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Original Article
DOI: 10.1016/j.reumae.2021.02.006
Available online 16 September 2021
Hospitalization and mortality from COVID-19 of patients with rheumatic inflammatory diseases in Andalusia
Hospitalizaciones y mortalidad por COVID-19 en pacientes con enfermedades inflamatorias reumáticas en Andalucía
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Natalia Mena-Vázqueza,b, Sara Manrique Arijaa,b,
Corresponding author
sarama_82@hotmail.com

Corresponding author.
, Marta Rojas-Giménezc,d, Enrique Raya-Álvareze, María Luisa Velloso-Feijoóf, C. López-Medinac,d, Consuelo Ramos-Giraldezf, Francisco Javier Godoy-Navarretea,b, Rocío Redondo-Rodrígueza,b, Alba María Cabezas-Lucenaa,b, M. Morales-Águilaa,b, C.M. Romero-Barcoa,g, Antonio Fernández-Nebroa,b,h
a Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain
b UGC de Reumatología, Hospital Regional Universitario de Málaga, Málaga, Spain
c Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain
d Hospital Universitario Reina Sofía de Córdoba, Córdoba, Spain
e Hospital Universitario San Cecilio, Granada, Spain
f Hospital Virgen De Valme, Sevilla, Spain
g Hospital Universitario Virgen de la Victoria de Málaga, Málaga, Spain
h Departamento de Medicina, Universidad de Málaga, Málaga, Spain
Received 20 November 2020. Accepted 18 February 2021
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Tables (5)
Table 1. Characteristics of the patients with RID-COVID-19 and controls with COVID-19.
Table 2. Multivariate analysis of hospitalisation in patients with COVID-19.
Table 3. Multivariate analysis of mortality in COVID-19 patients.
Table 4. Multivariate analysis of hospitalisation in patient with RD and COVID-19.
Table 5. Multivariate analysis of mortality in patients with RD and COVID-19.
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Abstract
Objective

To describe whether rheumatic inflammatory diseases (RID) are associated with a higher risk of hospitalization and/or mortality from COVID-19 and identify the factors associated with hospitalization and mortality in RID and COVID-19 in different Hospitals in Andalusia.

Methods

Design: Multicentre observational case-COntrol study. Patients: RID and COVID-19 from different centres in Andalusia. Controls: patients without RIS matched by sex, age and CRP-COVID.

Protocol A list of patients with PCR for COVID-19 was requested from the microbiology service from March 14 to April 14, 2020. The patients who had RID were identified and then consecutively a paired control for each case.

Variables The main outcome variable was hospital admission and mortality from COVID-19.

Statistical analysis Bivariate followed by binary logistic regression models (DV: mortality/hospital admission).

Results

One hundred and fifty-six patients were included, 78 with RID and COVID-19 and 78 without RID with COVID-19. The patients did not present characteristics of COVID-19 disease different from the general population, nor did they present higher hospital admission or mortality. The factor associated with mortality in patients with RID was advanced age (OR [95% CI], 1.1 [1.0–1.2]; P= .025), while the factors associated with hospitalization were advanced age (OR [95% CI], 1.1 [1.0–1.1]; P = .007) and hypertension (OR [95% CI], 3.9 [1.5–6.7]; P = .003).

Conclusion

Mortality and hospital admission due to COVID-19 do not seem to increase in RID. Advanced age was associated with mortality in RID and, in addition, HTN was associated with hospital admission.

Keywords:
Rheumatic inflammatory disease
COVID-19
Hospitalization
Mortality
Resumen
Objetivo

Describir si las enfermedades inflamatorias reumáticas (EIR) se asocian con mayor riesgo de hospitalización y/o mortalidad por COVID-19 e identificar los factores asociados a la hospitalización y mortalidad en EIR y COVID-19 en diferentes hospitales de Andalucía.

Métodos

Diseño: Estudio multicéntrico observacional de casos y controles. Pacientes Casos: EIR y COVID-19 de diferentes centros de Andalucía. Controles: pacientes sin EIR pareados por sexo, edad y PCR-COVID.

Protocolo Se solicitó al Servicio de Microbiología un listado de pacientes con PCR para COVID-19 desde 14 de marzo al 14 de abril de 2020. Se identificaron los pacientes que tuvieran EIR y luego consecutivamente un control pareado para cada caso.

Variables La variable de desenlace principal fue ingreso hospitalario y mortalidad por COVID-19.

Análisis estadístico Bivariante seguida de modelos de regresión logística binaria (variable dependiente: mortalidad/ingreso hospitalario).

Resultados

Se incluyeron 156 pacientes con COVID-19, 78 con EIR y 78 sin EIR. Los pacientes con EIR no presentaron características de la enfermedad COVID-19 diferentes a la población general, tampoco mayor ingreso hospitalario ni mortalidad. El factor asociado con mortalidad en los pacientes con EIR fue edad (OR [IC 95%], 1,1 [1,0–1,2]; p = 0,025), mientras que los factores asociados con ingreso hospitalario fueron edad (OR [IC 95%], 1,1 [1,1–1,2]; p = 0,007) e hipertensión arterial (OR [IC 95%], 3,9 [1,5–6,7]; p = 0,003).

Conclusión

La mortalidad y el ingreso hospitalario por COVID-19 no parecen aumentados en las EIR. La edad se asoció con mortalidad en EIR y, además, la hipertensión arterial se asoció con ingreso hospitalario.

Palabras clave:
Enfermedad inflamatoria reumática
COVID-19
Hospitalización
Mortalidad

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