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A recent study by the Task Force of the Canadian Scleroderma (CSRG) Group showed that about 30% of an unselected sample of patients with SS had a moderate or high risk for malnutrition.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Recently, a panel of U.S. experts has published a consensus on how to detect and manage malnutrition and GI disorders in SS.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> These are the leading cause of death in 5%–10% of patients with SS and GI involvement is associated with increased morbidity, mortality and reduced quality of life.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The main pathological changes consist of GI smooth muscle atrophy and intestinal wall fibrosis, with dysphagia and gastroesophageal reflux being the most common digestive manifestations in SS.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4</span></a></p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Oropharyngeal Dysphagia</span><p id="par0015" class="elsevierStylePara elsevierViewall">It is due to oropharyngeal dysmotility, hindering the passage of the bolus from the mouth to the oropharynx.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Patients may have skin involvement of the face and tongue, but these changes rarely affect oral<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> intake. However, 20% of patients with SS have a associated Sjögren's syndrome.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In this case, the reduction in saliva production is associated with oropharyngeal dysphagia due to the inability to properly lubricate the food bolus before being transferred into the esophagus. In addition, impairment of salivary secretion increases the risk of developing periodontal disease and accelerates tooth decay, making mastication difficult,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> so the evaluation of the oral cavity should be included routinely in the physical examination of such patients.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4,7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Oropharyngeal dysphagia is characterized by occurring a few seconds after initiating the act of swallowing, and the feeling is manifested by retention of food in the throat and the need to swallow repeatedly.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> It is often accompanied by regurgitation of the bolus into the nasopharynx, which may expel food through the nose or larynx. Dysfunction of the constrictor muscles of the pharynx can cause dysarthria, nasal voice and pharyngonasal regurgitation.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,8</span></a> In more severe cases, the patient cannot swallow saliva and drools.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,8</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Esophageal Dysphagia</span><p id="par0025" class="elsevierStylePara elsevierViewall">The difficulty in swallowing arises once the bolus has passed through the pharynx and upper esophageal sphincter. This type of dysphagia may be due to a motor or sensitive mechanical disturbance.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In SS, the overproduction of collagen leads to thickening and fibrosis. Muscles weaken and cause dysmotility, a mechanism that involves esophagea<span class="elsevierStyleSup">l</span> dysphagia.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> This alteration can range from a lack of coordination of esophageal motility to the existence of complete paralysis of the esophagus.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Esophageal dysfunction in SS mainly occurs in the lower two-thirds of the esophagus, causing esophageal sphincter weakness and profound loss of peristaltic<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> action. This dysfunction leads to reflux of stomach contents into the esophagus. Esophageal damage may manifest as a peptic ulcer or erosive esophagitis progressing to hemorrhage and ulceration.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The ulcer may scar or progress to an esophageal stricture, fistula, achalasia and Barrett's esophagus with the risk of neoplasia.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,4</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Dietary interventions not only depend on the degree of impairment but also must ensure adequate nutritional support, and are intended to modify the texture of foods, attaining adequate lubrication of food and a smooth consistency for each type of dysphagia, as well as reducing and/or preventing problems associated with itself.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,8,10–12</span></a> Dietary recommendations in cases of oropharyngeal dysphagia are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,8,11,12</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Gastroesophageal Reflux</span><p id="par0045" class="elsevierStylePara elsevierViewall">Gastroesophageal reflux is defined as the regurgitation of gastric contents into the esophagus and duodenum mainly due to loss of lower esophageal sphincter pressure 13. Recommendations are based on dietary changes and avoiding foods that promote reflux as well as reflux-inducing positions (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Esophageal Stricture</span><p id="par0050" class="elsevierStylePara elsevierViewall">Esophageal stricture is a narrowing of the esophagus causing difficulty for swallowing. It is characterized by the appearance of a feeling of difficulty passing food or retrosternal pain right after swallowing, chest pain during eating and regurgitation of undigested food.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,8</span></a> Most patients are able to pinpoint the zone where this occurs.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In this case, liquids are easier to swallow than solids. Virtually all foods can be liquefied, although for some of them it may be necessary to add a liquid (e.g. milk for grain, broth for meat, vegetables or fish). Dietary recommendations are presented in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,11,12</span></a></p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Sometimes, despite performing a dietary intervention with conventional diet components, one may need to resort to commercial preparations or enteral<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> nutrition.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Delayed Gastric Emptying or Gastroparesis</span><p id="par0065" class="elsevierStylePara elsevierViewall">Gastroparesis is a gastric motility disorder characterized by delayed emptying of solids and/or fluids from the stomach without any mechanical obstruction.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Gastroparesis can worsen gastroesophageal reflux.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Vascular ectasia is a cause of chronic gastrointestinal bleeding in patients with SS, who may experience a frank hemorrhage or bleeding causing microcytic or ferropenic anemia micro.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">Although no controlled trials evaluating the efficacy of dietary modification in the treatment of gastroparesis exist, and the clinical benefits are modest, some dietary recommendations may be useful in patients with milder forms of the disease.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall">Nutritional intervention is based on dietary measures to encourage gastric emptying such as correct mastication, eliminating alcohol because it slows gastric emptying, fractionating a diet characterized by low but frequent volumes of food (5–6 meals a day), which may be low-fat and low in fiber to prevent bezoar formation. The soft consistency food or liquid is better tolerated. Fluid intake during a meal may promote gastric emptying. Orthostatic position or simply walking after eating in addition to other measures may facilitate gastric emptying. Nutritional therapy should be tailored to the severity of the disease. When weight loss occurs, the patient should be evaluated for the use of oral supplementation with enteral diets (complete diets in liquid form which need not be masticated or require stomach emptying). In later stages, when the stomach cannot empty liquids, enteral nutrition via a jejunostomy tube may be required, but parenteral nutrition while should be restricted to patients with severe gastric dysmotility of the small intenstine.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,15</span></a></p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Bowel Involvement</span><p id="par0085" class="elsevierStylePara elsevierViewall">SS may affect both the small and large intestine, including the rectum and anus.</p><p id="par0090" class="elsevierStylePara elsevierViewall">In the small intestine, dysmotility involves the immobilization of intraluminal contents, which promotes bacterial growth and consequent diarrhea.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,4</span></a> Pharmacological treatment with antacids also can support and/or aggravate bacterial<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> overgrowth. All this contributes to impaired absorption of nutrients, causing malabsorption, which together with pseudoobstructions may lead to severe malnutrition.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–4,7</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Complications including the colon are: luminal dilatation or pneumatosis, pseudo-obstruction, constipation, diarrhea, fecal incontinence and bleeding, often hidden by telangiectasia<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> bleeding.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">In patients with severe manifestations of the small intestine and loss of response to antibiotics, one must consider artificial nutrition. An alternative may be nocturnal enteral nutrition, although in most cases it is more convenient and acceptable for the patient to undergo a percutaneous<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> gastrostomy. The natural history of the disease may require parenteral<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> nutrition.<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">(1)</span><p id="par0105" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Constipation</span>: due to intestinal<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> dysmotility. In the early stages there appears to be effective constipation<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> that can be initially treated with laxatives and soluble dietary fiber, which can also help improve fecal incontinence. Avoidance of non-absorbable carbohydrates such as sorbitol or lactulose is recommended as they may worsen the symptoms of bloating and discomfort, also favoring bacterial overgrowth.</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">(2)</span><p id="par0110" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Diarrhea</span>: dietary advice in this case has a limited effect, with the main objective being the reduction of clinical symptoms such as postprandial discomfort, bloating and loss of weight.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The first step is to prescribe a diet low in fiber which may be easily digested and absorbed.</p></li></ul></p><p id="par0115" class="elsevierStylePara elsevierViewall">Restricting carbohydrates from the diet may reduce intestinal fermentation, as they are the main energy source of bacteria, and helps reduce symptoms.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> For this reason, the dietitian-nutritionist's diet should be tailored individually, based on progression, patient tolerance and habits.</p><p id="par0120" class="elsevierStylePara elsevierViewall">Sometimes lactose intolerance appears, forcing its removal from the diet plan. Some studies have detected the anomalous presence of Lactobacillus or other probiotics in the small intestine, so their usefulness is questionable in these patients.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> In any case, patients with advanced stages of the disease may be candidates for artificial nutrition.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Methods for Screening for Malnutrition</span><p id="par0125" class="elsevierStylePara elsevierViewall">To optimize resources and improve health care efficiency, questionnaires have been considered useful in clinical practice as a systematic way of screening to detect the involvement of different portions of the GIT. There are validated questionnaires developed by the CSRG<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>). To assess the risk of malnutrition,<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> the Malnutrition Universal Screening Test (MUST)<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> has already been used in this disease<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> and is considered a practical tool for use in outpatient settings (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Proposal for a Nutritional Intervention Protocol in Patients With Systemic Sclerosis</span><p id="par0130" class="elsevierStylePara elsevierViewall">The overall assessment of the nutritional status of patients with SS should include a survey on the food habits of the patient, ruling out any GI symptoms due to GI involvement (such as dysphagia, gastroparesis, nausea, vomiting, heartburn, rhythm disturbances…) through a validated questionnaire developed by the CSRG, and consider intercurrent disease.</p><p id="par0135" class="elsevierStylePara elsevierViewall">On physical examination one must determine the weight, height, body mass index, and a complete inspection of the oropharyngeal cavity (teeth, chewing ability and salivation, the presence of infection), assessing the condition of the skin and mucosa to rule out nutritional deficiencies and the existence of edema.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">One may assess the risk of malnutrition by MUST and consider the evaluation of laboratory parameters. The basic analytical determinations established by the U.S. expert panel include: blood count, hemoglobin, vitamin A, folic acid, ferritin, vitamin B<span class="elsevierStyleInf">12</span>.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In the absence of folic acid supplementation, the detection of elevated plasma levels of this component may suggest the presence of bacterial overgrowth in the intestine. Low levels of vitamin A may be indicative of the existence of intestinal malabsorption, for which determination of zinc, 25-OH vitamin D and vitamin K levels and prothrombin<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> time are recommended.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Although these patients generally have normal plasma albumin levels, and malnutrition is mostly caloric (marasmus), its determination in plasma may be useful for the diagnosis of mixed or protein-energy malnutrition (marasmus-kwashiorkor).</p><p id="par0150" class="elsevierStylePara elsevierViewall">Depending on the symptoms and test results, one must consider assessing the need for additional tests (endoscopy, radiology tests, breath test, etc.).<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,14</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">Dietary advice in writing should be provided and related to the pathology in question (<a class="elsevierStyleCrossRefs" href="#tbl0005">Tables 1–3</a>), and the need to refer the patient to the dietitian-nutritionist assessed, providing a food registry form to the patient (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0160" class="elsevierStylePara elsevierViewall">The involvement of multiple parts of the digestive tract and the development of highly personalized dietary recommendations are fundamental. In case the oral intake is insufficient with conventional foods, nutritional supplements are indicated orally.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> The indications for oral nutritional supplements and artificial nutrition do not differ from other chronic diseases.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,18</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Follow-up is done by weighing the patient, as it constitutes the best indicator of malnutrition,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and normalization of laboratory parameters in case of alterations.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conclusions</span><p id="par0170" class="elsevierStylePara elsevierViewall">Alterations of the GIT in patients with SS are very common. Throughout the entire gastrointestinal tract, manifestations are observed in relation to the concerned section. The common denominator of the GIT's condition is malnutrition. Malnutrition is associated with increased morbidity, mortality and reduced quality of life. Screening, detecting and early intervention by a multidisciplinary team, including nutritional intervention, are priorities in patients with SS.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflict of Interest</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres125776" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec113062" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres125775" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec113063" "titulo" => "Palabras clave" ] 4 => array:3 [ "identificador" => "sec0005" "titulo" => "Introduction" "secciones" => array:6 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Oropharyngeal Dysphagia" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Esophageal Dysphagia" ] 2 => array:2 [ "identificador" => "sec0020" "titulo" => "Gastroesophageal Reflux" ] 3 => array:2 [ "identificador" => "sec0025" "titulo" => "Esophageal Stricture" ] 4 => array:2 [ "identificador" => "sec0030" "titulo" => "Delayed Gastric Emptying or Gastroparesis" ] 5 => array:2 [ "identificador" => "sec0035" "titulo" => "Bowel Involvement" ] ] ] 5 => array:2 [ "identificador" => "sec0040" "titulo" => "Methods for Screening for Malnutrition" ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Proposal for a Nutritional Intervention Protocol in Patients With Systemic Sclerosis" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusions" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflict of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2011-06-16" "fechaAceptado" => "2011-09-09" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec113062" "palabras" => array:6 [ 0 => "Systemic sclerosis" 1 => "Nutrition" 2 => "Diet" 3 => "Malnutrition" 4 => "Gastrointestinal system" 5 => "Therapeutic approach" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec113063" "palabras" => array:7 [ 0 => "Esclerosis sistémica" 1 => "Nutrición" 2 => "Dietista" 3 => "Desnutrición" 4 => "Tracto gastrointestinal" 5 => "Abordaje terapéutico" 6 => "Malnutrición" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Systemic sclerosis is a connective tissue disease characterized by inflammation and fibrosis of multiple organs (skin, gastrointestinal tract, lung, kidney and heart). After the skin, the organ most affected with a frequency of 75%–90%, the gastrointestinal tract is more often involved.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Gastrointestinal tract involvement is manifested by the appearance of oropharyngeal dysphagia, esophageal dysphagia, gastroesophageal reflux, gastroparesis, pseudo-obstruction, bacterial overgrowth and intestinal malabsorption, constipation, diarrhea and/or fecal incontinence. These effects influence food intake and intestinal absorption leading to the gradual emergence of nutritional deficiencies. About 30% of patients with systemic sclerosis are at risk of malnutrition. In 5%–10%, gastrointestinal disorders are the leading cause of death.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Therapeutic strategies currently available are limited and aimed at reducing clinical symptoms. The multidisciplinary management of these patients, including nutritional intervention, helps improve gastrointestinal symptoms, and avoid malnutrition, morbidity and improve quality of life.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La esclerosis sistémica es una enfermedad del tejido conectivo caracterizada por inflamación y fibrosis de múltiples órganos (piel, aparato digestivo, pulmón, riñón y corazón). Después de la piel, el órgano más afectado, con una frecuencia del 75 al 90%, es el tracto gastrointestinal.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La afectación del tracto gastrointestinal se manifiesta por la aparición de disfagia orofaríngea, disfagia esofágica, reflujo gastroesofágico, gastroparesia, seudoobstrucción, sobrecrecimiento bacteriano y malabsorción intestinal, estreñimiento, diarrea y/o incontinencia fecal. Estas afectaciones condicionan la ingesta alimentaria y la absorción intestinal y conducen a la aparición progresiva de deficiencias nutricionales. Alrededor de un 30% de los pacientes con esclerosis sistémica presentan un riesgo de malnutrición. En el 5-10%, los trastornos gastrointestinales son la principal causa de muerte.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Las estrategias terapéuticas existentes en la actualidad son limitadas y están dirigidas a reducir la sintomatología clínica. El manejo multidisciplinar de dichos pacientes, que incluya la intervención nutricional, contribuye a mejorar la sintomatología gastrointestinal, además de evitar la malnutrición, la morbilidad y aumentar la calidad de vida.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">Please, cite this article as: Recasens MA, et al. Nutrición en la esclerosis sistémica. Reumatol Clin. 2012;<span class="elsevierStyleBold">8</span>:135–40.</p>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1519 "Ancho" => 2334 "Tamanyo" => 215257 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Adapted Malnutrition Universal Screening Test (MUST).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2085 "Ancho" => 2972 "Tamanyo" => 194207 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Food Registry Sheet.</p>" ] ] 2 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Eat and chew slowly</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Eat small amounts of food and often (5–6 meals a day)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">To facilitate swallowing it is recommended that food to be consumed slightly cold</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Drink water or other liquids between bites to aid swallowing</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Carry a water bottle and drink in small sips of water throughout the day (6–8 glasses of water a day total) to ensure all bodily functions as well as production and quality of saliva</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">The consumption of sugar-free gum may help in some cases to stimulate the production of saliva and prevention of dental cavities</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Soften food with oil, butter, margarine or sauces, especially meat and vegetables</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Moisten dry foods like bread or crackers in liquid</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Get the desired consistency by adding water, milk or broth or thickeners (cornstarch, flour, commercial infant cereal or prepared specific)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Recommended foods</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Milk, yogurt, puddings, custards, cream, cheese \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ice creams, sorbets, puddings, mousses, soufflés… \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gelatin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Food with soft texture or can be crushed, pureed vegetables, pureed vegetables, omelets, scrambled eggs, fruit compote \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Foods to avoid</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sticky foods such as boiled rice, sliced bread, mashed potatoes, banana… \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Foods such as grilled meat, artichokes, asparagus… \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dry foods such as nuts, toast, potato “chip”, cookies… \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fish with bones and meat with small bones (rabbit) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab212248.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Dietary Recommendations in Case of Swallowing Problems.</p>" ] ] 3 => array:7 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Drink plenty of fluids (6–8 glasses a day)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Make small volume but frequent meals (5–6 a day)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Eat and chew slowly</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Eat soft consistency or pureed foods</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Avoid extremes</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Avoid fat (butter, cream…)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Use simple cooking (grilled, baked, steamed, boiled)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Sit for 1–2<span class="elsevierStyleHsp" style=""></span>h after meals, because gravity will aid peristalsis</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Elevate the head of the bed and eat 2–3<span class="elsevierStyleHsp" style=""></span>hours before bedtime</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Avoid the following food</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alcohol \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Carbonated beverages: glusoft drinks, cola… \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Chocolate and derivatives \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Caffeine (coffee, tea) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Wine, vinegar \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Spices (pepper, mustard, cloves, oregano…) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Citrus fruits (orange, tangerine, lemon, grapefruit…) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fermented cheeses (Manchego, Cabrales, Roquefort…) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Whole grains bread, brown rice, whole wheat pasta, whole grains, bran… \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Garlic and onion \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>According to tolerance: cucumber, peppers and melons \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab212247.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Dietary Recommendations in Cases of Gastroesophageal Reflux.</p>" ] ] 4 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Liquid foods are easier to swallow than solids. Virtually any food or food can be liquefied. Grind or blend all possible foods to get a semi-solid or soft texture, adding any liquid or food support such as: cereal with milk, beef broth, vegetable broth with rice or vegetables, milk or water with fruit, cake and ice cream or sorbet … smoothie crushed texture should be smooth</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Chew food thoroughly</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Drink fluids to stay well hydrated (6–8 glasses a day)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Avoid dry foods like toast or biscuits, cookies, French fries or “chips”, snacks, nuts…</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Avoid sticky foods like textured white bread, dried fruit, mashed potatoes, soft candy…</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Avoid foods high in fiber or chips (bread, artichokes, asparagus…)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Avoid spicy foods spice and vinegar, and do not eat salty foods</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">Recommended semisolid food</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Porridge \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>“Baby jars” or commercial purees \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Meals baked egg souffle type \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cakes vegetables, meat or fish \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pudding, mousse, jello, pudding, custard, ice cream, sorbet \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fruit Compote \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab212246.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Dietary Recommendations in Cases of Esophageal Stenosis.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "<span class="elsevierStyleItalic">Source</span>: Baron et al.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. I have (or had) a lack of appetite almost every day \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2. I have (or had) difficulty swallowing; food or liquid sometimes sticks in my chest when I swallow \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3. I have (or had) food or a sour taste returning to my nose and mouth \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4. I wake up (or have done so) with a breathless sensation at night \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5. I have (or had) a burning sensation in my stomach or lower chest that ascends to my throat almost every day \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6. I have (or had) a sensation of fullness shortly after starting to eat on most days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7. I have (or had) visible abdominal swelling or the sensation of abdominal swelling (making me loosen my clothes) almost every day \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8. I have (or had) nausea and/or vomiting almost every day \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9. I have (or had) constipation almost every day \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10. I have (or had) diarrhea almost every day \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11. I need (or have needed) antibiotics to control diarrhea \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12. I have (or had) greasy, foul smelling stools \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13. I have (or had) fecal incontinence (soiling my clothing) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14. I need (or have needed) intravenous feeding \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab212249.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Questionnaire Used by the Canadian Scleroderma Agency Research Group.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:18 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esclerosis sistémica y tracto gastrointestinal. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 15 | 19 | 34 |
2024 October | 132 | 80 | 212 |
2024 September | 285 | 54 | 339 |
2024 August | 163 | 81 | 244 |
2024 July | 144 | 51 | 195 |
2024 June | 160 | 68 | 228 |
2024 May | 186 | 50 | 236 |
2024 April | 152 | 55 | 207 |
2024 March | 176 | 48 | 224 |
2024 February | 145 | 32 | 177 |
2024 January | 151 | 33 | 184 |
2023 December | 183 | 24 | 207 |
2023 November | 173 | 45 | 218 |
2023 October | 190 | 47 | 237 |
2023 September | 170 | 51 | 221 |
2023 August | 174 | 36 | 210 |
2023 July | 76 | 34 | 110 |
2023 June | 100 | 53 | 153 |
2023 May | 99 | 84 | 183 |
2023 April | 92 | 20 | 112 |
2023 March | 149 | 65 | 214 |
2023 February | 108 | 52 | 160 |
2023 January | 127 | 46 | 173 |
2022 December | 119 | 36 | 155 |
2022 November | 127 | 39 | 166 |
2022 October | 123 | 45 | 168 |
2022 September | 109 | 48 | 157 |
2022 August | 108 | 65 | 173 |
2022 July | 107 | 55 | 162 |
2022 June | 102 | 34 | 136 |
2022 May | 151 | 76 | 227 |
2022 April | 139 | 104 | 243 |
2022 March | 178 | 88 | 266 |
2022 February | 207 | 55 | 262 |
2022 January | 173 | 55 | 228 |
2021 December | 116 | 67 | 183 |
2021 November | 125 | 73 | 198 |
2021 October | 143 | 76 | 219 |
2021 September | 114 | 75 | 189 |
2021 August | 97 | 62 | 159 |
2021 July | 85 | 46 | 131 |
2021 June | 91 | 62 | 153 |
2021 May | 126 | 87 | 213 |
2021 April | 288 | 162 | 450 |
2021 March | 135 | 59 | 194 |
2021 February | 94 | 42 | 136 |
2021 January | 116 | 44 | 160 |
2020 December | 78 | 40 | 118 |
2020 November | 76 | 39 | 115 |
2020 October | 90 | 25 | 115 |
2020 September | 113 | 44 | 157 |
2020 August | 109 | 39 | 148 |
2020 July | 220 | 39 | 259 |
2020 June | 95 | 32 | 127 |
2020 May | 162 | 33 | 195 |
2020 April | 69 | 34 | 103 |
2020 March | 33 | 10 | 43 |
2020 February | 2 | 0 | 2 |
2020 January | 4 | 0 | 4 |
2019 September | 6 | 0 | 6 |
2019 June | 2 | 0 | 2 |
2019 March | 2 | 0 | 2 |
2019 January | 1 | 0 | 1 |
2018 December | 2 | 0 | 2 |
2018 May | 7 | 1 | 8 |
2018 April | 124 | 17 | 141 |
2018 March | 159 | 25 | 184 |
2018 February | 83 | 14 | 97 |
2018 January | 73 | 8 | 81 |
2017 December | 87 | 13 | 100 |
2017 November | 71 | 19 | 90 |
2017 October | 78 | 9 | 87 |
2017 September | 72 | 12 | 84 |
2017 August | 86 | 7 | 93 |
2017 July | 101 | 9 | 110 |
2017 June | 114 | 17 | 131 |
2017 May | 105 | 17 | 122 |
2017 April | 127 | 15 | 142 |
2017 March | 141 | 16 | 157 |
2017 February | 79 | 9 | 88 |
2017 January | 95 | 7 | 102 |
2016 December | 140 | 24 | 164 |
2016 November | 136 | 17 | 153 |
2016 October | 223 | 13 | 236 |
2016 September | 263 | 28 | 291 |
2016 August | 230 | 12 | 242 |
2016 July | 71 | 15 | 86 |
2015 December | 2 | 0 | 2 |
2015 September | 1 | 0 | 1 |
2015 August | 4 | 0 | 4 |
2015 July | 98 | 7 | 105 |
2015 June | 166 | 27 | 193 |
2015 May | 187 | 43 | 230 |
2015 April | 172 | 20 | 192 |
2015 March | 239 | 25 | 264 |
2015 February | 202 | 5 | 207 |
2015 January | 154 | 14 | 168 |
2014 December | 151 | 11 | 162 |
2014 November | 120 | 22 | 142 |
2014 October | 154 | 21 | 175 |
2014 September | 105 | 20 | 125 |
2014 August | 116 | 14 | 130 |
2014 July | 135 | 21 | 156 |
2014 June | 133 | 24 | 157 |
2014 May | 125 | 20 | 145 |
2014 April | 120 | 16 | 136 |
2014 March | 120 | 23 | 143 |
2014 February | 124 | 29 | 153 |
2014 January | 146 | 32 | 178 |
2013 December | 94 | 30 | 124 |
2013 November | 122 | 31 | 153 |
2013 October | 90 | 28 | 118 |
2013 September | 98 | 32 | 130 |
2013 August | 91 | 28 | 119 |
2013 July | 104 | 34 | 138 |
2013 June | 81 | 37 | 118 |
2013 May | 89 | 52 | 141 |
2013 April | 88 | 54 | 142 |
2013 March | 82 | 45 | 127 |
2013 February | 84 | 31 | 115 |
2013 January | 68 | 37 | 105 |
2012 December | 77 | 42 | 119 |
2012 November | 68 | 33 | 101 |
2012 October | 66 | 44 | 110 |
2012 September | 25 | 5 | 30 |
2012 July | 7 | 0 | 7 |
2012 June | 14 | 0 | 14 |