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        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">The aim of this pilot study was to evaluate the initial response to 16 weeks of treatment with infliximab and etanercept of disease activity and quality of life in a cohort of 37 patients with established rheumatoid arthritis&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Patients were selected from the Unit of Rheumatology in Hospital Cl&#237;nico San Cecilio from Granada&#44; refractory to conventional treatment with disease modifying antirheumatic drugs&#46; To assess the disease activity&#44; Disease activity score &#40;DAS28&#41; was used and the measurement of quality of life was evaluated with the Spanish version of the SF-36 Health Survey &#40;SF-36&#41; and the RA-specific questionnaire QoL Scale &#40;Quality of Life in Rheumatoid Arthritis&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Preliminary results show a significant decrease in inflammatory activity of the disease and consequently in HRQL scores&#46; The comparison with the general reference population shows a deviation well below average&#44; especially in the &#8220;physical function&#8221; dimension with a rising response pattern in all dimensions&#46; The correlation between specific scores &#40;QoL-RA scale&#41; and generic ones &#40;SF-36&#41; for HQ-treatment also showed significance&#44; especially with the physical aggregate&#46;</p> <span class="elsevierStyleSectionTitle">Discussion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">An important limitation of the present study is the number of patients and the duration of the treatment&#59; despite this&#44; improvements in functional parameters and quality of life are evident and remain roughly stable since the first weeks of treatment&#46; This allows us to continue the study and increase the number of patients&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The preliminary results obtained with TNF-blockers after 16 weeks of treatment in RA objectively show the effectiveness of these drugs and also the perception by the patients of the effect on their quality of life&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">El objetivo de este estudio piloto ha sido valorar la respuesta inicial tras 16 semanas de tratamiento con infliximab y etanercept sobre la actividad de la enfermedad y la calidad de vida &#40;CV&#41;&#44; en una cohorte de 37 pacientes con artritis reumatoide establecida&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los pacientes fueron seleccionados en el Servicio de Reumatolog&#237;a del Hospital Cl&#237;nico San Cecilio de Granada&#44; por ser refractarios al tratamiento convencional con f&#225;rmacos antirreum&#225;ticos modificadores de la enfermedad&#46; Para evaluar la actividad de la enfermedad se utiliz&#243; el &#237;ndice DAS28 &#40;Disease Activity Score&#41; y para CV&#44; la versi&#243;n espa&#241;ola del Cuestionario de Salud SF-36&#40;Health Survey SF-36&#41; y el cuestionario espec&#237;fico QoL-RA Scale &#40;Quality of Life in Rheumatoid Arthritis&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Los resultados preliminares muestran una disminuci&#243;n significativa en la actividad inflamatoria y consecuentemente en las puntuaciones de la CV&#46; La comparaci&#243;n con la poblaci&#243;n general de referencia muestra una desviaci&#243;n muy por debajo de la media&#44; especialmente en la dimensi&#243;n &#171;funci&#243;n f&#237;sica&#187; con un patr&#243;n de respuesta ascendente en todas las dimensiones&#46; La correlaci&#243;n entre puntuaciones espec&#237;ficas &#40;QoL-RA Scale&#41; y gen&#233;ricas &#40;SF-36&#41; de CV postratamiento tambi&#233;n mostraron significaci&#243;n&#44; especialmente con el agregado f&#237;sico&#46;</p> <span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Consideramos una limitaci&#243;n importante del estudio el n&#250;mero de pacientes y el tiempo de evoluci&#243;n postratamiento&#46; No obstante&#44; las mejor&#237;as en los diferentes par&#225;metros funcionales y de CV son objetivables y permanecen pr&#225;cticamente estables desde las primeras semanas de tratamiento&#44; lo que nos permitir&#225; continuar el estudio y ampliar el n&#250;mero de pacientes&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Los resultados preliminares obtenidos con anti-TNF alfa tras 16 semanas de tratamiento en artritis reumatoide muestran la efectividad de los f&#225;rmacos objetivamente y subjetivamente seg&#250;n la percepci&#243;n del paciente sobre su CV&#46;</p>"
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Vol. 7. Issue 3.
Pages 167-171 (May - June 2011)
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Vol. 7. Issue 3.
Pages 167-171 (May - June 2011)
Original article
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The impact of therapy with TNF-blockers on health-related quality of life in rheumatoid arthritis patients. A pilot study
Calidad de vida relacionada con la salud tras terapia anti-factor de necrosis tumoral alfa en pacientes con artritis reumatoide. Un estudio piloto
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Gracia María Ábalos Medinaa, Gonzalo Ruiz Villaverdeb, Daniel Sánchez Canoc, Ricardo Ruiz Villaverded,
Corresponding author
dismenios@hotmail.com

Corresponding author.
, Jesús Ramírez Rodrigoe, Enrique Raya Álvareza, Carmen Villaverde Gutiérreze
a Servicio de Reumatología, Hospital Universitario San Cecilio, Granada, Spain
b Servicio de Radiodiagnóstico, Complejo Hospitalario Virgen de las Nieves, Granada, Spain
c Unidad de Enfermedades Autoinmunes, Hospital Universitario San Cecilio, Granada, Spain
d Servicio de Dermatología, Complejo Hospitalario Ciudad de Jaén, Jaén, Spain
e Universidad de Granada, Granada, Spain
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Abstract
Introduction

The aim of this pilot study was to evaluate the initial response to 16 weeks of treatment with infliximab and etanercept of disease activity and quality of life in a cohort of 37 patients with established rheumatoid arthritis.

Patients and method

Patients were selected from the Unit of Rheumatology in Hospital Clínico San Cecilio from Granada, refractory to conventional treatment with disease modifying antirheumatic drugs. To assess the disease activity, Disease activity score (DAS28) was used and the measurement of quality of life was evaluated with the Spanish version of the SF-36 Health Survey (SF-36) and the RA-specific questionnaire QoL Scale (Quality of Life in Rheumatoid Arthritis).

Results

Preliminary results show a significant decrease in inflammatory activity of the disease and consequently in HRQL scores. The comparison with the general reference population shows a deviation well below average, especially in the “physical function” dimension with a rising response pattern in all dimensions. The correlation between specific scores (QoL-RA scale) and generic ones (SF-36) for HQ-treatment also showed significance, especially with the physical aggregate.

Discussion

An important limitation of the present study is the number of patients and the duration of the treatment; despite this, improvements in functional parameters and quality of life are evident and remain roughly stable since the first weeks of treatment. This allows us to continue the study and increase the number of patients.

Conclusions

The preliminary results obtained with TNF-blockers after 16 weeks of treatment in RA objectively show the effectiveness of these drugs and also the perception by the patients of the effect on their quality of life.

Keywords:
Quality of life
Rheumatoid arthritis
TNF-blocker-therapy
Resumen
Introducción

El objetivo de este estudio piloto ha sido valorar la respuesta inicial tras 16 semanas de tratamiento con infliximab y etanercept sobre la actividad de la enfermedad y la calidad de vida (CV), en una cohorte de 37 pacientes con artritis reumatoide establecida.

Pacientes y método

Los pacientes fueron seleccionados en el Servicio de Reumatología del Hospital Clínico San Cecilio de Granada, por ser refractarios al tratamiento convencional con fármacos antirreumáticos modificadores de la enfermedad. Para evaluar la actividad de la enfermedad se utilizó el índice DAS28 (Disease Activity Score) y para CV, la versión española del Cuestionario de Salud SF-36(Health Survey SF-36) y el cuestionario específico QoL-RA Scale (Quality of Life in Rheumatoid Arthritis).

Resultados

Los resultados preliminares muestran una disminución significativa en la actividad inflamatoria y consecuentemente en las puntuaciones de la CV. La comparación con la población general de referencia muestra una desviación muy por debajo de la media, especialmente en la dimensión «función física» con un patrón de respuesta ascendente en todas las dimensiones. La correlación entre puntuaciones específicas (QoL-RA Scale) y genéricas (SF-36) de CV postratamiento también mostraron significación, especialmente con el agregado físico.

Discusión

Consideramos una limitación importante del estudio el número de pacientes y el tiempo de evolución postratamiento. No obstante, las mejorías en los diferentes parámetros funcionales y de CV son objetivables y permanecen prácticamente estables desde las primeras semanas de tratamiento, lo que nos permitirá continuar el estudio y ampliar el número de pacientes.

Conclusiones

Los resultados preliminares obtenidos con anti-TNF alfa tras 16 semanas de tratamiento en artritis reumatoide muestran la efectividad de los fármacos objetivamente y subjetivamente según la percepción del paciente sobre su CV.

Palabras clave:
Calidad de vida
Artritis reumatoide
Terapia anti-TNF alfa
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