Continuing medical education
Citrullinated proteins in Rheumatoid Arthritis
Proteínas citrulinadas en artritis reumatoide
Elizabeth Olivares Martínez, Diego F. Hernández Ramírez, Carlos A. Núñez-Álvarez
, Javier Cabiedes1
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Laboratorio de Inmunología, Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
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Hernández Ramírez, Carlos A. Núñez-Álvarez, Javier Cabiedes" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Elizabeth" "apellidos" => "Olivares Martínez" ] 1 => array:2 [ "nombre" => "Diego F." "apellidos" => "Hernández Ramírez" ] 2 => array:4 [ "nombre" => "Carlos A." "apellidos" => "Núñez-Álvarez" "email" => array:1 [ 0 => "nuac80df@yahoo.com.mx" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 3 => array:3 [ "nombre" => "Javier" "apellidos" => "Cabiedes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Laboratorio de Inmunología, Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Proteínas citrulinadas en artritis reumatoide" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2009-07-24" "fechaAceptado" => "2009-09-24" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112634" "palabras" => array:3 [ 0 => "Citrullination" 1 => "Rheumatoid arthritis" 2 => "Anti-citrullinated protein antibodies" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112635" "palabras" => array:3 [ 0 => "Citrulinación" 1 => "Artritis reumatoide" 2 => "Anticuerpos antiproteínas citrulinadas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in addition to which it has shown to be a predictor of severity in patients with rheumatoid arthritis, suggesting an important participation in the pathogenesis of the disease.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La artritis reumatoide es una enfermedad autoinmune de etiología multifactorial caracterizada por inflamación de las articulaciones y presencia de múltiples autoanticuerpos. Recientemente, el estudio de los anticuerpos antiproteínas citrulinadas (APS) ha adquirido gran interés debido a su alta especificidad y sensibilidad para el diagnóstico, además de que se ha demostrado que es predictor de severidad en pacientes con artritis reumatoide; lo cual sugiere un papel importante en la patogénesis de la enfermedad.</p>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Note: Section accredited by SEAFORMEC with 1.7 créditos. See questions for article at: URL: <span class="elsevierStyleInterRef" href="http://www.reumatologiaclinica.org/">http://www.reumatologiaclinica.org</span>.</p>" ] 1 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara">In memoriam of our teacher and fried.</p>" "identificador" => "fn0005" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of rheumatoid arthritis: update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.C. Hochberg" 1 => "T.D. Spector" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Epidem Rev." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 8 | 17 | 25 |
| 2024 October | 34 | 48 | 82 |
| 2024 September | 45 | 22 | 67 |
| 2024 August | 61 | 43 | 104 |
| 2024 July | 44 | 43 | 87 |
| 2024 June | 55 | 33 | 88 |
| 2024 May | 63 | 39 | 102 |
| 2024 April | 29 | 25 | 54 |
| 2024 March | 46 | 33 | 79 |
| 2024 February | 49 | 26 | 75 |
| 2024 January | 52 | 31 | 83 |
| 2023 December | 29 | 33 | 62 |
| 2023 November | 35 | 22 | 57 |
| 2023 October | 48 | 29 | 77 |
| 2023 September | 58 | 45 | 103 |
| 2023 August | 32 | 19 | 51 |
| 2023 July | 59 | 25 | 84 |
| 2023 June | 55 | 26 | 81 |
| 2023 May | 41 | 17 | 58 |
| 2023 April | 55 | 8 | 63 |
| 2023 March | 73 | 31 | 104 |
| 2023 February | 48 | 29 | 77 |
| 2023 January | 39 | 23 | 62 |
| 2022 December | 52 | 40 | 92 |
| 2022 November | 50 | 28 | 78 |
| 2022 October | 44 | 37 | 81 |
| 2022 September | 31 | 34 | 65 |
| 2022 August | 44 | 43 | 87 |
| 2022 July | 46 | 47 | 93 |
| 2022 June | 72 | 34 | 106 |
| 2022 May | 65 | 52 | 117 |
| 2022 April | 59 | 45 | 104 |
| 2022 March | 54 | 59 | 113 |
| 2022 February | 46 | 43 | 89 |
| 2022 January | 68 | 38 | 106 |
| 2021 December | 54 | 41 | 95 |
| 2021 November | 38 | 54 | 92 |
| 2021 October | 45 | 50 | 95 |
| 2021 September | 37 | 39 | 76 |
| 2021 August | 44 | 32 | 76 |
| 2021 July | 47 | 45 | 92 |
| 2021 June | 55 | 40 | 95 |
| 2021 May | 60 | 43 | 103 |
| 2021 April | 63 | 129 | 192 |
| 2021 March | 121 | 27 | 148 |
| 2021 February | 44 | 24 | 68 |
| 2021 January | 35 | 31 | 66 |
| 2020 December | 37 | 18 | 55 |
| 2020 November | 36 | 14 | 50 |
| 2020 October | 12 | 8 | 20 |
| 2020 September | 40 | 16 | 56 |
| 2020 August | 19 | 18 | 37 |
| 2020 July | 14 | 21 | 35 |
| 2020 June | 17 | 9 | 26 |
| 2020 May | 22 | 10 | 32 |
| 2020 April | 30 | 18 | 48 |
| 2020 March | 14 | 13 | 27 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 6 | 0 | 6 |
| 2019 June | 1 | 0 | 1 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 2 | 0 | 2 |
| 2018 May | 1 | 1 | 2 |
| 2018 April | 16 | 17 | 33 |
| 2018 March | 27 | 16 | 43 |
| 2018 February | 13 | 8 | 21 |
| 2018 January | 8 | 3 | 11 |
| 2017 December | 10 | 6 | 16 |
| 2017 November | 9 | 8 | 17 |
| 2017 October | 18 | 8 | 26 |
| 2017 September | 12 | 11 | 23 |
| 2017 August | 10 | 11 | 21 |
| 2017 July | 11 | 10 | 21 |
| 2017 June | 24 | 20 | 44 |
| 2017 May | 20 | 14 | 34 |
| 2017 April | 15 | 10 | 25 |
| 2017 March | 15 | 20 | 35 |
| 2017 February | 10 | 5 | 15 |
| 2017 January | 13 | 10 | 23 |
| 2016 December | 26 | 14 | 40 |
| 2016 November | 30 | 7 | 37 |
| 2016 October | 32 | 7 | 39 |
| 2016 September | 27 | 5 | 32 |
| 2016 August | 17 | 7 | 24 |
| 2016 July | 7 | 8 | 15 |
| 2016 June | 1 | 0 | 1 |
| 2016 March | 2 | 0 | 2 |
| 2016 February | 2 | 24 | 26 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 10 | 0 | 10 |
| 2015 October | 4 | 0 | 4 |
| 2015 September | 1 | 0 | 1 |
| 2015 August | 1 | 15 | 16 |
| 2015 July | 21 | 6 | 27 |
| 2015 June | 45 | 7 | 52 |
| 2015 May | 81 | 26 | 107 |
| 2015 April | 39 | 25 | 64 |
| 2015 March | 47 | 12 | 59 |
| 2015 February | 38 | 18 | 56 |
| 2015 January | 55 | 14 | 69 |
| 2014 December | 49 | 15 | 64 |
| 2014 November | 35 | 15 | 50 |
| 2014 October | 47 | 16 | 63 |
| 2014 September | 39 | 12 | 51 |
| 2014 August | 34 | 19 | 53 |
| 2014 July | 35 | 21 | 56 |
| 2014 June | 56 | 18 | 74 |
| 2014 May | 41 | 22 | 63 |
| 2014 April | 48 | 23 | 71 |
| 2014 March | 46 | 33 | 79 |
| 2014 February | 48 | 14 | 62 |
| 2014 January | 48 | 11 | 59 |
| 2013 December | 30 | 13 | 43 |
| 2013 November | 40 | 20 | 60 |
| 2013 October | 40 | 17 | 57 |
| 2013 September | 43 | 19 | 62 |
| 2013 August | 47 | 17 | 64 |
| 2013 July | 37 | 23 | 60 |
| 2013 June | 48 | 24 | 72 |
| 2013 May | 31 | 24 | 55 |
| 2013 April | 41 | 20 | 61 |
| 2013 March | 35 | 19 | 54 |
| 2013 February | 38 | 14 | 52 |
| 2013 January | 33 | 15 | 48 |
| 2012 December | 25 | 15 | 40 |
| 2012 November | 12 | 12 | 24 |
| 2012 October | 14 | 9 | 23 |
| 2012 September | 9 | 3 | 12 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 3 | 0 | 3 |
| 2012 May | 3 | 0 | 3 |
| 2012 April | 1 | 0 | 1 |
| 2012 March | 6 | 0 | 6 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 6 | 0 | 6 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 4 | 0 | 4 |
| 2011 October | 2 | 0 | 2 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 3 | 0 | 3 |
| 2011 July | 4 | 0 | 4 |
| 2011 June | 3 | 0 | 3 |
| 2011 May | 3 | 0 | 3 |
| 2011 March | 2 | 0 | 2 |
| 2011 February | 2 | 0 | 2 |
| 2011 January | 12 | 0 | 12 |
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