Efficacy of adalimumab in Behçet's disease. Description of 6 cases
Eficacia del adalimumab en la enfermedad de Behçet: descripción de 6 casos
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Description of 6 cases" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "258" "paginaFinal" => "261" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Javier Calvo Catalá, Cristina Campos Fernandez, Amalia Rueda Cid, Maria Isabel Gonzalez-Cruz Cervellera, Aurelio Baixauli Rubio, Maria Dolores Pastor Cubillo" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Javier" "apellidos" => "Calvo Catalá" "email" => array:1 [ 0 => "calvo_jav@gva.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Cristina" "apellidos" => "Campos Fernandez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Amalia" "apellidos" => "Rueda Cid" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Maria Isabel" "apellidos" => "Gonzalez-Cruz Cervellera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Aurelio" "apellidos" => "Baixauli Rubio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Maria Dolores" "apellidos" => "Pastor Cubillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Reumatología y Metabolismo Óseo, Consorcio Hospital General Universitario, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital de Manises, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia del adalimumab en la enfermedad de Behçet: descripción de 6 casos" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-07-02" "fechaAceptado" => "2010-10-05" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec112794" "palabras" => array:4 [ 0 => "Behçet's disease" 1 => "Uveitis" 2 => "Adalimumab" 3 => "Anti-TNF" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec112793" "palabras" => array:4 [ 0 => "Enfermedad de Behçet" 1 => "Uveítis" 2 => "Adalimumab" 3 => "Anti-TNF" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Behçet's disease (BD) is a systemic vasculitis, with a more aggressive course in young males. Orogenital ulcers, uveitis and cutaneous lesions are the most frequent manifestations.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We analyzed the effects of adalimumab on six patients with BD pretreated with inmunosupressive therapy, two of whom had received infliximab. We observed a good clinical response in all patients. To date, after a mean follow-up of 26.8 months, patients continue receiving adalimumab, with good clinical control, no adverse effects have been reported with adalimumab.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La enfermedad de Behçet (EB) es una vasculitis sistémica, y afecta con mayor agresividad a varones jóvenes. Sus manifestaciones más frecuentes son las aftas orogenitales, la uveítis y las lesiones cutáneas.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Analizamos 6 pacientes con EB, que recibieron adalimumab para controlar la enfermedad. Todos habían recibido terapia inmunosupresora, además 2 de ellos recibieron infliximab. Observamos una buena respuesta clínica al fármaco. Actualmente, con un seguimiento medio de 26,8 meses, los pacientes siguen en tratamiento con adalimumab, con buen control clínico y sin que se hayan detectado efectos adversos relacionados con el anti-TNF.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:20 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of age of onset and patient's sex on the prevalence and severity of manifestations of Behçet's syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Yazici" 1 => "Y. Tüzün" 2 => "H. Pazarli" 3 => "S. Yurdakul" 4 => "Y. Ozyazgan" 5 => "H. Ozdoğan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "1984" "volumen" => "43" "paginaInicial" => "783" "paginaFinal" => "789" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6524980" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The long-term mortality and morbidity of Behçet syndrome: a 2-decade outcome survey of 387 patients followed at a dedicated center" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Kural-Seyahi" 1 => "I. Fresko" 2 => "N. Seyahi" 3 => "Y. Ozyazgan" 4 => "C. Mat" 5 => "V. Hamuryudan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Medicine (Baltimore)" "fecha" => "2003" "volumen" => "82" "paginaInicial" => "60" "paginaFinal" => "76" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of biologic therapies in the management of systemic vasculitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.T. Chan" 1 => "O. Flossmann" 2 => "C. Mukhtyar" 3 => "D.R. Jayne" 4 => "R.A. Luqmani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.autrev.2006.01.003" "Revista" => array:6 [ "tituloSerie" => "Autoimmun Rev" "fecha" => "2006" "volumen" => "5" "paginaInicial" => "273" "paginaFinal" => "278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16697969" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adalimumab for sight-threatening uveitis in Behçet's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B. Mushtaq" 1 => "T. Saeed" 2 => "R.D. Situnayake" 3 => "P.I. Murray" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.eye.6702352" "Revista" => array:6 [ "tituloSerie" => "Eye" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "824" "paginaFinal" => "825" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16601736" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of Behçet's disease with adalimumab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. Callejas-Rubio" 1 => "D. Sánchez-Cano" 2 => "R. Ríos-Férnandez" 3 => "N. Ortego-Centeno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2008" "volumen" => "131" "paginaInicial" => "438" "paginaFinal" => "439" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of infliximab and adalimumab in the treatment of a patient with severe neuro-Behçet's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Belzunegui" 1 => "L. López" 2 => "I. Paniagua" 3 => "J.J. Intxausti" 4 => "O. Maíz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2008" "volumen" => "26" "numero" => "4 Suppl 50" "paginaInicial" => "S133" "paginaFinal" => "S134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19026138" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Yildiz N, Alkan H, Ardic F, Topuz O. Successful treatment with adalimumab in a patient with coexisting Behçet's disease and ankylosing spondylitis. Rheumatol Int. Published online 2010 march 30." ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adalimumab treatment for life threatening pulmonary artery aneurysm in Behçet disease: a case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.W. Lee" 1 => "S.Y. Lee" 2 => "K.N. Kim" 3 => "J.K. Jung" 4 => "W.T. Chung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-009-1272-2" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2010" "volumen" => "29" "paginaInicial" => "91" "paginaFinal" => "93" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19816754" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intestinal Behçet's disease: Maintenance of remission with adalimumab monotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Ariyachaipanich" 1 => "C. Berkelhammer" 2 => "H. Nicola" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ibd.20869" "Revista" => array:6 [ "tituloSerie" => "Inflamm Bowel Dis" "fecha" => "2009" "volumen" => "15" "paginaInicial" => "1769" "paginaFinal" => "1771" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19177427" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Takase K, Ohno S, Ideguchi H, Uchio E, Takeno M, Ishigatsubo Y. Successful switching to adalimumab in an infliximab-allergic patient with severe Behçet disease-related uveitis. Rheumatol Int Published online. 2009." ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of recalcitrant genital ulcers of Behçet's disease with adalimumab after failure of infliximab and etanercept" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Olivieri" 1 => "S. D’Angelo" 2 => "A. Padula" 3 => "P. Leccese" 4 => "G.A. Mennillo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2009" "volumen" => "27" "numero" => "2 Suppl 53" "paginaInicial" => "S112" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19822056" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adalimumab: a new modality for Behçet's disease?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.A. Van Laar" 1 => "T. Missotten" 2 => "P.L. Van Daele" 3 => "A. Jamnitski" 4 => "G.S. Baarsma" 5 => "P.M. Van Hagen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2006.064279" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2007" "volumen" => "66" "paginaInicial" => "565" "paginaFinal" => "566" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17124248" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International Study Group for Behçet's Disease [no authors listed]" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Criteria for diagnosis of Behçet's disease" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1990" "volumen" => "335" "paginaInicial" => "1078" "paginaFinal" => "1080" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1970380" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "III Actualización del Consenso de la Sociedad Española de Reumatología sobre terapia biológica en la artritis reumatoide" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Rodríguez-Valverde" 1 => "R. Cáliz Cáliz" 2 => "J.M. Álvaro-Gracia Álvaro" 3 => "J.L. Marenco de la Fuente" 4 => "J. Mulero Mendoza" 5 => "J. Tornero Molina" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1699-258X(06)73097-2" "Revista" => array:7 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2006" "volumen" => "2" "numero" => "Suppl 2" "paginaInicial" => "S52" "paginaFinal" => "S59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21794377" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic levels of the T cell regulatory cytokines IL-10 and IL-12 in Behçet's disease;soluble TNFR-75 as a biological marker of disease activity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Turan" 1 => "H. Gallati" 2 => "H. Erdi" 3 => "A. Gürler" 4 => "B.A. Michel" 5 => "P.M. Villiger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "1997" "volumen" => "24" "paginaInicial" => "128" "paginaFinal" => "132" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9002023" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vgamma9Vdelta2 T cells recovered from eyes of patients with Behcet's disease recognize non-peptide prenyl pyrophosphate antigens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "G.M. Verjans" 1 => "P.M. Van Hagen" 2 => "A. Van der Kooi" 3 => "A.D. Osterhaus" 4 => "G.S. Baarsma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neuroimmunol" "fecha" => "2002" "volumen" => "130" "paginaInicial" => "46" "paginaFinal" => "54" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12225887" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current concepts in the etiology and treatment of behcet disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C. Evereklioglu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.survophthal.2005.04.009" "Revista" => array:6 [ "tituloSerie" => "Surv Ophthalmol" "fecha" => "2005" "volumen" => "50" "paginaInicial" => "297" "paginaFinal" => "350" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15967189" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-TNF therapy in the management of Behçet's disease−review and basis for recommendations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.P. Sfikakis" 1 => "N. Markomichelakis" 2 => "E. Alpsoy" 3 => "S. Assaad-Khalil" 4 => "B. Bodaghi" 5 => "A. Gul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/kem034" "Revista" => array:6 [ "tituloSerie" => "Rheumatology" "fecha" => "2007" "volumen" => "46" "paginaInicial" => "736" "paginaFinal" => "741" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17403712" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EULAR Expert Committee. EULAR recommendations for the management of Behçet disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Hatemi" 1 => "A. Silman" 2 => "D. Bang" 3 => "B. Bodaghi" 4 => "A.M. Chamberlain" 5 => "A. Gul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2007.080432" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2008" "volumen" => "67" "paginaInicial" => "1656" "paginaFinal" => "1662" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18245110" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of Behçet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behçet disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "G. Hatemi" 1 => "A. Silman" 2 => "D. Bang" 3 => "B. Bodaghi" 4 => "A.M. Chamberlain" 5 => "A. Gul" 6 => "M.H. Houman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2008.087957" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "1528" "paginaFinal" => "1534" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18420940" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735743/0000000700000004/v1_201305061625/S2173574311700569/v1_201305061625/en/main.assets" "Apartado" => array:4 [ "identificador" => "17376" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Case Report" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/21735743/0000000700000004/v1_201305061625/S2173574311700569/v1_201305061625/en/main.pdf?idApp=UINPBA00004M&text.app=https://reumatologiaclinica.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173574311700569?idApp=UINPBA00004M" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 18 | 24 |
| 2024 October | 36 | 52 | 88 |
| 2024 September | 38 | 32 | 70 |
| 2024 August | 51 | 46 | 97 |
| 2024 July | 21 | 50 | 71 |
| 2024 June | 25 | 33 | 58 |
| 2024 May | 27 | 40 | 67 |
| 2024 April | 16 | 24 | 40 |
| 2024 March | 22 | 40 | 62 |
| 2024 February | 22 | 28 | 50 |
| 2024 January | 15 | 22 | 37 |
| 2023 December | 21 | 37 | 58 |
| 2023 November | 18 | 26 | 44 |
| 2023 October | 31 | 31 | 62 |
| 2023 September | 21 | 43 | 64 |
| 2023 August | 14 | 16 | 30 |
| 2023 July | 19 | 23 | 42 |
| 2023 June | 10 | 23 | 33 |
| 2023 May | 11 | 11 | 22 |
| 2023 April | 9 | 9 | 18 |
| 2023 March | 20 | 28 | 48 |
| 2023 February | 20 | 25 | 45 |
| 2023 January | 11 | 24 | 35 |
| 2022 December | 28 | 30 | 58 |
| 2022 November | 24 | 32 | 56 |
| 2022 October | 26 | 31 | 57 |
| 2022 September | 19 | 35 | 54 |
| 2022 August | 23 | 50 | 73 |
| 2022 July | 21 | 46 | 67 |
| 2022 June | 18 | 50 | 68 |
| 2022 May | 21 | 45 | 66 |
| 2022 April | 29 | 53 | 82 |
| 2022 March | 22 | 63 | 85 |
| 2022 February | 19 | 44 | 63 |
| 2022 January | 20 | 38 | 58 |
| 2021 December | 19 | 38 | 57 |
| 2021 November | 18 | 61 | 79 |
| 2021 October | 39 | 71 | 110 |
| 2021 September | 29 | 52 | 81 |
| 2021 August | 27 | 62 | 89 |
| 2021 July | 17 | 54 | 71 |
| 2021 June | 28 | 45 | 73 |
| 2021 May | 21 | 50 | 71 |
| 2021 April | 79 | 123 | 202 |
| 2021 March | 28 | 33 | 61 |
| 2021 February | 37 | 32 | 69 |
| 2021 January | 28 | 31 | 59 |
| 2020 December | 25 | 30 | 55 |
| 2020 November | 29 | 23 | 52 |
| 2020 October | 15 | 15 | 30 |
| 2020 September | 20 | 22 | 42 |
| 2020 August | 19 | 26 | 45 |
| 2020 July | 21 | 20 | 41 |
| 2020 June | 25 | 23 | 48 |
| 2020 May | 25 | 23 | 48 |
| 2020 April | 10 | 16 | 26 |
| 2020 March | 13 | 7 | 20 |
| 2020 February | 2 | 0 | 2 |
| 2020 January | 10 | 0 | 10 |
| 2019 September | 4 | 0 | 4 |
| 2019 June | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 January | 1 | 0 | 1 |
| 2018 May | 2 | 3 | 5 |
| 2018 April | 22 | 9 | 31 |
| 2018 March | 29 | 17 | 46 |
| 2018 February | 13 | 2 | 15 |
| 2018 January | 8 | 3 | 11 |
| 2017 December | 14 | 5 | 19 |
| 2017 November | 15 | 4 | 19 |
| 2017 October | 16 | 9 | 25 |
| 2017 September | 15 | 10 | 25 |
| 2017 August | 10 | 6 | 16 |
| 2017 July | 5 | 6 | 11 |
| 2017 June | 22 | 7 | 29 |
| 2017 May | 25 | 7 | 32 |
| 2017 April | 12 | 20 | 32 |
| 2017 March | 14 | 33 | 47 |
| 2017 February | 12 | 5 | 17 |
| 2017 January | 19 | 8 | 27 |
| 2016 December | 45 | 7 | 52 |
| 2016 November | 24 | 5 | 29 |
| 2016 October | 38 | 4 | 42 |
| 2016 September | 28 | 3 | 31 |
| 2016 August | 20 | 6 | 26 |
| 2016 July | 15 | 7 | 22 |
| 2016 June | 0 | 6 | 6 |
| 2016 May | 1 | 14 | 15 |
| 2016 April | 1 | 10 | 11 |
| 2016 March | 0 | 8 | 8 |
| 2016 February | 1 | 8 | 9 |
| 2016 January | 2 | 0 | 2 |
| 2015 December | 6 | 0 | 6 |
| 2015 October | 0 | 12 | 12 |
| 2015 September | 1 | 0 | 1 |
| 2015 July | 7 | 5 | 12 |
| 2015 June | 23 | 21 | 44 |
| 2015 May | 36 | 22 | 58 |
| 2015 April | 23 | 36 | 59 |
| 2015 March | 33 | 21 | 54 |
| 2015 February | 27 | 14 | 41 |
| 2015 January | 55 | 15 | 70 |
| 2014 December | 34 | 33 | 67 |
| 2014 November | 13 | 21 | 34 |
| 2014 October | 19 | 27 | 46 |
| 2014 September | 21 | 14 | 35 |
| 2014 August | 16 | 25 | 41 |
| 2014 July | 15 | 19 | 34 |
| 2014 June | 50 | 18 | 68 |
| 2014 May | 36 | 18 | 54 |
| 2014 April | 24 | 21 | 45 |
| 2014 March | 35 | 19 | 54 |
| 2014 February | 26 | 11 | 37 |
| 2014 January | 23 | 18 | 41 |
| 2013 December | 29 | 16 | 45 |
| 2013 November | 20 | 13 | 33 |
| 2013 October | 28 | 15 | 43 |
| 2013 September | 27 | 20 | 47 |
| 2013 August | 35 | 15 | 50 |
| 2013 July | 27 | 43 | 70 |
| 2013 June | 23 | 21 | 44 |
| 2013 May | 31 | 24 | 55 |
| 2013 April | 35 | 25 | 60 |
| 2013 March | 29 | 19 | 48 |
| 2013 February | 23 | 22 | 45 |
| 2013 January | 19 | 20 | 39 |
| 2012 December | 18 | 22 | 40 |
| 2012 November | 16 | 20 | 36 |
| 2012 October | 11 | 21 | 32 |
| 2012 September | 12 | 4 | 16 |
| 2012 July | 1 | 0 | 1 |
| 2012 June | 1 | 0 | 1 |
| 2012 May | 1 | 0 | 1 |
| 2012 April | 4 | 0 | 4 |
| 2012 March | 5 | 0 | 5 |
| 2012 February | 2 | 0 | 2 |
| 2012 January | 4 | 0 | 4 |
| 2011 December | 5 | 0 | 5 |
| 2011 November | 8 | 0 | 8 |
| 2011 October | 3 | 0 | 3 |
| 2011 September | 2 | 0 | 2 |
| 2011 August | 1 | 0 | 1 |
| 2011 July | 4 | 0 | 4 |
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