TY - JOUR T1 - Clinical phenotype and outcome in lupus according to age: a comparison between juvenile and adult onset JO - Reumatología Clínica T2 - AU - Fonseca,Rita AU - Aguiar,Francisca AU - Rodrigues,Mariana AU - Brito,Iva SN - 1699258X M3 - 10.1016/j.reuma.2016.10.011 DO - 10.1016/j.reuma.2016.10.011 UR - https://reumatologiaclinica.org/es-clinical-phenotype-outcome-in-lupus-articulo-S1699258X16301565 AB - ObjectiveTo study differences in demographic, clinical and immunologic characteristics, activity and cumulative organ damage according to age of onset in systemic lupus erythematosus (SLE). MethodsCross-sectional study was performed including 204 SLE patients. Characteristics were compared between juvenile and adult-onset SLE patients using parametric and nonparametric tests (SPSS 23.0). ResultsJuvenile-SLE patients had malar rash more often (78.9% vs 53%; p=0.001), oral ulcers (45.5% vs 17.5%; p=0.001), neurological involvement (13.1% vs 3.6%; p=0.02) nephritis (50% vs 33.9%), p=0.04) and haematological manifestations such as hemolytic anaemia (23.6% vs 5.4%; p=0.002) and leukopenia (46.1% vs 4.2%; p<0.001). Arthritis was more prevalent in adult-onset patients (70.9% vs 90%; p<0.04). Overall, 20% of juvenile patients had chronic damage (Systemic Lupus International Collaborating Clinics/Damage Index [SLICC/DI]≥1), However, the percentage of patients with irreversible damage was higher in the adult SLE patient group (24%, p=0.04). No statistically significant differences were found in other characteristics studied. ConclusionIn summary, our study confirms the existence of differences in clinical manifestations, according to age at diagnosis of SLE. Juvenile-SLE patients showed a more aggressive clinical presentation. ER -