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Vol. 20. Issue 9.
Pages 459-462 (November 2024)
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Vol. 20. Issue 9.
Pages 459-462 (November 2024)
Original Article
Fibromyalgia with elevated rheumatoid factor is associated with poor therapeutic response but not with progression to rheumatoid arthritis. Prospective cohort study
La fibromialgia con factor reumatoide elevado se asocia a mala respuesta terapéutica pero no con progresión a artritis reumatoide. Estudio de cohortes prospectivo
Freddy Liñán Ponce
Corresponding author
droctavio77@gmail.com

Corresponding author.
, Juan Leiva Goicochea, David Sevilla Rodríguez, Elmer Hidalgo Bravo, Ginna Obregón Atanacio, Inés Loyola Macalapú, Paola Jáuregui Rojas, Jackeline Yampufe Canani
Servicio de Reumatología, Hospital Víctor Lazarte Echegaray, Trujillo, Peru
Article information
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Statistics
Tables (4)
Table 1. Distribution of patients with FM according to age and sex.
Table 2. RF variation at 6 and 12 months.
Table 3. FIQR at 6 and 12 months in patients with FM.
Table 4. Progression to RA in subjects with FM at 6 and 12 months.
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Abstract
Objetive

Evaluate response to treatment and progression to rheumatoid arthritis (RA) in patients with fibromyalgia (FM) associated with elevated rheumatoid factor (RF).

Material and methods

Prospective cohort study. The sample consisted of 124 patients with FM: 62 with high RF (>20 U/mL) and 62 with negative RF (0−20 U/mL). All patients were evaluated using FM treatment improvement score (FIQR) and progression to RA according to EULAR/ACR 2010 criteria at 6 and 12 months. Pearson's χ2 test for homogeneity was used to relate variables of improvement to FM treatment and progression to RA.

Results

The response to treatment was lower in the high RF group (24 and 20 patients improved at 6 and 12 months, respectively, compared to 45 and 38 patients in the negative RF group), with a significant difference. Progression to rheumatoid arthritis was similar in both groups (5 in the high RF group and 4 in the negative RF group), with a non-significant relationship.

Conclusions

FM with elevated RF is associated with a poor therapeutic response but not with progression to RA.

Keywords:
Fibromyalgia
Rheumatoid arthritis
Rheumatoid factor
Resumen
Objetivo

Evaluar respuesta a tratamiento y progresión a artritis reumatoide (AR) en pacientes con fibromialgia (FM) asociado a factor reumatoide (FR) elevado.

Material y métodos

Estudio de cohortes prospectivo. La muestra se conformó por 124 pacientes con FM: 62 con FR elevado (>20 U/mL) y 62 con FR negativo (0−20 U/mL). Todos los pacientes fueron evaluados mediante una puntuación de mejora de tratamiento de FM (FIQR) y progresión a AR según criterios EULAR/ACR 2010 a los 6 y 12 meses. Se usó la prueba χ2 de Pearson de homogeneidad para relacionar variables de mejora al tratamiento de FM y progresión a AR.

Resultados

La respuesta al tratamiento de FM fue menor en el grupo FR elevado (24 y 20 pacientes mejoraron a los 6 y 12 meses respectivamente, comparados con los 45 y 38 pacientes del grupo FR negativo), hallándose diferencia significativa. La progresión a artritis reumatoide fue similar en ambos grupos (5 en el grupo FR elevado y 4 en FR negativo) siendo una relación no significativa.

Conclusiones

La FM con FR elevado se asocia a mala respuesta terapéutica pero no con progresión a AR.

Palabras clave:
Fibromialgia
Artritis reumatoide
Factor reumatoide

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