TY - JOUR T1 - Is obesity a predictor for lack of response to treatment in psoriatic arthritis? A systematic review JO - Reumatología Clínica (English Edition) T2 - AU - Gratacós,Jordi AU - Galíndez,Eva AU - Otón,Teresa SN - 21735743 M3 - 10.1016/j.reumae.2019.06.003 DO - 10.1016/j.reumae.2019.06.003 UR - https://reumatologiaclinica.org/en-is-obesity-predictor-for-lack-articulo-S2173574320300198 AB - ObjectivesTo update the study of the association between obesity and treatment response in psoriatic arthritis. MethodsUpdating a systematic review of clinical trials, prospective or retrospective longitudinal studies and case–control studies in psoriatic arthritis in which obesity was assessed as a predictor of efficacy or toxicity. Risks of bias were assessed with validated scales. A meta-analysis of the results of studies with similar outcome variables and weight measurements was performed. ResultsTwenty-one studies were included (6 review of clinical trials, 6 longitudinal studies, 7 registers and one case–control studie), with moderate quality. The risk of achieving an ACR20 response if weight≥100kg was estimated at OR=1.42 (1–2.08) and that of withdrawing treatment in an OR of 1.60 (95% CI: 1.34–1.92). ConclusionsThere seems to be a greater risk of withdrawal of treatment due to inefficacy and difficulty in achieving remission in patients with psoriatic arthritis if they are obese. ER -