array:23 [
  "pii" => "S2173574320300976"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2018.05.006"
  "estado" => "S300"
  "fechaPublicacion" => "2020-09-01"
  "aid" => "1234"
  "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2018"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Reumatol Clin. 2020;16:364-5"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574319301182"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.06.006"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "1244"
    "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2020;16:366-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
      "titulo" => "Constitutional syndrome and fever in a patient with atypical presentation of calcium pyrophosphate deposition disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "366"
          "paginaFinal" => "367"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "S&#237;ndrome constitucional y fiebre prolongada en relaci&#243;n con enfermedad por dep&#243;sito de pirofosfato c&#225;lcico de presentaci&#243;n at&#237;pica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2108
              "Ancho" => 2167
              "Tamanyo" => 303104
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Increased uptake of the radiopharmaceutical product &#40;18F-FDG&#41; in PET-CAT at atlantoaxial joint &#40;A&#41;&#44; left sternoclavicular joint &#40;B&#41;&#44; right costovertebral joint in T1 &#40;C&#41; and right sacroiliac joint &#40;D&#41; levels&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fernando Lozano Morillo, Isabel de la C&#225;mara Fern&#225;ndez, Elena Rabad&#225;n Rubio"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Lozano Morillo"
            ]
            1 => array:2 [
              "nombre" => "Isabel de la"
              "apellidos" => "C&#225;mara Fern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Rabad&#225;n Rubio"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X1830127X"
        "doi" => "10.1016/j.reuma.2018.06.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1830127X?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574319301182?idApp=UINPBA00004M"
    "url" => "/21735743/00000016000005P1/v1_202008141736/S2173574319301182/v1_202008141736/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S217357431930108X"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.05.003"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "1238"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2020;16:362-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "IgA vasculitis induced by acenocoumarol"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "362"
          "paginaFinal" => "363"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Vasculitis IgA inducida por acenocumarol"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 673
              "Ancho" => 900
              "Tamanyo" => 82524
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the patient who presented with palpable purpura in lower limbs with formation of haemorrhagic blisters&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sara Esteban Terradillos, Jos&#233; Gabriel Erdozain Castiella, Juan Manuel Goiri Aparicio, Juan Antonio Rat&#243;n Nieto, Aitor Fern&#225;ndez Larrinoa Santamaria, Juan Monte Armenteros"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Sara"
              "apellidos" => "Esteban Terradillos"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Gabriel"
              "apellidos" => "Erdozain Castiella"
            ]
            2 => array:2 [
              "nombre" => "Juan Manuel"
              "apellidos" => "Goiri Aparicio"
            ]
            3 => array:2 [
              "nombre" => "Juan Antonio"
              "apellidos" => "Rat&#243;n Nieto"
            ]
            4 => array:2 [
              "nombre" => "Aitor"
              "apellidos" => "Fern&#225;ndez Larrinoa Santamaria"
            ]
            5 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "Monte Armenteros"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X18301219"
        "doi" => "10.1016/j.reuma.2018.05.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X18301219?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431930108X?idApp=UINPBA00004M"
    "url" => "/21735743/00000016000005P1/v1_202008141736/S217357431930108X/v1_202008141736/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
    "titulo" => "Post-infectious Digital Ischemia Successfully Treated with Iloprost in a Child"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "364"
        "paginaFinal" => "365"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Teresa Martins-Rocha, Jos&#233; Pedro Matias, Margarida Vicente Ferreira, B&#225;rbara Mota, Iva Brito"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Teresa"
            "apellidos" => "Martins-Rocha"
            "email" => array:1 [
              0 => "teresa.asmr@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jos&#233; Pedro"
            "apellidos" => "Matias"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Margarida"
            "apellidos" => "Vicente Ferreira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "B&#225;rbara"
            "apellidos" => "Mota"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Iva"
            "apellidos" => "Brito"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Rheumatology Department&#44; Centro Hospitalar de S&#227;o Jo&#227;o&#44; Porto&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Pediatrics&#44; Centro Hospitalar de S&#227;o Jo&#227;o&#44; Porto&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Rheumatology Department&#44; Faculty de Medicine University of Porto &#40;FMUP&#41;&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Isquemia digital postinfecciosa infantil tratada con &#233;xito con iloprost"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1112
            "Ancho" => 1867
            "Tamanyo" => 242350
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ischemic lesions at the admission &#40;A&#41;&#44; at the 13th &#40;B&#41; and at the 21st day &#40;C&#41; of therapy with intravenous iloprost&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report a case of a 14-month-old girl&#44; with no relevant pathological history&#44; which presented additive bullous lesions on her hands and feet fingertips&#46; She had no previous burn&#44; trauma or other associated events&#46; One week before&#44; she was diagnosed with Acute Otitis Media and was treated with amoxicillin&#47;clavulanic acid for 8 days&#46; Later on&#44; the fingertip lesions progressively evolved into necrotic lesions and&#44; after two months of the initial presentation&#44; she was observed at our hospital&#46; Objectively&#44; she was afebrile and presented digital plaques of dry necrosis&#44; with edema and redness of the distal end of the affected fingers&#44; without fluctuation or drainage of any content &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Peripheral arterial pulses were symmetric and no vascular or heart bruits were audible&#46; As iloprost has been described to be safe and effective for the treatment of ischemic digits in children&#44; intravenous iloprost &#40;0&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;kg&#47;min for 5 days followed by 0&#46;6<span class="elsevierStyleHsp" style=""></span>ng&#47;kg&#47;min&#41; and acetylsalicylic acid were started&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1-4</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Concerning laboratory studies&#44; she had CRP &#40;50<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41; and ESR &#40;60<span class="elsevierStyleHsp" style=""></span>mm&#47;1st hour&#41; elevation&#59; negative serologies for EBV&#44; Herpes simplex&#44; CMV&#44; parvovirus and <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>&#59; negative antistreptolysin O titer and blood cultures&#46; Pro-thrombotic and immunological studies &#40;complement levels&#44; rheumatoid factor&#44; ANA&#44; anti-ENA&#44; anti-dsDNA&#44; ANCA and antiphospholipid antibodies&#41; were unremarkable&#46; Echocardiogram&#44; chest and hands X-rays&#44; and abdominal ultrasound were normal&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">She completed 21 days of iloprost and gradually presented resolution of the fingertip lesions&#46; Considering the previous infection and the diagnostic work-up&#44; we considered the digital ischemia in a probable post-infectious context&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Digital ischemia is described in meningococcal infection&#44; which can present extrameningeal involvement in up to 19&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> Additionally&#44; few cases were also reported with other infectious agents&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;6</span></a> Among others&#44; treatment with antiplatelet drugs&#44; topical nitrates and sympathetic blockade is described&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> Besides our report&#44; favorable response to iloprost was documented in 4 children with post-infectious digital ischemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;4&#44;8</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">No specific funding was received from any bodies in the public&#44; commercial or not-for-profit sectors to carry out the work described in this manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Funding"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Conflicts of interest"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2018-04-16"
    "fechaAceptado" => "2018-05-29"
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1112
            "Ancho" => 1867
            "Tamanyo" => 242350
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ischemic lesions at the admission &#40;A&#41;&#44; at the 13th &#40;B&#41; and at the 21st day &#40;C&#41; of therapy with intravenous iloprost&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Iloprost for the treatment of digital ischaemia in pediatric septic shock&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Garcia Soler"
                            1 => "G&#46; Milano Manso"
                            2 => "J&#46;M&#46; Camacho Alonso"
                            3 => "J&#46; Manuel Gonzalez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2011"
                        "volumen" => "136"
                        "paginaInicial" => "695"
                        "paginaFinal" => "696"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iloprost treatment for refractory Raynaud&#39;s phenomenon in two infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;S&#46; Shouval"
                            1 => "M&#46; Mukamel"
                            2 => "F&#46; Zulian"
                            3 => "J&#46; Amir"
                            4 => "L&#46; Harel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "numero" => "3 Suppl 49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and efficacy of iloprost for the treatment of ischaemic digits in paediatric connective tissue diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Zulian"
                            1 => "F&#46; Corona"
                            2 => "V&#46; Gerloni"
                            3 => "F&#46; Falcini"
                            4 => "A&#46; Buoncompagni"
                            5 => "M&#46; Scarazatti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "229"
                        "paginaFinal" => "233"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of prostacyclin &#40;iloprost&#41; in digital vasculitis secondary to meningococcaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Siddiqui"
                            1 => "A&#46;R&#46; Razak"
                            2 => "B&#46; Kneafsey"
                            3 => "N&#46; Delanty"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2003.024745"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2004"
                        "volumen" => "75"
                        "paginaInicial" => "506"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14966179"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology&#44; treatment and outcome of meningococcemia&#58; a review and recent experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Kirsch"
                            1 => "R&#46;P&#46; Barton"
                            2 => "L&#46; Kitchen"
                            3 => "B&#46;P&#46; Giroir"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00006454-199611000-00009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Infect Dis J"
                        "fecha" => "1996"
                        "volumen" => "15"
                        "paginaInicial" => "967"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8933544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spontaneous pneumothorax with symmetrical digital gangrene -a rare complication of chickenpox"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Singh"
                            1 => "T&#46;R&#46; Khan"
                            2 => "K&#46;P&#46; Kushwaha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12098-012-0905-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Pediatr"
                        "fecha" => "2013"
                        "volumen" => "80"
                        "paginaInicial" => "706"
                        "paginaFinal" => "707"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23229917"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do new strategies in meningococcemia produce better outcomes&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Leclerc"
                            1 => "S&#46; Leteurtre"
                            2 => "R&#46; Cremer"
                            3 => "C&#46; Fourier"
                            4 => "A&#46; Sadik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00003246-200001000-00003"
                      "Revista" => array:5 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "28"
                        "numero" => "9 Suppl"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10667493"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute meningococcaemia complicated by late onset gastrointestinal vasculitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Seaton"
                            1 => "D&#46; Nathwani"
                            2 => "J&#46; Dick"
                            3 => "D&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jinf.2000.0719"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect"
                        "fecha" => "2000"
                        "volumen" => "41"
                        "paginaInicial" => "190"
                        "paginaFinal" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11023771"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/00000016000005P1/v1_202008141736/S2173574320300976/v1_202008141736/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "5795"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Images in Clinical Rheumatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/00000016000005P1/v1_202008141736/S2173574320300976/v1_202008141736/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300976?idApp=UINPBA00004M"
]
Share
Journal Information

Statistics

Follow this link to access the full text of the article

Images in Clinical Rheumatology
Post-infectious Digital Ischemia Successfully Treated with Iloprost in a Child
Isquemia digital postinfecciosa infantil tratada con éxito con iloprost
Teresa Martins-Rochaa,
Corresponding author
teresa.asmr@gmail.com

Corresponding author.
, José Pedro Matiasb, Margarida Vicente Ferreirab, Bárbara Motab, Iva Britoa,c
a Rheumatology Department, Centro Hospitalar de São João, Porto, Portugal
b Department of Pediatrics, Centro Hospitalar de São João, Porto, Portugal
c Rheumatology Department, Faculty de Medicine University of Porto (FMUP), Portugal
Read
3343
Times
was read the article
1254
Total PDF
2089
Total HTML
Share statistics
 array:23 [
  "pii" => "S2173574320300976"
  "issn" => "21735743"
  "doi" => "10.1016/j.reumae.2018.05.006"
  "estado" => "S300"
  "fechaPublicacion" => "2020-09-01"
  "aid" => "1234"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
  "copyrightAnyo" => "2018"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "sco"
  "cita" => "Reumatol Clin. 2020;16:364-5"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173574319301182"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.06.006"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "1244"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Reumatol Clin. 2020;16:366-7"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
      "titulo" => "Constitutional syndrome and fever in a patient with atypical presentation of calcium pyrophosphate deposition disease"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "366"
          "paginaFinal" => "367"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "S&#237;ndrome constitucional y fiebre prolongada en relaci&#243;n con enfermedad por dep&#243;sito de pirofosfato c&#225;lcico de presentaci&#243;n at&#237;pica"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2108
              "Ancho" => 2167
              "Tamanyo" => 303104
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Increased uptake of the radiopharmaceutical product &#40;18F-FDG&#41; in PET-CAT at atlantoaxial joint &#40;A&#41;&#44; left sternoclavicular joint &#40;B&#41;&#44; right costovertebral joint in T1 &#40;C&#41; and right sacroiliac joint &#40;D&#41; levels&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Fernando Lozano Morillo, Isabel de la C&#225;mara Fern&#225;ndez, Elena Rabad&#225;n Rubio"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Fernando"
              "apellidos" => "Lozano Morillo"
            ]
            1 => array:2 [
              "nombre" => "Isabel de la"
              "apellidos" => "C&#225;mara Fern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Elena"
              "apellidos" => "Rabad&#225;n Rubio"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X1830127X"
        "doi" => "10.1016/j.reuma.2018.06.009"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X1830127X?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574319301182?idApp=UINPBA00004M"
    "url" => "/21735743/00000016000005P1/v1_202008141736/S2173574319301182/v1_202008141736/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S217357431930108X"
    "issn" => "21735743"
    "doi" => "10.1016/j.reumae.2018.05.003"
    "estado" => "S300"
    "fechaPublicacion" => "2020-09-01"
    "aid" => "1238"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and Sociedad Espa&#241;ola de Reumatolog&#237;a y Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "crp"
    "cita" => "Reumatol Clin. 2020;16:362-3"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Report</span>"
      "titulo" => "IgA vasculitis induced by acenocoumarol"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "362"
          "paginaFinal" => "363"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Vasculitis IgA inducida por acenocumarol"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Fig&#46; 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 673
              "Ancho" => 900
              "Tamanyo" => 82524
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the patient who presented with palpable purpura in lower limbs with formation of haemorrhagic blisters&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Sara Esteban Terradillos, Jos&#233; Gabriel Erdozain Castiella, Juan Manuel Goiri Aparicio, Juan Antonio Rat&#243;n Nieto, Aitor Fern&#225;ndez Larrinoa Santamaria, Juan Monte Armenteros"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Sara"
              "apellidos" => "Esteban Terradillos"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233; Gabriel"
              "apellidos" => "Erdozain Castiella"
            ]
            2 => array:2 [
              "nombre" => "Juan Manuel"
              "apellidos" => "Goiri Aparicio"
            ]
            3 => array:2 [
              "nombre" => "Juan Antonio"
              "apellidos" => "Rat&#243;n Nieto"
            ]
            4 => array:2 [
              "nombre" => "Aitor"
              "apellidos" => "Fern&#225;ndez Larrinoa Santamaria"
            ]
            5 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "Monte Armenteros"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S1699258X18301219"
        "doi" => "10.1016/j.reuma.2018.05.006"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X18301219?idApp=UINPBA00004M"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S217357431930108X?idApp=UINPBA00004M"
    "url" => "/21735743/00000016000005P1/v1_202008141736/S217357431930108X/v1_202008141736/en/main.assets"
  ]
  "en" => array:16 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Images in Clinical Rheumatology</span>"
    "titulo" => "Post-infectious Digital Ischemia Successfully Treated with Iloprost in a Child"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "364"
        "paginaFinal" => "365"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Teresa Martins-Rocha, Jos&#233; Pedro Matias, Margarida Vicente Ferreira, B&#225;rbara Mota, Iva Brito"
        "autores" => array:5 [
          0 => array:4 [
            "nombre" => "Teresa"
            "apellidos" => "Martins-Rocha"
            "email" => array:1 [
              0 => "teresa.asmr@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Jos&#233; Pedro"
            "apellidos" => "Matias"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Margarida"
            "apellidos" => "Vicente Ferreira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "B&#225;rbara"
            "apellidos" => "Mota"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Iva"
            "apellidos" => "Brito"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Rheumatology Department&#44; Centro Hospitalar de S&#227;o Jo&#227;o&#44; Porto&#44; Portugal"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Department of Pediatrics&#44; Centro Hospitalar de S&#227;o Jo&#227;o&#44; Porto&#44; Portugal"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Rheumatology Department&#44; Faculty de Medicine University of Porto &#40;FMUP&#41;&#44; Portugal"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Isquemia digital postinfecciosa infantil tratada con &#233;xito con iloprost"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1112
            "Ancho" => 1867
            "Tamanyo" => 242350
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ischemic lesions at the admission &#40;A&#41;&#44; at the 13th &#40;B&#41; and at the 21st day &#40;C&#41; of therapy with intravenous iloprost&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report a case of a 14-month-old girl&#44; with no relevant pathological history&#44; which presented additive bullous lesions on her hands and feet fingertips&#46; She had no previous burn&#44; trauma or other associated events&#46; One week before&#44; she was diagnosed with Acute Otitis Media and was treated with amoxicillin&#47;clavulanic acid for 8 days&#46; Later on&#44; the fingertip lesions progressively evolved into necrotic lesions and&#44; after two months of the initial presentation&#44; she was observed at our hospital&#46; Objectively&#44; she was afebrile and presented digital plaques of dry necrosis&#44; with edema and redness of the distal end of the affected fingers&#44; without fluctuation or drainage of any content &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Peripheral arterial pulses were symmetric and no vascular or heart bruits were audible&#46; As iloprost has been described to be safe and effective for the treatment of ischemic digits in children&#44; intravenous iloprost &#40;0&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;kg&#47;min for 5 days followed by 0&#46;6<span class="elsevierStyleHsp" style=""></span>ng&#47;kg&#47;min&#41; and acetylsalicylic acid were started&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1-4</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Concerning laboratory studies&#44; she had CRP &#40;50<span class="elsevierStyleHsp" style=""></span>mg&#47;L&#41; and ESR &#40;60<span class="elsevierStyleHsp" style=""></span>mm&#47;1st hour&#41; elevation&#59; negative serologies for EBV&#44; Herpes simplex&#44; CMV&#44; parvovirus and <span class="elsevierStyleItalic">Mycoplasma pneumoniae</span>&#59; negative antistreptolysin O titer and blood cultures&#46; Pro-thrombotic and immunological studies &#40;complement levels&#44; rheumatoid factor&#44; ANA&#44; anti-ENA&#44; anti-dsDNA&#44; ANCA and antiphospholipid antibodies&#41; were unremarkable&#46; Echocardiogram&#44; chest and hands X-rays&#44; and abdominal ultrasound were normal&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">She completed 21 days of iloprost and gradually presented resolution of the fingertip lesions&#46; Considering the previous infection and the diagnostic work-up&#44; we considered the digital ischemia in a probable post-infectious context&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Digital ischemia is described in meningococcal infection&#44; which can present extrameningeal involvement in up to 19&#37; of patients&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a> Additionally&#44; few cases were also reported with other infectious agents&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;6</span></a> Among others&#44; treatment with antiplatelet drugs&#44; topical nitrates and sympathetic blockade is described&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a> Besides our report&#44; favorable response to iloprost was documented in 4 children with post-infectious digital ischemia&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;4&#44;8</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">No specific funding was received from any bodies in the public&#44; commercial or not-for-profit sectors to carry out the work described in this manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:3 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Funding"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Conflicts of interest"
        ]
        2 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2018-04-16"
    "fechaAceptado" => "2018-05-29"
    "multimedia" => array:1 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1112
            "Ancho" => 1867
            "Tamanyo" => 242350
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ischemic lesions at the admission &#40;A&#41;&#44; at the 13th &#40;B&#41; and at the 21st day &#40;C&#41; of therapy with intravenous iloprost&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Iloprost for the treatment of digital ischaemia in pediatric septic shock&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Garcia Soler"
                            1 => "G&#46; Milano Manso"
                            2 => "J&#46;M&#46; Camacho Alonso"
                            3 => "J&#46; Manuel Gonzalez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2011"
                        "volumen" => "136"
                        "paginaInicial" => "695"
                        "paginaFinal" => "696"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Iloprost treatment for refractory Raynaud&#39;s phenomenon in two infants"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46;S&#46; Shouval"
                            1 => "M&#46; Mukamel"
                            2 => "F&#46; Zulian"
                            3 => "J&#46; Amir"
                            4 => "L&#46; Harel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Clin Exp Rheumatol"
                        "fecha" => "2008"
                        "volumen" => "26"
                        "numero" => "3 Suppl 49"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Safety and efficacy of iloprost for the treatment of ischaemic digits in paediatric connective tissue diseases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Zulian"
                            1 => "F&#46; Corona"
                            2 => "V&#46; Gerloni"
                            3 => "F&#46; Falcini"
                            4 => "A&#46; Buoncompagni"
                            5 => "M&#46; Scarazatti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2004"
                        "volumen" => "43"
                        "paginaInicial" => "229"
                        "paginaFinal" => "233"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of prostacyclin &#40;iloprost&#41; in digital vasculitis secondary to meningococcaemia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K&#46; Siddiqui"
                            1 => "A&#46;R&#46; Razak"
                            2 => "B&#46; Kneafsey"
                            3 => "N&#46; Delanty"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/jnnp.2003.024745"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Neurol Neurosurg Psychiatry"
                        "fecha" => "2004"
                        "volumen" => "75"
                        "paginaInicial" => "506"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14966179"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathophysiology&#44; treatment and outcome of meningococcemia&#58; a review and recent experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46;A&#46; Kirsch"
                            1 => "R&#46;P&#46; Barton"
                            2 => "L&#46; Kitchen"
                            3 => "B&#46;P&#46; Giroir"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00006454-199611000-00009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Infect Dis J"
                        "fecha" => "1996"
                        "volumen" => "15"
                        "paginaInicial" => "967"
                        "paginaFinal" => "978"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8933544"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spontaneous pneumothorax with symmetrical digital gangrene -a rare complication of chickenpox"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Singh"
                            1 => "T&#46;R&#46; Khan"
                            2 => "K&#46;P&#46; Kushwaha"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s12098-012-0905-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Pediatr"
                        "fecha" => "2013"
                        "volumen" => "80"
                        "paginaInicial" => "706"
                        "paginaFinal" => "707"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23229917"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do new strategies in meningococcemia produce better outcomes&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "F&#46; Leclerc"
                            1 => "S&#46; Leteurtre"
                            2 => "R&#46; Cremer"
                            3 => "C&#46; Fourier"
                            4 => "A&#46; Sadik"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/00003246-200001000-00003"
                      "Revista" => array:5 [
                        "tituloSerie" => "Crit Care Med"
                        "fecha" => "2000"
                        "volumen" => "28"
                        "numero" => "9 Suppl"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10667493"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute meningococcaemia complicated by late onset gastrointestinal vasculitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;A&#46; Seaton"
                            1 => "D&#46; Nathwani"
                            2 => "J&#46; Dick"
                            3 => "D&#46; Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/jinf.2000.0719"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Infect"
                        "fecha" => "2000"
                        "volumen" => "41"
                        "paginaInicial" => "190"
                        "paginaFinal" => "191"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11023771"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/00000016000005P1/v1_202008141736/S2173574320300976/v1_202008141736/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "5795"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Images in Clinical Rheumatology"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/00000016000005P1/v1_202008141736/S2173574320300976/v1_202008141736/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320300976?idApp=UINPBA00004M"
]
Article information
ISSN: 21735743
Original language: English
The statistics are updated each day
Year/Month Html Pdf Total
2024 November 4 4 8
2024 October 40 28 68
2024 September 45 14 59
2024 August 55 36 91
2024 July 37 31 68
2024 June 51 28 79
2024 May 48 28 76
2024 April 56 27 83
2024 March 33 22 55
2024 February 52 22 74
2024 January 76 33 109
2023 December 30 22 52
2023 November 36 34 70
2023 October 33 18 51
2023 September 75 38 113
2023 August 71 12 83
2023 July 36 16 52
2023 June 35 33 68
2023 May 49 23 72
2023 April 28 4 32
2023 March 46 18 64
2023 February 35 23 58
2023 January 29 14 43
2022 December 49 33 82
2022 November 48 18 66
2022 October 54 25 79
2022 September 38 18 56
2022 August 52 34 86
2022 July 47 40 87
2022 June 33 26 59
2022 May 39 31 70
2022 April 37 36 73
2022 March 68 39 107
2022 February 62 28 90
2022 January 69 30 99
2021 December 40 38 78
2021 November 32 33 65
2021 October 42 36 78
2021 September 41 39 80
2021 August 25 22 47
2021 July 35 21 56
2021 June 23 21 44
2021 May 142 43 185
2021 April 86 100 186
2021 March 27 15 42
Show all

Follow this link to access the full text of the article

Idiomas
Reumatología Clínica (English Edition)
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?