Elsevier

Clinics in Chest Medicine

Volume 31, Issue 3, September 2010, Pages 479-488
Clinics in Chest Medicine

Pulmonary Manifestations of Systemic Lupus Erythematosus

https://doi.org/10.1016/j.ccm.2010.05.001Get rights and content

Section snippets

Epidemiology and risk factors

Susceptibility to SLE has a genetic component, and familial clustering of cases is seen. From 5% to 12% of first-degree relatives of SLE patients will themselves develop the disease during their lifetime. Several susceptibility loci as well as specific gene polymorphisms have been identified, although the relationships are complex and vary by ethnicity.7 Not all studies of SLE-related genetic markers have looked separately at lung involvement; but among those that have, both protective

Pleural Disease

More so than in any other connective tissue disease, the pleura is often involved in patients with SLE. Approximately 30% to 50% of patients with SLE will develop symptomatic pleural inflammation over the course of their disease, and a larger number if asymptomatic effusions are included.10, 11 In 5% to 10% of patients, pleuritis is an initial manifestation of their SLE.12 The typical presentation of pleural involvement in SLE is sharp chest pain with a deep breath (pleurisy). Nonpleuritic

Summary

Pulmonary disease may complicate SLE and is an important cause of morbidity and mortality. Early detection of pulmonary disease in a patient with SLE is of importance because therapy ranges from aggressive immunosuppression for lupus pneumonitis, to anticoagulation for antiphospholipid antibody syndrome, to lowering immunosuppression while starting antimicrobial therapy in settings where infection is the culprit. Treatment strategies for pulmonary disease in SLE are based on limited data

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