Proceedings of the XVIIth World Congress of the Transplantation SocietyAntiphospholipid antibody syndrome and posttransplant renal thrombosis☆
Section snippets
Materials and methods
During the study period of June 1995 till December 1996, a total of 174 patients (88 males, 86 females) awaiting either primary or retransplantation was included in this study. The following two criteria were used to determine if a patient had APAS. The first included a history of clotting disorders, including one or more of the following: (1) biopsy–established microrenal angiopathy, (2) >2 episodes of A–V shunt thrombosis, (3) cerebrovascular thrombosis, (4) thrombocytopenia, and/or (5)
Results
Of the 174 patients awaiting kidney transplantation, 78 received their transplants during the study period. The transplanted kidneys were from either cadaveric or living donors. The donor specific compatibility for recipients of primary transplants were determined by negative T cell flow cytometry21 and T cell (AHG) and B cell cytotoxicity crossmatches,20 whereas the donor specific compatibility for regraft recipients were determined by an additional assay—viz, the negative skin crossmatch
Discussion
The data supported the hypothesis that ESRD patients with antiphospholipid antibody syndrome are at high risk for the development of posttransplant renal thrombosis. These results are statistically highly significant (P < .0001). Since circulating ACA is central to the definition of APAS, our patients’ sera were further tested to determine if a specific isotype of ACA was associated with posttransplant renal thrombosis. ACA of either isotype (ie, IgG or IgM) was associated with posttransplant
References (28)
Blood
(1994)- et al.
Immunology Today
(1986) - et al.
J Lab Clin Med
(1963) - et al.
Arch Intern Med
(1977) - Bick RL. In: Disorders of Thrombosis and Hemostatis: Clinical and Laboratory Practice. Chicago: ASCP Press; 1992:...
- et al.
Am J Hematol
(1986) - et al.
Clin Exp Immunol
(1987) - et al.
Prog Hemostas Thromb
(1982) - et al.
Ann Intern Med
(1979) Br J Hematol
(1990)
Postgrad Med J
J Rheumatol
Am Soc Clin Pathol Pres Hemostasis Thrombosis
J Rheumatol
Cited by (13)
Antiphospholipid antibodies and renal transplant: A systematic review and meta-analysis
2019, Seminars in Arthritis and RheumatismCitation Excerpt :Because the articles included in the meta-analysis expressed aPL in ways that made it difficult to extract or utilise data separately, we arbitrarily combined all aPL together, regardless of isotype and specificity, unless indicated in the relevant result section. The diagnosis of allograft thrombosis was consistently biopsy proven [11,14,15,23,25–31] and occasionally supported by renal ultrasound or radionuclide scanning before biopsy [18]. Two specific studies defined non allograft thrombosis as de novo coronary artery disease, cerebrovascular disease, peripheral vascular disease post renal allograft transplant [17,22].
Management of end-stage renal disease patients with antiphospholipid antibody syndrome
2005, Transplantation ProceedingsAntiphospholipid antibodies: Discovery, definitions, detection and disease
2003, Progress in Lipid ResearchAntiphospholipid antibodies: Risk assessments for solid organ, bone marrow, and tissue transplantation
2001, Rheumatic Disease Clinics of North America
- ☆
Supported in part by Mimmi Halley Smith Trust.