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Vol. 19. Issue 3.
Pages 168-170 (March 2023)
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Vol. 19. Issue 3.
Pages 168-170 (March 2023)
Case report
CLIPPERS Syndrome After Vaccination. An Unusual ASIA Presentation
Síndrome de CLIPPERS posterior a vacunación. Una presentación inusual de ASIA
Juan Saénz-Silvaa, Alberto Ordinola Navarrob,
Corresponding author

Corresponding author.
a Department of Neurology, Hospital de Especialidades «Dr. Antonio Fraga Mouret»,Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
b Department of Internal medicine, Hospital de Especialidades «Dr. Antonio Fraga Mouret», Centro Médico Nacional La Raza del Instituto Mexicano del Seguro Social, Mexico City, Mexico
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The chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) and autoimmune/inflammatory syndrome induced by adjuvants (ASIA) were described a decade ago. There are a limited number of reports and these diseases are still underdiagnosed.

We presented a 35 years-old patient with clinical manifestations of cerebellum affection and enhancement in the MRI, with the influenza vaccine as the only triggering factor.

Infectious diseases, malignancy, and additional systemic involvement were ruled out; therefore, on suspicion of CLIPPERS syndrome, the patient received corticosteroid therapy with an adequate response.

The knowledge of CLIPPERS syndrome as an unusual ASIA presentation and high response to the corticosteroids may lead to a timely diagnosis, appropriate treatment, and follow up with better outcomes for patients.

Neurology manifestations
Vaccine-related event

La inflamación linfocítica crónica con realce perivascular pontino que responde a los esteroides (CLIPPERS) y el síndrome autoinmune/inflamatorio inducido por adyuvantes (ASIA) se describieron hace una década. Hay un número limitado de reportes y estas enfermedades aún están infra diagnosticadas.

Presentamos un paciente de 35 años con cuadro clínico de afectación del cerebelo y realce en la RM, con la vacuna anti-influenza como único factor desencadenante.

Se descartaron enfermedades infecciosas, malignidad y afectación sistémica, por lo tanto, ante sospecha de síndrome de CLIPPERS, recibió tratamiento con corticoesteroides con una respuesta adecuada.

El conocimiento del síndrome de CLIPPERS como una presentación inusual de ASIA y su alta respuesta a los corticosteroides puede conducir a un diagnóstico oportuno, un tratamiento adecuado y un seguimiento con mejores resultados para los pacientes.

Palabras clave:
Manifestaciones neurológicas
Eventos relacionados a vacunación


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