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Available online 5 August 2024
Efficacy of psychological interventions to reduce anxiety and depression in patients with lupus. A systematic review and meta-analysis
Eficacia de las intervenciones psicológicas para reducir la ansiedad y depresión en pacientes con lupus. Una revisión sistemática y metaanálisis
Jose Luis Vicente-Escudero
Psychological Instrumentation Unit (SUIP), Biosanitary Research Service (SIB), Scientific and Technical Research Area (ACTI), University of Murcia (UMU), Spain
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Tables (4)
Table 1. Description of the characteristics of the studies included in the meta-analysis.
Table 2. Analysis of the methodological quality of the studies included in the meta-analysis.
Table 3. Overall effect size, by intervention modality and by individual studies included in the meta-analysis.
Table 4. Meta-regression analysis.
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Abstract

The presence of anxiety and depression symptoms in patients with lupus is common, and some research reports that psychological interventions can reduce them, therefore we conducted a systematic review and meta-analysis of the efficacy of psychological interventions in adults with systemic lupus erythematosus. Randomized and non-randomized clinical trials with adult population diagnosed with lupus, treated with psychological intervention, and compared with similar groups were selected. Several databases were searched in July 2023. Fourteen studies were included in the meta-analysis, with moderate effect sizes for anxiety and depression in group intervention modalities. Factors such as percentage of sample with lupus, gender, medication, and interventions with relaxation components influenced the results. Group psychological intervention programs are effective in reducing symptoms in patients with lupus, although further research on treatment modulating variables is needed.

Keywords:
Psychological intervention
Lupus
Anxiety
Depression
Meta-analysis
Resumen

La presencia de síntomas de ansiedad y depresión en pacientes con lupus es común, y algunas investigaciones informan que las intervenciones psicológicas pueden reducirlos, por ello se realizó una revisión sistemática y un metaanálisis de la eficacia de las intervenciones psicológicas en adultos con lupus eritematoso sistémico. Se seleccionaron ensayos clínicos aleatorizados y no aleatorizados con población adulta diagnosticada de lupus, tratados mediante intervención psicológica, y se compararon con grupos similares. Se buscó en diversas bases de datos en julio de 2023. Se incluyeron 14 estudios en el metaanálisis con tamaños de efecto moderados para la ansiedad y la depresión en modalidades de intervención grupales. Factores como el porcentaje de muestra con lupus, el género, la medicación y las intervenciones con componentes de relajación influyeron en los resultados. Los programas grupales de intervención psicológica son efectivos para reducir los síntomas en pacientes con lupus, aunque se necesitan más investigaciones sobre variables moduladoras del tratamiento.

Palabras clave:
Intervención psicológica
Lupus
Ansiedad
Depresión
Metaanálisis

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