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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To establish the influence of cytokines on anxious-depressive manifestations in fibromyalgia &#40;FM&#41; patients&#46;</p> <span class="elsevierStyleSectionTitle">Material and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The study comprised 56 women &#40;50&#46;5 &#91;7&#46;8&#93; years&#41; with FM and 32 healthy female controls &#40;39&#46;65 &#91;9&#46;24&#93; years&#41;&#46; Psychiatric symptoms were analyzed using the Hamilton Depression Rating Scale &#40;HDRS&#41; and the Hamilton Anxiety Rating Scale &#40;HARS&#41;&#44; while pain was assessed by means of a Visual Analog Scale &#40;VAS&#41;&#46; Proinflammatory cytokines IL-6&#44; IL-8&#44; IL-10&#44; and TNF&#945; were assayed in serum using the Luminex-xMAP method&#46; The statistical analysis was carried out using the SSPS statistical package&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">IL-8 values were significantly lower &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;013&#41; in patients than in controls&#46; No differences were observed among IL-6&#44; IL-10&#44; and TNF&#945; levels&#46; When comparing cytokine levels with patient age&#44; we observed a significant reduction in IL-6&#44; IL-8&#44; and TNF&#945; in older patients&#46; The values of these cytokines showed no relationship to the anxious-depressive symptoms&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In our series no differences in serum cytokines were seen between patients with FM and controls&#44; with the exception of a reduction in IL-8 among patients with FM&#44; and which could be attributed to the older age of these patients&#46;</p>"
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Vol. 4. Issue 4.
Pages 136-139 (July - August 2008)
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Vol. 4. Issue 4.
Pages 136-139 (July - August 2008)
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Correlation Between Cytokines and Anxious-Depressive Symptoms in Patients With Fibromyalgia
Correlación entre citocinas y síntomas ansiosodepresivos en pacientes con fibromialgia
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José-Raúl García-Lozanoa,
Corresponding author
jraul.garcia.sspa@juntadeandalucia.es

Correspondence: Servicio de Inmunología. Hospital Universitario Virgen del Rocío. Avda. Manuel Siurot, s/n. 41013 Sevilla. España.
, Carmen Capilla-Sevillab, Olga García-Lópezb, Isabel Moreno-Gallegoc
a Servicio de Inmunología, Hospital Universitario Virgen del Rocío, Sevilla, Spain
b Servicio de Psiquiatría, Hospital Universitario Virgen del Rocío, Sevilla, Spain
c Servicio de Reumatología, Hospital Universitario Virgen del Rocío, Sevilla, Spain
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Article information
Objective

To establish the influence of cytokines on anxious-depressive manifestations in fibromyalgia (FM) patients.

Material and method

The study comprised 56 women (50.5 [7.8] years) with FM and 32 healthy female controls (39.65 [9.24] years). Psychiatric symptoms were analyzed using the Hamilton Depression Rating Scale (HDRS) and the Hamilton Anxiety Rating Scale (HARS), while pain was assessed by means of a Visual Analog Scale (VAS). Proinflammatory cytokines IL-6, IL-8, IL-10, and TNFα were assayed in serum using the Luminex-xMAP method. The statistical analysis was carried out using the SSPS statistical package.

Results

IL-8 values were significantly lower (P=.013) in patients than in controls. No differences were observed among IL-6, IL-10, and TNFα levels. When comparing cytokine levels with patient age, we observed a significant reduction in IL-6, IL-8, and TNFα in older patients. The values of these cytokines showed no relationship to the anxious-depressive symptoms.

Conclusions

In our series no differences in serum cytokines were seen between patients with FM and controls, with the exception of a reduction in IL-8 among patients with FM, and which could be attributed to the older age of these patients.

Key words:
Cytokines
Fibromyalgia
Pain
Objetivo

Determinar la influencia de las citocinas en las manifestaciones ansioso-depresivas de pacientes con fibromialgia.

Material y método

En el estudio se incluyó a 56 mujeres con fibromialgia (50,5±7,8 años) y 32 mujeres sanas como controles (39,65±9,24 años). Los síntomas psiquiátricos fueron analizados con la Hamilton Depression Rating Scale (HDRS) y la Hamilton Anxiety Rating Scale (HARS), mientras que el dolor fue valorado por medio de una escala visual analógica. Las concentraciones de citocinas proinflamatorias de interleucina (IL)-6, IL-8, IL-10 y factor de necrosis tumoral alfa (TNFα) se midieron en suero mediante Luminex-xMAP. El análisis estadístico se realizó con el programa estadístico SSPS.

Resultados

Las concentraciones de IL-8 fueron estadísticamente más bajas en pacientes que en controles (p=0,013). No se observaron diferencias con respecto a las concentraciones de IL-6, IL-10 y TNFα. Al comparar los valores de citocinas con la edad de los pacientes, se observó una reducción significativa de IL-6, IL-8 y TNFα en los pacientes de mayor edad. No se observó relación entre los valores de estas citocinas y los síntomas ansioso-depresivos.

Conclusiones

En nuestra serie no hay diferencias en las concentraciones séricas de citocinas entre pacientes con fibromialgia y controles, con la excepción de una reducción de IL-8 en los pacientes con fibromialgia que podría ser debida a la mayor edad de los pacientes con respecto a los controles.

Palabras clave:
Citocinas
Fibromialgia
Dolor
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Copyright © 2008. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
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