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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Alarcón-Segovia" 1 => "M.E. Alarcón-Riquelme" 2 => "M.H. Cardiel" 3 => "F. Caeiro" 4 => "L. Massardo" 5 => "A.R. Villa" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.20999" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2005" "volumen" => "52" "paginaInicial" => "1138" "paginaFinal" => "1147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15818688" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." 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Kruglyak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1205-1299" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2005" "volumen" => "37" "paginaInicial" => "1299" "paginaFinal" => "1300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16314858" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genomewide association study identifies IL23R as an inflammatory bowel disease gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.H. Duerr" 1 => "K.D. Taylor" 2 => "S.R. Brant" 3 => "J.D. Rioux" 4 => "M.S. Silverberg" 5 => "M.J. Daly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1126/science.1135245" "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "2006" "volumen" => "314" "paginaInicial" => "1461" "paginaFinal" => "1463" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17068223" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genome-wide association: A promising start to a long race" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.M. Evans" 1 => "L.R. Cardon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tig.2006.05.001" "Revista" => array:6 [ "tituloSerie" => "Trends Genet" "fecha" => "2006" "volumen" => "22" "paginaInicial" => "350" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16713652" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.J. Smyth" 1 => "J.D. Cooper" 2 => "R. Bailey" 3 => "S. Field" 4 => "O. Burren" 5 => "L.J. Smink" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1800" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2006" "volumen" => "38" "paginaInicial" => "617" "paginaFinal" => "619" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16699517" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "The Wellcome Trust Case Control Consortium (WTCCC)" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nature05911" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "2007" "volumen" => "447" "paginaInicial" => "661" "paginaFinal" => "678" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17554300" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Two independent alleles at 6q23 associated with risk of rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.M. Plenge" 1 => "C. Cotsapas" 2 => "L. Davies" 3 => "A.L. Price" 4 => "P.I. De Bakker" 5 => "J. Maller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng.2007.27" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2007" "volumen" => "39" "paginaInicial" => "1477" "paginaFinal" => "1482" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17982456" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research" "etal" => true "autores" => array:5 [ 0 => "R. Saxena" 1 => "B.F. Voight" 2 => "V. Lyssenko" 3 => "N.P. Burtt" 4 => "P.I. De Bakker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1126/science.1142358" "Revista" => array:6 [ "tituloSerie" => "Science" "fecha" => "2007" "volumen" => "316" "paginaInicial" => "1331" "paginaFinal" => "1336" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17463246" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Zeggini" 1 => "L.J. Scott" 2 => "R. Saxena" 3 => "B.F. Voight" 4 => "J.L. Marchini" 5 => "T. Hu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng.120" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2008" "volumen" => "40" "paginaInicial" => "638" "paginaFinal" => "645" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18372903" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficiency and power in genetic association studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.I. De Bakker" 1 => "R. Yelensky" 2 => "I. Pe’er" 3 => "S.B. Gabriel" 4 => "M.J. Daly" 5 => "D. Altshuler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1669" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2005" "volumen" => "37" "paginaInicial" => "1217" "paginaFinal" => "1223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16244653" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genome-wide association studies for common diseases and complex traits" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.N. Hirschhorn" 1 => "M.J. Daly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nrg1521" "Revista" => array:6 [ "tituloSerie" => "Nat Rev Genet" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "95" "paginaFinal" => "108" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15716906" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Principal components analysis corrects for stratification in genome-wide association studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.L. Price" 1 => "N.J. Patterson" 2 => "R.M. Plenge" 3 => "M.E. Weinblatt" 4 => "N.A. Shadick" 5 => "D. Reich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1847" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2006" "volumen" => "38" "paginaInicial" => "904" "paginaFinal" => "909" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16862161" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of two independent risk factors for lupus within the MHC in United Kingdom families" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.M. Fernando" 1 => "C.R. Stevens" 2 => "P.C. Sabeti" 3 => "E.C. Walsh" 4 => "A.J. McWhinnie" 5 => "A. Shah" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pgen.0030192" "Revista" => array:5 [ "tituloSerie" => "PLoS Genet" "fecha" => "2007" "volumen" => "3" "paginaInicial" => "e192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17997607" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomewide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN)" "etal" => false "autores" => array:5 [ 0 => "J.B. Harley" 1 => "M.E. Alarcón-Riquelme" 2 => "L.A. Criswell" 3 => "C.O. Jacob" 4 => "R.P. Kimberly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng.81" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2008" "volumen" => "40" "paginaInicial" => "204" "paginaFinal" => "210" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18204446" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Hom" 1 => "R.R. Graham" 2 => "B. Modrek" 3 => "K.E. Taylor" 4 => "W. Ortmann" 5 => "S. Garnier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0707865" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2008" "volumen" => "358" "paginaInicial" => "900" "paginaFinal" => "909" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18204098" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.V. Kozyrev" 1 => "A.K. Abelson" 2 => "J. Wojcik" 3 => "A. Zaghlool" 4 => "M.V. Linga Reddy" 5 => "E. Sanchez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng.79" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2008" "volumen" => "40" "paginaInicial" => "211" "paginaFinal" => "216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18204447" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Sigurdsson" 1 => "G. Nordmark" 2 => "H.H. Goring" 3 => "K. Lindroos" 4 => "A.C. Wiman" 5 => "G. Sturfelt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/428480" "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "2005" "volumen" => "76" "paginaInicial" => "528" "paginaFinal" => "537" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15657875" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.R. Graham" 1 => "S.V. Kozyrev" 2 => "E.C. Baechler" 3 => "M.V. Reddy" 4 => "R.M. Plenge" 5 => "J.W. Bauer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng1782" "Revista" => array:6 [ "tituloSerie" => "Nat Genet" "fecha" => "2006" "volumen" => "38" "paginaInicial" => "550" "paginaFinal" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16642019" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic association of IRF5 with SLE in Mexicans: Higher frequency of the risk haplotype and its homozygozity than Europeans" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.V. Reddy" 1 => "R. Velázquez-Cruz" 2 => "V. Baca" 3 => "G. Lima" 4 => "J. Granados" 5 => "L. Orozco" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00439-007-0367-6" "Revista" => array:6 [ "tituloSerie" => "Hum Genet" "fecha" => "2007" "volumen" => "121" "paginaInicial" => "721" "paginaFinal" => "727" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17476532" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000600000001/v1_201305061603/S2173574310700010/v1_201305061603/en/main.assets" "Apartado" => array:4 [ "identificador" => "17335" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Editorial" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000600000001/v1_201305061603/S2173574310700010/v1_201305061603/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574310700010?idApp=UINPBA00004M" ]
Journal Information
Vol. 6. Issue 1.
Pages 1-2 (January - February 2010)
Vol. 6. Issue 1.
Pages 1-2 (January - February 2010)
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Systemic lupus erythematosus. “What do we know and where are we heading?”
Genética del lupus eritematoso generalizado. ¿Qué se sabe y a dónde se va?
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References
[1.]
D. Alarcón-Segovia, M.E. Alarcón-Riquelme, M.H. Cardiel, F. Caeiro, L. Massardo, A.R. Villa, et al.
Familial aggregation of systemic lupus erythematosus, rheumatoid arthritis, and other autoimmune diseases in 1,177 lupus patients from the GLADEL cohort.
Arthritis Rheum, 52 (2005), pp. 1138-1147
[2.]
K.A. Frazer, D.G. Ballinger, D.R. Cox, D.A. Hinds, L.L. Stuve, International HapMap Consortium, et al.
A second generation human haplotype map of over 3.1 million SNPs.
Nature, 449 (2007), pp. 851-861
[3.]
L. Kruglyak.
Power tools for human genetics.
Nat Genet, 37 (2005), pp. 1299-1300
[4.]
R.H. Duerr, K.D. Taylor, S.R. Brant, J.D. Rioux, M.S. Silverberg, M.J. Daly, et al.
A genomewide association study identifies IL23R as an inflammatory bowel disease gene.
Science, 314 (2006), pp. 1461-1463
[5.]
D.M. Evans, L.R. Cardon.
Genome-wide association: A promising start to a long race.
Trends Genet, 22 (2006), pp. 350-354
[6.]
D.J. Smyth, J.D. Cooper, R. Bailey, S. Field, O. Burren, L.J. Smink, et al.
A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.
Nat Genet, 38 (2006), pp. 617-619
[7.]
The Wellcome Trust Case Control Consortium (WTCCC).
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
Nature, 447 (2007), pp. 661-678
[8.]
R.M. Plenge, C. Cotsapas, L. Davies, A.L. Price, P.I. De Bakker, J. Maller, et al.
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.
Nat Genet, 39 (2007), pp. 1477-1482
[9.]
R. Saxena, B.F. Voight, V. Lyssenko, N.P. Burtt, P.I. De Bakker, Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research, et al.
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
Science, 316 (2007), pp. 1331-1336
[10.]
E. Zeggini, L.J. Scott, R. Saxena, B.F. Voight, J.L. Marchini, T. Hu, et al.
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Nat Genet, 40 (2008), pp. 638-645
[11.]
P.I. De Bakker, R. Yelensky, I. Pe’er, S.B. Gabriel, M.J. Daly, D. Altshuler.
Efficiency and power in genetic association studies.
Nat Genet, 37 (2005), pp. 1217-1223
[12.]
J.N. Hirschhorn, M.J. Daly.
Genome-wide association studies for common diseases and complex traits.
Nat Rev Genet, 6 (2005), pp. 95-108
[13.]
A.L. Price, N.J. Patterson, R.M. Plenge, M.E. Weinblatt, N.A. Shadick, D. Reich.
Principal components analysis corrects for stratification in genome-wide association studies.
Nat Genet, 38 (2006), pp. 904-909
[14.]
M.M. Fernando, C.R. Stevens, P.C. Sabeti, E.C. Walsh, A.J. McWhinnie, A. Shah, et al.
Identification of two independent risk factors for lupus within the MHC in United Kingdom families.
PLoS Genet, 3 (2007), pp. e192
[15.]
J.B. Harley, M.E. Alarcón-Riquelme, L.A. Criswell, C.O. Jacob, R.P. Kimberly, International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN).
Genomewide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Nat Genet, 40 (2008), pp. 204-210
[16.]
G. Hom, R.R. Graham, B. Modrek, K.E. Taylor, W. Ortmann, S. Garnier, et al.
Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
N Engl J Med, 358 (2008), pp. 900-909
[17.]
S.V. Kozyrev, A.K. Abelson, J. Wojcik, A. Zaghlool, M.V. Linga Reddy, E. Sanchez, et al.
Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus.
Nat Genet, 40 (2008), pp. 211-216
[18.]
S. Sigurdsson, G. Nordmark, H.H. Goring, K. Lindroos, A.C. Wiman, G. Sturfelt, et al.
Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
Am J Hum Genet, 76 (2005), pp. 528-537
[19.]
R.R. Graham, S.V. Kozyrev, E.C. Baechler, M.V. Reddy, R.M. Plenge, J.W. Bauer, et al.
A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.
Nat Genet, 38 (2006), pp. 550-555
[20.]
M.V. Reddy, R. Velázquez-Cruz, V. Baca, G. Lima, J. Granados, L. Orozco, et al.
Genetic association of IRF5 with SLE in Mexicans: Higher frequency of the risk haplotype and its homozygozity than Europeans.
Hum Genet, 121 (2007), pp. 721-727
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