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                ]
              ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genomewide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM&#44; PXK&#44; KIAA1542 and other loci"
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                        0 => array:3 [
                          "colaboracion" => "International Consortium for Systemic Lupus Erythematosus Genetics &#40;SLEGEN&#41;"
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                          "autores" => array:5 [
                            0 => "J&#46;B&#46; Harley"
                            1 => "M&#46;E&#46; Alarc&#243;n-Riquelme"
                            2 => "L&#46;A&#46; Criswell"
                            3 => "C&#46;O&#46; Jacob"
                            4 => "R&#46;P&#46; Kimberly"
                          ]
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                    0 => array:2 [
                      "doi" => "10.1038/ng.81"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "204"
                        "paginaFinal" => "210"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18204446"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Hom"
                            1 => "R&#46;R&#46; Graham"
                            2 => "B&#46; Modrek"
                            3 => "K&#46;E&#46; Taylor"
                            4 => "W&#46; Ortmann"
                            5 => "S&#46; Garnier"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa0707865"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2008"
                        "volumen" => "358"
                        "paginaInicial" => "900"
                        "paginaFinal" => "909"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18204098"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "A&#46;K&#46; Abelson"
                            2 => "J&#46; Wojcik"
                            3 => "A&#46; Zaghlool"
                            4 => "M&#46;V&#46; Linga Reddy"
                            5 => "E&#46; Sanchez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng.79"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2008"
                        "volumen" => "40"
                        "paginaInicial" => "211"
                        "paginaFinal" => "216"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18204447"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Sigurdsson"
                            1 => "G&#46; Nordmark"
                            2 => "H&#46;H&#46; Goring"
                            3 => "K&#46; Lindroos"
                            4 => "A&#46;C&#46; Wiman"
                            5 => "G&#46; Sturfelt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/428480"
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                        "tituloSerie" => "Am J Hum Genet"
                        "fecha" => "2005"
                        "volumen" => "76"
                        "paginaInicial" => "528"
                        "paginaFinal" => "537"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15657875"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A common haplotype of interferon regulatory factor 5 &#40;IRF5&#41; regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
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                            1 => "S&#46;V&#46; Kozyrev"
                            2 => "E&#46;C&#46; Baechler"
                            3 => "M&#46;V&#46; Reddy"
                            4 => "R&#46;M&#46; Plenge"
                            5 => "J&#46;W&#46; Bauer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/ng1782"
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                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2006"
                        "volumen" => "38"
                        "paginaInicial" => "550"
                        "paginaFinal" => "555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16642019"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genetic association of IRF5 with SLE in Mexicans&#58; Higher frequency of the risk haplotype and its homozygozity than Europeans"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;V&#46; Reddy"
                            1 => "R&#46; Vel&#225;zquez-Cruz"
                            2 => "V&#46; Baca"
                            3 => "G&#46; Lima"
                            4 => "J&#46; Granados"
                            5 => "L&#46; Orozco"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00439-007-0367-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hum Genet"
                        "fecha" => "2007"
                        "volumen" => "121"
                        "paginaInicial" => "721"
                        "paginaFinal" => "727"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17476532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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