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Vol. 1. Issue 1.
Pages 52-55 (May - June 2005)
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Vol. 1. Issue 1.
Pages 52-55 (May - June 2005)
Caso clínico
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Vasculitis asociadas a ANCA en artritis reumatoide. Descripción de un caso de poliangeitis microscópica y otro de enfermedad de Wegener
Vasculitis associated with anti-neutrophil cytoplasmic autoantibodies in rheumatoid arthritis. Report of a case of microscopic polyangiitis and another case of Wegener’s granulomatosis
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A. Ruiz-Zorrilla, M. Picazo, I. González-Álvaro, R. Gómez-Gil, R. García de Vicuña??
Corresponding author
vicuna1@mi.madritel.es

Correspondencia: Dra. R. García de Vicuña. Servicio de Reumatología. Hospital Universitario de la Princesa. UAM. Diego de León, 62. 28006 Madrid. España.
Servicio de Reumatología. Hospital Universitario de la Princesa. UAM. Madrid. España
Article information

La vasculitis es una complicación infrecuente de la arthritis reumatoide que se asocia con un aumento claro de la morbimortalidad, aunque son muy raras las manifestaciones sistémicas como glomerulonefritis, vasculitis cerebral o vasculitis pulmonar. A su vez, las vasculitis sistémicas con afectación renal se asocian en menos del 5% a poliartritis franca y la asociación con artritis reumatoide es excepcional. La determinación de los anticuerpos anticitoplasma de neutrófilo (ANCA), utilizados en el contexto clínico apropiado, se ha convertido en una importante herramienta diagnóstica de las vasculitis sistémicas de pequeño vaso. Presentamos 2 pacientes diagnosticados de artritis reumatoide que posteriormente desarrollaron vasculitis sistémica, en los que la determinación de ANCA fue decisiva en el diagnóstico precoz.

Palabras clave:
Artritis reumatoide
Vasculitis
ANCA

Vasculitis is an uncommon complication of rheumatoid arthritis that is associated with a clear increase in morbidity and mortality, although systemic manifestations such as glomerulonephritis, cerebral vasculitis or pulmonary vasculitis are very rare. Systemic vasculitis with renal involvement is associated with overt polyarthritis in less than 5% and association with rheumatoid arthritis is exceptional. Determination of anti-neutrophil cytoplasmic autoantibodies (ANCA), used in the appropriate clinical context, has become an important diagnostic tool in small-vessel systemic vasculitides. We present two patients with rheumatoid arthritis who subsequently developed systemic vasculitis. ANCA determination was decisive in the early diagnosis of these patients.

Key words:
Rheumatoid arthritis
Vasculitis,
ANCA
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Copyright © 2005. Elsevier España S.L. Barcelona
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Reumatología Clínica (English Edition)

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