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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We thank the Editors for allowing us to respond to the letter to the editor about our recently published article in <span class="elsevierStyleItalic">Reumatolog&#237;a Cl&#237;nica</span> titled &#8220;Threshold based on bone mineral density for therapeutic decision-making in postmenopausal women and men over 50 years old under glucocorticoid therapy&#46;&#8221;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In addition&#44; we thank the author of the letter to the editor for his interest in this article&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The PICO questions from Guidelines for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis were developed by a prestigious expert panel on behalf of the three national societies from Argentina linked to bone metabolism and are intended to provide an evidence-based framework to guide health care professionals treating patients under glucocorticoid therapy&#46; The involved societies consider adherence to the recommendations within this guideline to be voluntary&#44; with the decision regarding their application to be made by the physician according to each patient&#39;s circumstances&#46; Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee any specific outcome and cannot adequately all circumstances&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In these guidelines all the authors agreed to stratify the populations in premenopausal women and men<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>50 years&#59; postmenopausal women and men aged 50 and older&#44; and pediatrics&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Dr&#46; Messina refer that &#8220;no modern clinical practice guideline considers the <span class="elsevierStyleItalic">T</span>-score value almost exclusively like this article&#8221;&#46; First&#44; we do not consider the <span class="elsevierStyleItalic">T</span>-score exclusively&#44; we invite you to read our article carefully&#46; Second&#44; many guidelines listed below have historically defined <span class="elsevierStyleItalic">T</span>-score arbitrarily&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#8211;7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Further&#44; the guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis&#58; an update of Brazilian Society of Rheumatology &#40;2020&#41;&#44; recommends for example a <span class="elsevierStyleItalic">T</span>-score for prevention and treatment in men&#58; &#8220;Recommendation&#58; For prevention&#44; we consider a <span class="elsevierStyleItalic">T</span>-score<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#8722;1 SD for men&#44; and for treatment&#44; a <span class="elsevierStyleItalic">T</span>-score<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#8722;1&#46;89 SD is considered &#40;A&#41;&#8221;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">T</span>-score threshold of &#8804;&#8722;1&#46;7 by DXA&#44; was not arbitrarily chosen&#44; as was described in methodology section&#46; But is important to highlight that this article only consider the methodological procedure that explain why <span class="elsevierStyleItalic">T</span>-score<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>1&#46;7 was chosen as threshold based on BMD for therapeutic decision-making in postmenopausal women and men over 50 years old under glucocorticoid therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> In the Guidelines previously published you can find all the reasons &#8211; including FRAX &#8211; explained in detail&#44; beyond the densitometric threshold&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Finally&#44; we did not include some references because&#44; as the author of the editor&#39;s letter should have noted&#44; the guideline included systematic literature searches up to October 2020&#46; The articles mentioned as not quoted were published after &#40;Pereira RMR&#44; et al&#46; Arch Osteoporos&#46; 2021 Mar 1&#59;16&#40;1&#41;&#58;49 and Messina OD&#44; et al&#46; Aging Clin Exp Res&#46; 2022 Nov&#59;34&#40;11&#41;&#58;2591&#8211;2602&#41;&#46; Further&#44; the article by Messina OD was published after &#40;2022 November&#41; we submitted our article &#40;2022 August&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">We respect the opinion&#44; but it should be noted that the published guidelines and recommendations were developed by a group of experts on behalf of the three national scientific societies linked to bone metabolism&#58; AAOMM &#40;Argentinean Association of Osteology and Mineral Metabolism&#41;&#44; SAO &#40;Argentinean Osteoporosis Society&#41; and SAR &#40;Argentinean Rheumatology Society&#41;&#46; In addition&#44; the guidelines were carried out according to GRADE methodology&#44; they were submitted to external review by prestigious experts in bone diseases&#44; in addition to peer review carried out by each journal&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contribution</span><p id="par0050" class="elsevierStylePara elsevierViewall">All authors read&#44; discussed&#44; and approved the final manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">No conflicts of interest&#46;</p></span></span>"
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Letter to the Editor
Response to Letter to the Editor: Thresholds based on bone mineral density for therapeutic decision-making in postmenopausal women and men older than 50 years old under glucocorticoid therapy
Respuesta carta al editor: Umbrales densitométricos de densidad mineral ósea para considerar tratamiento en pacientes mujeres postmenopáusicas y hombres mayores de 50 años en tratamiento con glucocorticoides
María Lorena Brancea,b,c,
Corresponding author
lorenabrance@gmail.com

Corresponding author.
, María Silvia Larroudéd, Luis Fernando Sommae, Luis Agustín Ramirez Stiebena,b,f, Lucas R. Brunb,c
a Reumatología y Enfermedades Óseas, Rosario, Argentina
b Bone Biology Laboratory, School of Medicine, Rosario National University, Argentina
c National Council of Scientific and Technical Research (CONICET), Argentina
d Centro Rossi, Buenos Aires, Argentina
e Consultorio de Reumatologia y Osteoporosis, Lujan, Argentina
f Hospital Privado de Rosario (Grupo Gamma), Rosario, Argentina
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        "titulo" => "Respuesta carta al editor&#58; Umbrales densitom&#233;tricos de densidad mineral &#243;sea para considerar tratamiento en pacientes mujeres postmenop&#225;usicas y hombres mayores de 50 a&#241;os en tratamiento con glucocorticoides"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We thank the Editors for allowing us to respond to the letter to the editor about our recently published article in <span class="elsevierStyleItalic">Reumatolog&#237;a Cl&#237;nica</span> titled &#8220;Threshold based on bone mineral density for therapeutic decision-making in postmenopausal women and men over 50 years old under glucocorticoid therapy&#46;&#8221;</p><p id="par0010" class="elsevierStylePara elsevierViewall">In addition&#44; we thank the author of the letter to the editor for his interest in this article&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The PICO questions from Guidelines for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis were developed by a prestigious expert panel on behalf of the three national societies from Argentina linked to bone metabolism and are intended to provide an evidence-based framework to guide health care professionals treating patients under glucocorticoid therapy&#46; The involved societies consider adherence to the recommendations within this guideline to be voluntary&#44; with the decision regarding their application to be made by the physician according to each patient&#39;s circumstances&#46; Guidelines and recommendations are intended to promote beneficial or desirable outcomes but cannot guarantee any specific outcome and cannot adequately all circumstances&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">In these guidelines all the authors agreed to stratify the populations in premenopausal women and men<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>50 years&#59; postmenopausal women and men aged 50 and older&#44; and pediatrics&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Dr&#46; Messina refer that &#8220;no modern clinical practice guideline considers the <span class="elsevierStyleItalic">T</span>-score value almost exclusively like this article&#8221;&#46; First&#44; we do not consider the <span class="elsevierStyleItalic">T</span>-score exclusively&#44; we invite you to read our article carefully&#46; Second&#44; many guidelines listed below have historically defined <span class="elsevierStyleItalic">T</span>-score arbitrarily&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">3&#8211;7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Further&#44; the guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis&#58; an update of Brazilian Society of Rheumatology &#40;2020&#41;&#44; recommends for example a <span class="elsevierStyleItalic">T</span>-score for prevention and treatment in men&#58; &#8220;Recommendation&#58; For prevention&#44; we consider a <span class="elsevierStyleItalic">T</span>-score<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#8722;1 SD for men&#44; and for treatment&#44; a <span class="elsevierStyleItalic">T</span>-score<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>&#8722;1&#46;89 SD is considered &#40;A&#41;&#8221;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">T</span>-score threshold of &#8804;&#8722;1&#46;7 by DXA&#44; was not arbitrarily chosen&#44; as was described in methodology section&#46; But is important to highlight that this article only consider the methodological procedure that explain why <span class="elsevierStyleItalic">T</span>-score<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>1&#46;7 was chosen as threshold based on BMD for therapeutic decision-making in postmenopausal women and men over 50 years old under glucocorticoid therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> In the Guidelines previously published you can find all the reasons &#8211; including FRAX &#8211; explained in detail&#44; beyond the densitometric threshold&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Finally&#44; we did not include some references because&#44; as the author of the editor&#39;s letter should have noted&#44; the guideline included systematic literature searches up to October 2020&#46; The articles mentioned as not quoted were published after &#40;Pereira RMR&#44; et al&#46; Arch Osteoporos&#46; 2021 Mar 1&#59;16&#40;1&#41;&#58;49 and Messina OD&#44; et al&#46; Aging Clin Exp Res&#46; 2022 Nov&#59;34&#40;11&#41;&#58;2591&#8211;2602&#41;&#46; Further&#44; the article by Messina OD was published after &#40;2022 November&#41; we submitted our article &#40;2022 August&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">We respect the opinion&#44; but it should be noted that the published guidelines and recommendations were developed by a group of experts on behalf of the three national scientific societies linked to bone metabolism&#58; AAOMM &#40;Argentinean Association of Osteology and Mineral Metabolism&#41;&#44; SAO &#40;Argentinean Osteoporosis Society&#41; and SAR &#40;Argentinean Rheumatology Society&#41;&#46; In addition&#44; the guidelines were carried out according to GRADE methodology&#44; they were submitted to external review by prestigious experts in bone diseases&#44; in addition to peer review carried out by each journal&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors&#8217; contribution</span><p id="par0050" class="elsevierStylePara elsevierViewall">All authors read&#44; discussed&#44; and approved the final manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">No conflicts of interest&#46;</p></span></span>"
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