TY - JOUR T1 - AA amyloidosis associated with morbid obesity (clinical case) JO - Reumatología Clínica T2 - AU - Beridze Vaktangova,Nana AU - García Moreira,Vanesa AU - García Castañón,Sandra AU - Rodríguez Aguilar,Raúl AU - Domínguez Iglesias,Francisco SN - 1699258X M3 - 10.1016/j.reuma.2018.09.001 DO - 10.1016/j.reuma.2018.09.001 UR - https://reumatologiaclinica.org/es-aa-amyloidosis-associated-with-morbid-articulo-S1699258X18301967 AB - We present the case of a 45-year-old woman who was hospitalized due to severe macrocytic anemia and renal failure. The patient presented a morbid obesity.The immunological study showed anti-ENA anti-SSA (Ro52) positive, with negative antinuclear antibodies. Also in the proteinogram (serum immunofixation) the presence of monoclonal bands IgG lambda and IgG kappa, monoclonal component 7.2% (4.68g/L), with elevation of free light chains (kappa 95.94mg/L (3.3–19.4), evidenced, lambda 145.17mg/L (5.71–26.3)).The bone marrow study showed an infiltration of 5% of plasma cells and positive for AA amyloid. Finally, a percutaneous renal biopsy was performed, which again showed amyloid infiltration.In the genetic study, 2 mutations of the family Mediterranean fever gene (MEFV) have been identified.Secondary AA amyloidosis has been described associated with obesity, in addition to a percentage of cases of unknown etiology. ER -