Liver transplantationComplicationsThe Significance of Antiphospholipid Antibodies in Liver Recipients
Section snippets
Materials and Methods
We examined 33 Caucasian recipients of deceased-donor liver transplantation including 21 women and 12 men who displayed stable graft function. Their overall mean age was 44.7 ± 14.1 years. The mean interval between liver transplantation and beginning the study (assessment 1) was 33.9 ± 27.5 months and the mean interval between historical thrombosis (thrombosis 1) and assessment 1 was 38.6 ± 36.5 months. A subgroup of patients was identified who were free of a history of significant thrombotic
Results
The prevalence of APLAs in liver transplant patients was higher than that in the general population, ranging from 0% to 25% depending on the APLA type. The most common antibodies were anti-β2GPI IgM antibodies (21.21% at assessment 1 and 25% at assessment 2; Table 1). When we compared the prevalence of individual APLA types, we noticed a significant difference in aCL between the T(−) and T(+) subgroup at assessment 1 (P = .0183). This finding was not, however, confirmed at assessment 2 6 months
Discussion
APLAs in liver transplant patients have been the subject of isolated reports in the literature.4 According to the most recent data, aCL are observed among 8.5% of liver transplant patients.1 Collier et al reported a 6.3% prevalence of aCL IgG among all liver transplant patients and 8.8% among those who develop HAT.5 According to other authors, high APLA levels in patients awaiting liver transplantation return to normal as early as 1 month following liver transplantation.4 In our study, the
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Prevalence of Antiphospholipid Antibody Positivity and Association of Pretransplant Lupus Anticoagulant Positivity With Early Allograft Dysfunction in Liver Transplantation
2018, Transplantation ProceedingsCitation Excerpt :The prevalence of aPL in the general population was reported to be 1% to 5% [10]. In a recent study, the prevalence of anti-β2GPI IgM and aCL IgG antibodies was reported to be 25% and 15.6%, respectively, in 33 recipients who underwent OLT [11]. However, the prevalence of aPL positivity was derived from relatively small studies on patients who underwent OLT.
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