Original article
Anti-transglutaminase, antigladin and ultra purified anti-gladin antibodies in patients with a diagnosis of rheumatoid arthritis
Anticuerpos anti-transglutaminasa, anti-gliadina y anti-gliadina ultra-purificada en pacientes con diagnóstico de artritis reumatoide del adulto
José Dionisio Castillo-Ortiza, Sergio Durán-Barragánb, Adriana Sánchez-Ortíza, Cesar Ramos-Remusb,c,
Corresponding author
a Hospital de Especialidades, UMAE Centro Médico Nacional de Occidente del Instituto Mexicano del Seguro Social, Guadalajara, Mexico
b Unidad de Investigación en Enfermedades Crónico-Degenerativas, Guadalajara, Mexico
c Hospital General Regional 45, Instituto Mexicano del Seguro Social, Guadalajara, Mexico
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] 3 => array:4 [ "nombre" => "Cesar" "apellidos" => "Ramos-Remus" "email" => array:1 [ 0 => "rramos@cencar.udg.mx" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Hospital de Especialidades, UMAE Centro Médico Nacional de Occidente del Instituto Mexicano del Seguro Social, Guadalajara, Mexico" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Unidad de Investigación en Enfermedades Crónico-Degenerativas, Guadalajara, Mexico" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hospital General Regional 45, Instituto Mexicano del Seguro Social, Guadalajara, Mexico" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Anticuerpos anti-transglutaminasa, anti-gliadina y anti-gliadina ultra-purificada en pacientes con diagnóstico de artritis reumatoide del adulto" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-12" "fechaAceptado" => "2010-03-08" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112615" "palabras" => array:4 [ 0 => "Rheumatoid arthritis" 1 => "Celiac disease" 2 => "Anti-tissue transglutaminase" 3 => "Anti-gliadin and ultra purified anti-gliadin antibodies" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112614" "palabras" => array:4 [ 0 => "Artritis reumatoide" 1 => "Enfermedad celiaca" 2 => "Anticuerpos anti-transglutaminasa tisular" 3 => "Anti-gliadina y anti-Gliadina ultra-purificada" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Celiac disease (CD) is an enteric disease caused by dietary gluten in individuals with genetic predisposition. One of the clinical manifestations of CD is peripheral arthritis that may simulate RA.</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the frequency of anti-gliadin (aGL), anti-tissue transglutaminase (aTGT) and ultra purified anti-gliadin (AGLU) antibodies in patients with RA.</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study. We included consecutive patients diagnosed as RA (ACR). Demographic and clinical data were registered by direct interview and serum levels of aGL, aTGT and aGLU were determined using ELISA.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Eighty-five RA patients were included; 87% were women. Mean age was 44<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>12 years, mean disease duration 12<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>9 years. IgG aGL antibodies were positive in 16 patients, IgA aGL antibodies in 29 patients, Aglu in 14 patients and only one patient had aTGT.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It is possible that CD may be the correct diagnosis in a patient with polyarthritis, even if the patient meets the ACR criteria for RA. In other words, CD should be considered among the differential diagnoses in a patient with polyarthritis.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La enfermedad celiaca (EC) es una afección entérica ocasionada por la ingesta de granos que contienen gluten. Una manifestación clínica poco reconocida es la artritis periférica, que puede simular artritis reumatoide.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar la frecuencia de anti-Gliadina (aGL), anti Transglutaminasa Tisular (aTGT) y anti-Gliadina Ultra-purificada (aGLU) en pacientes con diagnóstico de AR.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Es un estudio transversal de pacientes con AR (criterios ACR). Se registraron variables demográficas y clínicas y se les realizaron determinaciones séricas de anticuerpos aGL, aGLU y aTGT por ELISA.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 85 pacientes con AR. El 87% de los pacientes fueron mujeres. El promedio de edad fue de 44 años ± 12, con una media de 12<span class="elsevierStyleHsp" style=""></span>±<span class="elsevierStyleHsp" style=""></span>9 años de evolución. Los anticuerpos aGL IgG estuvieron positivos en 16 pacientes, los aGL IgA en 29 pacientes, la aGLU en 14 pacientes y solo un paciente fue positivo para aTGT.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Es posible que pacientes con poliartritis y que cumplan con los criterios de clasificación de AR puedan tener de hecho EC. De otra forma, la EC debe considerarse dentro del diagnóstico diferencial de poliartritis.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 17 | 23 |
| 2024 October | 24 | 45 | 69 |
| 2024 September | 23 | 40 | 63 |
| 2024 August | 39 | 48 | 87 |
| 2024 July | 33 | 53 | 86 |
| 2024 June | 35 | 29 | 64 |
| 2024 May | 39 | 36 | 75 |
| 2024 April | 34 | 27 | 61 |
| 2024 March | 38 | 50 | 88 |
| 2024 February | 29 | 23 | 52 |
| 2024 January | 24 | 25 | 49 |
| 2023 December | 22 | 42 | 64 |
| 2023 November | 21 | 36 | 57 |
| 2023 October | 21 | 38 | 59 |
| 2023 September | 39 | 38 | 77 |
| 2023 August | 17 | 13 | 30 |
| 2023 July | 31 | 28 | 59 |
| 2023 June | 17 | 23 | 40 |
| 2023 May | 17 | 11 | 28 |
| 2023 April | 19 | 9 | 28 |
| 2023 March | 32 | 32 | 64 |
| 2023 February | 21 | 21 | 42 |
| 2023 January | 24 | 19 | 43 |
| 2022 December | 29 | 42 | 71 |
| 2022 November | 23 | 24 | 47 |
| 2022 October | 29 | 27 | 56 |
| 2022 September | 30 | 33 | 63 |
| 2022 August | 25 | 44 | 69 |
| 2022 July | 23 | 38 | 61 |
| 2022 June | 28 | 42 | 70 |
| 2022 May | 31 | 54 | 85 |
| 2022 April | 36 | 38 | 74 |
| 2022 March | 38 | 60 | 98 |
| 2022 February | 42 | 34 | 76 |
| 2022 January | 25 | 41 | 66 |
| 2021 December | 45 | 51 | 96 |
| 2021 November | 55 | 49 | 104 |
| 2021 October | 77 | 56 | 133 |
| 2021 September | 50 | 43 | 93 |
| 2021 August | 54 | 46 | 100 |
| 2021 July | 28 | 35 | 63 |
| 2021 June | 32 | 49 | 81 |
| 2021 May | 40 | 43 | 83 |
| 2021 April | 72 | 103 | 175 |
| 2021 March | 38 | 28 | 66 |
| 2021 February | 32 | 35 | 67 |
| 2021 January | 35 | 20 | 55 |
| 2020 December | 37 | 22 | 59 |
| 2020 November | 23 | 23 | 46 |
| 2020 October | 20 | 17 | 37 |
| 2020 September | 19 | 22 | 41 |
| 2020 August | 33 | 21 | 54 |
| 2020 July | 11 | 17 | 28 |
| 2020 June | 29 | 19 | 48 |
| 2020 May | 17 | 17 | 34 |
| 2020 April | 28 | 22 | 50 |
| 2020 March | 24 | 14 | 38 |
| 2020 February | 1 | 0 | 1 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 December | 3 | 0 | 3 |
| 2018 May | 3 | 3 | 6 |
| 2018 April | 25 | 9 | 34 |
| 2018 March | 24 | 12 | 36 |
| 2018 February | 11 | 5 | 16 |
| 2018 January | 13 | 3 | 16 |
| 2017 December | 9 | 7 | 16 |
| 2017 November | 19 | 4 | 23 |
| 2017 October | 17 | 9 | 26 |
| 2017 September | 10 | 16 | 26 |
| 2017 August | 11 | 6 | 17 |
| 2017 July | 9 | 11 | 20 |
| 2017 June | 28 | 9 | 37 |
| 2017 May | 25 | 10 | 35 |
| 2017 April | 16 | 8 | 24 |
| 2017 March | 10 | 5 | 15 |
| 2017 February | 6 | 1 | 7 |
| 2017 January | 13 | 3 | 16 |
| 2016 December | 36 | 12 | 48 |
| 2016 November | 25 | 2 | 27 |
| 2016 October | 42 | 14 | 56 |
| 2016 September | 34 | 6 | 40 |
| 2016 August | 24 | 6 | 30 |
| 2016 July | 8 | 4 | 12 |
| 2016 June | 0 | 7 | 7 |
| 2016 May | 1 | 6 | 7 |
| 2016 April | 3 | 13 | 16 |
| 2016 March | 1 | 19 | 20 |
| 2016 February | 2 | 19 | 21 |
| 2015 December | 7 | 0 | 7 |
| 2015 October | 3 | 13 | 16 |
| 2015 September | 3 | 0 | 3 |
| 2015 August | 1 | 10 | 11 |
| 2015 July | 21 | 4 | 25 |
| 2015 June | 15 | 20 | 35 |
| 2015 May | 37 | 17 | 54 |
| 2015 April | 24 | 21 | 45 |
| 2015 March | 26 | 17 | 43 |
| 2015 February | 25 | 19 | 44 |
| 2015 January | 26 | 17 | 43 |
| 2014 December | 34 | 19 | 53 |
| 2014 November | 16 | 19 | 35 |
| 2014 October | 28 | 21 | 49 |
| 2014 September | 12 | 17 | 29 |
| 2014 August | 12 | 26 | 38 |
| 2014 July | 24 | 25 | 49 |
| 2014 June | 39 | 22 | 61 |
| 2014 May | 21 | 36 | 57 |
| 2014 April | 16 | 6 | 22 |
| 2014 March | 39 | 22 | 61 |
| 2014 February | 17 | 16 | 33 |
| 2014 January | 23 | 28 | 51 |
| 2013 December | 26 | 16 | 42 |
| 2013 November | 16 | 19 | 35 |
| 2013 October | 25 | 24 | 49 |
| 2013 September | 28 | 23 | 51 |
| 2013 August | 26 | 17 | 43 |
| 2013 July | 25 | 14 | 39 |
| 2013 June | 16 | 17 | 33 |
| 2013 May | 22 | 20 | 42 |
| 2013 April | 21 | 23 | 44 |
| 2013 March | 12 | 22 | 34 |
| 2013 February | 18 | 22 | 40 |
| 2013 January | 14 | 24 | 38 |
| 2012 December | 22 | 17 | 39 |
| 2012 November | 10 | 17 | 27 |
| 2012 October | 10 | 15 | 25 |
| 2012 September | 6 | 4 | 10 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 2 | 0 | 2 |
| 2012 May | 2 | 0 | 2 |
| 2012 April | 7 | 0 | 7 |
| 2012 March | 3 | 0 | 3 |
| 2012 February | 4 | 0 | 4 |
| 2012 January | 2 | 0 | 2 |
| 2011 December | 7 | 0 | 7 |
| 2011 November | 3 | 0 | 3 |
| 2011 October | 7 | 0 | 7 |
| 2011 July | 1 | 0 | 1 |
| 2011 June | 2 | 0 | 2 |
| 2011 February | 1 | 0 | 1 |
| 2011 January | 12 | 0 | 12 |
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