Original article
The impact of therapy with TNF-blockers on health-related quality of life in rheumatoid arthritis patients. A pilot study
Calidad de vida relacionada con la salud tras terapia anti-factor de necrosis tumoral alfa en pacientes con artritis reumatoide. Un estudio piloto
Gracia María Ábalos Medinaa, Gonzalo Ruiz Villaverdeb, Daniel Sánchez Canoc, Ricardo Ruiz Villaverded,
, Jesús Ramírez Rodrigoe, Enrique Raya Álvareza, Carmen Villaverde Gutiérreze
Corresponding author
a Servicio de Reumatología, Hospital Universitario San Cecilio, Granada, Spain
b Servicio de Radiodiagnóstico, Complejo Hospitalario Virgen de las Nieves, Granada, Spain
c Unidad de Enfermedades Autoinmunes, Hospital Universitario San Cecilio, Granada, Spain
d Servicio de Dermatología, Complejo Hospitalario Ciudad de Jaén, Jaén, Spain
e Universidad de Granada, Granada, Spain
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Un estudio piloto" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-02-15" "fechaAceptado" => "2010-06-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112730" "palabras" => array:3 [ 0 => "Quality of life" 1 => "Rheumatoid arthritis" 2 => "TNF-blocker-therapy" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112731" "palabras" => array:3 [ 0 => "Calidad de vida" 1 => "Artritis reumatoide" 2 => "Terapia anti-TNF alfa" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aim of this pilot study was to evaluate the initial response to 16 weeks of treatment with infliximab and etanercept of disease activity and quality of life in a cohort of 37 patients with established rheumatoid arthritis.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients were selected from the Unit of Rheumatology in Hospital Clínico San Cecilio from Granada, refractory to conventional treatment with disease modifying antirheumatic drugs. To assess the disease activity, Disease activity score (DAS28) was used and the measurement of quality of life was evaluated with the Spanish version of the SF-36 Health Survey (SF-36) and the RA-specific questionnaire QoL Scale (Quality of Life in Rheumatoid Arthritis).</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Preliminary results show a significant decrease in inflammatory activity of the disease and consequently in HRQL scores. The comparison with the general reference population shows a deviation well below average, especially in the “physical function” dimension with a rising response pattern in all dimensions. The correlation between specific scores (QoL-RA scale) and generic ones (SF-36) for HQ-treatment also showed significance, especially with the physical aggregate.</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">An important limitation of the present study is the number of patients and the duration of the treatment; despite this, improvements in functional parameters and quality of life are evident and remain roughly stable since the first weeks of treatment. This allows us to continue the study and increase the number of patients.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The preliminary results obtained with TNF-blockers after 16 weeks of treatment in RA objectively show the effectiveness of these drugs and also the perception by the patients of the effect on their quality of life.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio piloto ha sido valorar la respuesta inicial tras 16 semanas de tratamiento con infliximab y etanercept sobre la actividad de la enfermedad y la calidad de vida (CV), en una cohorte de 37 pacientes con artritis reumatoide establecida.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los pacientes fueron seleccionados en el Servicio de Reumatología del Hospital Clínico San Cecilio de Granada, por ser refractarios al tratamiento convencional con fármacos antirreumáticos modificadores de la enfermedad. Para evaluar la actividad de la enfermedad se utilizó el índice DAS28 (Disease Activity Score) y para CV, la versión española del Cuestionario de Salud SF-36(Health Survey SF-36) y el cuestionario específico QoL-RA Scale (Quality of Life in Rheumatoid Arthritis).</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los resultados preliminares muestran una disminución significativa en la actividad inflamatoria y consecuentemente en las puntuaciones de la CV. La comparación con la población general de referencia muestra una desviación muy por debajo de la media, especialmente en la dimensión «función física» con un patrón de respuesta ascendente en todas las dimensiones. La correlación entre puntuaciones específicas (QoL-RA Scale) y genéricas (SF-36) de CV postratamiento también mostraron significación, especialmente con el agregado físico.</p> <span class="elsevierStyleSectionTitle">Discusión</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Consideramos una limitación importante del estudio el número de pacientes y el tiempo de evolución postratamiento. No obstante, las mejorías en los diferentes parámetros funcionales y de CV son objetivables y permanecen prácticamente estables desde las primeras semanas de tratamiento, lo que nos permitirá continuar el estudio y ampliar el número de pacientes.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Los resultados preliminares obtenidos con anti-TNF alfa tras 16 semanas de tratamiento en artritis reumatoide muestran la efectividad de los fármacos objetivamente y subjetivamente según la percepción del paciente sobre su CV.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Four-year follow-up of infliximab therapy in rheumatoid arthritis patients with long-tanding refractory disease: attrition and long-term evolution of disease activity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Vander Cruyssen" 1 => "S. Van Looly" 2 => "B. Wyns" 3 => "R. Westhovens" 4 => "P. Durez" 5 => "F. Van den Bosch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar2001" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2006" "volumen" => "8" "paginaInicial" => "R112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16978395" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Active-controlled study of patients receiving infliximab for the treatment of rheumatoid arthritis of early onset (ASPIRE) study group" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Smolen" 1 => "D.M. Van der Heijde" 2 => "E.W. St Clair" 3 => "P. Emery" 4 => "J.M. Bathon" 5 => "E. Keystone" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.21678" "Revista" => array:6 [ "tituloSerie" => "Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab: results from the ASPIRE trial. Arthritis Rheum" "fecha" => "2006" "volumen" => "54" "paginaInicial" => "702" "paginaFinal" => "710" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16508926" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expectativas, preferencias y satisfacción de los pacientes con artritis reumatoide en tratamiento con infliximab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Carbonell" 1 => "X. Badia" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2008" "volumen" => "131" "paginaInicial" => "493" "paginaFinal" => "499" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life issues in patient with inflammatory bowel disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.J. Irvine" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "1997" "volumen" => "92" "paginaInicial" => "18S" "paginaFinal" => "24S" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9395348" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La medida de la calidad de vida relacionada con la salud en los ensayos clínicos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "X. Badía" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Farmacoeconomía: evaluación económica de los medicamentos. Madrid: Editores médicos" "paginaInicial" => "51" "paginaFinal" => "76" "serieFecha" => "1995" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sobre la adaptación transcultural de medidas de la calidad de vida relacionada con la salud para su uso en España" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "X. Badía" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1995" "volumen" => "105" "paginaInicial" => "56" "paginaFinal" => "58" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Monés Xiol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Can it really by measured? Rev Esp Enferm Dig" "fecha" => "2000" "volumen" => "92" "paginaInicial" => "349" "paginaFinal" => "353" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality appraisal of clinical practice guidelines and consensus statements on the use of biologic agents in reumatoid arthritis: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.A. López-Olivo" 1 => "M.A. Kallen" 2 => "Z. Ortiz" 3 => "B. Skidmore" 4 => "M.E. Suarez-Almazor" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.24207" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2008" "volumen" => "59" "paginaInicial" => "1625" "paginaFinal" => "1638" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18975351" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor necrosis factor (TNF) inhibitor therapy for rheumatoid artritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Segal" 1 => "N.L. Rhodus" 2 => "K. Patel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medical management and pharmacology update" "fecha" => "2008" "volumen" => "106" "paginaInicial" => "778" "paginaFinal" => "787" "itemHostRev" => array:3 [ "pii" => "S0016508510001095" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estudio comparativo de efectividad de los inhibidores del factor de necrosis tumoral alfa en la artritis reumatoide establecida" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Arenere Mendoza" 1 => "F.J. Manero Ruiz" 2 => "P. Carrera Lasfuentes" 3 => "H. Navarro Aznárez" 4 => "A. Pecondón Español" 5 => "M.J. Rabanaque Hernández" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2010" "volumen" => "134" "paginaInicial" => "665" "paginaFinal" => "670" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of rheumatoid arthritis improvement criteria including simplified joint counts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Van Gestel" 1 => "C.J. Haagsma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/1529-0131(199810)41:10<1845::AID-ART17>3.0.CO;2-K" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1998" "volumen" => "41" "paginaInicial" => "1845" "paginaFinal" => "1850" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9778226" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rat" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Wells" 1 => "J.C. Becker" 2 => "J. Teng" 3 => "M. Dougados" 4 => "M. Schiff" 5 => "J. Smolen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2007.084459" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "954" "paginaFinal" => "960" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18490431" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La versión española del SF-36 Health Survey (Cuestionario de Salud SF-36): un instrumento para la medida de resultados clínicos" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Alonso" 1 => "L. Prieto" 2 => "J.M. Antó" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1995" "volumen" => "104" "paginaInicial" => "771" "paginaFinal" => "776" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.T. Felson" 1 => "J.J. Anderson" 2 => "M. Boers" 3 => "C. Bombardier" 4 => "M. Chernoff" 5 => "B. Fried" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "The Committee on Outcome Measures in Rheumatoid Arthritis Clinical Trials. Arthritis Rheum" "fecha" => "1993" "volumen" => "36" "paginaInicial" => "729" "paginaFinal" => "740" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An english and spanish quality of life measure for rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.L. Danao" 1 => "G.V. Padilla" 2 => "D.A. Johnson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Care Res" "fecha" => "2001" "volumen" => "45" "paginaInicial" => "167" "paginaFinal" => "173" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Medición de la calidad de vida en la artritis reumatoide" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "F. Ballina" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Reumatol Clin (Barc)" "fecha" => "2002" "volumen" => "29" "paginaInicial" => "56" "paginaFinal" => "64" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of infliximab treatment on quality of life in patients with inflammatory rheumatic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Han" 1 => "J.S. Smolen" 2 => "A. Kavanaugh" 3 => "D. van der Heijde" 4 => "J. Braun" 5 => "R. Westhovens" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/ar2306" "Revista" => array:5 [ "tituloSerie" => "Arthritis Res Ther" "fecha" => "2007" "volumen" => "9" "paginaInicial" => "R103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17922913" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A network meta-analysis of randomized controlled trials of biologics for rheumatoid arthritis: a Cochrane overview" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Singh" 1 => "R. Christensen" 2 => "G.A. Wells" 3 => "M.E. Suarez-Almazor" 4 => "R. Buchbinder" 5 => "M.A. Lopez-Olivo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1503/cmaj.091391" "Revista" => array:7 [ "tituloSerie" => "CMAJ" "fecha" => "2009" "volumen" => "181" "paginaInicial" => "787" "paginaFinal" => "796" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19884297" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827810004782" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infusion-related reactions to infliximab in patients with rheumatoid arthritis in a clinical practice setting: relationship to dose, antihistamine pretreatment, and infusion number" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Wasserman" 1 => "D.A. Weber" 2 => "J.A. Guthrie" 3 => "V.P. Bykerk" 4 => "P. Lee" 5 => "E.C. Keystone" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2004" "volumen" => "31" "paginaInicial" => "1912" "paginaFinal" => "1917" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15468353" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Calidad de vida en pacientes con artritis reumatoide en tratamiento ambulatorio con anti-TNF" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.C. Fernández Lisón" 1 => "B. Vázquez Domínguez" 2 => "J. Luis Fernández" 3 => "P. Moreno Álvarez" 4 => "I. Fruns Giménez" 5 => "J. Liso Rubio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Farm Hosp" "fecha" => "2008" "volumen" => "32" "paginaInicial" => "178" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18840348" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid and sustained health utility gain in anti-tumour necrosis factor-treated inflammatory arthritis: observational data during 7 years in southern Sweden" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Gülfe" 1 => "L.E. Kristensen" 2 => "T. Saxne" 3 => "L.T. Jacobsson" 4 => "I.F. Petersson" 5 => "P. Geborek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2008.103473" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2010" "volumen" => "69" "paginaInicial" => "352" "paginaFinal" => "357" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19282310" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quality of life evaluated by Short Form-8 in patients with rheumatoid arthritis who were receiving infusion of infliximab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H. Ogawa" 1 => "M. Itokazu" 2 => "Y. Ito" 3 => "K. Matsumoto" 4 => "I. Takigami" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10165-008-0113-5" "Revista" => array:6 [ "tituloSerie" => "Mod Rheumatol" "fecha" => "2009" "volumen" => "19" "paginaInicial" => "27" "paginaFinal" => "32" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18712459" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000700000003/v1_201305061622/S2173574311700363/v1_201305061622/en/main.assets" "Apartado" => array:4 [ "identificador" => "17338" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000700000003/v1_201305061622/S2173574311700363/v1_201305061622/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700363?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 17 | 26 |
| 2024 October | 29 | 31 | 60 |
| 2024 September | 38 | 22 | 60 |
| 2024 August | 48 | 52 | 100 |
| 2024 July | 33 | 39 | 72 |
| 2024 June | 33 | 39 | 72 |
| 2024 May | 28 | 29 | 57 |
| 2024 April | 29 | 20 | 49 |
| 2024 March | 34 | 34 | 68 |
| 2024 February | 22 | 35 | 57 |
| 2024 January | 34 | 22 | 56 |
| 2023 December | 56 | 35 | 91 |
| 2023 November | 20 | 28 | 48 |
| 2023 October | 43 | 33 | 76 |
| 2023 September | 34 | 31 | 65 |
| 2023 August | 16 | 14 | 30 |
| 2023 July | 17 | 22 | 39 |
| 2023 June | 16 | 28 | 44 |
| 2023 May | 24 | 28 | 52 |
| 2023 April | 11 | 9 | 20 |
| 2023 March | 29 | 27 | 56 |
| 2023 February | 27 | 38 | 65 |
| 2023 January | 17 | 23 | 40 |
| 2022 December | 24 | 48 | 72 |
| 2022 November | 33 | 24 | 57 |
| 2022 October | 23 | 30 | 53 |
| 2022 September | 20 | 31 | 51 |
| 2022 August | 27 | 43 | 70 |
| 2022 July | 19 | 34 | 53 |
| 2022 June | 22 | 42 | 64 |
| 2022 May | 20 | 52 | 72 |
| 2022 April | 21 | 47 | 68 |
| 2022 March | 21 | 43 | 64 |
| 2022 February | 18 | 31 | 49 |
| 2022 January | 16 | 32 | 48 |
| 2021 December | 18 | 44 | 62 |
| 2021 November | 25 | 41 | 66 |
| 2021 October | 27 | 61 | 88 |
| 2021 September | 20 | 40 | 60 |
| 2021 August | 17 | 45 | 62 |
| 2021 July | 14 | 42 | 56 |
| 2021 June | 18 | 43 | 61 |
| 2021 May | 24 | 34 | 58 |
| 2021 April | 45 | 82 | 127 |
| 2021 March | 31 | 27 | 58 |
| 2021 February | 28 | 21 | 49 |
| 2021 January | 9 | 20 | 29 |
| 2020 December | 16 | 17 | 33 |
| 2020 November | 27 | 24 | 51 |
| 2020 October | 16 | 15 | 31 |
| 2020 September | 27 | 19 | 46 |
| 2020 August | 22 | 16 | 38 |
| 2020 July | 14 | 8 | 22 |
| 2020 June | 26 | 19 | 45 |
| 2020 May | 39 | 14 | 53 |
| 2020 April | 25 | 19 | 44 |
| 2020 March | 14 | 5 | 19 |
| 2020 February | 2 | 0 | 2 |
| 2020 January | 4 | 0 | 4 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 5 | 3 | 8 |
| 2018 April | 17 | 8 | 25 |
| 2018 March | 14 | 11 | 25 |
| 2018 February | 8 | 6 | 14 |
| 2018 January | 10 | 4 | 14 |
| 2017 December | 8 | 5 | 13 |
| 2017 November | 7 | 7 | 14 |
| 2017 October | 11 | 9 | 20 |
| 2017 September | 11 | 5 | 16 |
| 2017 August | 9 | 6 | 15 |
| 2017 July | 9 | 7 | 16 |
| 2017 June | 19 | 5 | 24 |
| 2017 May | 25 | 13 | 38 |
| 2017 April | 23 | 5 | 28 |
| 2017 March | 20 | 34 | 54 |
| 2017 February | 7 | 3 | 10 |
| 2017 January | 11 | 5 | 16 |
| 2016 December | 32 | 16 | 48 |
| 2016 November | 15 | 1 | 16 |
| 2016 October | 25 | 9 | 34 |
| 2016 September | 21 | 4 | 25 |
| 2016 August | 15 | 1 | 16 |
| 2016 July | 17 | 9 | 26 |
| 2016 June | 0 | 7 | 7 |
| 2016 May | 0 | 11 | 11 |
| 2016 April | 0 | 18 | 18 |
| 2016 March | 3 | 7 | 10 |
| 2016 February | 1 | 0 | 1 |
| 2015 December | 4 | 0 | 4 |
| 2015 November | 1 | 0 | 1 |
| 2015 October | 2 | 18 | 20 |
| 2015 September | 2 | 17 | 19 |
| 2015 August | 4 | 0 | 4 |
| 2015 July | 5 | 5 | 10 |
| 2015 June | 13 | 8 | 21 |
| 2015 May | 52 | 20 | 72 |
| 2015 April | 49 | 11 | 60 |
| 2015 March | 18 | 14 | 32 |
| 2015 February | 34 | 13 | 47 |
| 2015 January | 23 | 19 | 42 |
| 2014 December | 27 | 20 | 47 |
| 2014 November | 13 | 12 | 25 |
| 2014 October | 24 | 12 | 36 |
| 2014 September | 15 | 14 | 29 |
| 2014 August | 18 | 18 | 36 |
| 2014 July | 22 | 12 | 34 |
| 2014 June | 43 | 17 | 60 |
| 2014 May | 47 | 11 | 58 |
| 2014 April | 33 | 10 | 43 |
| 2014 March | 37 | 18 | 55 |
| 2014 February | 32 | 10 | 42 |
| 2014 January | 30 | 8 | 38 |
| 2013 December | 30 | 10 | 40 |
| 2013 November | 22 | 10 | 32 |
| 2013 October | 39 | 9 | 48 |
| 2013 September | 37 | 14 | 51 |
| 2013 August | 31 | 7 | 38 |
| 2013 July | 44 | 8 | 52 |
| 2013 June | 34 | 9 | 43 |
| 2013 May | 35 | 14 | 49 |
| 2013 April | 29 | 14 | 43 |
| 2013 March | 20 | 9 | 29 |
| 2013 February | 26 | 11 | 37 |
| 2013 January | 14 | 17 | 31 |
| 2012 December | 23 | 30 | 53 |
| 2012 November | 19 | 13 | 32 |
| 2012 October | 6 | 8 | 14 |
| 2012 September | 6 | 4 | 10 |
| 2012 June | 2 | 0 | 2 |
| 2012 May | 2 | 0 | 2 |
| 2012 April | 6 | 0 | 6 |
| 2012 March | 2 | 0 | 2 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 3 | 0 | 3 |
| 2011 December | 4 | 0 | 4 |
| 2011 November | 8 | 0 | 8 |
| 2011 October | 3 | 0 | 3 |
| 2011 September | 1 | 0 | 1 |
| 2011 August | 7 | 0 | 7 |
| 2011 July | 5 | 0 | 5 |
| 2011 June | 9 | 0 | 9 |
| 2011 May | 2 | 0 | 2 |
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