TY - JOUR T1 - Syphilis in the setting of anti-tumor necrosis factor alpha therapy JO - Reumatología Clínica (English Edition) T2 - AU - Iglesias-Plaza,Ana AU - Iglesias-Sancho,Maribel AU - Quintana-Codina,Mónica AU - García-Miguel,Javier AU - Salleras-Redonnet,Montse SN - 21735743 M3 - 10.1016/j.reumae.2019.03.001 DO - 10.1016/j.reumae.2019.03.001 UR - https://reumatologiaclinica.org/en-syphilis-in-setting-anti-tumor-necrosis-articulo-S2173574319300371 AB - Inhibitors of tumor necrosis factor-alpha (anti-TNF-alpha) are widely used in different medical specialties. The main adverse effect of these agents is the increased risk of infection. We report the case of a 30-year-old man with ankylosing spondylitis who had begun receiving golimumab two weeks earlier. He presented with a 10-day history of salmon-colored lesions on trunk, palms and soles. The clinical suspicion was secondary syphilis. Treponemal and nontreponemal tests confirmed the diagnosis of syphilis. Lumbar puncture was also performed, although there was no neurological involvement, to rule out neurosyphilis. Cases of syphilis in patients in treatment with TNF-alpha inhibitors are uncommon in the literature and there are no established protocols. ER -