array:23 [
  "pii" => "S2173574311700053"
  "issn" => "21735743"
  "doi" => "10.1016/S2173-5743(11)70005-3"
  "estado" => "S300"
  "fechaPublicacion" => "2011-01-01"
  "aid" => "70005"
  "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
  "copyrightAnyo" => "2011"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Reumatol Clin. 2011;7:27-9"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2222
    "formatos" => array:3 [
      "EPUB" => 43
      "HTML" => 1261
      "PDF" => 918
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S2173574311700065"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(11)70006-5"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "aid" => "70006"
    "copyright" => "Sociedad Española de Reumatología and Colegio Mexicano de Reumatología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2011;7:30-44"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2650
      "formatos" => array:3 [
        "EPUB" => 56
        "HTML" => 1829
        "PDF" => 765
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Consensus on the use of Rituximab in Rheumatoid Arthritis&#46; A document with evidence based recommendations"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "30"
          "paginaFinal" => "44"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Consenso de uso de rituximab en artritis reumatoide&#46; Un documento con recomendaciones basadas en la evidencia"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Emilio Mart&#237;n Mola, Blanca Hern&#225;ndez, Miriam Garc&#237;a-Arias, Jos&#233; Mar&#237;a &#193;lvaro-Gracia, Alejandro Balsa, Juan G&#243;mez-Reino, Jos&#233; L&#46; Marenco de la Fuente, V&#237;ctor Mart&#237;nez-Taboada, Jos&#233; Andr&#233;s Rom&#225;n Ivorra, Raimon Sanmart&#237;"
          "autores" => array:11 [
            0 => array:2 [
              "nombre" => "Emilio"
              "apellidos" => "Mart&#237;n Mola"
            ]
            1 => array:2 [
              "nombre" => "Blanca"
              "apellidos" => "Hern&#225;ndez"
            ]
            2 => array:2 [
              "nombre" => "Miriam"
              "apellidos" => "Garc&#237;a-Arias"
            ]
            3 => array:2 [
              "nombre" => "Jos&#233; Mar&#237;a"
              "apellidos" => "&#193;lvaro-Gracia"
            ]
            4 => array:2 [
              "nombre" => "Alejandro"
              "apellidos" => "Balsa"
            ]
            5 => array:2 [
              "nombre" => "Juan"
              "apellidos" => "G&#243;mez-Reino"
            ]
            6 => array:2 [
              "nombre" => "Jos&#233; L&#46;"
              "apellidos" => "Marenco de la Fuente"
            ]
            7 => array:2 [
              "nombre" => "V&#237;ctor"
              "apellidos" => "Mart&#237;nez-Taboada"
            ]
            8 => array:2 [
              "nombre" => "Jos&#233; Andr&#233;s Rom&#225;n"
              "apellidos" => "Ivorra"
            ]
            9 => array:2 [
              "nombre" => "Raimon"
              "apellidos" => "Sanmart&#237;"
            ]
            10 => array:1 [
              "colaborador" => "Expert Group on Rituximab"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700065?idApp=UINPBA00004M"
    "url" => "/21735743/0000000700000001/v1_201305061616/S2173574311700065/v1_201305061616/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S2173574311700041"
    "issn" => "21735743"
    "doi" => "10.1016/S2173-5743(11)70004-1"
    "estado" => "S300"
    "fechaPublicacion" => "2011-01-01"
    "aid" => "70004"
    "copyright" => "Sociedad Espa&#241;ola de Reumatolog&#237;a and Colegio Mexicano de Reumatolog&#237;a"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Reumatol Clin. 2011;7:20-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2539
      "formatos" => array:3 [
        "EPUB" => 41
        "HTML" => 1427
        "PDF" => 1071
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Prevalence of symptoms of anxiety and depression in patients with psoriatic arthritis attending rheumatology clinics"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "20"
          "paginaFinal" => "26"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Prevalencia de s&#237;ntomas de ansiedad y de depresi&#243;n en pacientes con artritis psori&#225;sica en consultas de reumatolog&#237;a"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Mercedes Freire, Jes&#250;s Rodr&#237;guez, Ingrid M&#246;ller, Antonio Valc&#225;rcel, Carmelo Tornero, Gemma D&#237;az, Yolanda Armend&#225;riz, Silvia Paredes"
          "autores" => array:8 [
            0 => array:2 [
              "nombre" => "Mercedes"
              "apellidos" => "Freire"
            ]
            1 => array:2 [
              "nombre" => "Jes&#250;s"
              "apellidos" => "Rodr&#237;guez"
            ]
            2 => array:2 [
              "nombre" => "Ingrid"
              "apellidos" => "M&#246;ller"
            ]
            3 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "Valc&#225;rcel"
            ]
            4 => array:2 [
              "nombre" => "Carmelo"
              "apellidos" => "Tornero"
            ]
            5 => array:2 [
              "nombre" => "Gemma"
              "apellidos" => "D&#237;az"
            ]
            6 => array:2 [
              "nombre" => "Yolanda"
              "apellidos" => "Armend&#225;riz"
            ]
            7 => array:2 [
              "nombre" => "Silvia"
              "apellidos" => "Paredes"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700041?idApp=UINPBA00004M"
    "url" => "/21735743/0000000700000001/v1_201305061616/S2173574311700041/v1_201305061616/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Anti-transglutaminase&#44; antigladin and ultra purified anti-gladin antibodies in patients with a diagnosis of rheumatoid arthritis"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "27"
        "paginaFinal" => "29"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Jos&#233; Dionisio Castillo-Ortiz, Sergio Dur&#225;n-Barrag&#225;n, Adriana S&#225;nchez-Ort&#237;z, Cesar Ramos-Remus"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "Jos&#233;"
            "apellidos" => "Dionisio Castillo-Ortiz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Sergio"
            "apellidos" => "Dur&#225;n-Barrag&#225;n"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Adriana"
            "apellidos" => "S&#225;nchez-Ort&#237;z"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "Cesar"
            "apellidos" => "Ramos-Remus"
            "email" => array:1 [
              0 => "rramos&#64;cencar&#46;udg&#46;mx"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Hospital de Especialidades&#44; UMAE Centro M&#233;dico Nacional de Occidente del Instituto Mexicano del Seguro Social&#44; Guadalajara&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Unidad de Investigaci&#243;n en Enfermedades Cr&#243;nico-Degenerativas&#44; Guadalajara&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Hospital General Regional 45&#44; Instituto Mexicano del Seguro Social&#44; Guadalajara&#44; Mexico"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Anticuerpos anti-transglutaminasa&#44; anti-gliadina y anti-gliadina ultra-purificada en pacientes con diagn&#243;stico de artritis reumatoide del adulto"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2010-01-12"
    "fechaAceptado" => "2010-03-08"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec112615"
          "palabras" => array:4 [
            0 => "Rheumatoid arthritis"
            1 => "Celiac disease"
            2 => "Anti-tissue transglutaminase"
            3 => "Anti-gliadin and ultra purified anti-gliadin antibodies"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec112614"
          "palabras" => array:4 [
            0 => "Artritis reumatoide"
            1 => "Enfermedad celiaca"
            2 => "Anticuerpos anti-transglutaminasa tisular"
            3 => "Anti-gliadina y anti-Gliadina ultra-purificada"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Celiac disease &#40;CD&#41; is an enteric disease caused by dietary gluten in individuals with genetic predisposition&#46; One of the clinical manifestations of CD is peripheral arthritis that may simulate RA&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To determine the frequency of anti-gliadin &#40;aGL&#41;&#44; anti-tissue transglutaminase &#40;aTGT&#41; and ultra purified anti-gliadin &#40;AGLU&#41; antibodies in patients with RA&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Cross-sectional study&#46; We included consecutive patients diagnosed as RA &#40;ACR&#41;&#46; Demographic and clinical data were registered by direct interview and serum levels of aGL&#44; aTGT and aGLU were determined using ELISA&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Eighty-five RA patients were included&#59; 87&#37; were women&#46; Mean age was 44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12 years&#44; mean disease duration 12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 years&#46; IgG aGL antibodies were positive in 16 patients&#44; IgA aGL antibodies in 29 patients&#44; Aglu in 14 patients and only one patient had aTGT&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">It is possible that CD may be the correct diagnosis in a patient with polyarthritis&#44; even if the patient meets the ACR criteria for RA&#46; In other words&#44; CD should be considered among the differential diagnoses in a patient with polyarthritis&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La enfermedad celiaca &#40;EC&#41; es una afecci&#243;n ent&#233;rica ocasionada por la ingesta de granos que contienen gluten&#46; Una manifestaci&#243;n cl&#237;nica poco reconocida es la artritis perif&#233;rica&#44; que puede simular artritis reumatoide&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Determinar la frecuencia de anti-Gliadina &#40;aGL&#41;&#44; anti Transglutaminasa Tisular &#40;aTGT&#41; y anti-Gliadina Ultra-purificada &#40;aGLU&#41; en pacientes con diagn&#243;stico de AR&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Es un estudio transversal de pacientes con AR &#40;criterios ACR&#41;&#46; Se registraron variables demogr&#225;ficas y cl&#237;nicas y se les realizaron determinaciones s&#233;ricas de anticuerpos aGL&#44; aGLU y aTGT por ELISA&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 85 pacientes con AR&#46; El 87&#37; de los pacientes fueron mujeres&#46; El promedio de edad fue de 44 a&#241;os &#177; 12&#44; con una media de 12<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>9 a&#241;os de evoluci&#243;n&#46; Los anticuerpos aGL IgG estuvieron positivos en 16 pacientes&#44; los aGL IgA en 29 pacientes&#44; la aGLU en 14 pacientes y solo un paciente fue positivo para aTGT&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Es posible que pacientes con poliartritis y que cumplan con los criterios de clasificaci&#243;n de AR puedan tener de hecho EC&#46; De otra forma&#44; la EC debe considerarse dentro del diagn&#243;stico diferencial de poliartritis&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluating patients with arthritis of recent onset&#58; studies in pathogenesis and prognosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46;S&#46; El-Gabalawy"
                            1 => "P&#46; Duray"
                            2 => "R&#46; Goldbach-Mansky"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2000"
                        "volumen" => "284"
                        "paginaInicial" => "2368"
                        "paginaFinal" => "2373"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11066188"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Celiac disease genetics&#58; current concepts and practical applications"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;M&#46; Sollid"
                            1 => "B&#46;A&#46; Lie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Gastroenterol Hepatol"
                        "fecha" => "2005"
                        "volumen" => "3"
                        "paginaInicial" => "843"
                        "paginaFinal" => "851"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16234020"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Seroprevalence&#44; correlates&#44; and characteristics of undetected celiac disease in England"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; West"
                            1 => "R&#46;F&#46; Logan"
                            2 => "P&#46;G&#46; Hill"
                            3 => "A&#46; Lloyd"
                            4 => "S&#46; Lewis"
                            5 => "R&#46; Hubbard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gut"
                        "fecha" => "2003"
                        "volumen" => "52"
                        "paginaInicial" => "960"
                        "paginaFinal" => "965"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12801951"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of celiac disease among children in Finland"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; M&#228;ki"
                            1 => "K&#46; Mustalahti"
                            2 => "J&#46; Kokkonen"
                            3 => "P&#46; Kulmala"
                            4 => "M&#46; Haapalahti"
                            5 => "T&#46; Karttunen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa021687"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2003"
                        "volumen" => "348"
                        "paginaInicial" => "2517"
                        "paginaFinal" => "2524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12815137"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Tatar"
                            1 => "R&#46; Elsurer"
                            2 => "H&#46; Simsek"
                            3 => "Y&#46;H&#46; Balaban"
                            4 => "G&#46; Hascelik"
                            5 => "O&#46;I&#46; Ozcebe"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "2004"
                        "volumen" => "49"
                        "paginaInicial" => "1479"
                        "paginaFinal" => "1484"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15481323"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of celiac disease in at-risk and not-at-risk groups in the United States&#58; a large multicenter study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Fasano"
                            1 => "I&#46; Berti"
                            2 => "T&#46; Gerarduzzi"
                            3 => "T&#46; Not"
                            4 => "R&#46;B&#46; Colletti"
                            5 => "S&#46; Drago"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Intern Med"
                        "fecha" => "2003"
                        "volumen" => "163"
                        "paginaInicial" => "286"
                        "paginaFinal" => "292"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12578508"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Undiagnosed coeliac disease at age seven&#58; population based prospective birth cohort study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;J&#46; Bingley"
                            1 => "A&#46;J&#46; Williams"
                            2 => "A&#46;J&#46; Norcross"
                            3 => "D&#46;J&#46; Unsworth"
                            4 => "R&#46;J&#46; Lock"
                            5 => "A&#46;R&#46; Ness"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/bmj.328.7435.322"
                      "Revista" => array:6 [
                        "tituloSerie" => "BMJ"
                        "fecha" => "2004"
                        "volumen" => "328"
                        "paginaInicial" => "322"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14764493"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The diagnostic accuracy of serologic tests for celiac disease&#58; a systematic review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Rostom"
                            1 => "C&#46; Dub&#233;"
                            2 => "A&#46; Cranney"
                            3 => "N&#46; Saloojee"
                            4 => "R&#46; Sy"
                            5 => "C&#46; Garritty"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "numero" => "4 Suppl 1"
                        "paginaInicial" => "S38"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15825125"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "What are the sensitivity and specificity of serologic tests for celiac disease&#63; Do sensitivity and specificity vary in different populations&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46;D&#46; Hill"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2005"
                        "volumen" => "128"
                        "numero" => "4 Suppl 1"
                        "paginaInicial" => "S25"
                        "paginaFinal" => "S32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15825123"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Common and private genetic background for rheumatoid arthritis and celiac disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;J&#46; Coenen"
                            1 => "G&#46; Trynka"
                            2 => "S&#46; Heskamp"
                            3 => "B&#46; Franke"
                            4 => "C&#46;C&#46; Van Diemen"
                            5 => "J&#46; Smolonska"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Rheum Dis"
                        "fecha" => "2009"
                        "volumen" => "68"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "182"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis&#58; the effects on arthritis correlate with a reduction in antibodies to food antigens"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "I&#46; Hafstr&#246;m"
                            1 => "B&#46; Ringertz"
                            2 => "A&#46; Sp&#229;ngberg"
                            3 => "L&#46; Von Zweigbergk"
                            4 => "S&#46; Brannemark"
                            5 => "I&#46; Nylander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#41;"
                        "fecha" => "2001"
                        "volumen" => "40"
                        "paginaInicial" => "1175"
                        "paginaFinal" => "1179"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arthritis associated with bowel disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46; Neumann"
                            1 => "V&#46; Wright"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Gastroenterol"
                        "fecha" => "1983"
                        "volumen" => "12"
                        "paginaInicial" => "767"
                        "paginaFinal" => "795"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6193911"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0002937899703893"
                          "estado" => "S300"
                          "issn" => "00029378"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The American Rheumatism Association 1987 revised criteria for the classification of Rheumatoid Arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Arnett"
                            1 => "S&#46; Edworthy"
                            2 => "D&#46; Bloch"
                            3 => "D&#46; McShane"
                            4 => "J&#46; Fries"
                            5 => "N&#46; Cooper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "1988"
                        "volumen" => "31"
                        "paginaInicial" => "315"
                        "paginaFinal" => "324"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3358796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Celiac sprue &#40;the great modern-day imposter&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46; Lee"
                            1 => "P&#46; Green"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Opin Rheumatol"
                        "fecha" => "2006"
                        "volumen" => "18"
                        "paginaInicial" => "101"
                        "paginaFinal" => "107"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16344626"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of undiagnosed celiac syndrome in osteoporotic women"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Nuti"
                            1 => "G&#46; Martini"
                            2 => "R&#46; Valenti"
                            3 => "S&#46; Giovani"
                            4 => "S&#46; Salvadori"
                            5 => "A&#46; Avanzati"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Intern Med"
                        "fecha" => "2001"
                        "volumen" => "250"
                        "paginaInicial" => "361"
                        "paginaFinal" => "366"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11576323"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735743/0000000700000001/v1_201305061616/S2173574311700053/v1_201305061616/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "17338"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Original Article"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000700000001/v1_201305061616/S2173574311700053/v1_201305061616/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700053?idApp=UINPBA00004M"
]
Share
Journal Information
Vol. 7. Issue 1.
Pages 27-29 (January - February 2011)
Share
Share
Download PDF
More article options
Vol. 7. Issue 1.
Pages 27-29 (January - February 2011)
Original article
Full text access
Anti-transglutaminase, antigladin and ultra purified anti-gladin antibodies in patients with a diagnosis of rheumatoid arthritis
Anticuerpos anti-transglutaminasa, anti-gliadina y anti-gliadina ultra-purificada en pacientes con diagnóstico de artritis reumatoide del adulto
Visits
5875
José Dionisio Castillo-Ortiza, Sergio Durán-Barragánb, Adriana Sánchez-Ortíza, Cesar Ramos-Remusb,c,
Corresponding author
rramos@cencar.udg.mx

Corresponding author.
a Hospital de Especialidades, UMAE Centro Médico Nacional de Occidente del Instituto Mexicano del Seguro Social, Guadalajara, Mexico
b Unidad de Investigación en Enfermedades Crónico-Degenerativas, Guadalajara, Mexico
c Hospital General Regional 45, Instituto Mexicano del Seguro Social, Guadalajara, Mexico
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Abstract

Celiac disease (CD) is an enteric disease caused by dietary gluten in individuals with genetic predisposition. One of the clinical manifestations of CD is peripheral arthritis that may simulate RA.

Objective

To determine the frequency of anti-gliadin (aGL), anti-tissue transglutaminase (aTGT) and ultra purified anti-gliadin (AGLU) antibodies in patients with RA.

Methods

Cross-sectional study. We included consecutive patients diagnosed as RA (ACR). Demographic and clinical data were registered by direct interview and serum levels of aGL, aTGT and aGLU were determined using ELISA.

Results

Eighty-five RA patients were included; 87% were women. Mean age was 44±12 years, mean disease duration 12±9 years. IgG aGL antibodies were positive in 16 patients, IgA aGL antibodies in 29 patients, Aglu in 14 patients and only one patient had aTGT.

Conclusions

It is possible that CD may be the correct diagnosis in a patient with polyarthritis, even if the patient meets the ACR criteria for RA. In other words, CD should be considered among the differential diagnoses in a patient with polyarthritis.

Keywords:
Rheumatoid arthritis
Celiac disease
Anti-tissue transglutaminase
Anti-gliadin and ultra purified anti-gliadin antibodies
Resumen

La enfermedad celiaca (EC) es una afección entérica ocasionada por la ingesta de granos que contienen gluten. Una manifestación clínica poco reconocida es la artritis periférica, que puede simular artritis reumatoide.

Objetivo

Determinar la frecuencia de anti-Gliadina (aGL), anti Transglutaminasa Tisular (aTGT) y anti-Gliadina Ultra-purificada (aGLU) en pacientes con diagnóstico de AR.

Métodos

Es un estudio transversal de pacientes con AR (criterios ACR). Se registraron variables demográficas y clínicas y se les realizaron determinaciones séricas de anticuerpos aGL, aGLU y aTGT por ELISA.

Resultados

Se incluyeron 85 pacientes con AR. El 87% de los pacientes fueron mujeres. El promedio de edad fue de 44 años ± 12, con una media de 12±9 años de evolución. Los anticuerpos aGL IgG estuvieron positivos en 16 pacientes, los aGL IgA en 29 pacientes, la aGLU en 14 pacientes y solo un paciente fue positivo para aTGT.

Conclusiones

Es posible que pacientes con poliartritis y que cumplan con los criterios de clasificación de AR puedan tener de hecho EC. De otra forma, la EC debe considerarse dentro del diagnóstico diferencial de poliartritis.

Palabras clave:
Artritis reumatoide
Enfermedad celiaca
Anticuerpos anti-transglutaminasa tisular
Anti-gliadina y anti-Gliadina ultra-purificada
Full text is only aviable in PDF
References
[1.]
H.S. El-Gabalawy, P. Duray, R. Goldbach-Mansky.
Evaluating patients with arthritis of recent onset: studies in pathogenesis and prognosis.
JAMA, 284 (2000), pp. 2368-2373
[2.]
L.M. Sollid, B.A. Lie.
Celiac disease genetics: current concepts and practical applications.
Clin Gastroenterol Hepatol, 3 (2005), pp. 843-851
[3.]
J. West, R.F. Logan, P.G. Hill, A. Lloyd, S. Lewis, R. Hubbard, et al.
Seroprevalence, correlates, and characteristics of undetected celiac disease in England.
Gut, 52 (2003), pp. 960-965
[4.]
M. Mäki, K. Mustalahti, J. Kokkonen, P. Kulmala, M. Haapalahti, T. Karttunen, et al.
Prevalence of celiac disease among children in Finland.
N Engl J Med, 348 (2003), pp. 2517-2524
[5.]
G. Tatar, R. Elsurer, H. Simsek, Y.H. Balaban, G. Hascelik, O.I. Ozcebe, et al.
Screening of tissue transglutaminase antibody in healthy blood donors for celiac disease screening in the Turkish population.
Dig Dis Sci, 49 (2004), pp. 1479-1484
[6.]
A. Fasano, I. Berti, T. Gerarduzzi, T. Not, R.B. Colletti, S. Drago, et al.
Prevalence of celiac disease in at-risk and not-at-risk groups in the United States: a large multicenter study.
Arch Intern Med, 163 (2003), pp. 286-292
[7.]
P.J. Bingley, A.J. Williams, A.J. Norcross, D.J. Unsworth, R.J. Lock, A.R. Ness.
Undiagnosed coeliac disease at age seven: population based prospective birth cohort study.
[8.]
A. Rostom, C. Dubé, A. Cranney, N. Saloojee, R. Sy, C. Garritty, et al.
The diagnostic accuracy of serologic tests for celiac disease: a systematic review.
Gastroenterology, 128 (2005), pp. S38-46
[9.]
I.D. Hill.
What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations?.
Gastroenterology, 128 (2005), pp. S25-S32
[10.]
M.J. Coenen, G. Trynka, S. Heskamp, B. Franke, C.C. Van Diemen, J. Smolonska, et al.
Common and private genetic background for rheumatoid arthritis and celiac disease.
Ann Rheum Dis, 68 (2009), pp. 182
[11.]
I. Hafström, B. Ringertz, A. Spångberg, L. Von Zweigbergk, S. Brannemark, I. Nylander, et al.
A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens.
Rheumatology (Oxford), 40 (2001), pp. 1175-1179
[12.]
V. Neumann, V. Wright.
Arthritis associated with bowel disease.
Clin Gastroenterol, 12 (1983), pp. 767-795
[13.]
F. Arnett, S. Edworthy, D. Bloch, D. McShane, J. Fries, N. Cooper, et al.
The American Rheumatism Association 1987 revised criteria for the classification of Rheumatoid Arthritis.
Arthritis Rheum, 31 (1988), pp. 315-324
[14.]
S. Lee, P. Green.
Celiac sprue (the great modern-day imposter).
Curr Opin Rheumatol, 18 (2006), pp. 101-107
[15.]
R. Nuti, G. Martini, R. Valenti, S. Giovani, S. Salvadori, A. Avanzati.
Prevalence of undiagnosed celiac syndrome in osteoporotic women.
J Intern Med, 250 (2001), pp. 361-366
Copyright © 2011. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
Download PDF
Idiomas
Reumatología Clínica (English Edition)
Article options
Tools
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?