Infliximab in Ankylosing Spondylitis Associated With Chronic Hepatitis B Infection. Role of Lamivudine Therapy
Infliximab en la espondilitis anquilosante asociada a infección crónica por el virus de la hepatitis B. Papel del tratamiento con lamivudina
Jesús Sanz Sanz
, Lucía Silva Fernández, José Luis Calleja Panero, Mónica Fernández-Castro, José Luis Andreu Sánchez
Corresponding author
jessanz@ya.com
Correspondence. Servicio de Reumatología. Hospital Universitario Puerta de Hierro. San Martín de Porres, 4. 28035 Madrid. España.
Correspondence. Servicio de Reumatología. Hospital Universitario Puerta de Hierro. San Martín de Porres, 4. 28035 Madrid. España.
Servicio de Reumatología, Hospital Universitario Puerta de Hierro, Madrid, Spain
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"idiomaDefecto" => true "titulo" => "Infliximab in Ankylosing Spondylitis Associated With Chronic Hepatitis B Infection. Role of Lamivudine Therapy" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "159" "paginaFinal" => "161" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Jesús Sanz Sanz, Lucía Silva Fernández, José Luis Calleja Panero, Mónica Fernández-Castro, José Luis Andreu Sánchez" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Jesús" "apellidos" => "Sanz Sanz" "email" => array:1 [ 0 => "jessanz@ya.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Lucía" "apellidos" => "Silva Fernández" ] 2 => array:2 [ "nombre" => "José Luis" "apellidos" => "Calleja Panero" ] 3 => array:2 [ "nombre" => "Mónica" "apellidos" => "Fernández-Castro" ] 4 => array:2 [ "nombre" => "José Luis" "apellidos" => "Andreu Sánchez" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Reumatología, Hospital Universitario Puerta de Hierro, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Correspondence. Servicio de Reumatología. Hospital Universitario Puerta de Hierro. San Martín de Porres, 4. 28035 Madrid. España." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Infliximab en la espondilitis anquilosante asociada a infección crónica por el virus de la hepatitis B. Papel del tratamiento con lamivudina" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-05-21" "fechaAceptado" => "2007-09-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111879" "palabras" => array:3 [ 0 => "Ankylosing spondylitis" 1 => "Hepatitis B" 2 => "Infliximab" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111878" "palabras" => array:3 [ 0 => "Espondilitis anquilosante" 1 => "Hepatitis B" 2 => "Infliximab" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Anti-tumor necrosis factor-a (TNF) therapy has been associated with reactivation of hepatitis B virus infection. Case reports have suggested the concomitant need of lamivudine treatment in patients with HBV infection treated with antiTNFa agents. We describe a case of ankylosing spondylitis with positive HBV surface antigen (HBsAg) treated with infliximab and lamivudine. Clinical response was excellent but when lamivudine therapy was stopped, reactivation of replication viral occurred. After the reintroduction of lamivudine, viral replication was controlled and liver function tests were normalized. Preventive long-term lamivudine therapy is mandatory when anti-TNFa therapy is maintained in patients with chronic HBV infection.</p>" ] "es" => array:1 [ "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El tratamiento con agentes contra el factor de necrosis tumoral (TNF) alfa se ha asociado a la reactivación de la infección crónica por el virus de la hepatitis B. Algunos casos publicados indican la necesidad de tratamiento crónico con lamivudina cuando se utilizan los agentes anti-TNFa. Describimos el caso de un paciente con espondilitis anquilosante y antígeno de superficie positivo tratado con infliximab y lamivudina. La respuesta clínica fue excelente, pero cuando el paciente interrumpió el tratamiento con lamivudina, se observó reactivación de la replicación viral. Una vez reinstaurado dicho tratamiento, se controló nuevamente la replicación viral y se normalizaron las concentraciones de transaminasas. Esta observación indica que en pacientes con infección crónica por VHB que necesitan tratamiento anti-TNFa, se requiere un tratamiento preventivo a largo plazo con lamivudina.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 19 | 23 |
| 2024 October | 20 | 36 | 56 |
| 2024 September | 30 | 22 | 52 |
| 2024 August | 39 | 36 | 75 |
| 2024 July | 27 | 30 | 57 |
| 2024 June | 38 | 38 | 76 |
| 2024 May | 36 | 42 | 78 |
| 2024 April | 29 | 22 | 51 |
| 2024 March | 32 | 49 | 81 |
| 2024 February | 24 | 26 | 50 |
| 2024 January | 22 | 21 | 43 |
| 2023 December | 16 | 37 | 53 |
| 2023 November | 21 | 25 | 46 |
| 2023 October | 17 | 35 | 52 |
| 2023 September | 25 | 36 | 61 |
| 2023 August | 18 | 16 | 34 |
| 2023 July | 18 | 39 | 57 |
| 2023 June | 19 | 20 | 39 |
| 2023 May | 17 | 10 | 27 |
| 2023 April | 11 | 11 | 22 |
| 2023 March | 30 | 31 | 61 |
| 2023 February | 24 | 26 | 50 |
| 2023 January | 17 | 18 | 35 |
| 2022 December | 21 | 28 | 49 |
| 2022 November | 27 | 22 | 49 |
| 2022 October | 23 | 23 | 46 |
| 2022 September | 21 | 28 | 49 |
| 2022 August | 24 | 44 | 68 |
| 2022 July | 24 | 43 | 67 |
| 2022 June | 19 | 21 | 40 |
| 2022 May | 24 | 53 | 77 |
| 2022 April | 29 | 43 | 72 |
| 2022 March | 33 | 45 | 78 |
| 2022 February | 31 | 38 | 69 |
| 2022 January | 38 | 38 | 76 |
| 2021 December | 16 | 42 | 58 |
| 2021 November | 30 | 44 | 74 |
| 2021 October | 75 | 46 | 121 |
| 2021 September | 30 | 44 | 74 |
| 2021 August | 23 | 40 | 63 |
| 2021 July | 24 | 30 | 54 |
| 2021 June | 23 | 46 | 69 |
| 2021 May | 23 | 34 | 57 |
| 2021 April | 54 | 77 | 131 |
| 2021 March | 58 | 30 | 88 |
| 2021 February | 33 | 22 | 55 |
| 2021 January | 26 | 27 | 53 |
| 2020 December | 32 | 24 | 56 |
| 2020 November | 17 | 18 | 35 |
| 2020 October | 19 | 7 | 26 |
| 2020 September | 18 | 28 | 46 |
| 2020 August | 15 | 15 | 30 |
| 2020 July | 22 | 18 | 40 |
| 2020 June | 18 | 21 | 39 |
| 2020 May | 18 | 18 | 36 |
| 2020 April | 16 | 17 | 33 |
| 2020 March | 12 | 6 | 18 |
| 2020 February | 3 | 0 | 3 |
| 2020 January | 2 | 0 | 2 |
| 2019 August | 1 | 0 | 1 |
| 2019 July | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2018 December | 1 | 0 | 1 |
| 2018 May | 4 | 2 | 6 |
| 2018 April | 23 | 14 | 37 |
| 2018 March | 33 | 19 | 52 |
| 2018 February | 9 | 6 | 15 |
| 2018 January | 14 | 4 | 18 |
| 2017 December | 12 | 9 | 21 |
| 2017 November | 11 | 7 | 18 |
| 2017 October | 11 | 5 | 16 |
| 2017 September | 10 | 6 | 16 |
| 2017 August | 9 | 16 | 25 |
| 2017 July | 13 | 13 | 26 |
| 2017 June | 25 | 11 | 36 |
| 2017 May | 26 | 10 | 36 |
| 2017 April | 22 | 6 | 28 |
| 2017 March | 17 | 18 | 35 |
| 2017 February | 8 | 4 | 12 |
| 2017 January | 11 | 7 | 18 |
| 2016 December | 30 | 15 | 45 |
| 2016 November | 22 | 8 | 30 |
| 2016 October | 29 | 6 | 35 |
| 2016 September | 31 | 15 | 46 |
| 2016 August | 25 | 7 | 32 |
| 2016 July | 11 | 3 | 14 |
| 2016 February | 1 | 0 | 1 |
| 2016 January | 1 | 0 | 1 |
| 2015 December | 2 | 0 | 2 |
| 2015 October | 3 | 0 | 3 |
| 2015 July | 21 | 6 | 27 |
| 2015 June | 21 | 12 | 33 |
| 2015 May | 31 | 22 | 53 |
| 2015 April | 22 | 17 | 39 |
| 2015 March | 38 | 13 | 51 |
| 2015 February | 30 | 15 | 45 |
| 2015 January | 14 | 15 | 29 |
| 2014 December | 22 | 13 | 35 |
| 2014 November | 19 | 11 | 30 |
| 2014 October | 21 | 14 | 35 |
| 2014 September | 19 | 13 | 32 |
| 2014 August | 28 | 17 | 45 |
| 2014 July | 18 | 15 | 33 |
| 2014 June | 44 | 7 | 51 |
| 2014 May | 33 | 27 | 60 |
| 2014 April | 46 | 11 | 57 |
| 2014 March | 40 | 17 | 57 |
| 2014 February | 32 | 12 | 44 |
| 2014 January | 36 | 18 | 54 |
| 2013 December | 25 | 9 | 34 |
| 2013 November | 28 | 9 | 37 |
| 2013 October | 26 | 12 | 38 |
| 2013 September | 27 | 14 | 41 |
| 2013 August | 28 | 14 | 42 |
| 2013 July | 23 | 6 | 29 |
| 2013 June | 23 | 16 | 39 |
| 2013 May | 19 | 14 | 33 |
| 2013 April | 31 | 15 | 46 |
| 2013 March | 23 | 14 | 37 |
| 2013 February | 13 | 15 | 28 |
| 2013 January | 21 | 12 | 33 |
| 2012 December | 9 | 12 | 21 |
| 2012 November | 2 | 8 | 10 |
| 2012 October | 9 | 9 | 18 |
| 2012 September | 8 | 5 | 13 |
| 2012 June | 1 | 0 | 1 |
| 2012 May | 1 | 0 | 1 |
| 2012 April | 6 | 0 | 6 |
| 2012 March | 2 | 0 | 2 |
| 2012 February | 3 | 0 | 3 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 2 | 0 | 2 |
| 2011 November | 5 | 0 | 5 |
| 2011 October | 1 | 0 | 1 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 1 | 0 | 1 |
| 2011 July | 3 | 0 | 3 |
| 2011 June | 3 | 0 | 3 |
| 2011 May | 1 | 0 | 1 |
| 2011 March | 2 | 0 | 2 |
| 2011 February | 2 | 0 | 2 |
| 2011 January | 4 | 0 | 4 |
| 2010 December | 4 | 0 | 4 |
| 2010 November | 8 | 0 | 8 |
| 2010 October | 5 | 0 | 5 |
| 2010 September | 6 | 0 | 6 |
| 2010 August | 4 | 0 | 4 |
| 2010 July | 4 | 0 | 4 |
| 2010 June | 2 | 0 | 2 |
| 2010 May | 9 | 0 | 9 |
| 2010 April | 7 | 0 | 7 |
| 2010 March | 5 | 0 | 5 |
| 2010 February | 7 | 0 | 7 |
| 2010 January | 1 | 0 | 1 |
| 2009 December | 5 | 0 | 5 |
| 2009 November | 18 | 0 | 18 |
| 2009 October | 7 | 0 | 7 |
| 2009 September | 7 | 0 | 7 |
| 2009 August | 5 | 0 | 5 |
| 2009 July | 6 | 0 | 6 |
| 2009 June | 5 | 0 | 5 |
| 2009 May | 9 | 0 | 9 |
| 2009 April | 19 | 0 | 19 |
| 2009 March | 8 | 0 | 8 |
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