Elsevier

Clinical Nutrition

Volume 34, Issue 2, April 2015, Pages 189-194
Clinical Nutrition

Review
Non coeliac gluten sensitivity – A new disease with gluten intolerance

https://doi.org/10.1016/j.clnu.2014.08.012Get rights and content
Under a Creative Commons license
open access

Summary

Until recently gluten intolerance has been believed to be typical of celiac disease (CD) and wheat allergy (WA). In the last few years, however, several study results have been published that have proved that gluten intolerance can also affect people who do not suffer from any of the above mentioned diseases. The new syndrome has been named non-celiac gluten sensitivity (NCGS) or gluten sensitivity (GS). It has been included in the new list of gluten-related disorders published in 2012. Researchers believe that NCGS is the most common syndrome of gluten intolerance. This review discusses many aspects of NCGS epidemiology, pathophysiology, clinical spectrum, and treatment and current tools to identify patients suffering from CD, WA, and NCGS.

Keywords

Non-celiac gluten sensitivity
Gluten sensitivity
Gluten intolerance
Gluten-related disorders
Celiac disease
Gluten-free diet

Abbreviations

AGA
antigliadin antibodies
ASD
autism spectrum disorders
CD
celiac disease
DGP
deamidated gliadin peptide
EMA
endomysium antibodies
GFCF
gluten-free casein free
GFD
gluten-free diet
GS
gluten sensitivity
IBS
irritable bowel syndrome
NCGS
non-celiac gluten sensitivity
tTG
transglutaminase antibodies
WA
wheat allergy

Cited by (0)