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Vol. 7. Issue 1.
Pages 68-71 (January - February 2011)
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Vol. 7. Issue 1.
Pages 68-71 (January - February 2011)
Continuing medical education
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Citrullinated proteins in Rheumatoid Arthritis
Proteínas citrulinadas en artritis reumatoide
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Elizabeth Olivares Martínez, Diego F. Hernández Ramírez, Carlos A. Núñez-Álvarez
Corresponding author
nuac80df@yahoo.com.mx

Corresponding author.
, Javier Cabiedes1
Laboratorio de Inmunología, Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
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Abstract

Rheumatoid arthritis is an autoimmune disease of multifactorial etiology characterized by inflammation of the joints and presence of autoantibodies directed against multiple autoantigens. Recently the study of the anti-citrullinated protein antibodies (ACP) has acquired great interest due to its high specificity and sensitivity for diagnosis, in addition to which it has shown to be a predictor of severity in patients with rheumatoid arthritis, suggesting an important participation in the pathogenesis of the disease.

Keywords:
Citrullination
Rheumatoid arthritis
Anti-citrullinated protein antibodies
Resumen

La artritis reumatoide es una enfermedad autoinmune de etiología multifactorial caracterizada por inflamación de las articulaciones y presencia de múltiples autoanticuerpos. Recientemente, el estudio de los anticuerpos antiproteínas citrulinadas (APS) ha adquirido gran interés debido a su alta especificidad y sensibilidad para el diagnóstico, además de que se ha demostrado que es predictor de severidad en pacientes con artritis reumatoide; lo cual sugiere un papel importante en la patogénesis de la enfermedad.

Palabras clave:
Citrulinación
Artritis reumatoide
Anticuerpos antiproteínas citrulinadas
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