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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Beh&#231;et&#39;s disease &#40;BD&#41; is a systemic vasculitis&#44; with a more aggressive course in young males&#46; Orogenital ulcers&#44; uveitis and cutaneous lesions are the most frequent manifestations&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We analyzed the effects of adalimumab on six patients with BD pretreated with inmunosupressive therapy&#44; two of whom had received infliximab&#46; We observed a good clinical response in all patients&#46; To date&#44; after a mean follow-up of 26&#46;8 months&#44; patients continue receiving adalimumab&#44; with good clinical control&#44; no adverse effects have been reported with adalimumab&#46;</p>"
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Vol. 7. Issue 4.
Pages 258-261 (July - August 2011)
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Vol. 7. Issue 4.
Pages 258-261 (July - August 2011)
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Efficacy of adalimumab in Behçet's disease. Description of 6 cases
Eficacia del adalimumab en la enfermedad de Behçet: descripción de 6 casos
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Javier Calvo Cataláa,
Corresponding author
calvo_jav@gva.es

Corresponding author.
, Cristina Campos Fernandeza, Amalia Rueda Cida, Maria Isabel Gonzalez-Cruz Cervelleraa, Aurelio Baixauli Rubiob, Maria Dolores Pastor Cubilloa
a Servicio de Reumatología y Metabolismo Óseo, Consorcio Hospital General Universitario, Valencia, Spain
b Servicio de Medicina Interna, Hospital de Manises, Valencia, Spain
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Abstract

Behçet's disease (BD) is a systemic vasculitis, with a more aggressive course in young males. Orogenital ulcers, uveitis and cutaneous lesions are the most frequent manifestations.

We analyzed the effects of adalimumab on six patients with BD pretreated with inmunosupressive therapy, two of whom had received infliximab. We observed a good clinical response in all patients. To date, after a mean follow-up of 26.8 months, patients continue receiving adalimumab, with good clinical control, no adverse effects have been reported with adalimumab.

Keywords:
Behçet's disease
Uveitis
Adalimumab
Anti-TNF
Resumen

La enfermedad de Behçet (EB) es una vasculitis sistémica, y afecta con mayor agresividad a varones jóvenes. Sus manifestaciones más frecuentes son las aftas orogenitales, la uveítis y las lesiones cutáneas.

Analizamos 6 pacientes con EB, que recibieron adalimumab para controlar la enfermedad. Todos habían recibido terapia inmunosupresora, además 2 de ellos recibieron infliximab. Observamos una buena respuesta clínica al fármaco. Actualmente, con un seguimiento medio de 26,8 meses, los pacientes siguen en tratamiento con adalimumab, con buen control clínico y sin que se hayan detectado efectos adversos relacionados con el anti-TNF.

Palabras clave:
Enfermedad de Behçet
Uveítis
Adalimumab
Anti-TNF
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Copyright © 2011. Sociedad Española de Reumatología and Colegio Mexicano de Reumatología
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