TY - JOUR T1 - The HLA-B*51 Allele is strongly associated with Behçet Disease in an Argentinean population JO - Reumatología Clínica T2 - AU - Muñoz,Sebastián Andrés AU - Orden,Alberto Omar AU - Kostianovsky,Alex AU - Pisoni,Cecilia N. AU - Scolnik,Marina AU - Luissi,Aurelia AU - Bottinelli,Yanina AU - Vijoditz,Gustavo AU - Garcia,Mercedes AU - Pena,Claudia AU - Pera,Mariana AU - Rillo,Oscar AU - Alvarellos,Teresita AU - Más,Luciana M. AU - Trunzo,Arturo Luis AU - Allievi,Alberto SN - 1699258X M3 - 10.1016/j.reuma.2018.07.002 DO - 10.1016/j.reuma.2018.07.002 UR - https://reumatologiaclinica.org/es-the-hla-b51-allele-is-strongly-articulo-S1699258X18301347 AB - ObjectiveTo assess the association between the HLA-B*51 allele and Behçet Disease (BD) in Argentinean patients. MethodsWe enrolled 34 consecutive Argentinean patients with definitive diagnosis of BD between October 2016 and March 2017. None of the patients had the HLA-B*51 allele determined at study entry. Unrelated controls (n=240) were randomly obtained from the national cadaveric donor database. Demographic and clinical features of the patients were recorded by attending physicians through a questionnaire. ResultsMean age of cases was 42 years old. Nineteen (55.8%) were male, and the mean age at diagnosis was 35 years old; twenty (58.8%) were Mestizos, 8 (23.5%) were Caucasian, and 6 (17.6%) were Amerindians. Thirteen (38.2%) of 34 cases were HLA-B*51 allele positive; 11 were heterozygous and 2 homozygous for the allele. Thirty-four (14.2%) of 240 controls were positive for the HLA-B*51 allele. The association between BD and HLA-B*51 allele was greater than that of control group (OR=3.75; p=0.0012). ConclusionsThe HLA-B*51 allele is strongly associated with BD in Argentinean patients. Our finding is consistent with previous studies indicating that the HLA-B*51 allele is an important susceptibility gene in BD regardless the geographical region and ethnicity. ER -