Systemic Lupus Erythematosus in a 6 Month Old Female Child
Lupus eritematoso sistémico en una lactante de 6 meses
Rogelio Martínez Ramírez
, Zoilo Morel Ayala, Samara Mendieta Zerón, Enrique Faugier Fuentes, Rocío Maldonado Velázquez
Corresponding author
rexmtz@hotmail.com
Correspondence: Departamento de Reumatología. Hospital Infantil de México Federico Gómez. Dr. Márquez, 162. Col. Doctores. Delegación Cuauhtémoc. 06720 México DF. México.
Correspondence: Departamento de Reumatología. Hospital Infantil de México Federico Gómez. Dr. Márquez, 162. Col. Doctores. Delegación Cuauhtémoc. 06720 México DF. México.
Departamento de Reumatología, Hospital Infantil de México Federico Gómez, México DF, Mexico
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Hospital Infantil de México Federico Gómez. Dr. Márquez, 162. Col. Doctores. Delegación Cuauhtémoc. 06720 México DF. México." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Lupus eritematoso sistémico en una lactante de 6 meses" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2007-09-08" "fechaAceptado" => "2007-12-04" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec111951" "palabras" => array:3 [ 0 => "Systemic lupus erythematosus" 1 => "Infant" 2 => "Systemic complications" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec111950" "palabras" => array:3 [ 0 => "Lupus eritematoso sistémico" 1 => "Lactante" 2 => "Complicaciones sistémicas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Systemic lupus erythematosus (SLE) is an uncommon disease, particularly in the first decade of life. Finding it before the first year of life is very rare and it entails a difficult diagnosis to document because the clinical manifestations can be very variable and can simulate a great variety of diseases.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In the pediatric age, incidence of SLE is 0.36–0.9/100 000 children, with greater prevalence in females 3:1 under 12 years of age and 10:1 in patients over 12 years. There is a very low incidence of SLE before 4 years of age.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">We present the clinical case of a 9 month-old female in whom 4 criteria of SLE were clearly documented at 6 months of age. In a review of literature, this is the youngest patient reported with SLE.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Physicians must be very alert of the higher risk of systemic complications in children that are diagnosed with SLE at an early age.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El lupus eritematoso sistémico (LES) es poco frecuente, particularmente en la primera década de la vida; su inicio antes de 1 año de edad es muy raro y conlleva un diagnóstico difícil de documentar, ya que las manifestaciones pueden ser muy variables y parecerse a las de una gran variedad de enfermedades.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En la edad pediátrica la incidencia de LES se estima en 0,36–0,9/100.000 niños, con prevalencia mayor en mujeres que en varones (aproximadamente 3:1 en menores de 12 años y 10:1 en niños mayores). Sin embargo, el inicio de LES antes de los 4 años ocurre con muy baja incidencia.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de una lactante de la que se documentaron claramente más de cuatro criterios diagnósticos de LES desde los 6 meses de edad. Por lo revisado en la literatura, podría ser el caso de la paciente más pequeña que se haya publicado.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los médicos deben estar atentos al mayor riesgo de complicaciones sistémicas en niños con LES que se inicia a una edad temprana y realizar un diagnóstico oportuno de esta enfermedad.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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