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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">On 31 December 2019&#44; the Chinese health authorities informed the World Health Organization &#40;WHO&#41; of a series of pneumonia cases linked to a live animal market in the city of Wuhan&#46; The WHO declared global spread of COVID-19&#44; caused by the SARS-CoV-2 coronavirus&#44; a pandemic on 11 March 2020&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#8211;3</span></a> Since then&#44; a wide range of clinical manifestations and severity has been observed in patients&#44; from asymptomatic or paucisymptomatic positive to life-threatening cases with severe respiratory involvement&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#44;5</span></a> Severe lung damage may be caused by cytokine storms that produce hyperinflammation and are also responsible for the inflammatory activity of immune-mediated inflammatory diseases &#40;IMID&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6&#44;7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We know that the pathophysiology of IMID predisposes to an increased risk of infection by modifying the host immune response&#44; which is crucial for the outcome of SARS-CoV-2 infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Different therapies have been used to treat IMID over the years&#44; although biological disease-modifying antirheumatic drugs and small molecule Janus kinase &#40;JAK&#41; inhibitors&#44; which act by blocking the expression of proinflammatory cytokines such as interleukin IL-1&#44; IL-6&#44; tumour necrosis factor-alpha &#40;TNF&#945;&#41; that use JAK pathways to transmit intracellular signals&#44; have revolutionised the management and control of flares in recent decades&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5&#44;8</span></a> Therefore&#44; these biological agents and small molecules&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> such as tocilizumab&#44; anakinra and baricitinib&#44; have been introduced into SARS-CoV-2 treatment protocols to improve the prognosis of the most severe cases&#44; which&#44; from a more theoretical point of view&#44; can modify the course of the disease and improve the prognosis of patients affected by SARS-CoV-2&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">There is limited evidence on the risk of contracting SARS-CoV-2 infection and its prognosis in patients with IMID&#46; To date&#44; both the prevalence and behaviour of these inflammatory diseases have been reported not to differ in this population group&#44;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;13</span></a> and the baseline treatments used for their treatment do not worsen the prognosis of the infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;13</span></a> However&#44; a recent publication in a Spanish population observed that having an IMID&#44; and the different therapies used&#44; have some impact on SARS-CoV-2 infection&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In addition&#44; the rapid spread of COVID-19 infection worldwide raises questions about the impact of the virus on pregnant patients&#46; Recently&#44; the Center for Disease Control and Prevention &#40;CDC&#41;&#44; based on current evidence&#44; concluded that pregnant women are at increased risk of COVID-19 infection compared to the general population and at increased risk of preterm delivery&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> To compound this&#44; pregnant patients diagnosed with rheumatic diseases have an immunocompromised status&#44; which added to the use of disease-modifying treatments&#44; may mean this group of patients are more vulnerable to coronavirus infection&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> However&#44; the number of reported cases of pregnant patients with inflammatory diseases is limited and the impact of coronavirus on these patients is unknown&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Our study analyses the demographic and clinical characteristics and prognosis of patients with IMID within a cohort of patients hospitalised in our centre for SARS-CoV-2 infection&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Methods</span><p id="par0025" class="elsevierStylePara elsevierViewall">We conducted a retrospective observational cohort study in a Spanish university hospital with 258 inpatient beds&#44; including 12 in the Intensive Care Unit &#40;ICU&#41;&#44; serving a population of about 190&#44;000 inhabitants&#46; Patients were included aged 18 years or older admitted to a university hospital consecutively with SARS-CoV-2 infection from 26 February to 20 May 2020&#44; both dates inclusive&#46; SARS-CoV-2 infection was confirmed by polymerase chain reaction &#40;PCR&#41; diagnostic test on a nasopharyngeal exudate or sputum sample&#46; If the result was negative&#44; a second test was performed if the patient&#39;s clinical manifestations were highly suggestive of the disease and&#47;or they had laboratory or radiological criteria suggestive of infection&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Patients who refused to give their informed consent to treatments for SARS-CoV-2 infection approved in the hospital protocol were excluded&#44; as were readmissions of the same patient&#44; only the first hospital admission was considered&#46; Pregnant or breastfeeding women were included&#46; Patients were treated according to medical criteria and local treatment protocols&#44; based on the recommendations of the health authorities&#44; in line with the scientific evidence available at the time&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The demographic data&#44; comorbidities&#44; clinical symptoms&#44; laboratory results&#44; radiological tests and treatment of each patient were obtained from the hospital&#39;s electronic medical records&#46; The IMID included were rheumatoid arthritis &#40;RA&#41;&#44; psoriatic arthritis &#40;PsA&#41;&#44; ankylosing spondylitis &#40;AS&#41;&#44; systemic lupus erythematosus &#40;SLE&#41;&#44; polymyalgia rheumatica &#40;PRM&#41;&#44; giant cell arteritis &#40;GCA&#41;&#44; Sj&#246;gren&#39;s syndrome &#40;SS&#41;&#44; vasculitis&#44; systemic scleroderma &#40;SSc&#41;&#44; psoriasis &#40;P&#41;&#44; Crohn&#39;s disease &#40;CD&#41;&#44; ulcerative colitis &#40;UC&#41; and other autoimmune diseases &#40;including Beh&#231;et&#39;s disease and inflammatory myopathies&#41;&#46; PsA and Pso were included under psoriatic disease &#40;PD&#41;&#46; Data were also collected from patients receiving inflammatory disease treatment as a dichotomous yes&#47;no variable&#44; including biological treatments and JAK inhibitors&#46; Clinical data were collected by direct download or by individualised manual review of the electronic health records&#46; A secure data collection form was designed in the corporate health record software for the remaining demographic data&#44; comorbidities&#44; clinical symptoms&#44; and radiological tests&#46; To ensure correct collection&#44; these forms were validated by the principal investigators&#44; MRV and DEQ&#44; before they were entered into the database&#44; to improve the quality of the data collected and reduce missing data to a minimum&#46; Personal data were dissociated and pseudo-anonymised in the database for further statistical analysis by an independent expert&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Statistical analysis</span><p id="par0035" class="elsevierStylePara elsevierViewall">For the statistical analysis&#44; quantitative variables are expressed as medians and interquartile range &#40;IQR&#41;&#46; The Student&#8217;s t-test for normally distributed variables and the Mann-Whitney U-test for non-normally distributed variables were used to analyse mean differences&#46; Categorical variables are represented as absolute frequencies and percentages&#46; Pearson&#8217;s &#967;<span class="elsevierStyleSup">2</span> test or Fisher&#39;s exact test was used to compare categorical variables&#44; and if necessary&#44; the Mantel-Haenszel test for trend&#46; The level of statistical significance established for all the comparison tests was <span class="elsevierStyleItalic">P</span>&#160;&#60;&#160;&#46;05&#46; The SPSS statistical package &#40;IBM Corp&#46; Released 2010&#46; IBM SPSS Statistics for Windows&#44; Version 19&#46;0&#46; Armonk&#44; NY&#58; IBM Corp&#46;&#41; was used for the statistical analysis and processing of the data&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The study protocol was approved on 22 June by the Ethics Committee for Research with Medicines &#40;CEIm&#41; prior to its implementation and classified by the Spanish Agency for Medicines and Health Products &#40;AEMPS&#41;&#46; Exemption was obtained from requesting written informed consent from patients&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Results</span><p id="par0045" class="elsevierStylePara elsevierViewall">Of the 612 patients with suspected SARS-CoV-2 infection at the start of admission&#44; 246 were PCR positive&#44; and 23 had IMID&#44; 9 of whom were confirmed as infectious disease cases by PCR test &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; The most frequent IMID were the following in this order&#58; psoriatic disease &#40;43&#46;5&#37;&#41;&#44; ulcerative colitis &#40;26&#46;1&#37;&#41;&#44; Crohn&#39;s disease &#40;17&#46;4&#37;&#41;&#44; and enteritis &#40;13&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">Of the patients admitted with suspected SARS-CoV-2 infection &#40;n&#160;&#61;&#160;612&#41;&#44; 23 had IMID&#44; 12 women &#40;44&#46;7&#37;&#41; and 11 men &#40;55&#46;3&#37;&#41;&#44; and there were no pregnant women&#46; Of the 23 patients with IMID&#44; 9 were diagnosed with SARS-CoV-2 infection&#44; compared to 14 patients in whom SARS-CoV-2 infection was ruled out&#46; There was no correlation between SARS-CoV-2 infection and IMID &#40;<span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;55&#41;&#46; Similarly&#44; no statistical differences were observed by age or sex between the infected and non-infected patients admitted with IMID&#58; 5 infected women &#40;55&#46;6&#37;&#41; vs&#46; 7 non-infected women &#40;50&#37;&#41;&#44; 4 infected men &#40;36&#46;4&#37;&#41; vs&#46; 7 non-infected men &#40;50&#37;&#41;&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Among the infected patients&#44; PD was the most prevalent of the IMID&#44; but no statistically significant differences were observed with respect to the other IMID detected&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The symptoms at the onset of the infection presented by the patients with IMID were similar in frequency to those of the rest of the patients studied&#46; Fever was the most frequent symptom observed on admission &#40;78&#46;3&#37;&#41;&#44; followed by dyspnoea &#40;43&#46;5&#37;&#41; and dry cough &#40;43&#46;5&#37;&#41; &#40;data pending publication&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">On analysis of the comorbidities presented by the patients with IMID&#44; no differences were observed with respect to the rest of the patients admitted in terms of demographic characteristics&#44; cardiovascular risk factors or chronic lung diseases&#46; However&#44; there was a trend towards a higher percentage of obesity &#40;38&#46;5&#37; vs&#46; 22&#46;7&#37;&#41; and treatment with angiotensin-converting enzyme inhibitors &#40;ACE inhibitors&#41; or angiotensin II receptor blockers &#40;ARBs&#41; &#40;65&#46;4&#37; vs&#46; 42&#46;8&#37;&#41;&#44; compared to other patients admitted for suspected SARS-CoV-2 infection&#46; Therefore&#44; although the differences were not statistically significant&#44; patients with IMID were more likely to have cardiovascular risk factors&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">When analysing the 23 patients with IMID&#44; differences that did not reach statistical significance between infected and non-infected individuals were observed in relation to cardiovascular disease &#40;44&#46;4&#37; in infected vs&#46; 7&#46;1&#37; in non-infected&#59; <span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;06&#41;&#44; and obesity &#40;55&#46;6&#37; in infected vs&#46; 14&#46;3&#37; in non-infected <span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;07&#41;&#46; Regarding the presence of thromboembolic disease&#44; arterial hypertension &#40;HTN&#41;&#44; diabetes mellitus &#40;DM&#41; or ischaemic heart disease&#44; no differences were observed between infected and non-infected patients&#46; Nor was there a difference in the use of home treatment with ACE inhibitors&#44; anticoagulants&#44; glucocorticoids &#40;GC&#41;&#44; anti-rheumatic disease-modifying drugs&#44; or biological therapies&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">None of the IMID patients had a flare of their underlying disease during their hospital stay&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">We collected data in our cohort on the number of symptomatic days prior to hospital admission and the number of days of hospital stay&#46; On analysis of this information&#44; we observed no significant differences between patients with and without IMID&#46; There were also no differences in ICU admissions between patients with and without IMID &#40;3&#46;8&#37; vs&#46; 3&#46;9&#37;&#41;&#46; In terms of outcomes of death&#44; which occurred in 43 infected patients &#40;16&#46;9&#37;&#41;&#44; we observed no differences between patients with or without IMID &#40;19&#46;2&#37; vs&#46; 16&#37;&#44; <span class="elsevierStyleItalic">P</span>&#160;&#61;&#160;&#46;73&#41; either &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discussion</span><p id="par0085" class="elsevierStylePara elsevierViewall">Unlike studies published to date&#44; in our cohort we assessed the epidemiological and clinical characteristics of patients with IMID&#44; who&#44; due to severity on arrival at the hospital emergency department&#44; required hospitalisation for suspected SARS-CoV-2 infection&#46; The articles published to date on the prevalence of SARS-CoV-2 infection in patients with IMID in different geographical areas are mainly European&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#44;13&#44;19</span></a> Furthermore&#44; they describe the characteristics of patients with a history of IMID and the impact of the disease itself or related treatments on the morbidity and mortality of SARS-CoV-2 disease&#44; which does not demonstrate an association between immunosuppressive treatments and respiratory complications associated with COVID-19 infection&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Our study does not enable us to establish the population prevalence of SARS-CoV-2 disease among patients with IMID in our area&#44; but it does allow us to describe the prevalence of SARS-CoV-2 infection among patients with IMID hospitalised for suspected infection&#44; and their clinical course&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">According to the distribution by disease observed in our study population&#44; 23 patients had diseases included in the IMID spectrum&#46; The diseases identified among patients admitted with IMID were PsA&#44; Pso&#44; CD and CU&#46; No admissions were collected from patients with RA&#44; AS&#44; SLE&#44; or other connective tissue diseases&#46; These results are in line with those of other working groups&#44;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;14&#44;19</span></a> where the aggregate data of patients with IMID showed more cases of SARS-CoV-2 infection than those with other autoimmune diseases&#46; No patients with PMR were recorded&#44; even though this is a typical disease of advanced age&#44; a factor associated with greater severity of viral infection&#44; and for which the baseline treatment is GC&#46; It could be that following health recommendations or due to mobility difficulties&#44; the patients attended hospital less frequently&#46; It is noteworthy that the prevalence of infection in SLE was lower than in other diseases&#44; perhaps because using GC in SLE patients acts as a protective factor against severe COVID-19 disease&#44; as treatment with GC in severe COVID-19 cases has been shown to be beneficial for the outcome of the infection&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;22</span></a> However&#44; hydroxychloroquine&#44; which is the standard treatment for SLE&#44; has not been shown to improve the clinical course of SARS-CoV-2&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> despite the fact that it was administered to infected patients at the beginning of the pandemic under the hypothesis of improving the prognosis of the disease&#46; The small number of IMID patients in our cohort means we cannot draw firm conclusions about the effect of inflammatory disease or underlying immunosuppressive therapies on the course of COVID-19 infection&#46; However&#44; it is striking that the immunocompromised patients do not have higher morbidity or mortality from SARS-CoV-2 compared to the other patients&#44; as has been reported in other series&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;12</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">No pregnant patients with rheumatic diseases requiring admission due to SARS-CoV-2 infection were recorded in our cohort&#44; as in other European groups&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> despite the greater predisposition to infection due to the association between pregnancy&#44; IMID and immunosuppressive treatments&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">The clinical presentation of the patients with IMID&#44; as well as severity on admission&#44; are like those of the other patients in our study cohort&#46; Likewise&#44; patients with rheumatological diseases in other series presented more frequently with dry cough&#44; dyspnoea&#44; and fever&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;12&#44;19</span></a> However&#44; as has been mentioned in other series of patients with chronic inflammatory diseases&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> in our population&#44; patients with IMID have more comorbidities&#44; and specifically there is a higher percentage of obesity&#46; Obesity is a determining factor in cardiovascular disease in IMID&#44; and has been recognised as a major cause of morbidity and mortality in these diseases&#46; Obesity is also a risk factor for more severe SARS-CoV-2<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> infection and therefore a worse clinical outcome&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">The baseline immunosuppressive treatment was discontinued in the patients admitted with IMID&#44; in accordance with the recommendations of scientific societies&#46;<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">26&#44;27</span></a> Nevertheless&#44; no flare of the underlying disease was reported&#46; The treatment received by the patients was identical to that of the other patients hospitalised for the infection&#44; following the recommendations of the national guidelines and our hospital&#8217;s protocol&#46; The mean number of days of hospital and ICU stay&#44; and case fatality did not differ from that of the other infected patients &#40;data pending publication&#41;&#46; These results suggest the determinant role of IMID&#44; and immunomodulatory or immunosuppressive treatments previously received by these patients in the management of SARS-CoV-2 infection and in the outcomes of these patients&#46; Most immunosuppressive drugs used in IMID have a long half-life&#44; and therefore withdrawal after diagnosis of the infection does not guarantee immediate elimination of the drug from the blood&#46; Nevertheless&#44; most of the patients affected by SARS-CoV-2 had a good clinical outcome&#44; as has been demonstrated in other series&#44;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> with no differences in the outcome of SARS-CoV-2 between patients with and without IMID&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">As a limitation of our study&#44; we should mention that we were only able to identify the most clinically severe cases of IMID patients since&#44; on the recommendations of the health authorities&#44; patients with milder symptoms were instructed to remain at home and only patients who consulted the hospital emergency department with admission criteria underwent PCR testing&#46; Therefore&#44; we were unable to establish the true prevalence of the infection in our study population or to make more realistic associations&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">As this is a retrospective study&#44; no causal relationships can be extracted from it&#46; Moreover&#44; as it was conducted in a single hospital&#44; our results cannot be directly extrapolated to other healthcare settings&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">From this study&#44; we can conclude that immune-mediated diseases and their treatments do not seem to determine clinical outcomes after the hospital admission of patients infected with SARS-CoV-2&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Funding</span><p id="par0125" class="elsevierStylePara elsevierViewall">This study was funded by a &#8220;<span class="elsevierStyleItalic">Beca de Ayuda a la Investigaci&#243;n en Reumatolog&#237;a 2020</span>&#8221; &#40;Grant for Research Assistance in Rheumatology&#41;&#44; awarded by the <span class="elsevierStyleItalic">Fundaci&#243;n Valenciana de Reumatolog&#237;a</span>&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Conflict of interests</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors have no conflict of interests to declare&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Background</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Immune-mediated inflammatory diseases &#40;IMID&#41; predispose to a higher infection risk by modifying the host&#39;s immune response&#44; which acts as a key factor in SARS-CoV-2 infection resolution&#46; Recent publications show that IMID patients and its treatments do not worsen the outcome of SARS-CoV-2 infection&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Objectives</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">To describe the clinical characteristics and outcomes of patients with IMID who required hospital admission due to SARS-CoV-2 infection&#46; Secondly&#44; to compare clinical characteristics and outcomes between patients who required hospital admission due to SARS-CoV-2 infection with IMID and those who were not affected&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Methods</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We performed an observational retrospective cohort study&#44; including admitted patients with suspected SARS-CoV-2 infection&#44; treated according to medical criteria and local protocols based on the best available scientific evidence&#46; Clinical data were collected from their electronical clinical history&#46; Statistical analysis determined the differences in the characteristics and clinical outcome of the infection in IMID patients&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Of a total number of 612 revised patients&#44; 23 had an IMID and 9 of them were positive for the SARS-CoV-2 infection&#46; We did not observe a correlation between these two disorders&#46; There was a higher frequency of obesity and cardiovascular disease among IMID patients&#44; but without statistical significance&#46; The clinical outcomes were no different between hospitalized IMID and non IMID patients&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusion</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">IMID and its treatments do not determine the outcome of patients admitted with SARS-CoV-2 infection&#46;</p></span>"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Fundamentos</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Las enfermedades inflamatorias inmunomediadas &#40;IMID&#41; predisponen a un aumento del riesgo infeccioso al modificar la respuesta inmune del hu&#233;sped&#44; que resulta crucial para la resoluci&#243;n de la infecci&#243;n por SARS-CoV-2&#46; Las &#250;ltimas publicaciones indican que los pacientes con IMID y sus tratamientos de base no empeoran el pron&#243;stico de la infecci&#243;n por SARS-CoV-2&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Objetivos</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Describir las caracter&#237;sticas cl&#237;nicas y la evoluci&#243;n de pacientes con IMID que requirieron ingreso hospitalario por infecci&#243;n por SARS-CoV-2&#46; En segundo lugar&#44; comparar las caracter&#237;sticas cl&#237;nicas y la evoluci&#243;n entre pacientes que requirieron ingreso hospitalario por infecci&#243;n por SARS-CoV-2 con IMID y aquellos que no la presentaban&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">M&#233;todos</span><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Estudio observacional de cohortes retrospectivo&#44; que incluy&#243; pacientes ingresados por sospecha de SARS-CoV-2&#44; tratados seg&#250;n el criterio m&#233;dico y los protocolos basados en la evidencia cient&#237;fica&#46; La recogida de datos cl&#237;nicos se realiz&#243; por descarga directa o mediante revisi&#243;n manual de la historia cl&#237;nica electr&#243;nica&#46; El an&#225;lisis estad&#237;stico determin&#243; las diferencias de caracter&#237;sticas y evoluci&#243;n cl&#237;nica de la infecci&#243;n en pacientes con IMID&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Resultados</span><p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">De los 612 pacientes revisados&#44; 23 padec&#237;an IMID y 9 de ellos fueron diagnosticados de infecci&#243;n por SARS-CoV-2&#46; No se observ&#243; correlaci&#243;n entre infecci&#243;n por SARS-CoV-2 e IMID&#46; Los pacientes con IMID presentaban mayor prevalencia de enfermedad cardiovascular y obesidad&#44; aunque no significativamente&#46; Asimismo&#44; los pacientes con IMID no presentaron una evoluci&#243;n cl&#237;nica durante el ingreso hospitalario diferente respecto al resto de pacientes&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conclusi&#243;n</span><p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Las IMID y los tratamientos de las mismas no determinan el pron&#243;stico del ingreso hospitalario de la infecci&#243;n por SARS-CoV-2&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Please cite this article as&#58; Robustillo-Villarino M&#44; &#193;lvarez-Arroyo L&#44; Carrera-Hueso FJ&#44; Barreda-Altaba I&#44; Nieto-Cid M&#44; Girona-Sanz AM&#44; et al&#46; Caracter&#237;sticas de pacientes con enfermedades inflamatorias inmunomediadas hospitalizados por infecci&#243;n por SARS-CoV-2&#46; Reumatol Clin&#46; 2022&#59;18&#58;331&#8211;337&#46;</p>"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">ACEis&#58; Angiotensin-converting enzyme inhibitors&#59; ARBs&#58; Angiotensin II receptor blockers&#59; BMI&#58; Body Mass Index&#59; COPD&#58; Chronic Obstructive Pulmonary Disease&#59; DMARDs&#58; Disease modifying anti-rheumatic drugs&#59; HIV&#58; Human Immunodeficiency Virus&#59; NA&#58; Not assessable&#46;</p>"
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                  \t\t\t\t">3 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hypertension</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;47&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;42&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dyslipidaemia</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;43&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;50&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Diabetes</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;17&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Chronic kidney disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;8&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;14&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Cardiovascular disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;21&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;06&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COPD</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Asthma</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;7&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Other chronic lung diseases</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;21&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;28&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Pulmonary embolism or deep vein thrombosis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Cancer</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;13&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HIV</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Home treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;4&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;7&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACEis or ARBs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;39&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;35&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Biological drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>DMARDs&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean glucocorticoid dose&#47;day &#40;mg&#41; &#40;Prednisone or equivalent&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Cerebrovascular disease</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dyslipidaemia</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Obesity &#40;BMI&#8805;30&#160;kg&#47;m</span><span class="elsevierStyleSup">2</span><span class="elsevierStyleItalic">&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">57 &#40;23&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;55&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#46;04&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">HIV</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dementia</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;11&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Pulmonary embolism or deep vein thrombosis</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>ACEis or ARBs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">111 &#40;45&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">4 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Biological drugs&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;07&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead colgroup " colspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Symptoms</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fever&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">181 &#40;73&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">9 &#40;100&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dyspnoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">126 &#40;51&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">4 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dry cough&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">150 &#40;61&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">6 &#40;66&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Expectoration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;14&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sore throat&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Myalgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52 &#40;21&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Headache&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;11&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dizziness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diarrhoea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;22&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>General malaise&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#40;52&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;44&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anosmia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Demographic characteristics and comorbidities of patients admitted for confirmed COVID-19 to the la Plana hospital&#46;</p>"
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        "texto" => "<p id="par0140" class="elsevierStylePara elsevierViewall">We would like to thank our colleagues at the hospital who were on the front line in treating patients during the COVID-19 pandemic&#46; They also contributed to the data collection that was required to undertake this study&#46;</p>"
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