was read the article
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The virus entry, replication, assembly and shedding indicating infectivity are shown at the left, while the right side displays the innate antiviral response characterized by an interferon signature. The center of the figure represents intracellular events unchained by the presence of the virus, driving cell and mitochondrial stress and eventually ending in hypoxic damage. The sites of action of different immunomodulatory drugs are marked. ACE2: angiotensin converting enzyme 2, ANT: adenine nucleotide translocation, CARD: caspase activation and recruitment domains, CQ: chloroquine, CyD: cyclophilin D, ER: endoplasmic reticulum, FK506: tacrolimus, HSR: heat shock response (also unfolded-protein response of the cytosol), IFN: interferon, IRF: interferon regulatory factor, iJAK: inhibitor of Janus kinases, MAS: macrophage activation syndrome, MAVS: mitochondrial antiviral proteins, MDA5: melanoma differentiation-activated protein 5, mtUPR: mitochondrial unfolded-protein response, NFκB: transcriptional activator kappa B, polyA: polyadenylated, PTM: postranslational modifications, RIG-1: retinoic acid inducible gene 1, RLR: RIG-1-like receptors, Th: T helper lymphocytes, TCZ: tocilizumab, vRNA: viral RNA.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Olga Sanchez-Pernaute, Fredeswinda I. 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"apellidos" => "Romero-Bueno" ] 2 => array:2 [ "nombre" => "Albert" "apellidos" => "Selva-O’Callaghan" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321001775?idApp=UINPBA00004M" "url" => "/21735743/0000001700000009/v1_202110300812/S2173574321001775/v1_202110300812/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2173574320301465" "issn" => "21735743" "doi" => "10.1016/j.reumae.2020.04.004" "estado" => "S300" "fechaPublicacion" => "2021-11-01" "aid" => "1410" "copyright" => "Elsevier España, S.L.U. and Sociedad Española de Reumatología y Colegio Mexicano de Reumatología" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Reumatol Clin. 2021;17:554" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Fibromyalgia. 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Viejas opiniones frente a nuevos conocimientos" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio Collado, Javier Rivera, Cayetano Alegre, Benigno Casanueva" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Antonio" "apellidos" => "Collado" ] 1 => array:2 [ "nombre" => "Javier" "apellidos" => "Rivera" ] 2 => array:2 [ "nombre" => "Cayetano" "apellidos" => "Alegre" ] 3 => array:2 [ "nombre" => "Benigno" "apellidos" => "Casanueva" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S1699258X20300759" "doi" => "10.1016/j.reuma.2020.04.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699258X20300759?idApp=UINPBA00004M" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574320301465?idApp=UINPBA00004M" "url" => "/21735743/0000001700000009/v1_202110300812/S2173574320301465/v1_202110300812/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Reply" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "555" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Alejandro Olive Marqués" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Alejandro" "apellidos" => "Olive Marqués" "email" => array:1 [ 0 => "aolive.germanstrias@gencat.cat" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Réplica" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">I am grateful for the interest aroused by the recently published leading article in REUMATOLOGÍA CLÍNICA<span class="elsevierStyleSmallCaps">.</span><a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> I would like to comment on the interesting issues expressed in the recently received elegant letter to the editor.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Several months ago the coordinators of the 2019, 8th edition of Reumatopics proposed that I participate in the roundtable entitled “Fibromyalgia in debate”. The format of this roundtable was standard: one speaker in favour and one against. It was suggested I should be the one against fibromyalgia. I consulted several colleagues about this: some told me to accept, others said not to “entangle myself” in it. I accepted and the roundtable was a success. You may check it out on: portaldelsocio.ser.es/reumatopics19. Afterwards I received appraisal from the roundtable participants: it had been highly praised and what was more important: it extended links between those for and those against fibromyalgia. These links are missing from your letter.</p><p id="par0015" class="elsevierStylePara elsevierViewall">I usually always write my papers. This was what I proposed to the Editorial Committee of REUMATOLOGÍA CLÍNICA. I myself chose the format of the leading article. It is worth recalling that a leading article is a short article which expresses an opinion or interprets the facts of others. The leading article should be brilliant, well argued or course, imperative or conciliatory. It emotionally and intellectually stimulates its readers. It may be the origin of substantial reactions towards controversy and debate. The leading article expresses a personal opinion on the theme. What’s more, I envisaged ideological stances which would transcend mere critical argumentation.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> In my humble opinion the finished leading article met with expectations and I am satisfied that controversy was aroused. The Editorial Committee of REUMATOLOGÍA CLÍNICA is exempt from all responsibility.</p><p id="par0020" class="elsevierStylePara elsevierViewall">You use the word “recovery”. I did not intend to recover anything in the leader. I insist, it is my personal opinion, it is a story of the history of fibromyalgia, exactly as I, and probably many other rheumatologists of my generation, have experienced it. It may be that the concept of psychogenic rheumatism – created by the pioneers of rheumatology – was a mistake, but there can be not the least bit of doubt that without the concept of psychogenic rheumatism, fibromyalgia would not exist today. Numerous examples may be found in the history of medicine.</p><p id="par0025" class="elsevierStylePara elsevierViewall">I regret that you perceive the writer to have scarce knowledge, regarding terminology used. I am not claiming that fibromyalgia is one of my specific areas. I accept your comments regarding nomenclature but not de-authorisation, which I believe to be an inappropriate term.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally, I am very pleased that we agree about the financial cost of fibromyalgia. These data are not open to debate. Healthcare policies carried out have not been successful. Last but not least, it is a duty of the specialists dedicated to fibromyalgia and of the scientific societies to recruit young rheumatologists. In other words, to make rheumatology scientifically appealing. The leader reflects this, as does your learned opinion.</p><p id="par0035" class="elsevierStylePara elsevierViewall">My final point: “<span class="elsevierStyleItalic">All wisdom is not new wisdom”.</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-04-16" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Olive Marqués A. Réplica. Reumatol Clin. 2021;17:555.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La voz pasiva de la fibromialgia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Olive" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.reuma.2019.12.001" "Revista" => array:2 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2020" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibromialgia. Viejas opiniones frente a nuevos conocimientos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Collado" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2020" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "El marco adecuado: tipo de articulo Medicina clínica. En: Manual de estilo. Caldeiro MA, Feliu E, Foz M, Gracia D, Herranz G Lience E, et al. Barcelonan Doyma 1993; p. 15–31." ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "El ingenio de Churchill" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Langworth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "fecha" => "2015" "paginaInicial" => "56" "editorial" => "Plataforma editorial" "editorialLocalizacion" => "Barcelona" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000001700000009/v1_202110300812/S2173574321000678/v1_202110300812/en/main.assets" "Apartado" => array:4 [ "identificador" => "8400" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000001700000009/v1_202110300812/S2173574321000678/v1_202110300812/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574321000678?idApp=UINPBA00004M" ]
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