicos de inter&#233;s&#46; Tras detectarse una anaemia ferrop&#233;nica&#44; se realiz&#243; una gastroscopia y la biopsia duodenal evidenci&#243; amiloidosis secundaria de tipo AA&#46; El estudio de enfermedades autoinflamatorias revel&#243; la variante heterocigota p&#46;R92Q en el gen <span class="elsevierStyleItalic">TNFRSF1A</span>&#44; siendo negativas las pruebas complementarias para otras causas de amiloidosis&#46; En el s&#237;ndrome TRAPS la amiloidosis secundaria puede asociarse a mutaciones que afectan a residuos ciste&#237;na&#44; no habi&#233;ndose evidenciado su asociaci&#243;n con la variante p&#46;R92Q&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conclusi&#243;n</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La amiloidosis secundaria puede estar presente en individuos portadores de la variante p&#46;RQ92&#44; por lo que es importante su diagn&#243;stico para intentar prevenir posibles complicaciones&#46;</p></span>"
        "secciones" => array:2 [
          0 => array:1 [
            "identificador" => "abst0010"
          ]
          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Conclusi&#243;n"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Nicol&#225;s-S&#225;nchez FJ&#44; Ar&#243;stegui-Gorospe JI&#44; Pallar&#233;s-Quixal J&#44; Nicol&#225;s-Sarrat FJ&#44; Sarrat-Nuevo RM&#44; Nogue Bou RM&#44; et al&#46; Mutaci&#243;n p&#46;RQ92 asociada a amiloidosis&#46; Reumatol Clin&#46; 2021&#59;17&#58;46&#8211;48&#46;</p>"
      ]
    ]
    "multimedia" => array:2 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 582
            "Ancho" => 1305
            "Tamanyo" => 241679
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0020"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Deposits in lamina propria of eosinophilic amorphous material and in the capillary walls &#40;HE&#44; 20&#215;&#41;&#46; &#40;B&#41; Congo red staining showing intensely positive deposits of amyloid material&#44; which showed apple-green birefringence with polarised light &#40;Congo red&#44; 20&#215;&#41;&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "fig0010"
        "etiqueta" => "Fig&#46; 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1600
            "Ancho" => 2153
            "Tamanyo" => 236628
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0025"
            "detalle" => "Fig&#46; "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">p&#46;R92Q mutation in heterozygosis&#46; Exon 4&#44; <span class="elsevierStyleItalic">TNFRSF1A</span> gene&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The autoinflammatory disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Federici"
                            1 => "R&#46; Caorsi"
                            2 => "M&#46; Gattorno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4414/smw.2012.13602"
                      "Revista" => array:5 [
                        "tituloSerie" => "Swiss Med Wkly"
                        "fecha" => "2012"
                        "volumen" => "142"
                        "paginaInicial" => "w13602"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22714396"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The phenotype of TNF receptor-associated autoinflammatory syndrome &#40;TRAPS&#41; at presentation&#58; a series of 158 cases from the Eurofever&#47;EUROTRAPS international registry"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "H&#46;J&#46; Lachmann"
                            1 => "R&#46; Papa"
                            2 => "K&#46; Gerhold"
                            3 => "L&#46; Obici"
                            4 => "I&#46; Touitou"
                            5 => "L&#46; Cantarini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/annrheumdis-2013-204184"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2014"
                        "volumen" => "73"
                        "paginaInicial" => "2160"
                        "paginaFinal" => "2167"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23965844"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adult-onset tumour necrosis factor receptor-associated periodic syndrome presenting with refractory chronic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Lopalco"
                            1 => "D&#46; Rigante"
                            2 => "A&#46; Vitale"
                            3 => "M&#46; Galeazzi"
                            4 => "F&#46; Iannone"
                            5 => "L&#46; Cantarini"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2015"
                        "volumen" => "33"
                        "numero" => "Suppl&#46; 94"
                        "paginaInicial" => "S171"
                        "paginaFinal" => "S172"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25936627"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disease phenotype and outcome depending on the age at disease onset in patients carrying the R92Q low-penetrance variant in <span class="elsevierStyleItalic">TNFRSF1A</span> gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Ruiz-Ortiz"
                            1 => "E&#46; Iglesias"
                            2 => "A&#46; Soriano"
                            3 => "S&#46; Buj&#225;n-Rivas"
                            4 => "M&#46; Espa&#241;ol-Rego"
                            5 => "R&#46; Castellanos-Moreira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3389/fimmu.2017.00299"
                      "Revista" => array:5 [
                        "tituloSerie" => "Front Immunol"
                        "fecha" => "2017"
                        "volumen" => "8"
                        "paginaInicial" => "299"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28396659"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical significance of P46L and R92Q substitutions in the tumour necrosis factor superfamily 1A gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Ravet"
                            1 => "S&#46; Rouaghe"
                            2 => "C&#46; Dod&#233;"
                            3 => "J&#46; Bienvenu"
                            4 => "J&#46; Stirnemann"
                            5 => "P&#46; L&#233;vy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2005.048611"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2006"
                        "volumen" => "65"
                        "paginaInicial" => "1158"
                        "paginaFinal" => "1162"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16569687"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Heterogeneity among patients with tumor necrosis factor receptor-associated periodic syndrome phenotypes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Aganna"
                            1 => "L&#46; Hammond"
                            2 => "P&#46;N&#46; Hawkins"
                            3 => "A&#46; Aldea"
                            4 => "S&#46;A&#46; McKee"
                            5 => "H&#46;K&#46; van Amstel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.11215"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2003"
                        "volumen" => "48"
                        "paginaInicial" => "2632"
                        "paginaFinal" => "2644"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13130484"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autosomal-dominant periodic fever with AA amyloidosis&#58; novel mutation in tumor necrosis factor receptor 1 gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Jadoul"
                            1 => "C&#46; Dode"
                            2 => "J&#46;P&#46; Cosyns"
                            3 => "D&#46; Abramowicz"
                            4 => "B&#46; Georges"
                            5 => "M&#46; Delphech"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1523-1755.2001.0590051677.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Kidney Int"
                        "fecha" => "2001"
                        "volumen" => "59"
                        "paginaInicial" => "1677"
                        "paginaFinal" => "1682"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11318938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of renal amyloidosis with etanercept in tumour necrosis factor receptor-associated periodic syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E&#46; Drewe"
                            1 => "M&#46;L&#46; Huggins"
                            2 => "A&#46;G&#46; Morgan"
                            3 => "M&#46;J&#46; Cassidy"
                            4 => "R&#46;J&#46; Powell"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "1405"
                        "paginaFinal" => "1408"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000001700000001/v1_202101140856/S2173574320300186/v1_202101140856/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "43296"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Case report"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001700000001/v1_202101140856/S2173574320300186/v1_202101140856/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300186?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 October 34 23 57
2024 September 40 22 62
2024 August 57 33 90
2024 July 44 30 74
2024 June 50 26 76
2024 May 58 22 80
2024 April 55 32 87
2024 March 37 25 62
2024 February 47 26 73
2024 January 31 17 48
2023 December 43 31 74
2023 November 40 31 71
2023 October 38 24 62
2023 September 108 34 142
2023 August 80 26 106
2023 July 27 25 52
2023 June 28 26 54
2023 May 48 27 75
2023 April 22 5 27
2023 March 55 32 87
2023 February 31 22 53
2023 January 31 28 59
2022 December 51 42 93
2022 November 50 29 79
2022 October 68 43 111
2022 September 46 23 69
2022 August 28 38 66
2022 July 54 35 89
2022 June 46 33 79
2022 May 42 43 85
2022 April 51 50 101
2022 March 37 45 82
2022 February 30 35 65
2022 January 32 44 76
2021 December 32 37 69
2021 November 36 44 80
2021 October 69 57 126
2021 September 48 44 92
2021 August 30 27 57
2021 July 32 28 60
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?