Letter to the Editor
Is “Joker” syndrome a distinctive characteristic of neuro-Behçet's disease
¿Síndrome del Guasón, característica distintiva de neuro-Behçet?
Read
6659
Timeswas read the article
1224
Total PDF
5435
Total HTML
Share statistics
array:24 [ "pii" => "S217357432030068X" "issn" => "21735743" "doi" => "10.1016/j.reumae.2020.01.001" "estado" => "S300" "fechaPublicacion" => "2021-06-01" "aid" => "1396" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "copyrightAnyo" => "2021" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Reumatol Clin. 2021;17:368-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S1699258X20300206" "issn" => "1699258X" "doi" => "10.1016/j.reuma.2020.01.005" "estado" => "S300" "fechaPublicacion" => "2021-06-01" "aid" => "1396" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Reumatol Clin. 2021;17:368-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Editor</span>" "titulo" => "¿Síndrome del Guasón, característica distintiva de neuro-Behçet?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "368" "paginaFinal" => "369" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Is «Joker» Syndrome a Distinctive Characteristic of Neuro-Behçet's Disease" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Gerardo Toantiu Jaimes-Piñon, Ildefonso Rodrìguez-Leyva, Carlos Abud Mendoza" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Gerardo" "apellidos" => "Toantiu Jaimes-Piñon" ] 1 => array:2 [ "nombre" => "Ildefonso" "apellidos" => "Rodrìguez-Leyva" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Abud Mendoza" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S217357432030068X" "doi" => "10.1016/j.reumae.2020.01.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357432030068X?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X20300206?idApp=UINPBA00004M" "url" => "/1699258X/0000001700000006/v1_202105200700/S1699258X20300206/v1_202105200700/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2173574321001015" "issn" => "21735743" "doi" => "10.1016/j.reumae.2020.01.006" "estado" => "S300" "fechaPublicacion" => "2021-06-01" "aid" => "1389" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Reumatol Clin. 2021;17:369-70" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Growth factors: Do they play a role in entheseal involvement in psoriatic arthritis and undifferentiated spondyloarthritis patients?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "369" "paginaFinal" => "370" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Factores de crecimiento: ¿desempeñan un papel en el compromiso enteseal en pacientes de artritis psoriásica y espondiloartritis indiferenciada?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cinzia Rotondo, Daniela Cici, Francesco Paolo Cantatore" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Cinzia" "apellidos" => "Rotondo" ] 1 => array:2 [ "nombre" => "Daniela" "apellidos" => "Cici" ] 2 => array:2 [ "nombre" => "Francesco Paolo" "apellidos" => "Cantatore" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321001015?idApp=UINPBA00004M" "url" => "/21735743/0000001700000006/v1_202105240506/S2173574321001015/v1_202105240506/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S2173574321001027" "issn" => "21735743" "doi" => "10.1016/j.reumae.2020.01.007" "estado" => "S300" "fechaPublicacion" => "2021-06-01" "aid" => "1394" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Reumatol Clin. 2021;17:366-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>" "titulo" => "Schwannomas mimicking rheumatologic conditions" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "366" "paginaFinal" => "367" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Schwannomas imitando patologías reumatológicas" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1500 "Ancho" => 1476 "Tamanyo" => 231626 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ultrasound (A, B) and MRI (C, D) images of the knee depicting a well-defined solid mass (*) localized in the popliteal region, originating from the tibial nerve (arrows), with a heterogeneous structure with low intensity MRI-signal on T1 sequences and high intensity on DP SPAIR (C) and T2 sequences (D).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Joana Silva-Dinis, Ana Valido, Joaquim Polido-Pereira, Nikita Khmelinskii" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Joana" "apellidos" => "Silva-Dinis" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Valido" ] 2 => array:2 [ "nombre" => "Joaquim" "apellidos" => "Polido-Pereira" ] 3 => array:2 [ "nombre" => "Nikita" "apellidos" => "Khmelinskii" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321001027?idApp=UINPBA00004M" "url" => "/21735743/0000001700000006/v1_202105240506/S2173574321001027/v1_202105240506/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Is “Joker” syndrome a distinctive characteristic of neuro-Behçet's disease" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor</span>," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "368" "paginaFinal" => "369" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Gerardo Toantiu Jaimes-Piñon, Ildefonso Rodrìguez-Leyva, Carlos Abud Mendoza" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Gerardo" "apellidos" => "Toantiu Jaimes-Piñon" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Ildefonso" "apellidos" => "Rodrìguez-Leyva" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:4 [ "nombre" => "Carlos" "apellidos" => "Abud Mendoza" "email" => array:1 [ 0 => "cabudm@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Hospital General número 50, Instituto Mexicano del Seguro Social (IMSS), San Luis Potosí, Mexico" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Facultad de Medicina, Universidad Autónoma San Luis Potosí (UASLP), San Luis Potosí, Mexico" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital Central «Dr. Ignacio Morones Prieto», San Luis Potosí, Mexico" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Síndrome del Guasón, característica distintiva de neuro-Behçet?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Laughter is an inherent and essential part of human behaviour. Its impact throughout our culture may be observed from the texts of the great civilisations, from classical Greece, to today's popular culture. The beneficial impact of laughter in medicine has been widely demonstrated in, for example, cardiovascular health, behaviour patterns and learning.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1–4</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">On the other end of the laughter type classification spectrum is abnormal laughter. This is defined as something which occurs without any previous stimulus and which is of inappropriate intensity. Similarly, to the first type of laughter, there are many references to abnormal laughter. One recent reference is the <span class="elsevierStyleItalic">Joker</span> antihero, whose distinctive trait is his scandalous, abnormal, and on occasions, malevolent laughter.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The aetiology of abnormal laughter, which is a component of pseudobulbar syndrome, is extensive and includes neurodegenerative, tumoral, traumatic and even vascular diseases. In Behçet's disease, primary systemic vasculitis of variably sized blood vessels and involvement of the central nervous system at disease onset is rare and occurs less frequently than that of other organs. Inappropriate laughter as part of the neuropsychiatric symptoms has been infrequently reported.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">5–7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">We report 2 cases of patients with Behçet's disease and with “joker syndrome” traits.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case 1</span><p id="par0025" class="elsevierStylePara elsevierViewall">Male, 23 years of age, previously healthy, with 6-month onset of constitutional symptoms, ataxia, dysmetria and dysarthria. Three months later additional symptoms of polyarthritis, pustular dermatosis, and oral and genital ulcers presented. Diagnosis ruled out infectious aetiologies and confirmed the existence of retinal vasculitis in fluorescein angiography and in magnetic resonance imaging, which showed predominantly mesencephalic inflammatory lesions. Behçet's disease was considered and was treated with methylprednisolone and cyclophosphamide with favourable response. During the course of the disease the patient again presented with ataxia, dysphagia, and dysarthria, accompanied by episodes of intense laughter. His mother reported that the laughter even occurred in situations such as when he was bathing or eating and when his attention was captured. The patient again received methylprednisolone by IV and cyclophosphamide, with subsequent maintenance therapy of azathioprine with partial response. Gait disorders persisted which led to the patient becoming bed-ridden, with dysphasia and a continuation of the inappropriate laughter. Treatment was changed to anti-TNF, but shortly after initiation of treatment the patient died from respiratory infectious complications.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Case 2</span><p id="par0030" class="elsevierStylePara elsevierViewall">Male, 39 years of age, previously healthy. He presented with a 4-month history of constitutional symptoms of low-grade fever, polyarthritis, oral and genital ulcers. Behçet's disease was diagnosed for which the patient was treated with glucocorticoids and cyclophosphamide. During follow-up, his family members, and the patient himself commented upon changes to his behaviour characterized by the appearance of involuntary and irrepressible laughter, even in serious situations or without any stimuli. The most dramatic event presented during the funeral of his daughter aged 12 where, despite being grief stricken, the patient burst into uncontrollable laughter and preferred to vacate the premises. The patient continued with immunosuppressant treatment based on methotrexate, with remission of symptoms.</p><p id="par0035" class="elsevierStylePara elsevierViewall">Behçet's disease, a chronic multisystemic inflammatory disease, is included in the Chapel Hill classification as vasculitis of blood vessels of varying size.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> An extremely high percentage of patients with this vasculitis, ranging from 5% to 50%, may present with neuropsychiatric symptoms. There are two suggested mechanisms to explain the clinical symptoms: parenchymatose inflammatory lesions (with involvement of the brain stem, mesodiencephalic union, cerebellar and cerebral hemispheres) and the thrombotic phenomenon. Pseudobulbar paralysis syndrome has been previously reported in this disease, but uncontrollable laughter being predominant as a symptom is extremely rare. This finding presented in both patients. In the first case there was mesodiencephalic involvement despite immunosuppressant treatment and evolution was not favourable.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Different disorders have received eponyms from other, non-medical areas. One such known case, the Pickwickian syndrome, was established by Charles Dickens in his novel <span class="elsevierStyleItalic">The Posthumous Papers of the Pickwick Club</span> published in 1837. Might we then speak of the “Joker syndrome” in the case of the inappropriate laughter in our patients with this neuropsychiatric expression related to Behcet's disease?</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case 1" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Case 2" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Toantiu Jaimes-Piñon G, Rodrìguez-Leyva I, Abud Mendoza C. ¿Síndrome del Guasón, característica distintiva de neuro-Behçet? Reumatol Clin. 2021;17:368–369.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:8 [ 0 => array:3 [ "identificador" => "bib0045" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of laughter therapy on anxiety: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Demir Doğan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/HNP.0000000000000363" "Revista" => array:6 [ "tituloSerie" => "Holist Nurs Pract" "fecha" => "2020" "volumen" => "34" "paginaInicial" => "35" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31725098" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0050" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Therapeutic benefits of laughter in mental health: a theoretical review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Yim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1620/tjem.239.243" "Revista" => array:6 [ "tituloSerie" => "Tohoku J Exp Med" "fecha" => "2016" "volumen" => "239" "paginaInicial" => "243" "paginaFinal" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27439375" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0055" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations of frequency of laughter with risk of all-cause mortality and cardiovascular disease incidence in a general population: findings from the Yamagata study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Sakurada" 1 => "T. Konta" 2 => "M. Watanabe" 3 => "K. Ishizawa" 4 => "Y. Ueno" 5 => "H. Yamashita" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2188/jea.JE20180249" "Revista" => array:2 [ "tituloSerie" => "J Epidemiol" "fecha" => "2019" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0060" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effectiveness of integrative laughter therapy to reduce anxiety improve self-esteem and increase happiness: a naturalistic study at a day hospital for addictive disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. De Francisco" 1 => "C. Torres" 2 => "S. de Andrés" 3 => "A. Millet" 4 => "M.T. Ricart" 5 => "E. Hernández-Martínez-Esparza" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3390/ijerph16214194" "Revista" => array:4 [ "tituloSerie" => "Int J Environ Res Public Health" "fecha" => "2019" "volumen" => "16" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31426304" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0065" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical characteristics and prognosis of neuro-Behçet's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.H. Sorgun" 1 => "M.A. Kural" 2 => "C. Yücesan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5152/eurjrheum.2018.18033" "Revista" => array:6 [ "tituloSerie" => "Eur J Rheumatol" "fecha" => "2018" "volumen" => "5" "paginaInicial" => "235" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30308139" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0070" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuro-Behçet's disease: epidemiology, clinical characteristics, and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A. Al-Araji" 1 => "D.P. Kidd" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1474-4422(09)70015-8" "Revista" => array:6 [ "tituloSerie" => "Lancet Neurol" "fecha" => "2009" "volumen" => "8" "paginaInicial" => "192" "paginaFinal" => "204" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19161910" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0075" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurobehçet disease: clinical and demographic characteristics" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.C. Casanova Peño" 1 => "V. de las Heras Revilla" 2 => "B. Parejo Carbonella" 3 => "D. di Capua Sacotoa" 4 => "M.E. Fuentes Ferrer" 5 => "R. García-Cobos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-1331.2012.03706.x" "Revista" => array:2 [ "tituloSerie" => "Eur J Neurol" "fecha" => "2012" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0080" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.C. Jennette" 1 => "R.J. Falk" 2 => "P.A. Bacon" 3 => "N. Basu" 4 => "M.C. Cid" 5 => "F. Ferrario" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.37715" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2013" "volumen" => "65" "paginaInicial" => "1" "paginaFinal" => "11" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23045170" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000001700000006/v1_202105240506/S217357432030068X/v1_202105240506/en/main.assets" "Apartado" => array:4 [ "identificador" => "8400" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001700000006/v1_202105240506/S217357432030068X/v1_202105240506/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357432030068X?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 18 | 3 | 21 |
| 2024 October | 285 | 38 | 323 |
| 2024 September | 211 | 26 | 237 |
| 2024 August | 218 | 40 | 258 |
| 2024 July | 275 | 36 | 311 |
| 2024 June | 300 | 42 | 342 |
| 2024 May | 320 | 37 | 357 |
| 2024 April | 245 | 24 | 269 |
| 2024 March | 189 | 41 | 230 |
| 2024 February | 160 | 39 | 199 |
| 2024 January | 135 | 39 | 174 |
| 2023 December | 100 | 41 | 141 |
| 2023 November | 176 | 67 | 243 |
| 2023 October | 190 | 53 | 243 |
| 2023 September | 150 | 38 | 188 |
| 2023 August | 98 | 16 | 114 |
| 2023 July | 244 | 26 | 270 |
| 2023 June | 114 | 30 | 144 |
| 2023 May | 105 | 37 | 142 |
| 2023 April | 56 | 6 | 62 |
| 2023 March | 120 | 27 | 147 |
| 2023 February | 151 | 23 | 174 |
| 2023 January | 107 | 16 | 123 |
| 2022 December | 109 | 25 | 134 |
| 2022 November | 184 | 34 | 218 |
| 2022 October | 184 | 33 | 217 |
| 2022 September | 180 | 33 | 213 |
| 2022 August | 158 | 37 | 195 |
| 2022 July | 113 | 49 | 162 |
| 2022 June | 105 | 27 | 132 |
| 2022 May | 97 | 32 | 129 |
| 2022 April | 68 | 38 | 106 |
| 2022 March | 76 | 50 | 126 |
| 2022 February | 68 | 38 | 106 |
| 2022 January | 61 | 37 | 98 |
| 2021 December | 58 | 40 | 98 |
| 2021 November | 6 | 6 | 12 |
| 2020 October | 1 | 0 | 1 |
Show all
