Eosynophilic Fasciitis. Favorable Response to Treatment With Cyclosporin A
Fascitis eosinofílica, respuesta favorable al tratamiento con ciclosporina A
Jorge Jaimes-Hernándeza,
, Claudia Irene Meléndez-Mercadob, Pablo Aranda-Pereirab
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jorjaimes@yahoo.com
Correspondence: Centro Médico ISSEMYM. Avda. Baja Velocidad, Paseo Tollocan 284, 5.° piso. San Jerónimo Chicahualco. Metepec. Estado de México. C.P. 52140. México.
Correspondence: Centro Médico ISSEMYM. Avda. Baja Velocidad, Paseo Tollocan 284, 5.° piso. San Jerónimo Chicahualco. Metepec. Estado de México. C.P. 52140. México.
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Favorable Response to Treatment With Cyclosporin A" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "55" "paginaFinal" => "58" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jorge Jaimes-Hernández, Claudia Irene Meléndez-Mercado, Pablo Aranda-Pereira" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Jorge" "apellidos" => "Jaimes-Hernández" "email" => array:1 [ 0 => "jorjaimes@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Claudia Irene" "apellidos" => "Meléndez-Mercado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Pablo" "apellidos" => "Aranda-Pereira" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "División de Medicina Interna, Departamento de Reumatología, Centro Médico ISSEMyM, Metepec, Estado de Mexico, Mexico" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Reumatología, Centro Médico ISSEMyM, Metepec, Estado de Mexico, Mexico" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Centro Médico ISSEMYM. Avda. Baja Velocidad, Paseo Tollocan 284, 5.° piso. San Jerónimo Chicahualco. Metepec. Estado de México. C.P. 52140. México." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fascitis eosinofílica, respuesta favorable al tratamiento con ciclosporina A" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-10-20" "fechaAceptado" => "2008-02-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111751" "palabras" => array:3 [ 0 => "Eosinophilic fasciitis" 1 => "Cyclosporine A" 2 => "Treatment" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111752" "palabras" => array:3 [ 0 => "Fascitis eosinofílica" 1 => "Ciclosporina A" 2 => "Tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Eosinophilic fasciitis (EF) is a disease of unknown aetiology characterized by cutaneous swelling and indurations. The disease affects predominantly the extremities and usually show an elevation of serum immunoglobulins, and eosinophilia.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Evaluation of the efficacy of cyclosporine A as a therapeutic alternative in patients with EF refractory to steroids.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We report 3 patients with clinical, laboratory and pathologic characteristics of EF who did not show a satisfactory response to steroids treatment. All patients disclosed scleroderma-like signs with orange skin, groove sign, and indurations of the affected extremities associated to peipheral eosinophilia and increased creatine-kinase. Epidermis histological findings were normal and intense linfocitary inflammation of the fascia was observed in all patients’ biopsies. All patients were treated for average of 8 months with prednisone 30–50<span class="elsevierStyleHsp" style=""></span>mg daily with an insufficient clinical response.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Patients started on cyclosporine A 5-7<span class="elsevierStyleHsp" style=""></span>mg/kg/day, showing a fast improvement (2 months). The treatment induces a clinical remission that permits to reduce or even stops the cyclosporine A treatment during follow-up.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It seems that cyclosporine A may be a effective therapeutic alternative in patients with EF refractory to steroids.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La fascitis eosinofílica (FE) es una enfermedad de origen desconocido, caracterizada por induración de la piel, debido a inflamación de las fascias del tejido conjuntivo. Afecta principalmente a las extremidades y se acompaña de elevación de inmunoglobulinas y eosinofilia periférica.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar la eficacia de ciclosporina A en pacientes con FE con resistencia al tratamiento convencional con glucocorticoides. Pacientes y método Presentamos 3 pacientes con manifestaciones clínicas y serológicas de FE que tuvieron resistencia al tratamiento estándar con glucocorticoides (30 a 50<span class="elsevierStyleHsp" style=""></span>mg/día, durante un período de hasta 8 meses). Las manifestaciones clínicas principales fueron: induración de la piel de las extremidades y el tronco que se acompañó de eosinofilia periférica y elevación de la creatincinasa. Histológicamente se observó un engrosamiento con intensa inflamación linfocitaria de las fascias.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Todos los pacientes fueron tratados con ciclosporina A, a dosis de 5 a 7<span class="elsevierStyleHsp" style=""></span>mg/kg/día con una rápida mejoría clínica (2 meses). El tratamiento condujo, en todos los casos, a una remisión clínica que permitió reducir e incluso retirar la ciclosporina A durante el seguimiento.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La ciclosporina A parece una alternativa terapéutica eficaz en el tratamiento de pacientes con FE resistente a glucocorticoides.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diffuse fasciitis with hypergammaglobulinemia and eosinophilia: a new syndrome?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L.E. 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Kerdel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "1999" "volumen" => "38" "paginaInicial" => "369" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10369548" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophilic fasciitis following exposure to trichloroethylene: successful treatment with cyclosporin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Hayashi" 1 => "A. Igarashi" 2 => "T. Matsuyama" 3 => "S. Harada" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2000" "volumen" => "142" "paginaInicial" => "830" "paginaFinal" => "832" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10792252" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eosinophilic fasciitis successfully treated with cyclosporine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Bukiej" 1 => "J. Dropinski" 2 => "G. Dyduch" 3 => "A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 16 | 25 |
| 2024 October | 37 | 37 | 74 |
| 2024 September | 59 | 20 | 79 |
| 2024 August | 40 | 39 | 79 |
| 2024 July | 41 | 36 | 77 |
| 2024 June | 43 | 33 | 76 |
| 2024 May | 57 | 33 | 90 |
| 2024 April | 50 | 40 | 90 |
| 2024 March | 28 | 29 | 57 |
| 2024 February | 26 | 23 | 49 |
| 2024 January | 21 | 18 | 39 |
| 2023 December | 38 | 28 | 66 |
| 2023 November | 22 | 22 | 44 |
| 2023 October | 26 | 34 | 60 |
| 2023 September | 30 | 40 | 70 |
| 2023 August | 23 | 13 | 36 |
| 2023 July | 20 | 22 | 42 |
| 2023 June | 17 | 38 | 55 |
| 2023 May | 15 | 11 | 26 |
| 2023 April | 14 | 14 | 28 |
| 2023 March | 22 | 29 | 51 |
| 2023 February | 37 | 37 | 74 |
| 2023 January | 13 | 23 | 36 |
| 2022 December | 24 | 32 | 56 |
| 2022 November | 26 | 30 | 56 |
| 2022 October | 19 | 33 | 52 |
| 2022 September | 27 | 33 | 60 |
| 2022 August | 29 | 51 | 80 |
| 2022 July | 27 | 40 | 67 |
| 2022 June | 26 | 36 | 62 |
| 2022 May | 20 | 45 | 65 |
| 2022 April | 43 | 52 | 95 |
| 2022 March | 35 | 53 | 88 |
| 2022 February | 38 | 49 | 87 |
| 2022 January | 49 | 43 | 92 |
| 2021 December | 24 | 51 | 75 |
| 2021 November | 22 | 49 | 71 |
| 2021 October | 29 | 50 | 79 |
| 2021 September | 23 | 42 | 65 |
| 2021 August | 36 | 46 | 82 |
| 2021 July | 28 | 35 | 63 |
| 2021 June | 34 | 47 | 81 |
| 2021 May | 32 | 49 | 81 |
| 2021 April | 48 | 76 | 124 |
| 2021 March | 45 | 40 | 85 |
| 2021 February | 56 | 35 | 91 |
| 2021 January | 30 | 23 | 53 |
| 2020 December | 28 | 26 | 54 |
| 2020 November | 25 | 31 | 56 |
| 2020 October | 16 | 11 | 27 |
| 2020 September | 26 | 37 | 63 |
| 2020 August | 24 | 24 | 48 |
| 2020 July | 22 | 18 | 40 |
| 2020 June | 31 | 21 | 52 |
| 2020 May | 34 | 14 | 48 |
| 2020 April | 28 | 16 | 44 |
| 2020 March | 24 | 7 | 31 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 5 | 0 | 5 |
| 2019 December | 1 | 0 | 1 |
| 2019 November | 1 | 0 | 1 |
| 2019 September | 6 | 0 | 6 |
| 2019 August | 1 | 0 | 1 |
| 2019 July | 3 | 0 | 3 |
| 2019 June | 2 | 0 | 2 |
| 2019 May | 2 | 0 | 2 |
| 2019 April | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 2 | 0 | 2 |
| 2019 January | 2 | 0 | 2 |
| 2018 December | 2 | 0 | 2 |
| 2018 May | 3 | 1 | 4 |
| 2018 April | 25 | 9 | 34 |
| 2018 March | 35 | 16 | 51 |
| 2018 February | 38 | 2 | 40 |
| 2018 January | 26 | 6 | 32 |
| 2017 December | 30 | 6 | 36 |
| 2017 November | 23 | 8 | 31 |
| 2017 October | 14 | 2 | 16 |
| 2017 September | 15 | 6 | 21 |
| 2017 August | 10 | 6 | 16 |
| 2017 July | 14 | 10 | 24 |
| 2017 June | 36 | 7 | 43 |
| 2017 May | 28 | 8 | 36 |
| 2017 April | 18 | 5 | 23 |
| 2017 March | 25 | 4 | 29 |
| 2017 February | 12 | 2 | 14 |
| 2017 January | 29 | 4 | 33 |
| 2016 December | 60 | 8 | 68 |
| 2016 November | 49 | 4 | 53 |
| 2016 October | 64 | 7 | 71 |
| 2016 September | 48 | 7 | 55 |
| 2016 August | 30 | 7 | 37 |
| 2016 July | 17 | 4 | 21 |
| 2016 April | 1 | 0 | 1 |
| 2016 January | 1 | 0 | 1 |
| 2015 December | 4 | 0 | 4 |
| 2015 November | 1 | 0 | 1 |
| 2015 October | 4 | 0 | 4 |
| 2015 September | 1 | 0 | 1 |
| 2015 August | 5 | 0 | 5 |
| 2015 July | 16 | 8 | 24 |
| 2015 June | 20 | 11 | 31 |
| 2015 May | 22 | 28 | 50 |
| 2015 April | 25 | 13 | 38 |
| 2015 March | 14 | 10 | 24 |
| 2015 February | 16 | 18 | 34 |
| 2015 January | 6 | 14 | 20 |
| 2014 December | 16 | 15 | 31 |
| 2014 November | 12 | 19 | 31 |
| 2014 October | 15 | 12 | 27 |
| 2014 September | 14 | 4 | 18 |
| 2014 August | 13 | 10 | 23 |
| 2014 July | 13 | 13 | 26 |
| 2014 June | 30 | 11 | 41 |
| 2014 May | 28 | 19 | 47 |
| 2014 April | 34 | 14 | 48 |
| 2014 March | 33 | 16 | 49 |
| 2014 February | 40 | 13 | 53 |
| 2014 January | 32 | 12 | 44 |
| 2013 December | 20 | 12 | 32 |
| 2013 November | 18 | 8 | 26 |
| 2013 October | 21 | 12 | 33 |
| 2013 September | 32 | 13 | 45 |
| 2013 August | 15 | 7 | 22 |
| 2013 July | 38 | 5 | 43 |
| 2013 June | 16 | 10 | 26 |
| 2013 May | 19 | 11 | 30 |
| 2013 April | 22 | 13 | 35 |
| 2013 March | 26 | 10 | 36 |
| 2013 February | 34 | 8 | 42 |
| 2013 January | 14 | 12 | 26 |
| 2012 December | 12 | 10 | 22 |
| 2012 November | 2 | 9 | 11 |
| 2012 October | 3 | 5 | 8 |
| 2012 September | 6 | 6 | 12 |
| 2012 July | 2 | 0 | 2 |
| 2012 June | 3 | 0 | 3 |
| 2012 May | 4 | 0 | 4 |
| 2012 April | 6 | 0 | 6 |
| 2012 March | 6 | 0 | 6 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 2 | 0 | 2 |
| 2011 October | 5 | 0 | 5 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 1 | 0 | 1 |
| 2011 June | 3 | 0 | 3 |
| 2011 May | 1 | 0 | 1 |
| 2011 March | 5 | 0 | 5 |
| 2011 February | 5 | 0 | 5 |
| 2011 January | 3 | 0 | 3 |
| 2010 December | 4 | 0 | 4 |
| 2010 November | 2 | 0 | 2 |
| 2010 October | 11 | 0 | 11 |
| 2010 September | 2 | 0 | 2 |
| 2010 August | 3 | 0 | 3 |
| 2010 July | 2 | 0 | 2 |
| 2010 June | 5 | 0 | 5 |
| 2010 May | 6 | 0 | 6 |
| 2010 April | 18 | 0 | 18 |
| 2010 March | 8 | 0 | 8 |
| 2010 February | 7 | 0 | 7 |
| 2010 January | 8 | 0 | 8 |
| 2009 November | 7 | 0 | 7 |
| 2009 October | 2 | 0 | 2 |
| 2009 September | 5 | 0 | 5 |
| 2009 August | 6 | 0 | 6 |
| 2009 July | 7 | 0 | 7 |
| 2009 June | 12 | 0 | 12 |
| 2009 May | 13 | 0 | 13 |
| 2009 April | 7 | 0 | 7 |
| 2009 March | 7 | 0 | 7 |
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