Systematic review on the use of adalimumab in autoinmune. Efficacy and safety in 54 patients
Revisión sistemática del uso de adalimumab en enfermedades autoinmunes. Eficacia y seguridad en 54 pacientes
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Efficacy and safety in 54 patients" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "127" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Cándido Díaz-Lagares, Rafael Belenguer, Manuel Ramos-Casals" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Cándido" "apellidos" => "Díaz-Lagares" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Rafael" "apellidos" => "Belenguer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "Manuel" "apellidos" => "Ramos-Casals" "email" => array:1 [ 0 => "mramos@clinic.ub.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Hospital Clinic, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Reumatología, Hospital 9 d’Octubre, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Revisión sistemática del uso de adalimumab en enfermedades autoinmunes. Eficacia y seguridad en 54 pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-03-04" "fechaAceptado" => "2009-06-10" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112420" "palabras" => array:3 [ 0 => "Adalimumab" 1 => "Autoimmune systemic diseases" 2 => "Uveitis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112421" "palabras" => array:3 [ 0 => "Adalimumab" 1 => "Enfermedades autoinmunes sistémicas" 2 => "Uveítis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze published evidence about adalimumab use in autoimmune diseases.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Systematic review of MEDLINE database of citations included from January 1990 to December 2008 employing the terms “adalimumab” and the different systemic autoimmune diseases.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Our search identified 241 potentially relevant citations. 154 were retrieved for detailed evaluation. Finally, 18 were selected as relevant, including 54 patients. The reported diseases were as follow: Behçet disease in 16 patients, idiopathic uveitis in 13, sarcoidosis in 5, uveitis associated with rheumatologic diseases in 5 (psoriasis in 2, ankylosing spondylitis in 1, juvenile idiopathic arthritis in 1, Crohn disease in 1), Vogt-Koyanagi-Harada disease in 4, Birdshot uveitis in 4, vasculitis in 3 (1 temporal arteritis, 1 Takayasu's disease, 1 skin vasculitis associated with rheumatoid arthritis), adult onset Still disease in 2, relapsing polychondritis in 1 and systemic sclerosis in 1. The clinical spectrum included uveitis (39 cases), skin and/or mucosae (9), vasculitis (3), arthritis (6), lung (3). These patients were refractory to standard therapy, including corticosteroids (42 cases, 78%), immunosuppressants (42, 78%) and biologics (29, 54%). Fifty (93%) patients responded to adalimumab. The clinical response was similar in those patients who had been treated with other biologic and in those who had not received biologic therapy before adalimumab. The patients were followed for 11.9 months. Twelve (22%) patients relapsed. Five (9%) patients suffer some side effect (3 local skin reaction, 1 angioedema, 1 lung fibrosis). One patient (2%) died due to progression of her disease.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Available data about the use of adalimumab in autoinmune diseases come from case reports and uncontrolled studies, that include patients with severe disease and refractory to standard therapy. In this setting, it seems to be an effective and safe treatment option, especially in patients with uveitis and Behçet's disease. This initial data must be confirmed by controlled assays before extending adalimumab use.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analizar la experiencia publicada sobre el uso de adalimumab en el tratamiento de enfermedades autoinmunes en adultos.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Se realizó una revisión sistemática de los artículos incluidos en la base de datos Medline desde el 1 de enero de 1990 al 31 de diciembre de 2008, combinando el término «adalimumab» con las diferentes enfermedades autoinmunes sistémicas. Se identificaron un total de 241 artículos, de los que 154 se revisaron a texto completo y 18 fueron finalmente seleccionados como relevantes.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">En los 18 artículos seleccionados se incluían 54 pacientes adultos con enfermedades autoinmunes tratados con adalimumab: 16 pacientes con enfermedad de Behçet; 13 con uveítis idiopática; 5 con sarcoidosis; 5 con uveítis asociadas a otras enfermedades (psoriasis en 2, espondilitis anquilosante en 1, artritis idiopática juvenil en 1, enfermedad de Crohn en 1); 4 con enfermedad de Vogt-Koyanagi-Harada; 4 con uveítis de Birdshot; 3 con vasculitis (arteritis de la temporal, enfermedad de Takayasu y una vasculitis cutánea asociada a artritis reumatoide), 2 con enfermedad de Still del adulto; uno con policondritis recidivante y un paciente con esclerosis sistémica. Las manifestaciones clínicas que motivaron la indicación fueron la uveítis (39 casos), afectación mucocutánea (9), vasculitis (3), artritis (6) y afectación pulmonar (3). En todos los casos se trataba de enfermedades refractarias a tratamiento con glucocorticoides (42 casos, 78%), inmunosupresores (42,78%) y otros biológicos (29,54%). Cincuenta (93%) pacientes respondieron a adalimumab. La respuesta fue similar tanto en aquellos que habían recibido otro biológico como en los que adalimumab era el primer biológico administrado. En 5 (9%) pacientes se describieron efectos adversos (3 reacciones cutáneas locales, un paciente con angioedema y una exacerbación de una fibrosis pulmonar). Tras un tiempo medio de seguimiento de 11,9 meses, 12 (22%) pacientes presentaron recidiva y uno (2%) falleció por exacerbación de su enfermedad de base.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La evidencia del uso de adalimumab en enfermedades autoinmunes proviene de casos aislados y ensayos no controlados, que incluyen en todos los casos a pacientes graves y refractarios a tratamiento convencional. En este contexto clínico, el uso de adalimumab aparece como una opción eficaz y segura, especialmente en pacientes con uveítis y enfermedad de Behçet.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:50 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 6 | 10 |
| 2024 October | 20 | 43 | 63 |
| 2024 September | 22 | 18 | 40 |
| 2024 August | 36 | 38 | 74 |
| 2024 July | 26 | 35 | 61 |
| 2024 June | 32 | 29 | 61 |
| 2024 May | 40 | 34 | 74 |
| 2024 April | 29 | 17 | 46 |
| 2024 March | 34 | 37 | 71 |
| 2024 February | 19 | 26 | 45 |
| 2024 January | 25 | 27 | 52 |
| 2023 December | 30 | 31 | 61 |
| 2023 November | 22 | 23 | 45 |
| 2023 October | 34 | 50 | 84 |
| 2023 September | 39 | 41 | 80 |
| 2023 August | 25 | 12 | 37 |
| 2023 July | 25 | 28 | 53 |
| 2023 June | 29 | 24 | 53 |
| 2023 May | 21 | 17 | 38 |
| 2023 April | 28 | 10 | 38 |
| 2023 March | 37 | 31 | 68 |
| 2023 February | 26 | 31 | 57 |
| 2023 January | 23 | 20 | 43 |
| 2022 December | 24 | 30 | 54 |
| 2022 November | 26 | 26 | 52 |
| 2022 October | 29 | 35 | 64 |
| 2022 September | 17 | 37 | 54 |
| 2022 August | 22 | 44 | 66 |
| 2022 July | 29 | 43 | 72 |
| 2022 June | 24 | 36 | 60 |
| 2022 May | 34 | 49 | 83 |
| 2022 April | 40 | 51 | 91 |
| 2022 March | 34 | 42 | 76 |
| 2022 February | 54 | 45 | 99 |
| 2022 January | 30 | 42 | 72 |
| 2021 December | 27 | 39 | 66 |
| 2021 November | 33 | 50 | 83 |
| 2021 October | 43 | 57 | 100 |
| 2021 September | 37 | 57 | 94 |
| 2021 August | 32 | 51 | 83 |
| 2021 July | 32 | 38 | 70 |
| 2021 June | 26 | 58 | 84 |
| 2021 May | 32 | 46 | 78 |
| 2021 April | 69 | 58 | 127 |
| 2021 March | 70 | 38 | 108 |
| 2021 February | 76 | 29 | 105 |
| 2021 January | 53 | 29 | 82 |
| 2020 December | 33 | 22 | 55 |
| 2020 November | 19 | 21 | 40 |
| 2020 October | 18 | 16 | 34 |
| 2020 September | 29 | 22 | 51 |
| 2020 August | 19 | 12 | 31 |
| 2020 July | 15 | 11 | 26 |
| 2020 June | 29 | 16 | 45 |
| 2020 May | 39 | 22 | 61 |
| 2020 April | 30 | 18 | 48 |
| 2020 March | 10 | 10 | 20 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 2 | 0 | 2 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 15 | 9 | 24 |
| 2018 March | 11 | 12 | 23 |
| 2018 February | 11 | 2 | 13 |
| 2018 January | 8 | 9 | 17 |
| 2017 December | 8 | 4 | 12 |
| 2017 November | 5 | 17 | 22 |
| 2017 October | 7 | 5 | 12 |
| 2017 September | 13 | 6 | 19 |
| 2017 August | 8 | 8 | 16 |
| 2017 July | 8 | 11 | 19 |
| 2017 June | 20 | 6 | 26 |
| 2017 May | 16 | 15 | 31 |
| 2017 April | 13 | 6 | 19 |
| 2017 March | 8 | 21 | 29 |
| 2017 February | 6 | 3 | 9 |
| 2017 January | 10 | 4 | 14 |
| 2016 December | 34 | 14 | 48 |
| 2016 November | 14 | 2 | 16 |
| 2016 October | 27 | 11 | 38 |
| 2016 September | 28 | 8 | 36 |
| 2016 August | 17 | 3 | 20 |
| 2016 July | 16 | 5 | 21 |
| 2016 June | 0 | 7 | 7 |
| 2016 April | 0 | 12 | 12 |
| 2016 March | 1 | 4 | 5 |
| 2016 January | 3 | 16 | 19 |
| 2015 December | 3 | 0 | 3 |
| 2015 November | 0 | 5 | 5 |
| 2015 October | 3 | 9 | 12 |
| 2015 September | 2 | 0 | 2 |
| 2015 August | 1 | 0 | 1 |
| 2015 July | 19 | 5 | 24 |
| 2015 June | 23 | 16 | 39 |
| 2015 May | 61 | 23 | 84 |
| 2015 April | 50 | 23 | 73 |
| 2015 March | 33 | 17 | 50 |
| 2015 February | 19 | 22 | 41 |
| 2015 January | 11 | 30 | 41 |
| 2014 December | 24 | 26 | 50 |
| 2014 November | 14 | 25 | 39 |
| 2014 October | 17 | 26 | 43 |
| 2014 September | 20 | 18 | 38 |
| 2014 August | 25 | 26 | 51 |
| 2014 July | 38 | 20 | 58 |
| 2014 June | 49 | 18 | 67 |
| 2014 May | 24 | 29 | 53 |
| 2014 April | 39 | 19 | 58 |
| 2014 March | 40 | 33 | 73 |
| 2014 February | 32 | 21 | 53 |
| 2014 January | 31 | 23 | 54 |
| 2013 December | 25 | 14 | 39 |
| 2013 November | 29 | 11 | 40 |
| 2013 October | 32 | 22 | 54 |
| 2013 September | 34 | 18 | 52 |
| 2013 August | 22 | 13 | 35 |
| 2013 July | 44 | 31 | 75 |
| 2013 June | 32 | 22 | 54 |
| 2013 May | 35 | 20 | 55 |
| 2013 April | 25 | 28 | 53 |
| 2013 March | 21 | 22 | 43 |
| 2013 February | 20 | 26 | 46 |
| 2013 January | 15 | 15 | 30 |
| 2012 December | 23 | 13 | 36 |
| 2012 November | 15 | 16 | 31 |
| 2012 October | 9 | 17 | 26 |
| 2012 September | 12 | 4 | 16 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 1 | 0 | 1 |
| 2012 May | 3 | 0 | 3 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 2 | 0 | 2 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 3 | 0 | 3 |
| 2011 October | 4 | 0 | 4 |
| 2011 August | 2 | 0 | 2 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 May | 3 | 0 | 3 |
| 2011 April | 4 | 0 | 4 |
| 2011 March | 5 | 0 | 5 |
| 2011 February | 2 | 0 | 2 |
| 2011 January | 9 | 0 | 9 |
| 2010 December | 9 | 0 | 9 |
| 2010 November | 19 | 0 | 19 |
| 2010 October | 15 | 0 | 15 |
| 2010 September | 5 | 0 | 5 |
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